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Targeting the innate immune response with improved vaccine adjuvants
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Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Immunobiology of Dendritic Cells
Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y.-J., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,634
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,193
Approaching the Asymptote? Evolution and Revolution in Immunology
Janeway, C. A. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,252
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,522
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection
Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne, A., Thomas, G., Philpott, D. J., & Sansonetti, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200651200 · Cited by 2,408
Mouse and human dendritic cell subtypes
Shortman, K., & Liu, Y.-J. (2002) · Nature Reviews Immunology · doi:10.1038/nri746 · Cited by 2,291
Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
Pasare, C., & Medzhitov, R. (2003) · Science · doi:10.1126/science.1078231 · Cited by 1,997
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364
Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
Martín-Fontecha, A., Thomsen, L. L., Brett, S., Gerard, C., Lipp, M., Lanzavecchia, A., & Sallusto, F. (2004) · Nature Immunology · doi:10.1038/ni1138 · Cited by 1,353
Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., et al. (2003) · Nature Immunology · doi:10.1038/ni945 · Cited by 1,323
Gordon, S. (2002) · Cell · doi:10.1016/s0092-8674(02)01201-1 · Cited by 1,155
The interface between innate and adaptive immunity
Hoebe, K., Janssen, E., & Beutler, B. (2004) · Nature Immunology · doi:10.1038/ni1004-971 · Cited by 916
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
Jurk, M., Heil, F., Vollmer, J., Schetter, C., Krieg, A. M., Wagner, H., Lipford, G., & Bauer, S. (2002) · Nature Immunology · doi:10.1038/ni0602-499 · Cited by 838
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
Lien, E., Means, T. K., Heine, H., Yoshimura, A., Kusumoto, S., Fukase, K., Fenton, M. J., Oikawa, M., Qureshi, N., Monks, B., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8541 · Cited by 727
PI3K and negative regulation of TLR signaling
Fukao, T., & Koyasu, S. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00139-x · Cited by 612
Adjuvants for human vaccines—current status, problems and future prospects
Gupta, R. K., & Siber, G. R. (1995) · Vaccine · doi:10.1016/0264-410x(95)00011-o · Cited by 551
Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner
Rutz, M., Metzger, J., Gellert, T., Luppa, P., Lipford, G. B., Wagner, H., & Bauer, S. (2004) · European Journal of Immunology · doi:10.1002/eji.200425218 · Cited by 503
Aluminium compounds for use in vaccines
Lindblad, E. B. (2004) · Immunology & Cell Biology · doi:10.1111/j.0818-9641.2004.01286.x · Cited by 488
Dillon, S., Agrawal, A., Van Dyke, T., Landreth, G., McCauley, L., Koh, A., Maliszewski, C., Akira, S., & Pulendran, B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4733 · Cited by 460
Recent advances in the discovery and delivery of vaccine adjuvants
O'Hagan, D. T., & Valiante, N. M. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1176 · Cited by 434
Self-citationToll-Dependent Control Mechanisms of CD4 T Cell Activation
Pasare, C., & Medzhitov, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.006 · Cited by 386
Antiviral and antitumor peptides from insects
Chernysh, S., Kim, S. I., Bekker, G., Pleskach, V. A., Filatova, N. A., Anikin, V. B., Platonov, V. G., & Bulet, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192301899 · Cited by 375
Aluminium adjuvants—in retrospect and prospect
Lindblad, E. B. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.03.032 · Cited by 362
Sato, M., Sano, H., Iwaki, D., Kudo, K., Konishi, M., Takahashi, H., Takahashi, T., Imaizumi, H., Asai, Y., & Kuroki, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.417 · Cited by 348
Modulating vaccine responses with dendritic cells and Toll‐like receptors
Pulendran, B. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00144.x · Cited by 325
Toll-Like Receptors and Their Ligands
Barton, G. M., & Medzhitov, R. (2002) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-59430-4_5 · Cited by 301
Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine
Cooper, C., Davis, H. L., Morris, M. L., Efler, S. M., KRIEG, A. M., Li, Y., Laframboise, C., Adhami, M. J. A., Khaliq, Y., Seguin, I., et al. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.058 · Cited by 245
Generation and maintenance of immunological memory
Gourley, T. S., Wherry, E. J., Masopust, D., & Ahmed, R. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.08.013 · Cited by 231
Vaccines in historic evolution and perspective: a narrative of vaccine discoveries
Hilleman, M. R. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00434-x · Cited by 227
Toll-like receptors and T-helper-1/T-helper-2 responses
Dabbagh, K., & Lewis, D. B. (2003) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200306000-00003 · Cited by 200
Role of adapters in Toll-like receptor signalling
Akira, S., Yamamoto, M., & Takeda, K. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310637 · Cited by 188
(2004) · CRC Press eBooks · doi:10.1201/9781439834404 · Cited by 181
Asai, Y., Ohyama, Y., Gen, K., & Ogawa, T. (2001) · Infection and Immunity · doi:10.1128/iai.69.12.7387-7395.2001 · Cited by 175
Mason, K. A., Ariga, H., Neal, R. E., Valdecanas, D. R., Hunter, N. R., Krieg, A. Μ., Whisnant, J. K., & Milas, L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.361.11.1 · Cited by 153
Bone Marrow‐Derived Dendritic Cells Serve as Potent Adjuvants for Peptide‐Based Antitumor Vaccines
Mayordomo, J. I., Zorina, T. D., Storkus, W. J., Zitvogel, L., García-Prats, M. D., DeLeo, A. B., & Lotze, M. T. (1997) · Stem Cells · doi:10.1002/stem.150094 · Cited by 135
Roberts, T. L., Sweet, M. J., Hume, D. A., & Stacey, K. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.605 · Cited by 131
Vaccine adjuvants : preparation methods and research protocols
O’Hagan, D. T. (2000) · Humana Press eBooks · Cited by 124
Technological Advances in High-Throughput Screening
Liu, B., Li, S., & Hu, J. (2004) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200404040-00006 · Cited by 120
Nakao, Y., Funami, K., Kikkawa, S., Taniguchi, M., Nishiguchi, M., Fukumori, Y., Seya, T., & Matsumoto, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1566 · Cited by 115
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling
Sandor, F., Latz, E., Re, F., Mandell, L., Repik, G., Golenbock, D. T., Espevik, T., Kurt‐Jones, E. A., & Finberg, R. W. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200304093 · Cited by 114
Ogawa, T., Asai, Y., Hashimoto, M., & Uchida, H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200209)32:9<2543::aid-immu2543>3.0.co;2-2 · Cited by 94
IL‐12‐Engineered Dendritic Cells Serve as Effective Tumor Vaccine Adjuvants in Vivoa
Zitvogel, L., Couderc, B. C., Mayordomo, J. I., Robbins, P. D., Lotze, M. T., & Storkus, W. J. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb52678.x · Cited by 87
4th Meeting on novel adjuvants currently in/close to human clinical testing
Pink, J. R., & Kiény, M.-P. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.021 · Cited by 51
2nd meeting on novel adjuvants currently in/close to human clinical testing
Kenney, R. T., Rabinovich, N. R., Pichyangkul, S., Price, V. L., & Engers, H. D. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00091-9 · Cited by 44
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Klebanoff, C. A., Acquavella, N., Yu, Z., & Restifo, N. P. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00979.x · Cited by 271
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Miyaji, E. N., Carvalho, E., Oliveira, M. L. S., Raw, I., & Ho, P. L. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011007500064 · Cited by 66
Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review
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Metadata
- Authors
- Pashine, A., Valiante, N. M., & Ulmer, J. B.
- Venue
- Nature Medicine
- Published
- 2005-04
- Volume
- 11
- Issue
- S4
- Pages
- S63-S68
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2135674359
- Cited by
- 555
- References
- 46
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- closed
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