A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Kuba, Keiji, Imai, Yumiko, Rao, Shuan, Gao, Hong, Guo, Feng, Guan, Bin, Huan, Yi, Yang, Peng, Zhang, Yanli, Deng, Wei, Bao, Linlin, Zhang, Binlin, Liu, Guang, Wang, Zhong, Chappell, Mark, Liu, Yanxin, Zheng, Dexian, Leibbrandt, Andreas, Wada, Teiji, Slutsky, Arthur S, Liu, Depei, Qin, Chuan, Jiang, Chengyu, Penninger, Josef M·2005·Nature Medicine

DOI 10.1038/nm1267

Cited by (1,007)

Items 501–600 of 1,007

Is nicotine exposure linked to cardiopulmonary vulnerability to COVID‐19 in the general population?
James L. Olds, Nadine Kabbani · 2020 · FEBS Journal
Drug Discovery Strategies for SARS-CoV-2
Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen, Wei Zheng · 2020 · Journal of Pharmacology and Experimental Therapeutics
COVID-19 and diabetes mellitus: how one pandemic worsens the other
William S. Azar, Rachel Njeim, Angie H Fares, Nadim S. Azar, Sami T. Azar, Mazen J. El Sayed, Assaad Antoine Eid · 2020 · Reviews in Endocrine and Metabolic Disorders
DPP4 and ACE2 in Diabetes and COVID-19: Therapeutic Targets for Cardiovascular Complications?
Inés Valencia, Concepción Peiró, Óscar Lorenzo, Carlos F. Sánchez‐Ferrer, Jürgen Eckel, Tania Romacho · 2020 · Frontiers in Pharmacology
Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study
Dennis Freuer, Jakob Linseisen, Christa Meisinger · 2021 · Metabolism
Current Status of COVID-19 Therapies and Drug Repositioning Applications
Altay, Ozlem, Mohammadi, Elyas, Lam, Simon, Turkez, Hasan, Boren, Jan, Nielsen, Jens, Uhlen, Mathias, Mardinoglu, Adil · 2020 · iScience
Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill
Laurent Bitker, Louise M. Burrell · 2019 · Critical Care Clinics
Cerebral venous thrombosis: Atypical presentation of COVID-19 in the young
David E. Klein, Richard Libman, Claudia Kirsch, Rohan Arora · 2020 · Journal of Stroke and Cerebrovascular Diseases
Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation
Steven Andrew Baker, Shirley Kwok, Gerald J. Berry, Thomas Jude Montine · 2021 · PLoS ONE
Thoughts on the alveolar phase of COVID-19
Robert J. Mason · 2020 · American Journal of Physiology-Lung Cellular and Molecular Physiology
Reflections on treatment of COVID-19 with traditional Chinese medicine
Hua Luo, Yan Gao, Jian Peng Zou, Siyuan Zhang, Hanbin Chen, Qiao Liu, Dechao Tan, Yan Han, Yonghua Zhao, Shengpeng Wang · 2020 · Chinese Medicine
Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
Enrique Rodilla, Alberto Saura, Iratxe Jiménez, Andrea Mendizábal, Araceli Pineda Cantero, Elizabeth Lorenzo-Hernández, Maria Del Pilar Fidalgo-Montero, Joaquín Fernández López-Cuervo, Ricardo Gil Sánchez, Elisa Rabadán Pejenaute et al. · 2020 · Journal of Clinical Medicine
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection
Vanessa Monteil, Matheus Dyczynski, Volker Martin Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia C. Youhanna, Haibo Zhang, Arthur S. Slutsky, Carmen Hurtado del Pozo, Moritz Horn et al. · 2020 · EMBO Molecular Medicine
Thyroid Function Abnormalities in COVID-19 Patients
Weibin Wang, Xingyun Su, Yongfeng Ding, Weina Fan, Weibin Zhou, Junwei Su, Zhendong Chen, Hong Zhao, Kaijin Xu, Qin Ni et al. · 2021 · Frontiers in Endocrinology
Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors
Artur Szczepański, Katarzyna Owczarek, Monika Bzowska, Katarzyna Gula, Inga Drebot, Marek Ochman, Beata Maksym, Zenon Rajfur, Judy A. Mitchell, Krzysztof Pyrć · 2019 · Viruses
COVID-19 and RAS: Unravelling an Unclear Relationship
Damiano D’Ardes, Andrea Boccatonda, Ilaria Rossi, Maria Teresa Guagnano, Francesca Santilli, Francesco Cipollone, Marco Bucci · 2020 · International Journal of Molecular Sciences
Use of RAAS Inhibitors and Risk of Clinical Deterioration in COVID-19: Results From an Italian Cohort of 133 Hypertensives
Carla Felice, Chiara Nardin, Gian Luca Di Tanna, Ugo Grossi, Enrico Bernardi, Luca Scaldaferri, Micaela Romagnoli, Luca Tonon, Paola Cavasin, Simone Novello et al. · 2020 · American Journal of Hypertension
Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions
Ilja L. Kruglikov, Manasi Shah, Philipp E. Scherer · 2020 · eLife
A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids
Jan A Wysocki, Minghao Ye, Luise Hassler, Ashwani Gupta, Yuguo Wang, Vlad Nicoleascu, Glenn C. Randall, Jason A. Wertheim, DANIEL C. BATLLE · 2021 · Journal of the American Society of Nephrology
COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality
Radheshyam Maurya, Prince Sebastian, Madhulika Namdeo, Moodu Devender, Arieh Gertler · 2021 · Frontiers in Immunology
Type 1 angiotensin receptor pharmacology: Signaling beyond G proteins
Cristina Oro, Hongwei Qian, Walter G. Thomas · 2006 · Pharmacology & Therapeutics
COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice
Cathleen M. Lutz, Leigh A. Maher, Charles Lee, Wonyoung Kang · 2020 · Human Genomics
In search of preventative strategies: novel high-CBD cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues
Bo Wang, Anna V. KOVALCHUK, Dongping Li, Rocio Rodriguez‐Juarez, Yaroslav Ilnytskyy, Igor Kovalchuk, Olga Kovalchuk · 2020 · Aging
Does infection of 2019 novel coronavirus cause acute and/or chronic sialadenitis?
Chenxing Wang, Heming Wu, Xu Ding, Huan Ji, Pengfei Jiao, Haiyang Song, Sheng Li, Hongming Du · 2020 · Medical Hypotheses
Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2
Marina Borro, Paolo Di Girolamo, Giovanna Gentile, Ottavia De Luca, Robert Preißner, Adriano Marcolongo, Stefano Ferracuti, Maurizio Simmaco · 2020 · International Journal of Environmental Research and Public Health
Expression of ACE2 in airways: Implication for COVID‐19 risk and disease management in patients with chronic inflammatory respiratory diseases
Yin Yao, Hai Wang, Zheng Liu · 2020 · Clinical & Experimental Allergy
Ibuprofen and NSAID Use in COVID-19 Infected Patients Is Not Associated with Worse Outcomes: A Prospective Cohort Study
Laila Carolina Abu Esba, Rahaf Ali Alqahtani, Abin Thomas, Nour Shamas, Lolowa Alswaidan, Gahdah Mardawi · 2020 · Infectious Diseases and Therapy
Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection
Liang Guo, Wenwen Bi, Xinling Wang, Wei Xu, Renhong Yan, Yuanyuan Zhang, Kai Zhao, Yaning Li, Mingfeng Zhang, Xia Cai et al. · 2020 · Cell Research
Bibliometric analysis of global scientific research on Coronavirus (COVID-19)
Hojat Dehghanbanadaki, Farhad Seif, Yasmin Vahidi, Farideh Razi, Ehsan Hashemi, Majid Khoshmirsafa, Hossein Aazami · 2020 · Medical Journal of the Islamic Republic of Iran
Chemotactic antiviral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells
Verena A. Lütschg, Karin Boucke, Silvio Hemmi, Urs F. Greber · 2011 · Nature Communications
COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment
Ramin Tolouian, Sepideh Zununi Vahed, Shahram Ghiyasvand, Audrey C. Tolouian, Mohammadreza Ardalan · 2020 · Journal of Renal Injury Prevention
Acute respiratory distress syndrome: a life threatening associated complication of SARS-CoV-2 infection inducing COVID-19
Riadh Badraoui, Mousa M. Alrashedi, Michèle Véronique Elmay, Fevzi Bardakçi · 2020 · Journal of Biomolecular Structure and Dynamics
Endothelial Cells in Emerging Viral Infections
Johanna Hol Fosse, Guttorm Haraldsen, Knut Falk, Reidunn Jetne Edelmann · 2021 · Frontiers in Cardiovascular Medicine
Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study
Halil İbrahim Güler, Gizem Tatar, Oktay Yıldız, Ali Osman Beldüz, Sevgi Kolaylı · 2021 · Archives of Microbiology
Recent Developments in Anti-Severe Acute Respiratory Syndrome Coronavirus Chemotherapy
Dale L. Barnard, Yohichi Kumaki · 2011 · Future Virology
COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness
Fenghe Du, Bao Liu, Shuyang Zhang · 2020 · Journal of Thrombosis and Thrombolysis
Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective
Choong-Ho Lee, Won Jun Choi · 2021 · Archives of Pharmacal Research
Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19
Matthew A. Sparks, Andrew Michael South, Paul A. Welling, James Matthew Luther, Jordana B. Cohen, James Brian Byrd, Louise M. Burrell, DANIEL C. BATLLE, Laurie A. Tomlinson, Vivek Bhalla et al. · 2020 · Clinical Journal of the American Society of Nephrology
At the heart of COVID‐19
Inayat Hussain Khan, Syeda Anum Zahra, Sevim Zaim, Amer Harky · 2020 · Journal of Cardiac Surgery
Natural products as home‐based prophylactic and symptom management agents in the setting of COVID ‐19
Thota Sai Manohar, Venkatesh Balan, Venketesh Sivaramakrishnan · 2020 · Phytotherapy Research
Association of Angiotensin‐Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With the Risk of Hospitalization and Death in Hypertensive Patients With COVID‐19
Rohan Khera, Callahan N. Clark, Yuan Lu, Yinglong Guo, Sheng Ren, Brandon Truax, Erica Sarah Spatz, Karthik Murugiah, Zhenqiu Lin, Saad B. Omer et al. · 2021 · Journal of the American Heart Association
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV
Shuren Li, Zi-jian Tang, Zai-han Li, Xuan Eric Liu · 2020 · European Journal of Clinical Microbiology & Infectious Diseases
Potential neurological impact of coronaviruses: implications for the novel SARS-CoV-2
Joy D. Iroegbu, Chibuzor W. Ifenatuoha, Omamuyovwi Meashack Ijomone · 2020 · Neurological Sciences
Severe Acute Respiratory Syndrome Coronavirus 2 Impact on the Central Nervous System: Are Astrocytes and Microglia Main Players or Merely Bystanders?
Verónica Murta, Alejandro Villarreal, Alberto Javier Ramos · 2020 · ASN NEURO
Glycyrrhizin: An old weapon against a novel coronavirus
Julian Chrzanowski, Alicja Chrzanowska, Wojciech Graboń · 2020 · Phytotherapy Research
Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus
Masaya Fukushi, Yoshiyuki Yoshinaka, Yusuke Matsuoka, Seisuke Hatakeyama, Yukihito Ishizaka, Teruo Kirikae, Takehiko Sasazuki, Tohru Miyoshi‐Akiyama · 2012 · Journal of Virology
Integrating microRNAs into a system biology approach to acute lung injury
Tong Zhou, Joe G. N. Garcia, Wei Zhang · 2011 · Translational research
Distinct Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury Pathways in Two Different Nonhuman Primate Species
Saskia L. Smits, Judith M. A. van den Brand, Anna de Lang, Lonneke M. E. Leijten, Wilfred F. J. van IJcken, Geert van Amerongen, Albert D. M. E. Osterhaus, Arno C. Andeweg, Bart L. Haagmans · 2011 · Journal of Virology
SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis
M. Victoria Delpino, Jorge Fabián Quarleri · 2020 · Frontiers in Cellular and Infection Microbiology
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection
Nazzarena Labò, Hidetaka Ohnuki, Giovanna Tosato · 2020 · Cells
Remdesivir Strongly Binds to Both RNA-Dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations
Hoang Linh Nguyen, Nguyen Quoc Thai, Duc Toan Truong, Mai Suan Li · 2020 · The Journal of Physical Chemistry B
Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19
Ana Isabel Rodriguez-Perez, Carmen M. Labandeira, María A. Pedrosa, Rita Valenzuela, Juan Antonio Suárez-Quintanilla, María Cortes-Ayaso, Plácido Mayán Conesa, José Luis Labandeira-García · 2021 · Journal of Autoimmunity
The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
Damien A. Leach, Andrea Mohr, Efstathios S. Giotis, Emine Cil, A. M. Isac, Laura L. Yates, William Barclay, Ralf Michael Zwacka, Charlotte Lynne Bevan, Greg Nicholas Brooke · 2021 · Nature Communications
Clinical and imaging features of COVID-19
Hạixia Chen, Li Ai, Hong Zhou Lu, Hongjun Li · 2020 · Radiology of Infectious Diseases
Update on neurological manifestations of COVID-19
Hanie Yavarpour‐Bali, Maryam Ghasemi‐Kasman · 2020 · Life Sciences
Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW
Shichao Zheng, Jan P. A. Baak, Shuang Li, Wenke Xiao, Hong Gang Ren, Huan Yang, Yanxiong Gan, Chuanbiao Wen · 2020 · Phytomedicine
Is there a role for the ACE2 receptor in SARS‐CoV‐2 interactions with platelets?
Robert A. Campbell, Éric Boilard, Matthew Thomas Rondina · 2020 · Journal of Thrombosis and Haemostasis
Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens
Francesca Bravi, Maria Elena Flacco, Tiziano Carradori, Carlo Alberto Volta, Giuseppe Cosenza, Aldo De Togni, Cecilia Acuti Martellucci, Giustino Parruti, Lorenzo Giovanni Mantovani, Lamberto Manzoli · 2020 · PLoS ONE
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission
Daniella Sabino Battagello, Guilherme Dragunas, Marianne Klein, Ana Luísa P. Ayub, Fernando Janczur Velloso, Ricardo G. Correa · 2020 · Clinical Science
Immunology, immunopathogenesis and immunotherapeutics of COVID-19; an overview
Leila Mohamed Khosroshahi, Mohsen Rokni, Tahmineh Mokhtari, Farshid Noorbakhsh · 2021 · International Immunopharmacology
The Fatty Acid Lipid Metabolism Nexus in COVID-19
Jerome E. Tanner, Caroline Alfieri · 2021 · Viruses
Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral Infections
Adivitiya, Manish Singh Kaushik, Soura Chakraborty, Shobi Veleri, Suneel Kateriya · 2021 · Biology
Neuroinflammation and Its Impact on the Pathogenesis of COVID-19
Mohammed M. Almutairi, Farzane Sivandzade, Thamer H. Albekairi, Faleh Alqahtani, Luca Cucullo · 2021 · Frontiers in Medicine
Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury
Sarzani, Riccardo, Giulietti, Federico, Di Pentima, Chiara, Giordano, Piero, Spannella, Francesco · 2020 · American Journal of Physiology-Lung Cellular and Molecular Physiology
Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung
Renda Soylemez Wiener, Yu Cao, Anne Hinds, María I. Ramirez, Mary C. Williams · 2007 · Journal of Cellular Biochemistry
Lower Incidence of COVID-19 at High Altitude: Facts and Confounders
Matiram Pun, Rachel Turner, Giacomo Strapazzon, Hermann Brugger, Erik Richard Swenson · 2020 · High Altitude Medicine & Biology
COVID-19: a review
Constantinos Papadopoulos, Sebastian Jen Kin Chong, Shameen Jaunoo · 2020 · IJS Short Reports
Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations
Pedro Antunes Pousa, Tamires Sara Campos Mendonça, Eduardo Araujo OLIVEIRA, Ana Cristina Simões e Silva · 2020 · Jornal de Pediatria
C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors
Nader Rahimi · 2020 · Biology
COVID-19 Associated Ischemic Stroke and Hemorrhagic Stroke: Incidence, Potential Pathological Mechanism, and Management
Zilan Wang, Yanbo Yang, Xiaolong Liang, Bixi Gao, Meirong Liu, Wen Li, Zhouqing Chen, Zhong Wang · 2020 · Frontiers in Neurology
Luteolin and abyssinone II as potential inhibitors of SARS-CoV-2: an in silico molecular modeling approach in battling the COVID-19 outbreak
Mohammad Mahfuz Ali Khan Shawan, Sajal Kumar Halder, Md. Ashraful Hasan · 2021 · Bulletin of the National Research Centre/Bulletin of the National Research Center
‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA
Peter I. Parry, Astrid Lefringhausen, Conny Turni, C. Neil, Robyn Cosford, Nicholas James Hudson, Julian Gillespie · 2023 · Biomedicines
Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection
Synat Keam, Dewi Megawati, Shailesh Kumar Patel, Ruchi Tiwari, Kuldeep Dhama, Harapan Harapan · 2020 · Reviews in Medical Virology
Diagnostic and Treatment Strategies for COVID-19
Humzah Jamshaid, Fatima Zahid, Intisar ud Din, Alam Zeb, Han Gon Choi, Gul Majid Khan, Fakhar ud Din · 2020 · AAPS PharmSciTech
Role of Drugs Used for Chronic Disease Management on Susceptibility and Severity of COVID‐19: A Large Case‐Control Study
Huadong Yan, Ana Maria Valdes, Amrita Vijay, Shanbo Wang, Lili Liang, Shiqing Yang, Hongxia Wang, Xiaoyan Tan, Jingyuan Du, Susu Jin et al. · 2020 · Clinical Pharmacology & Therapeutics
Impact of COVID-19 on the Cardiovascular System: A Review of Available Reports
Rema Sreenivasan Soumya, T. Govindan Unni, Kozhiparambil Gopalan Raghu · 2020 · Cardiovascular Drugs and Therapy
Compounds of Citrus medica and Zingiber officinale for COVID-19 inhibition: in silico evidence for cues from Ayurveda
Madathilkovilakath Haridas, Vijith Sasidhar, Prajeesh Nath, Abhithaj Jayanandan, A. Sabu, Rammanohar Puthiyedath · 2021 · Future Journal of Pharmaceutical Sciences
A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19
Johanna Reinold, Farnoush Farahpour, Christian Fehring, Sebastian Dolff, Margarethe Konik, Johannes Korth, Lukas van Baal, Daniel E. Hoffmann, Jan Buer, Oliver Witzke et al. · 2021 · Frontiers in Cellular and Infection Microbiology
Not just angiotensinases: new roles for the angiotensin-converting enzymes
D Lambert, Nicola E. Clarke, Anthony J. Turner · 2009 · Cellular and Molecular Life Sciences
Considerations around the SARS-CoV-2 Spike Protein with Particular Attention to COVID-19 Brain Infection and Neurological Symptoms
Kambiz Hassanzadeh, Helena Pérez‐Peña, Jessica Dragotto, Lucia Buccarello, Federico Iorio, Stefano Pieraccini, Giulio Sancini, Marco Feligioni · 2020 · ACS Chemical Neuroscience
Angiotensin-converting enzyme 2 and new insights into the renin–angiotensin system
D Lambert, Nigel M. Hooper, Anthony J. Turner · 2007 · Biochemical Pharmacology
Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network
Guilhem Solé, Emmanuelle Salort‐Campana, Yann Péréon, Tanya Stojkovic, Karim Wahbi, Pascal Cintas, D. Adams, Pascal Laforêt, V. Tiffreau, Isabelle Desguerre et al. · 2020 · Revue Neurologique
Renin-angiotensin-aldosterone system and COVID-19 infection
Joachim Alexandre, Jean‐Luc Cracowski, Vincent J. Richard, Béatrice Bouhanick · 2020 · Annales d Endocrinologie
Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies
Praveen Mathews Varghese, Anthony George Tsolaki, Hadida Yasmin, Abhishek Shastri, Janez Ferluga, Manu Vatish, Taruna Madan, Uday Kishore · 2020 · Immunobiology
SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin
Saeed Mehrzadi, Mohammad Yahya Karimi, Alireza Fatemi, Russel Joseph Reiter, Azam Hosseinzadeh · 2021 · Pharmacology & Therapeutics
The COVID-19 Vaccines: Recent Development, Challenges and Prospects
Yuxin Yan, Yoong Xin Pang, Zhuoyi Lyu, Ruiqi Wang, Xinyun Wu, Chong You, Haitao Zhao, Sivakumar Manickam, Edward Henry Lester, Tao Wu et al. · 2021 · Vaccines
Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice
Noriyo Nagata, Naoko Iwata, Hideki Hasegawa, Shuetsu Fukushi, Ayako Harashima, Yuko Sato, Masayuki Saijo, Fumihiro Taguchi, Shigeru Morikawa, Tetsutaro Sata · 2008 · American Journal Of Pathology
Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification
Yuan Li, Fuhao Chu, Ping Li, Nadia L. Johnson, Tao Li, Yan Wang, Rongxian An, WU Dan-tong, Jiena Chen, Zeqi Su et al. · 2021 · Journal of Ethnopharmacology
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry
Yanwen Chen, Travis Lear, John W. Evankovich, Mads Breum Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood et al. · 2021 · Nature Communications
Association of COVID-19 with Comorbidities: An Update
Sayan Chatterjee, Lakshmi Vineela Nalla, Monika Sharma, Nishant Sharma, Aditya A. Singh, Fehmina Mushtaque Malim, Manasi Ghatage, Mohd Mukarram, Abhijeet Pawar, Nidhi Parihar et al. · 2023 · ACS Pharmacology & Translational Science
Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response
Friederike Klempin, Valentina Mosienko, Susann Matthes, Daniel Campos Villela, Mihail Todiraş, Josef Martin Penninger, Michael Bäder, Robson A.S. Santos, Natalia V. Alenina · 2018 · Cellular and Molecular Life Sciences
Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises
Arefeh Basiri, Zahra Pazhouhnia, Nima Beheshtizadeh, Mahdieh Hoseinpour, Amene Saghazadeh, Nima Rezaei · 2020 · Stem Cell Reviews and Reports
SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes
Alexander G. Obukhov, Bruce R. Stevens, Ram Prasad, Sergio Li Calzi, Michael E. Boulton, Mohan K. Raizada, Gavin Y. Oudit, Maria B. Grant · 2020 · Diabetes
SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients
Ashutosh Kumar, Ravi Kant Narayan, Chiman Kumari, Muneeb A. Faiq, Maheswari Kulandhasamy, Kamla Kant, Vikas Pareek · 2020 · Medical Hypotheses
COVID-19 and the kidney
Mohamed Hassanein, Yeshwanter Radhakrishnan, John R. Sedor, Tushar J. Vachharajani, Vidula Vachharajani, Joshua J. Augustine, Sevag G. Demirjian, George Thomas · 2020 · Cleveland Clinic Journal of Medicine
Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID‐19
Paul P. Dobesh, Toby C. Trujillo · 2020 · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
Scott B. Biering, Francielle Tramontini Gomes de Sousa, Laurentia V. Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F. Blanc, Trishna S. Patel, Caroline M. Worthington, Dustin R. Glasner et al. · 2022 · Nature Communications
Commentary: COVID-19 and diabetes mellitus: What we know, how our patients should be treated now, and what should happen next
Angeliki M. Angelidi, Matthew J. Belanger, Christos Socrates Mantzoros · 2020 · Metabolism
The triumvirate: why hypertension, obesity, and diabetes are risk factors for adverse effects in patients with COVID-19
Shah, Harsh, Khan, Md Shahjalal Hossain, Dhurandhar, Nikhil V., Hegde, Vijay · 2021 · Acta Diabetologica
The Impact of SARS-Cov-2 Virus Infection on the Endocrine System
Noel Pratheepan Somasundaram, Ishara Ranathunga, Vithiya Ratnasamy, Piyumi Sachindra Alwis Wijewickrama, Harsha Anuruddhika Dissanayake, Nilukshana Yogendranathan, Kavinga Kalhari Kobawaka Gamage, Nipun Lakshitha de Silva, Manilka Sumanatilleke, Prasad Katulanda et al. · 2020 · Journal of the Endocrine Society