The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
Abstract
The molecular events that regulate engraftment and mobilization of hematopoietic stem cells and progenitors (HSC/Ps) are still incompletely defined. We have examined the role of the Rho GTPases Rac1 and Rac2 in HSC engraftment and mobilization. Rac1, but not the hematopoietic-specific Rac2, is required for the engraftment phase of hematopoietic reconstitution, because Rac1(-/-) HSCs did not rescue in vivo hematopoiesis after transplantation, but deletion of Rac1 after engraftment did not impair steady-state hematopoiesis. Rac1(-/-) HSC/Ps showed impaired spatial localization to the endosteum but near-normal homing to the medullary cavity in vivo. Interaction with the bone marrow microenvironment in vitro was markedly altered. Whereas post-engraftment deletion of Rac1 alone did not impair hematopoiesis, deficiency of both Rac1 and Rac2 led to massive mobilization of HSCs from the marrow associated with ineffective hematopoiesis and intense selection for Rac-expressing HSCs. This mobilization was reversible by re-expression of Rac1. In addition, a rationally designed, reversible small-molecule inhibitor of Rac activation led to transient mobilization of engraftable HSC/Ps. Rac proteins thus differentially regulate engraftment and mobilization phenotypes, suggesting that these biological processes and steady-state hematopoiesis are biochemically separable and that Rac proteins may be important molecular targets for stem cell modification.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several members of the Rho family, including Rac1 and Rac2, can be activated by SDF-1α stimulation and are required for SDF-1α–induced chemotaxis and homing of hematopoietic stem/progenitor cells.5,36”
From Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells (2008) · cites this paper as [36]
In the citing paper
“The Rac subfamily of Rho guanosine triphosphatases (GTPases) plays an essential role in regulating hematopoiesis (Gu et al., 2003;Yang et al., 2001;Cancelas et al., 2005;Cancelas and Williams, 2006).”
From Rac Guanosine Triphosphatases Represent Integrating Molecular Therapeutic Targets for BCR-ABL-Induced Myeloproliferative Disease (2007) · cites this paper as Cancelas et al., 2005
In the citing paper
“We have previously shown that both Rac1 and Rac2 are essential for the regulation of multiple HSC functions with unique as well as overlapping roles, including proliferation, apoptosis, homing, and retention (Gu et al., 2003;Cancelas et al., 2005).”
From Rac Guanosine Triphosphatases Represent Integrating Molecular Therapeutic Targets for BCR-ABL-Induced Myeloproliferative Disease (2007) · cites this paper as Cancelas et al., 2005
In the citing paper
“Rac1 is required for engraftment of HSC into the stem cell niche and regulates cell-cycle progression (Gu et al., 2003;Cancelas et al., 2005)”
From Rac Guanosine Triphosphatases Represent Integrating Molecular Therapeutic Targets for BCR-ABL-Induced Myeloproliferative Disease (2007) · cites this paper as Cancelas et al., 2005
In the citing paper
“Combinatorial expression of both proteins is necessary for normal HSC adhesion and migration and supports long-term hematopoiesis (Gu et al., 2003;Cancelas et al., 2005).”
From Rac Guanosine Triphosphatases Represent Integrating Molecular Therapeutic Targets for BCR-ABL-Induced Myeloproliferative Disease (2007) · cites this paper as Cancelas et al., 2005
7 more claims about this paper
Create a free account to see every claim other papers make about this one.
Citations
Cites
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4
Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., Nagler, A., Ben-Hur, H., Many, A., Shultz, L., et al. (1999) · Science · doi:10.1126/science.283.5403.845 · Cited by 1,644
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
Gao, Y., Dickerson, J. B., Guo, F., Zheng, J., & Zheng, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307512101 · Cited by 1,091
Self-citationHow do stem cells find their way home?
Lapidot, T., Dar, A., & Kollet, Ó. (2005) · Blood · doi:10.1182/blood-2005-04-1417 · Cited by 1,001
Current understanding of stem cell mobilization
Lapidot, T., & Petit, I. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00883-4 · Cited by 787
Nilsson, S. K., Johnston, H. M., & Coverdale, J. (2001) · Blood · doi:10.1182/blood.v97.8.2293 · Cited by 594
rac, a novel ras-related family of proteins that are botulinum toxin substrates
Didsbury, J., Weber, R. F., Bokoch, G. M., Evans, T., & Snyderman, R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84716-6 · Cited by 575
Roberts, A. W., Kim, C., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80019-9 · Cited by 556
Self-citationCdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity
Johnson, D. I. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.54-105.1999 · Cited by 535
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases
Gu, Y., Filippi, M.-D., Cancelas, J. A., Siefring, J. E., Williams, E. P., Jasti, A. C., Harris, C. E., Lee, A. W., Prabhakar, R., Atkinson, S. J., et al. (2003) · Science · doi:10.1126/science.1088485 · Cited by 510
Self-citation
Cited by
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Heasman, S. J., & Ridley, A. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2476 · Cited by 1,871
Bone-marrow haematopoietic-stem-cell niches
Wilson, A., & Trumpp, A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1779 · Cited by 1,419
Yin, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28568 · Cited by 810
Molecular biology of bcr-abl1–positive chronic myeloid leukemia
Quintás‐Cardama, A., & Cortes, J. E. (2008) · Blood · doi:10.1182/blood-2008-03-144790 · Cited by 762
GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
Bustelo, X. R., Sauzeau, V., & Berenjeno, I. M. (2007) · BioEssays · doi:10.1002/bies.20558 · Cited by 656
Uncertainty in the niches that maintain haematopoietic stem cells
Kiel, M. J., & Morrison, S. J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2279 · Cited by 610
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
Somervaille, T. C. P., & Cleary, M. L. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.020 · Cited by 582
The leukemic stem cell niche: current concepts and therapeutic opportunities
Lane, S., Scadden, D. T., & Gilliland, D. G. (2009) · Blood · doi:10.1182/blood-2009-01-202606 · Cited by 482
Shibata, S., Nagase, M., Yoshida, S., Kawarazaki, W., Kurihara, H., Tanaka, H., Miyoshi, J., Takai, Y., & Fujita, T. (2008) · Nature Medicine · doi:10.1038/nm.1879 · Cited by 479
Konstantinopoulos, P. A., Karamouzis, M. V., & Papavassiliou, A. G. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2221 · Cited by 460
Cell cycle regulation in hematopoietic stem cells
Pietras, E. M., Warr, M. R., & Passegué, E. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102131 · Cited by 447
Rac1 GTPase: A “Rac” of All Trades
Bosco, E. E., Mulloy, J. C., & Zheng, Y. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8552-x · Cited by 350
Self-citationStem Cell Trafficking in Tissue Development, Growth, and Disease
Laird, D. J., von Andrian, U. H., & Wagers, A. J. (2008) · Cell · doi:10.1016/j.cell.2008.01.041 · Cited by 335
Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia
Wei, J., Wunderlich, M., Fox, C., Alvarez, S., Cigudosa, J. C., Wilhelm, J. S., Zheng, Y., Cancelas, J. A., Gu, Y., Jansen, M., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.04.020 · Cited by 284
Self-citationLimiting Factors in Murine Hematopoietic Stem Cell Assays
Purton, L. E., & Scadden, D. T. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.08.016 · Cited by 309
The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization
Lévesque, J.-P., Helwani, F., & Winkler, I. G. (2010) · Leukemia · doi:10.1038/leu.2010.214 · Cited by 282
Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
Saci, A., Cantley, L. C., & Carpenter, C. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.017 · Cited by 275
Shibata, S., Mu, S., Kawarazaki, H., Muraoka, K., Ishizawa, K., Yoshida, S., Kawarazaki, W., Takeuchi, M., Ayuzawa, N., Miyoshi, J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43124 · Cited by 242
Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice
Rossi, L., Lin, K. K., Boles, N. C., Yang, L., King, K. Y., Jeong, M., Mayle, A., & Goodell, M. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.006 · Cited by 205
Yang, L. C., Wang, L., Geiger, H., Cancelas, J. A., Mo, J., & Zheng, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610819104 · Cited by 197
Self-citationTargeting the leukemic stem cell: the Holy Grail of leukemia therapy
Misaghian, N., Ligresti, G., Steelman, L. S., Bertrand, F. E., Bäsecke, J., Libra, M., Nicoletti, F., Stivala, F., Milella, M., Tafuri, A., et al. (2008) · Leukemia · doi:10.1038/leu.2008.246 · Cited by 191
Chromatin Regulatory Mechanisms in Pluripotency
Lessard, J. A., & Crabtree, G. R. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-051809-102012 · Cited by 186
Increased hematopoietic stem cell mobilization in aged mice
Xing, Z., Ryan, M. A., Daria, D., Nattamai, K., Zant, G. E. V., Wang, L., Zheng, Y., & Geiger, H. (2006) · Blood · doi:10.1182/blood-2005-12-010272 · Cited by 183
Self-citationCXC chemokine ligand 12 (CXCL12) and its receptor CXCR4
Nagasawa, T. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1123-8 · Cited by 180
Targeted CML therapy: controlling drug resistance, seeking cure
O’Hare, T., Corbin, A. S., & Druker, B. J. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.11.002 · Cited by 178
Stem-cell ecology and stem cells in motion
Papayannopoulou, T., & Scadden, D. T. (2008) · Blood · doi:10.1182/blood-2007-08-078147 · Cited by 177
Osteotropic cancers: From primary tumor to bone
Buijs, J. T., & van der Pluijm, G. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.044 · Cited by 176
Rho GTPases in hematopoiesis and hemopathies
Mulloy, J. C., Cancelas, J. A., Filippi, M., Kalfa, T. A., Guo, F., & Zheng, Y. (2009) · Blood · doi:10.1182/blood-2009-09-198127 · Cited by 172
Self-citationThomas, E. K., Cancelas, J. A., Chae, H.-D., Cox, A. D., Keller, P. J., Perrotti, D., Neviani, P., Druker, B. J., Setchell, K. D. R., Zheng, Y., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.10.015 · Cited by 147
Self-citationSignaling and cytoskeletal requirements in erythroblast enucleation
Konstantinidis, D. G., Pushkaran, S., Johnson, J. F., Cancelas, J. A., Manganaris, S., Harris, C. E., Williams, D. A., Zheng, Y., & Kalfa, T. A. (2012) · Blood · doi:10.1182/blood-2011-09-379263 · Cited by 146
Self-citationRegional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs
Guezguez, B., Campbell, C. J. V., Boyd, A. L., Karanu, F., Casado, F. L., Cresce, C. D., Collins, T. J., Shapovalova, Z., Xenocostas, A., & Bhatia, M. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.015 · Cited by 132
Will, B., Vogler, T. O., Narayanagari, S., Bartholdy, B., Todorova, T. I., da Silva Ferreira, M., Chen, J., Yu, Y., Mayer, J., Barreyro, L., et al. (2015) · Nature Medicine · doi:10.1038/nm.3936 · Cited by 127
Meacham, C. E., Ho, E. E., Dubrovsky, E., Gertler, F. B., & Hemann, M. T. (2009) · Nature Genetics · doi:10.1038/ng.451 · Cited by 126
Integrin β4 Regulates Migratory Behavior of Keratinocytes by Determining Laminin-332 Organization
Sehgal, B. U., DeBiase, P. J., Matzno, S., Chew, T., Claiborne, J. N., Hopkinson, S. B., Russell, A. J., Marinkovich, M. P., & Jones, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606317200 · Cited by 125
Wang, Z., Li, G., Tse, W., & Bunting, K. D. (2009) · Blood · doi:10.1182/blood-2008-09-181107 · Cited by 122
Lundin, V., Sugden, W. W., Theodore, L. N., Sousa, P., Han, A., Chou, S. S., Wrighton, P. J., Cox, A. G., Ingber, D. E., Goessling, W., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.006 · Cited by 122
Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling
Mitchell, T., Lo, A. N., Logan, M. R., Lacy, P., & Eitzen, G. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00239.2008 · Cited by 122
Rizo, A., Vellenga, E., de Haan, G., & Schuringa, J. J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl175 · Cited by 115
Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development
Guo, F., Cancelas, J. A., Hildeman, D., Williams, D. A., & Zheng, Y. (2008) · Blood · doi:10.1182/blood-2008-01-132068 · Cited by 100
Self-citationRac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
Kalfa, T. A., Pushkaran, S., Mohandas, N., Hartwig, J. H., Fowler, V. M., Johnson, J. F., Joiner, C. H., Williams, D. A., & Zheng, Y. (2006) · Blood · doi:10.1182/blood-2006-03-005942 · Cited by 113
Self-citationCellular players of hematopoietic stem cell mobilization in the bone marrow niche
Tay, J., Lévesque, J.-P., & Winkler, I. G. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2162-4 · Cited by 106
Fuchs, S. P., Herzog, D., Sumara, G., Büchmann-Møller, S., Civenni, G., Wu, X., Chrostek‐Grashoff, A., Suter, U., Ricci, R., Relvas, J. B., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.01.017 · Cited by 104
Thankamony, S. P., & Sackstein, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018064108 · Cited by 102
Bone Marrow–Derived Stem Cells and Radiation Response
Greenberger, J. S., & Epperly, M. W. (2009) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2008.11.006 · Cited by 101
Kawashima, T., Bao, Y. C., Nomura, Y., Moon, Y., Tonozuka, Y., Minoshima, Y., Hatori, T., Tsuchiya, A., Kiyono, M., Nosaka, T., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604073 · Cited by 100
Self-citationTakizawa, H., Nishimura, S., Takayama, N., Oda, A., Nishikii, H., Morita, Y., Kakinuma, S., Yamazaki, S., Okamura, S., Tamura, N., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39503 · Cited by 99
Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells
Sahin, A. O., & Buitenhuis, M. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.18975 · Cited by 99
Lane, S., & Gilliland, D. G. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2009.12.001 · Cited by 98
Mobilization and Homing of Hematopoietic Stem Cells
Suárez-Álvarez, B., López‐Vázquez, A., & López‐Larrea, C. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-2098-9_11 · Cited by 96
Therapeutic Options Against BCR-ABL1 T315I-Positive Chronic Myelogenous Leukemia
Quintás‐Cardama, A., & Cortes, J. E. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0117 · Cited by 95
Cell type-specific functions of Rho GTPases revealed by gene targeting in mice
Wang, L., & Zheng, Y. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.11.009 · Cited by 95
Self-citationGhiaur, G., Lee, A. W.-T., Bailey, J., Cancelas, J. A., Zheng, Y., & Williams, D. A. (2006) · Blood · doi:10.1182/blood-2006-02-001560 · Cited by 90
Self-citationGonzález‐Nieto, D., Li, L., Köhler, A., Ghiaur, G., Ishikawa, E., Sengupta, A., Madhu, M., Arnett, J. L., Santho, R. A., Dunn, S. K., et al. (2012) · Blood · doi:10.1182/blood-2011-07-368506 · Cited by 88
Self-citationCancelas, J. A., Jansen, M., & Williams, D. A. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.03.016 · Cited by 88
Self-citationPriestley, G. V., Scott, L. M., Ulyanova, T., & Papayannopoulou, T. (2005) · Blood · doi:10.1182/blood-2005-07-2670 · Cited by 88
Li, Q., Mullins, S., Sloane, B. F., & Mattingly, R. R. (2008) · Neoplasia · doi:10.1593/neo.07970 · Cited by 87
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells
Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D’Alessandro, A., Reisz, J. A., Zaberezhnyy, V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.009 · Cited by 86
Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56
Saito, Y., Kaneda, K., Suekane, A., Ichihara, E., Nakahata, S., Yamakawa, N., Nagai, K., Mizuno, N., Kogawa, K., Miura, I., et al. (2013) · Leukemia · doi:10.1038/leu.2013.75 · Cited by 85
Pai, S.-Y., Kim, C., & Williams, D. A. (2010) · Disease Markers · doi:10.1155/2010/380291 · Cited by 85
Self-citationRational Design and Applications of a Rac GTPase–Specific Small Molecule Inhibitor
Akbar, H., Cancelas, J. A., Williams, D. A., Zheng, J., & Zheng, Y. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)06043-5 · Cited by 85
Self-citationRho GTP ases control specific cytoskeleton‐dependent functions of hematopoietic stem cells
Nayak, R. C., Chang, K. H., Vaitinadin, N. S., & Cancelas, J. A. (2013) · Immunological Reviews · doi:10.1111/imr.12119 · Cited by 84
Self-citationDefinition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Barthel, S. R., Hays, D. L., Yazawa, E. M., Opperman, M. J., Walley, K. C., Nimrichter, L., Burdick, M. M., Gillard, B. M., Moser, M. T., Pantel, K., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-3264 · Cited by 84
Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia
Marriott, H. M., Jackson, L. E., Wilkinson, T. S., Simpson, A. J., Mitchell, T. J., Buttle, D. J., Cross, S. S., Ince, P. G., Hellewell, P. G., Whyte, M. K. B., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200707-990oc · Cited by 84
Goichberg, P., Kalinkovich, A., Borodovsky, N., Tesio, M., Petit, I., Nagler, A., Hardan, I., & Lapidot, T. (2005) · Blood · doi:10.1182/blood-2005-03-0941 · Cited by 82
Chae, H.-D., Lee, K. E., Williams, D. A., & Gu, Y. (2008) · Blood · doi:10.1182/blood-2007-06-093237 · Cited by 81
Self-citationIsozyme-specific stimulation of phospholipase C-γ2 by Rac GTPases
Piechulek, T., Rehlen, T., Walliser, C., Vatter, P., Moepps, B., & Gierschik, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509396200 · Cited by 80
Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion
La, H. M., & Hobbs, R. M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03201-6 · Cited by 80
Akbar, H., Kim, J. J. Y. B., Funk, K. M., Cancelas, J. A., Shang, X., Chen, L., Johnson, J. F., Williams, D. A., & Zheng, Y. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02646.x · Cited by 79
Self-citationThe small GTPase RhoG mediates glioblastoma cell invasion
Kwiatkowska, A., Didier, S., Ensign, S. P. F., Chuang, Y.-Y., White, T. G., Berens, M. E., Rushing, E. J., Eschbacher, J., Tran, N. L., Chan, A. Y., et al. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-65 · Cited by 76
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells
Jones, M., Chase, J., Brinkmeier, M. L., Xu, J., Weinberg, D. N., Schira, J., Friedman, A. D., Malek, S. N., Grembecka, J. E., Cierpicki, T., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78124 · Cited by 75
Ratajczak, M. Z., Reca, R., Wysoczynski, M., Yan, J., & Ratajczak, J. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.03.015 · Cited by 75
Fei, D. L., Zhen, T., Durham, B. H., Ferrarone, J. R., Zhang, T., Garrett, L. J., Yoshimi, A., Abdel-Wahab, O. I., Bradley, R. K., Liu, P., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812669115 · Cited by 75
SHIP is required for a functional hematopoietic stem cell niche
Hazen, A. L., Smith, M. J., Desponts, C., Winter, O., Moser, K., & Kerr, W. G. (2008) · Blood · doi:10.1182/blood-2008-02-138008 · Cited by 74
Rho GTPases and Regulation of Hematopoietic Stem Cell Localization
(2008) · Methods in Enzymology · doi:10.1016/s0076-6879(07)00427-2 · Cited by 54
Self-citationMizukawa, B., Wei, J., Shrestha, M., Wunderlich, M., Chou, F.-S., Griesinger, A., Harris, C. E., Kumar, A. R., Zheng, Y., Williams, D. A., et al. (2011) · Blood · doi:10.1182/blood-2011-04-351817 · Cited by 70
Self-citationLiu, W., Du, W., Shang, X., Wang, L., Evelyn, C. R., Florian, M. C., Ryan, M. A., Rayes, A., Zhao, X., Setchell, K. D. R., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0251-5 · Cited by 69
Self-citationGhiaur, G., Ferkowicz, M. J., Milsom, M. D., Bailey, J., Witte, D. P., Cancelas, J. A., Yöder, M. C., & Williams, D. A. (2007) · Blood · doi:10.1182/blood-2007-08-110114 · Cited by 69
Self-citationRac1 mediates intestinal epithelial cell apoptosis via JNK
Jin, S. K., Ray, R. M., & Johnson, L. R. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00031.2006 · Cited by 69
Ryan, M. A., Nattamai, K., Xing, E., Schleimer, D., Daria, D., Sengupta, A., Köhler, A., Liu, W., Gunzer, M., Jansen, M., et al. (2010) · Nature Medicine · doi:10.1038/nm.2217 · Cited by 67
Self-citationRac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis
Thomas, E. K., Cancelas, J. A., Zheng, Y., & Williams, D. A. (2008) · Leukemia · doi:10.1038/leu.2008.71 · Cited by 60
Self-citationPandey, D. B., Goyal, P., Dwivedi, S., & Siess, W. (2009) · Blood · doi:10.1182/blood-2008-10-183582 · Cited by 65
Rac Activation by the T-Cell Receptor Inhibits T Cell Migration
Cernuda‐Morollón, E., Millán, J., Shipman, M., Marelli‐Berg, F. M., & Ridley, A. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012393 · Cited by 64
Arnaud, M.-P., Vallée, A., Robert, G., Bonneau, J., Roy, C. L., Varin‐Blank, N., Rio, A.-G., Troadec, M., Galibert, M., & Gandemer, V. (2015) · Blood · doi:10.1182/blood-2015-02-628560 · Cited by 64
Mineralocorticoid receptor activation in obesity hypertension
Nagase, M., & Fujita, T. (2009) · Hypertension Research · doi:10.1038/hr.2009.86 · Cited by 64
Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease
He, W., Yan, L., Hu, D., Hao, J., Liou, Y., & Luo, G. (2025) · MedComm · doi:10.1002/mco2.70063 · Cited by 63
Kalfa, T. A., Pushkaran, S., Zhang, X., Johnson, J. F., Pan, D., Daria, D., Geiger, H., Cancelas, J. A., Williams, D. A., & Zheng, Y. (2010) · Haematologica · doi:10.3324/haematol.2009.006239 · Cited by 63
Self-citationThe Ins and Outs of Hematopoietic Stem Cells: Studies to Improve Transplantation Outcomes
Marquez‐Curtis, L. A., Turner, A. R., Sridharan, S., Ratajczak, M. Z., & Janowska‐Wieczorek, A. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9212-8 · Cited by 61
FMNL1 promotes proliferation and migration of leukemia cells
Favaro, P. M. B., Traina, F., Machado‐Neto, J. A., Lazarini, M., Lopes, M. R., Pereira, J. K. N., Costa, F. F., Infante, E., Ridley, A. J., & Saad, S. T. O. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0113057 · Cited by 59
Cancer stem cells: A stride towards cancer cure?
Sengupta, A., & Cancelas, J. A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22213 · Cited by 58
Self-citationRosowski, E. E., Deng, Q., Keller, N. P., & Huttenlocher, A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600928 · Cited by 57
Exploiting bone niches: progression of disseminated tumor cells to metastasis
Muscarella, A. M., Aguirre, S., Hao, X., Waldvogel, S. M., & Zhang, X. H.-F. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143764 · Cited by 56
Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells
Schreck, C., Istvánffy, R., Ziegenhain, C., Landspersky, T., Ruf, F., Henkel, L., Gärtner, F., Vieth, B., Florian, M. C., Mende, N., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151414 · Cited by 56
Stem Cell Migration: A Quintessential Stepping Stone to Successful Therapy
Weidt, C., Niggemann, B., Kasenda, B., Drell, T. L., Zänker, K. S., Dittmar, T., Drell, T. L., & Zänker, K. S. (2007) · Current Stem Cell Research & Therapy · doi:10.2174/157488807779317008 · Cited by 56
Park, H., Staehling-Hampton, K., Appleby, M. W., Brunkow, M. E., Habib, T., Zhang, Y., Ramsdell, F., Liggitt, H. D., Freie, B., Tsang, M., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080340 · Cited by 55
Bone Marrow Connexin-43 Expression Is Critical for Hematopoietic Regeneration After Chemotherapy
Presley, C. A., Lee, A. W.-T., Kastl, B., Igbinosa, I. I., Yamada, Y., Fishman, G. I., Gutstein, D. E., & Cancelas, J. A. (2005) · Cell Communication & Adhesion · doi:10.1080/15419060500514200 · Cited by 53
Self-citationTemporal Control of Rac in Schwann Cell–Axon Interaction Is Disrupted inNF2-Mutant Schwannoma Cells
Nakai, Y., Zheng, Y., MacCollin, M., & Ratner, N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4865-05.2006 · Cited by 53
Self-citationBlood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
Perlin, J. R., Sporrij, A., & Zon, L. I. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1559-8 · Cited by 52
Hall, T., Kim, H., Dabbah, M., Myers, J., Crawford, J. C., Morales‐Hernández, A., Caprio, C., Sriram, P., Kooienga, E., Derecka, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33092-4 · Cited by 52
Sengupta, A., Durán, Á., Ishikawa, E., Florian, M. C., Dunn, S. K., Ficker, A. M., Leitges, M., Geiger, H., Díaz-Meco, M. T., Moscat, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103132108 · Cited by 52
Self-citationRac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo
Sengupta, A., Arnett, J., Dunn, S., Williams, D. A., & Cancelas, J. A. (2010) · Blood · doi:10.1182/blood-2009-10-247437 · Cited by 52
Self-citation
Metadata
- Authors
- Cancelas, J. A., Lee, A. W., Prabhakar, R., Stringer, K. F., Zheng, Y., & Williams, D. A.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Williams, David A
- Venue
- Nature Medicine
- Published
- 2005-07-17
- Volume
- 11
- Issue
- 8
- Pages
- 886-891
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2064771788
- Semantic Scholar
- 3b030828bbdde5a8ef96ecb155d0b62bc0e67dee
- Cited by
- 278
- References
- 30
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 12 · 2019: 6 · 2018: 11 · 2017: 11 · 2016: 7 · 2015: 20 · 2014: 11 · 2013: 20 · 2012: 21
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM060523)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK62752)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Rac1, Rac2, Rho GTPases, hematopoietic stem cells, hematopoietic progenitor cells, engraftment, hematopoietic stem cell mobilization, endosteum, bone marrow microenvironment, hematopoiesis, stem cell targeting
- MeSH terms
- Aminoquinolines, Animals, Cell Movement, Flow Cytometry, Hematopoiesis, Hematopoietic Stem Cells, Neuropeptides, Pyrimidines, Signal Transduction, Bone Marrow Transplantation, Granulocyte Colony-Stimulating Factor, Gene Deletion, Hematopoietic Stem Cell Mobilization, rac GTP-Binding Proteins, rac1 GTP-Binding Protein, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
