Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

Alzheimer’s disease β-amyloid peptides are released in association with exosomes

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Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome

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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

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The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

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Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

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A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

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Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

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The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

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Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

Goetzl, E. J., Boxer, A. L., Schwartz, J. B., Abner, E. L., Petersen, R. C., Miller, B. L., & Kapogiannis, D. (2015) · Neurology · doi:10.1212/wnl.0000000000001702 · Cited by 466 · see citing works

Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease

Fagan, A. M., Xiong, C., Jasielec, M. S., Bateman, R. J., Goate, A. M., Benzinger, T. L. S., Ghetti, B., Martins, R. N., Masters, C. L., Mayeux, R., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007901 · Cited by 434 · see citing works

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

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Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease

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ALZHEIMER'S PRESENILE DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWN'S SYNDROME IN MIDDLE AGE FORM AN AGE RELATED CONTINUUM OF PATHOLOGICAL CHANGES

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Down syndrome and Alzheimer's disease: common pathways, common goals

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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease

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Phosphorylation of tau protein at sites Ser 396–404 is one of the earliest events in A lzheimer's disease and D own syndrome

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A potential function for neuronal exosomes: Sequestering intracerebral amyloid‐β peptide

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Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

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Inhibition of γ‐secretase causes increased secretion of amyloid precursor protein C‐terminal fragments in association with exosomes

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Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Goetzl, E. J., Boxer, A. L., Schwartz, J. B., Abner, E. L., Petersen, R. C., Miller, B. L., Carlson, O. D., Mustapić, M., & Kapogiannis, D. (2015) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.211 · Cited by 208 · see citing works

Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases

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Test Accuracy of Cognitive Screening Tests for Diagnosis of Dementia and Multidomain Cognitive Impairment in Stroke

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MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer

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The pattern of amyloid accumulation in the brains of adults with Down syndrome

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Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

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Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

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Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

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A novel DYRK1A (Dual specificity tyrosine phosphorylation‐regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro

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Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

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Hyperphosphorylation-Induced Tau Oligomers

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Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

Hartley, S. L., Handen, B. L., Devenny, D. A., Hardison, R. M., Mihaila, I., Price, J. C., Cohen, A. D., Klunk, W. E., Seltzer, M. M., Johnson, S. C., et al. (2014) · Brain · doi:10.1093/brain/awu173 · Cited by 100 · see citing works

RCAN1‐1L is overexpressed in neurons of Alzheimer's disease patients

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Aging and Down Syndrome

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Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated Phosphorylation

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Change in plasma Aβ peptides and onset of dementia in adults with Down syndrome

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The past and the future of Alzheimer's disease CSF biomarkers—a journey toward validated biochemical tests covering the whole spectrum of molecular events

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Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I

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Aging enhances release of exosomal cytokine mRNAs by Aβ 1‐42 ‐stimulated macrophages

Mitsuhashi, M., Taub, D. D., Kapogiannis, D., Eitan, E., Zukley, L. M., Mattson, M. P., Ferrucci, L., Schwartz, J. B., & Goetzl, E. J. (2013) · The FASEB Journal · doi:10.1096/fj.13-238980 · Cited by 70 · see citing works

Increase in β-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndrome

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Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome

Schupf, N., Lee, A., Park, N., Dang, L. T., Pang, D. I., Yale, A., Oh, D. K. T., Krinsky‐McHale, S. J., Jenkins, E. C., Luchsinger, J. A., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.06.020 · Cited by 36 · see citing works

Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults

Soriano, L. D. H., Xicota, L., Sánchez‐Benavides, G., Cuenca‐Royo, A., de Sola, S., Langohr, K., Fagundo, A. B., Farré, M., Dierssen, M., & de la Torre, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00301 · Cited by 31 · see citing works

Imaging biomarkers in tauopathies

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A distinct subfraction of Aβ is responsible for the high‐affinity Pittsburgh compound B‐binding site in Alzheimer's disease brain

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β -Secretases, Alzheimer’s Disease, and Down Syndrome

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Optimizing the CAMCOG test in the screening for mild cognitive impairment and incipient dementia: saving time with relevant domains

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The AMY Antigen Co-Occurs with Aβ and Follows Its Deposition in the Amyloid Plaques of Alzheimer's Disease and Down Syndrome

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Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

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Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

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Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

Mustapić, M., Eitan, E., Werner, J. K., Berkowitz, S. T., Lazaropoulos, M. P., Tran, J., Goetzl, E. J., & Kapogiannis, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00278 · Cited by 453 · see citing works

Dementia in Down syndrome: unique insights for Alzheimer disease research

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Alzheimer's disease associated with Down syndrome: a genetic form of dementia

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Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

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Mechanisms of secretion and spreading of pathological tau protein

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L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma

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Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

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Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Kapogiannis, D., Mustapic, M., Shardell, M. D., Berkowitz, S. T., Diehl, T. C., Spangler, R. D., Tran, J., Lazaropoulos, M. P., Chawla, S., Gulyani, S., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2462 · Cited by 241 · see citing works

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

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New windows into the brain: Central nervous system-derived extracellular vesicles in blood

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Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease

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MicroRNA Expression Levels Are Altered in the Cerebrospinal Fluid of Patients with Young-Onset Alzheimer’s Disease

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Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment

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Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

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Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV

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Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau

Rayaprolu, S., Higginbotham, L., Bagchi, P., Watson, C. M., Zhang, T., Levey, A. I., Rangaraju, S., & Seyfried, N. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00840-3 · Cited by 118 · see citing works

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity

Winston, C. N., Romero, H. K., Ellisman, M., Nauss, S. N., Julovich, D. A., Conger, T., Hall, J. R., Campana, W. M., O’Bryant, S. E., Nievergelt, C. M., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01005 · Cited by 111 · see citing works

Alzheimer's disease in Down syndrome: an overlooked population for prevention trials

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Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer’s Disease

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Further understanding the connection between Alzheimer's disease and Down syndrome

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Opportunities, barriers, and recommendations in Down syndrome research

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Effects of exercise on exosome release and cargo in in vivo and ex vivo models: A systematic review

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Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

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Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics

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Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age

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Exosomal biomarkers in Down syndrome and Alzheimer's disease

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Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo

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Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease

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Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

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Genetic and Pharmacological Discovery for Alzheimer’s Disease Using Caenorhabditis elegans

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A cell-based assay for CD63-containing extracellular vesicles

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The path to biomarker-based diagnostic criteria for the spectrum of neurodegenerative diseases

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Tissue Engineering and Regenerative Medicine 2017: A Year in Review

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Extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease

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Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies

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A Pilot Study of Urinary Exosomes in Alzheimer’s Disease

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Perspectives on Oxidative Stress in Alzheimer’s Disease and Predictions of Future Research Emphases

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Growth Hormone-Releasing Hormone Modulation of Neuronal Exosome Biomarkers in Mild Cognitive Impairment

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Brain‐derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer’s disease

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Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

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Altered Cerebrospinal Fluid Exosomal microRNA Levels in Young-Onset Alzheimer’s Disease and Frontotemporal Dementia

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Increased levels of plasma total tau in adult Down syndrome

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Recent advances in optical label‐free characterization of extracellular vesicles

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Blood Biomarkers for Alzheimer’s Disease in Down Syndrome

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Recent Advances on Extracellular Vesicles in Central Nervous System Diseases

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Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease

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Changes in the Morphology, Number, and Pathological Protein Levels of Plasma Exosomes May Help Diagnose Alzheimer’s Disease

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Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities

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Plasma α-synuclein and cognitive impairment in the Parkinson’s Associated Risk Syndrome: A pilot study

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Extracellular Vesicles in CNS Developmental Disorders

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Extracellular vesicles, new actors in the search for biomarkers of dementias

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Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal‐derived extracellular vesicles

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Long-Term Effects of SARS-CoV-2 in the Brain: Clinical Consequences and Molecular Mechanisms

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Extracellular vesicles and pancreatitis: mechanisms, status and perspectives

Jia, Y., Ding, Y., Mei, W., Wang, Y., Zheng, Z. G., Qu, Y., Liang, K., Li, J. X., Cao, F., & Li, F. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.54858 · Cited by 34 · see citing works

Exosomes as drug delivery vehicles and biomarkers for neurological and auditory systems

Mittal, R., Bencie, N., Langlie, J. A., Mittal, J., & Eshraghi, A. A. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30484 · Cited by 35 · see citing works

Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer’s and Parkinson’s disease models of neurodegeneration

Griffin, E. F., Yan, X., Caldwell, K. A., & Caldwell, G. A. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy308 · Cited by 32 · see citing works

Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

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Neuronal exosome proteins: novel biomarkers for predicting neonatal response to therapeutic hypothermia

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Extracellular vesicles in mammalian reproduction: a review

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Toward Exosome-Based Neuronal Diagnostic Devices

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Blood‐based biomarkers for Down syndrome and Alzheimer's disease: A systematic review

Petersen, M. E., & O’Bryant, S. E. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22714 · Cited by 27 · see citing works

Plasma amyloid and tau as dementia biomarkers in Down syndrome: Systematic review and meta‐analyses

Alhajraf, F., Ness, D., Hye, A., & Strydom, A. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22715 · Cited by 26 · see citing works

Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue

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Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis

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Circulating Exosomes of Neuronal Origin as Potential Early Biomarkers for Development of Stroke

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Focusing on cellular biomarkers: The endo-lysosomal pathway in Down syndrome.

Botté, A., & Potier, M. (2020) · Progress in Brain Research · doi:10.1016/bs.pbr.2019.10.002 · Cited by 20 · see citing works

Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study

Petersen, M. E., Zhang, F., Schupf, N., Krinsky‐McHale, S. J., Hall, J. R., Mapstone, M. E., Cheema, A. K., Silverman, W. P., Lott, I. T., Rafii, M. S., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12039 · Cited by 23 · see citing works

Biogenesis, Biologic Function and Clinical Potential of Exosomes in Different Diseases

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A Review of Biomarkers for Alzheimer’s Disease in Down Syndrome

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Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain

Ledreux, A., Thomas, S., Hamlett, E. D., Trautman, C. W., Gilmore, A., Hager, E. R., Paredes, D., Margittai, M., Fortea, J., & Granholm, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173931 · Cited by 22 · see citing works

Circulating exo-miR-154-5p regulates vascular dementia through endothelial progenitor cell-mediated angiogenesis

Han, X., Zhou, L., Tu, Y., Wei, J., Zhang, J., Jiang, G., Shi, Q., & Ying, H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.881175 · Cited by 22 · see citing works

Potential Mechanisms of Tunneling Nanotube Formation and Their Role in Pathology Spread in Alzheimer’s Disease and Other Proteinopathies

Kotarba, S., Kozłowska, M., Scios, M., Saramowicz, K., Barczuk, J., Granek, Z., Siwecka, N., Wiese, W., Golberg, M., Galita, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910797 · Cited by 21 · see citing works

Neuron-derived extracellular vesicle-based diagnostics for Tau and Alzheimer’s disease

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Exosome release and cargo in Down syndrome

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The Potential of Liquid Biopsy of the Brain Using Blood Extracellular Vesicles: The First Step Toward Effective Neuroprotection Against Neurodegenerative Diseases

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Inflammatory biomarkers and intellectual disability in patients with Down syndrome

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Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome

Andrews, E. J., Martini, A. C., & Head, E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.954999 · Cited by 20 · see citing works

Neural-Derived Extracellular Vesicles in Clinical Trials

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Clinical implications of extracellular vesicles in neurodegenerative diseases

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Down syndrome biobank consortium: a perspective

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The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome

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Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome

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Nanoscale flow cytometry‐based quantification of blood‐based extracellular vesicle biomarkers distinguishes MCI and Alzheimer's disease

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Extracellular vesicle-based point-of-care testing for diagnosis and monitoring of Alzheimer’s disease

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The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery

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Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma

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Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases

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From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approach

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Proteomics for comprehensive characterization of extracellular vesicles in neurodegenerative disease

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Vesicular trafficking and cell-cell communication in neurodevelopment and neurodegeneration

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Roles of Bile‐Derived Exosomes in Hepatobiliary Disease

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Prospects for the Use of Small Extracellular Vesicles as a Transport Vehicle through the Blood–Brain Barrier

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Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

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Regenerating islet-derived 1α (REG-1α) protein increases tau phosphorylation in cell and animal models of tauopathies

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Exosomes: new targets for understanding axon guidance in the developing central nervous system

Liu, M., & Teng, T. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1510862 · Cited by 10 · see citing works

Blood‐based biomarkers for Alzheimer's disease in Down syndrome: A systematic review and meta‐analysis

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Down syndrome and dementia: advances in the field

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Alpha‐synuclein co‐pathology in Down syndrome‐associated Alzheimer's disease

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Exosomal biomarkers in Down syndrome and Alzheimer's disease

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NFL and pTau species from plasma neuronal and astrocyte exosomes correlate with neuropathological development and neurodegeneration in Down Syndrome

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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

Fiandaca, M. S., Kapogiannis, D., Mapstone, M., Boxer, A., Eitan, E., Schwartz, J. B., Abner, E. L., Petersen, R. C., Federoff, H. J., Miller, B. L., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.008 · Cited by 959 · see citing works

Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome

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Blood‐based biomarkers for Alzheimer's disease in Down syndrome: A systematic review and meta‐analysis

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