A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Kuba, Keiji, Imai, Yumiko, Rao, Shuan, Gao, Hong, Guo, Feng, Guan, Bin, Huan, Yi, Yang, Peng +16 more·2005·Nature Medicine
DOI 10.1038/nm1267

Cited by (1,008)

Items 101–200 of 1,008

  1. Coronavirus Disease 2019 (COVID‐19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection
    Junyi Guo, Zheng Y. X. Huang, Li Lin, Jiagao Lv · 2020 · Journal of the American Heart Association
  2. Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation
    Chen, Jiawei, Jiang, Quanlong, Xia, Xian, Liu, Kangping, Yu, Zhengqing, Tao, Wanyu, Gong, Wenxuan, Han, Jing‐Dong J. · 2020 · Aging Cell
  3. Clinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review
    Ortiz-Prado, Esteban, Simbaña-Rivera, Katherine, Gómez- Barreno, Lenin, Rubio-Neira, Mario, Guaman, Linda P., Kyriakidis, Nikolaos C, Muslin, Claire, Jaramillo, Ana María Gómez, Barba-Ostria, Carlos, Cevallos-Robalino, Doménica et al. · 2020 · Diagnostic Microbiology and Infectious Disease
  4. Production of bioactive peptides during soybean fermentation and their potential health benefits
    Samurailatpam Sanjukta, Amit Kumar · 2016 · Trends in Food Science & Technology
  5. The effect of smoking on COVID‐19 severity: A systematic review and meta‐analysis
    Rohin K. Reddy, Walton N. Charles, Alexandros Sklavounos, Atul Dutt, Paul Townsend Seed, Ankur Khajuria · 2020 · Journal of Medical Virology
  6. COVID-19: a new challenge for human beings
    Penghui Yang, Xiliang Wang · 2020 · Cellular and Molecular Immunology
  7. Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques
    Li Liu, Qiang Wei, Xavier A. Alvarez, Haibo Wang, Yanhua Du, Hua Zhu, Hong Jiang, Jingying Zhou, Pokman Lam, Linqi Zhang et al. · 2011 · Journal of Virology
  8. Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019
    Zhu, Zhe, Cai, Ting, Fan, Lingyan, Lou, Kehong, Hua, Xin, Huang, Zuoan, Gao, Guosheng · 2020 · International Journal of Infectious Diseases
  9. The emerging role of ACE2 in physiology and disease
    Inge Hamming, Mark E. Cooper, Bart L. Haagmans, Nigel M. Hooper, Ron Korstanje, Albert D. M. E. Osterhaus, Wim Timens, AJ Turner, G. J. Navis, Harry van Goor · 2007 · The Journal of Pathology
  10. Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
    Thomas Sonnweber, Sabina Sahanic, Alex Pizzini, Anna Katharina Luger, Christoph Schwabl, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstätter, David Haschka, Verena Petzer et al. · 2020 · European Respiratory Journal
  11. Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans
    Jianshe Lang, Ning Yang, Jiejie Deng, Kangtai Liu, Peng Yang, Guigen Zhang, Chengyu Jiang · 2011 · PLoS ONE
  12. Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19
    Kai, Hisashi, Kai, Mamiko · 2020 · Hypertension Research
  13. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy
    Rosanna Asselta, Elvezia Maria Paraboschi, Alberto Mantovani, Stefano Duga · 2020 · Aging
  14. COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From Immunology to Treatment
    Amir A. Arastehfar, Agostinho Carvalho, Frank L. van de Veerdonk, Jeffrey D. Jenks, Philipp A. Koehler, Robert Krause, Oliver A. Cornely, David S. Perlin, Cornelia Lass‐Flörl, Martin Hoenigl · 2020 · Journal of Fungi
  15. Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract
    Joan C. Smith, Erin L. Sausville, Vishruth Girish, Monet Lou Yuan, Anand Vasudevan, Kristen M. John, Jason M. Sheltzer · 2020 · Developmental Cell
  16. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
    Sean X. Gu, Tarun Tyagi, Kanika Jain, Vivian W. Gu, Seung Hee Lee, Jonathan M. Hwa, Jennifer M. Kwan, Diane S. Krause, Alfred I. Lee, Stephanie Halene et al. · 2020 · Nature Reviews Cardiology
  17. Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research
    Graham Simmons, Paweł Zmora, Stefanie Gierer, Adeline Heurich, Stefan Pöhlmann · 2013 · Antiviral Research
  18. Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19
    Naidi Yang, Han‐Ming Shen · 2020 · International Journal of Biological Sciences
  19. Potential influence of COVID-19/ACE2 on the female reproductive system
    Yan Jing, Run-Qian Li, Haoran Wang, Chen Hao-Ran, Ya-Bin Liu, Yang Gao, Fei Chen · 2020 · Molecular Human Reproduction
  20. Use of renin–angiotensin–aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study
    Francisco José de Abajo, Sara Rodríguez‐Martín, Victoria Lerma, Gina Paola Mejía-Abril, Mónica Aguilar, Amelia García-Luque, Leonor Laredo, Olga Laosa, Gustavo Adolfo Centeno-Soto, María A. Gálvez et al. · 2020 · The Lancet
  21. Targeting the NLRP3 Inflammasome in Severe COVID-19
    Tracey L. Freeman, Talia H. Swartz · 2020 · Frontiers in Immunology
  22. Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study
    Chao Gao, Yue Cai, Kan Zhang, Lei Zhou, Yao Zhang, Xijing Zhang, Qi Li, Weiqin Li, Shiming Yang, Xiaoyan Zhao et al. · 2020 · European Heart Journal
  23. Human recombinant soluble ACE2 in severe COVID-19
    Alexander Zoufaly, Marko Poglitsch, Judith Helene Aberle, Wolfgang Hoepler, Tamara Seitz, Marianna Theresia Traugott, Alexander Grieb, Erich Pawelka, Hermann Laferl, Christoph Wenisch et al. · 2020 · The Lancet Respiratory Medicine
  24. Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
    Fatai S. Oladunni, Jun-Gyu Park, P. Pino, O. Gonzalez, A. Akhter, Anna Allué-Guardia, Angélica M. Olmo-Fontánez, S. Gautam, Andreu Garcia-Vilanova, Cheng-Jin Ye et al. · 2020 · Nature Communications
  25. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
    Zhen Zou, Yiwu Yan, Yuelong Shu, Rongbao Gao, Yang Sun, Xiao Li, Xiangwu Ju, Zhu Liang, Qiang Liu, Yan Zhao et al. · 2014 · Nature Communications
  26. Angiotensin-converting enzyme 2 in lung diseases
    K KUBA, Yohsuke Imai, Josef Martin Penninger · 2006 · Current Opinion in Pharmacology
  27. Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19)
    Neil Mehta, Ankur Kalra, Amy S. Nowacki, Scott Anjewierden, Zheyi Han, Pavan Bhat, Andres Carmona Rubio, Miriam S. Jacob, Gary W. Procop, Susan M. Harrington et al. · 2020 · JAMA Cardiology
  28. Acute respiratory distress syndrome
    Rob Mac Sweeney, Daniel Francis McAuley · 2016 · The Lancet
  29. Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches
    Yuefei Jin, Wangquan Ji, Haiyan Yang, Shuaiyin Chen, Weiguo Zhang, Guangcai Duan · 2020 · Signal Transduction and Targeted Therapy
  30. Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon
    Luisa Cervantes‐Barragán, Roland Züst, Friedemann Weber, Martin Spiegel, Karl Sebastian Lang, Shizuo Akira, Volker Thiel, Burkhard Ludewig · 2006 · Blood
  31. T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV
    William J. Liu, Min Jie Zhao, Kefang Liu, Kun Xu, Gary Wong, Wenjie Tan, George F. Gao · 2016 · Antiviral Research
  32. SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19?
    Gabriela M. Kuster, Otmar Pfister, Thilo Burkard, Qian Zhou, Raphael Twerenbold, Philip Haaf, Andreas Franz Widmer, Stefan Osswald · 2020 · European Heart Journal
  33. COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?
    Donato Gemmati, Barbara Bramanti, Maria Luisa Serino, Paola Secchiero, Giorgio Zauli, Veronica Tisato · 2020 · International Journal of Molecular Sciences
  34. Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
    Changhai Lei, Kewen Qian, Li Tian, Sheng Zhang, Wenyan Fu, Min Ding, Shi Hu · 2020 · Nature Communications
  35. ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19
    Bruna Garbes Gonçalves Pinto, Antônio Edson Rocha Oliveira, Youvika Singh, Leandro Jimenez, André N. A. Gonçalves, Rodrigo L.T. Ogava, Rachel L. Creighton, Jean Pierre Schatzmann Peron, Helder Imoto Nakaya · 2020 · The Journal of Infectious Diseases
  36. Risk Factors Associated With Clinical Outcomes in 323 Coronavirus Disease 2019 (COVID-19) Hospitalized Patients in Wuhan, China
    Ling Hu, Shaoqiu Chen, Yuanyuan Fu, Zitong Gao, Hui Long, Hongwei Ren, Yi Zuo, Huan Li, Jie Wang, Wen-xiong Yu et al. · 2020 · Clinical Infectious Diseases
  37. Human immunopathogenesis of severe acute respiratory syndrome (SARS)
    Cameron, Mark J., Bermejo-Martin, Jesus F., Danesh, Ali, Muller, Matthew P., Kelvin, David J. · 2008 · Virus Research
  38. Interferon-Mediated Immunopathological Events Are Associated with Atypical Innate and Adaptive Immune Responses in Patients with Severe Acute Respiratory Syndrome
    Cameron, Mark J., Ran, Longsi, Xu, Luoling, Danesh, Ali, Bermejo-Martin, Jesus F., Cameron, Cheryl M., Muller, Matthew P., Gold, Wayne L., Richardson, Susan E., Poutanen, Susan M. et al. · 2007 · Journal of Virology
  39. Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses
    Didier Raoult, Alimuddin I. Zumla, Franco Locatelli, Giuseppe Ippolito, Guido Kroemer · 2020 · Cell Stress
  40. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1–7) in regulation of cardiovascular function
    Carlos Maria Ferrario, Aaron J. Trask, Jewell A. Jessup · 2005 · American Journal of Physiology-Heart and Circulatory Physiology
  41. TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
    Konrad Hermann Stopsack, Lorelei Ann Mucci, Emmanuel S. Antonarakis, Peter S. Nelson, Philip W. Kantoff · 2020 · Cancer Discovery
  42. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis
    Brandon Michael Henry, Jens Vikse, Stefanie Woolridge Benoit, Emmanuel J. Favaloro, Giuseppe Lippi · 2020 · Clinica Chimica Acta
  43. Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes
    Dan Zhang, Rui Guo, Lei Lei, Hongjuan Liu, Yawen Wang, Yili Wang, Hongbo Qian, Tongxin Dai, Tianxiao Zhang, Yanjun Lai et al. · 2020 · Journal of Leukocyte Biology
  44. Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor
    Yanwei Li, Wei Zhou, Yang Li, Ran You · 2020 · Pharmacological Research
  45. COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers
    Ankit Bharat Patel, Ashish Verma · 2020 · JAMA
  46. Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19)
    Giuseppe Lippi, Andrew Michael South, Brandon Michael Henry · 2020 · Annals of Clinical Biochemistry International Journal of Laboratory Medicine
  47. SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells
    I‐Chueh Huang, Berend‐Jan Bosch, Fang Li, Wenhui Li, Kyoung Hoa Lee, Sorina Ghiran, Natalya Yu. Vasilieva, Terence S. Dermody, Stephen C. Harrison, Philip R. Dormitzer et al. · 2005 · Journal of Biological Chemistry
  48. COVID-19 and Cardiovascular Disease
    Mina K. Chung, David A. Zidar, Michael R. Bristow, Scott J. Cameron, Timothy An-thy Chan, Clifford V. Harding, Deborah H. Kwon, Tamanna K. Singh, John C. Tilton, Emily J. Tsai et al. · 2021 · Circulation Research
  49. Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide
    Fabián Sanchis‐Gomar, Carl J. Lavie, Mandeep R. Mehra, Brandon Michael Henry, Giuseppe Lippi · 2020 · Mayo Clinic Proceedings
  50. Global Epidemiology of Bat Coronaviruses
    Antonio C. P. Wong, Xin Li, Susanna K. P. Lau, Patrick C. Y. Woo · 2019 · Viruses
  51. Expression of elevated levels of pro‐inflammatory cytokines in SARS‐CoV‐infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS
    Li He, Yanqing Ding, Qiwei Zhang, X Che, Yuxian He, Hong Shen, Huichao Wang, Zonghui Li, Laura Zhao, J Geng et al. · 2006 · The Journal of Pathology
  52. Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms
    Elham Ahmadian, Seyed Mahdi Hosseiniyan Khatibi, Saiedeh Razi Soofiyani, Sima Abediazar, Mohammadali M. Shoja, Mohammadreza Ardalan, Sepideh Zununi Vahed · 2020 · Reviews in Medical Virology
  53. COVID-19: breaking down a global health crisis
    Saad I. Mallah, Omar Khaled Hassan Attia Ghorab, Sabrina Al-Salmi, Omar S. Abdellatif, Tharmegan Tharmaratnam, Mina Magued Abdalla Iskandar, Jessica Atef Nassef Sefen, Pardeep Sidhu, Bassam Atallah, Rania M. El-Lababidi et al. · 2021 · Annals of Clinical Microbiology and Antimicrobials
  54. Neurological Involvement in COVID-19 and Potential Mechanisms: A Review
    Aghagoli, Ghazal, Gallo Marin, Benjamin, Katchur, Nicole J., Chaves-Sell, Franz, Asaad, Wael F., Murphy, Sarah A. · 2021 · Neurocritical Care
  55. Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19
    Reinhold Hugo Kreutz, Engi Abd Elhady Algharably, Michel Azizi, Piotr Dobrowolski, Tomasz Jan Guzik, Andrzej Januszewicz, Alexandre Persu, Aleksander Prejbisz, Thomas Riemer, Ji‐Guang Wang et al. · 2020 · Cardiovascular Research
  56. Joint HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19
    Biykem Bozkurt, Richard J. Kovacs, Bob Harrington · 2020 · Journal of Cardiac Failure
  57. Severe Acute Respiratory Syndrome Coronavirus Infection of Human Ciliated Airway Epithelia: Role of Ciliated Cells in Viral Spread in the Conducting Airways of the Lungs
    Amy María Sims, Ralph Steven Baric, Boyd L. Yount, Susan E. Burkett, Peter L. Collins, Raymond John Pickles · 2005 · Journal of Virology
  58. COVID‐19 and Toll‐Like Receptor 4 (TLR4): SARS‐CoV‐2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
    Mohamed M. Aboudounya, Richard J. Heads · 2021 · Mediators of Inflammation
  59. The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2
    Shibi Muralidar, Senthil Visaga Ambi, Saravanan Sekaran, Uma Maheswari Krishnan · 2020 · Biochimie
  60. IL-6: Relevance for immunopathology of SARS-CoV-2
    Ekaterina O. Gubernatorova, Ekaterina A. Gorshkova, Almina I. Polinova, Marina S. Drutskaya · 2020 · Cytokine & Growth Factor Reviews
  61. Regulation and Repair of the Alveolar-Capillary Barrier in Acute Lung Injury
    Jahar Bhattacharya, Michael A. Matthay · 2013 · Annual Review of Physiology
  62. Effects of Angiotensin II Receptor Blockers and ACE (Angiotensin-Converting Enzyme) Inhibitors on Virus Infection, Inflammatory Status, and Clinical Outcomes in Patients With COVID-19 and Hypertension
    Guang Yang, Zihu Tan, Ling Zhou, Min Hee Yang, Lang Peng, Jinjin Liu, Jingling Cai, Ru Yang, Junyan Han, Yafei Huang et al. · 2020 · Hypertension
  63. Pathophysiology of COVID-19: Why Children Fare Better than Adults?
    Nitin Dhochak, Tanu Singhal, Sushil Kumar Kabra, Rakesh Lodha · 2020 · The Indian Journal of Pediatrics
  64. COVID-19 – A vascular disease
    Hasan Khalid Siddiqi, Peter Libby, Paul M. Ridker · 2020 · Trends in Cardiovascular Medicine
  65. CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2
    Razie Amraei, Wenqing Yin, Marc Arthur Napoleon, Ellen L. Suder, Jacob L. Berrigan, Qing Zhao, Judith Olejnik, Kevin Brown Chandler, Chaoshuang Xia, Jared E. Feldman et al. · 2021 · ACS Central Science
  66. Immune-mediated approaches against COVID-19
    Helena F. Florindo, Ron Kleiner, Daniella Vaskovich‐Koubi, Rita C. Acúrcio, Bárbara Carreira, Eilam Yeini, Galia Tiram, Yulia Liubomirski, Ronit Satchi‐Fainaro · 2020 · Nature Nanotechnology
  67. The discovery of angiotensin‐converting enzyme 2 and its role in acute lung injury in mice
    Yumiko Imai, Keiji Kuba, Josef Martin Penninger · 2008 · Experimental Physiology
  68. Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration
    Chhinder Pal Sodhi, Christine Wohlford-Lenane, Yukihiro Yamaguchi, Thomas Prindle, William B. Fulton, Sanxia Wang, Paul B. McCray, Mark C. Chappell, David Joel Hackam, Hongpeng Jia · 2017 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  69. Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease
    Stephanie Bertram, Ilona Glowacka, Marcel A. Müller, Hayley Lavender, Kerstin Gnirß, Inga Nehlmeier, Daniela Niemeyer, Yuxian He, Graham Simmons, Christian Drosten et al. · 2011 · Journal of Virology
  70. Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
    Hong Peng Jia, Dwight C. Look, Ping Tan, Lei Shi, Melissa A. Hickey, Lokesh Gakhar, Mark C. Chappell, Christine Wohlford-Lenane, Paul B. McCray · 2009 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  71. Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians
    Batah, Sabrina Setembre, Fabro, Alexandre Todorovic · 2021 · Respiratory Medicine
  72. The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?
    Dounia Darif, Ikram Hammi, Ayyoub Kihel, Imane El Idrissi Saik, Fadila Guessous, Khadija Akarid · 2021 · Microbial Pathogenesis
  73. COVID-19 for the Cardiologist
    Deepak S. Atri, Hasan Khalid Siddiqi, Joshua P. Lang, Victor Nauffal, David A. Morrow, Erin Ann Bohula · 2020 · JACC Basic to Translational Science
  74. Angiotensin‐converting enzyme 2 in the brain: properties and future directions
    Huijing Xia, Eric D. Lazartigues · 2008 · Journal of Neurochemistry
  75. Molecular pathology of emerging coronavirus infections
    Lisa E. Gralinski, Ralph Steven Baric · 2014 · The Journal of Pathology
  76. Lessons for COVID-19 immunity from other coronavirus infections
    Sariol, Alan, Perlman, Stanley · 2020 · Immunity
  77. Sex differences in severity and mortality from COVID-19: are males more vulnerable?
    Ajay Pradhan, Per‐Erik Olsson · 2020 · Biology of Sex Differences
  78. The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes
    Valentin Sencio, Marina Gomes Machado, François Trottein · 2021 · Mucosal Immunology
  79. Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China
    Robert L. Kruse · 2020 · F1000Research
  80. Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload
    Keiji Kuba, Liyong Zhang, Yumiko Imai, Sara Arab, Manyin Chen, Yuichiro Maekawa, Michael W. Leschnik, Andreas Leibbrandt, Mato Markovic, Julia Schwaighofer et al. · 2007 · Circulation Research
  81. From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses
    Nikhil Kirtipal, Shiv Bharadwaj, Sang Gu Kang · 2020 · Infection Genetics and Evolution
  82. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade
    Luca Perico, Ariela Benigni, Giuseppe Remuzzi · 2020 · The Nephron journals/Nephron journals
  83. Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2
    Jan A Wysocki, Minghao Ye, Eva Rodríguez, Francisco R. González‐Pacheco, Clara Barrios, Karla Evora, Manfred Schuster, Hans Loibner, K. Bridget Brosnihan, Carlos Maria Ferrario et al. · 2009 · Hypertension
  84. Severe air pollution links to higher mortality in COVID-19 patients: The “double-hit” hypothesis.
    Antonio Frontera, Lorenzo Cianfanelli, Konstantinos George Vlachos, Giovanni Landoni, George Cremona · 2020 · Journal of Infection
  85. Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease
    Hongpeng Jia · 2016 · Shock
  86. Acute Lung Injury – From Pathophysiology to Treatment
    Daniela Mokrá · 2021 · Physiological Research
  87. A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin
    Hasan, Anwarul, Paray, Bilal Ahamad, Hussain, Arif, Qadir, Fikry Ali, Attar, Farnoosh, Aziz, Falah Mohammad, Sharifi, Majid, Derakhshankhah, Hossein, Rasti, Behnam, Mehrabi, Masoumeh et al. · 2021 · Journal of Biomolecular Structure and Dynamics
  88. Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option?
    Konstantinos E. Farsalinos, Anastasia Barbouni, RAYMOND S. NIAURA · 2020 · Internal and Emergency Medicine
  89. Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19
    Guoping Li, Xiang He, Lei Zhang, Ran Qin, Junyi Wang, Anying Xiong, Dehong Wu, Feng Chen, Jinlyu Sun, Christopher Chia-Chi Chang · 2020 · Journal of Autoimmunity
  90. Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells
    Aleksandra Milewska, Mirosław Zarębski, Paulina Nowak, Karol Stożek, Jan Potempa, Krzysztof Pyrć · 2014 · Journal of Virology
  91. Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts
    Luka Nicin, Wesley Tyler Abplanalp, Hannah Mellentin, Badder Kattih, Lukas Stefan Tombor, David John, Jan Dieter Schmitto, Jörg Heineke, Fabian C. Emrich, Mani Arsalan et al. · 2020 · European Heart Journal
  92. Pharmaco-Immunomodulatory Therapy in COVID-19
    John G. Rizk, Kamyar Kalantar‐Zadeh, Mandeep R. Mehra, Carl J. Lavie, Youssef Rizk, Donald N. Forthal · 2020 · Drugs
  93. Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome
    Frank L. van de Veerdonk, Mihai Gheorghe Netea, Marcel van Deuren, Jos W. M. van der Meer, Quirijn de Mast, Roger J. M. Brüggemann, Hans van der Hoeven · 2020 · eLife
  94. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
    David H. Brann, Tatsuya Tsukahara, Caleb Weinreb, Marcela Lipovsek, Koen Van den Berge, Boying Gong, Rebecca Chance, Iain C. Macaulay, Hsin-jung Chou, Russell Fletcher et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  95. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
    Yang, Penghui, Gu, Hongjing, Zhao, Zhongpeng, Wang, Wei, Cao, Bin, Lai, Chengcai, Yang, Xiaolan, Zhang, LiangYan, Duan, Yueqiang, Zhang, Shaogeng et al. · 2014 · Scientific Reports
  96. Current status of potential therapeutic candidates for the COVID-19 crisis
    Jiancheng Zhang, Bing Xie, Kenji Hashimoto · 2020 · Brain Behavior and Immunity
  97. The Angiotensin-Converting Enzyme 2/Angiogenesis-(1–7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension
    Vinayak Shenoy, Anderson J. Ferreira, Yanfei Qi, Rodrigo A. Fraga-Silva, Carlos Díez-Freire, Autumn Dooies, Joo Yun Jun, Srinivas Sriramula, Nithya Mariappan, Dorna Pourang et al. · 2010 · American Journal of Respiratory and Critical Care Medicine
  98. Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports
    Souhel Najjar, Amanda Najjar, Derek J. Chong, Bidyut K. Pramanik, Claudia Kirsch, Ruben Kuzniecky, Steven V. Pacia, Salman Azhar · 2020 · Journal of Neuroinflammation
  99. Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations
    Simone M. R. Camargo, Dustin Singer, Victoria Makrides, Katja Huggel, Klaas Martinus Pos, Carsten Alexander Wagner, Keiji Kuba, Ursula G. Danilczyk, Flemming Skovby, Robert Kleta et al. · 2008 · Gastroenterology
  100. Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic
    Andrew Michael South, Laurie A. Tomlinson, Daniel L. Edmonston, Swapnil S. Hiremath, Matthew A. Sparks · 2020 · Nature Reviews Nephrology