Neuronal PTP1B regulates body weight, adiposity and leptin action

Bence, Kendra K, Delibegovic, Mirela, Xue, Bingzhong, Gorgun, Cem Z, Hotamisligil, Gokhan S, Neel, Benjamin G, Kahn, Barbara B·2006·Nature Medicine
DOI 10.1038/nm1435

Cited by (635)

Items 501–600 of 635

  1. G Protein-Coupled Receptor Interaction Prediction Based on Deep Transfer Learning
    Tengsheng Jiang, Yuhui Chen, Shixuan Guan, Zhongtian Hu, Weizhong Lu, Qiming Fu, Yijie Ding, Haiou Li, Hongjie Wu · 2021 · IEEE Transactions on Computational Biology and Bioinformatics
  2. A versatile and automatic on-line screening method: Transverse diffusion of laminar flow profiles-based capillary electrophoresis for exploring PTP1B inhibitors in natural products
    Juan Gao, Erwin Adams, Zhengjin Jiang, Ann Van Schepdael · 2024 · Journal of Chromatography A
  3. Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations
    Sarah Ashiqueali, Augusto Schneider, Xiang Zhu, Ewelina Juszczyk, Mishfak A. M. Mansoor, Yun Xia Zhu, Yimin Fang, Bianka M. Zanini, Driele Neske Garcia, Natalie Hayslip et al. · 2024 · Aging Cell
  4. Brain Inflammation and Endoplasmic Reticulum Stress
    I. Çakır, E. Nillni · 2018 · Springer eBooks
  5. PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress
    Mirela Delibegović, Nimesh Mody · 2013 · Springer eBooks
  6. ETS proto-oncogene 1 modulates PTP1B expression to participate in high glucose-mediated endothelial inflammation
    Lili Jiang, Jincai Liang, Tianhai Wang, Fufen Meng, Wenming Duan · 2022 · Acta Biochimica et Biophysica Sinica
  7. Discovery and evaluation of biphenyl derivatives of 2‐iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity
    Denis A. Babkov, O. N. Zhukovskaya, A. A. Brigadirova, Diana R. Prilepskaya, Alexandra A. Kolodina, Abbas Haider S. Abbas, Анатолий Савельевич Морковник, Masilamani Elizabeth Sobhia, Ketan Ghosh, А. А. Спасов · 2022 · Chemical Biology & Drug Design
  8. Protein Tyrosine Phosphatase 1B: A Novel Molecular Target for Retinal Degenerative Diseases
    Devaraj K. Basavarajappa, Vivek Gupta, Raju V. S. Rajala · 2011 · Advances in experimental medicine and biology
  9. Correction: Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis
    Carl Owen, Alicja Czopek, Abdelali Agouni, Louise Grant, Robert L. Judson, Emma K. Lees, George D. Mcilroy, Olga Göransson, Andy Welch, Kendra K. Bence et al. · 2012 · PLoS ONE
  10. Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte
    Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan H. Wells, Kuang‐Yu Jen, Tzu‐Ching Meng, Fawaz G. Haj · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  11. A novel, centrally acting mammalian aminosterol, ENT ‐03, induces weight loss in obese and lean rodents
    Denise Barbut, William A. Kinney, Hsiao‐Huei Chen, Alexandre F.R. Stewart, Jacob Hecksher‐Sørensen, Chen Zhang, Alexander Fleming, Michael B. Zemel, MICHAEL A. ZASLOFF · 2024 · Diabetes Obesity and Metabolism
  12. From leptin to lasers: the past and present of mouse models of obesity
    Joshua R. Barton, Adam Eugene Snook, Scott Arthur Waldman · 2021 · Expert Opinion on Drug Discovery
  13. Exploring the structure and conformational landscape of human leptin. A molecular dynamics approach
    Brenda Chimal‐Vega, Norma Paniagua‐Castro, Jonathan Carrillo Vazquez, Jorge L. Rosas‐Trigueros, Absalom Zamorano‐Carrillo, Claudia G. Benítez‐Cardoza · 2015 · Journal of Theoretical Biology
  14. No Association of PTPN1 Polymorphisms With Macronutrient Intake and Measures of Adiposity
    Florianne Bauer, N. Charlotte Onland‐Moret, Anne G. Niehoff, Clara C. Elbers, Diederick E. Grobbee, Cisca Wijmenga, Yvonne T. van der Schouw · 2008 · Obesity
  15. ANTIOBESITY EFFECTS OF HUMAN SOLUBLE LEPTIN IN MICE NOURISHED WITH A HIGH-FAT/HIGH FRUCTOSE DIET
    B. Chimal-Vega · 2014 · American Journal of Agricultural and Biological Sciences
  16. The Role of Adipose Tissue Vasculature in Energy Balance
    Hyun-Ju Kim, Sang-Hyun Choi, Boe‐Gwun Chun, Dong-Hoon Kim · 2011 · Journal of Korean Society of Pediatric Endocrinology
  17. Obese Mouse Models
    Deborah J. Good · 2008 · Humana Press eBooks
  18. Effect of PTP1B Inhibitors and Taurine on Blood Lipid Profiles in Adolescent Obesity
    Sun Hee Cheong, Hyeongjin Cho, Kyung Ja Chang · 2008 · Advances in experimental medicine and biology
  19. MOLECULAR MECHANISMS OF INSULIN RESISTANCE IN OBESITY
    André Marette · 2008
  20. La leptine : du gène aux effets sur l’équilibre énergétique
    Arnaud Basdevant, Cécile Ciangura · 2007 · Bulletin de l Académie Nationale de Médecine
  21. Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling
    Yan Sun, Vasanth Chanrasekhar, Chase W. Kessinger, Peiyang Tang, Yunan Gao, Sarah Kamli-Salino, Katherine Nelson, Mirela Delibegović, E. Dale Abel, Maria Irene Kontaridis · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Optimization of Indole- and Pyrazole-fused Glycyrrhetinic Acid Derivatives as Potent PTP1B Inhibitors: In Silico, In Vitro, In Vivo, and Metabolomic Studies
    M. López-Sánchez, Hannya Mendoza-Mota, Ledy De‐la‐Cruz‐Martínez, Félix Matadamas‐Martínez, Diana Laura Torres-Chacón, Rosendo Martínez‐Arellano, Juan Francisco Palacios‐Espinosa, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez-Franco et al. · 2025 · ACS Bio & Med Chem Au
  23. Dysregulated glucose metabolism in the visual cortex of human subjects with mild cognitive impairment and Alzheimer’s disease
    Ulrik Nygaard Mjaaseth, Ming-Fo Hsu, Joseph Arballo, Fawaz G. Haj, Viharkumar Patel · 2026 · Frontiers in Aging Neuroscience
  24. Role of PTPRT in obesity and its substrate paxillin tyrosine-88 in colorectal cancer
    Anthony J. Scott · 2014 · OhioLink ETD Center (Ohio Library and Information Network)
  25. Effects of Combination Treatment with Leptin and Liraglutide on Glucose Metabolism in Insulin-Dependent Diabetic Mice
    Linlin Fu, Mariko Sugiyama, Shahriar Kamal, Tsubasa Ide, Tadashi Takeda, Mitsuhiro Kuno, Hiroshi Takagi, Teruhiko Koike, Hiroshi Arima, Ryoichi Banno · 2025 · International Journal of Molecular Sciences
  26. Obesity: Nature or Nurture?
    Robert H. Lustig · 2010 · Endocrine updates
  27. Lard intake results in better hypothalamic leptin responsiveness than beef tallow intake during overnutrition
    Mutsumi Ikeda, Tamae Shiino, Kai Naruke, Nozomi Takahashi, Hanako Kanzaki, Ran Xu, Toshimi Shirozu, Misato Nakano, Miharu Murae, Yui Funatsu et al. · 2025 · PLoS ONE
  28. Addendum: Neuronal PTP1B regulates body weight, adiposity and leptin action
    Kendra K. Bence, Mirela Delibegović, Bingzhong Xue, Cem Z. Görgün, Gökhan S. Hotamışlıgil, Benjamin G. Neel, Barbara B. Kahn · 2010 · Nature Medicine
  29. Hypothalamic Alterations in Obesity
    Licio Augusto Velloso · 2014 · Journal of Molecular and Genetic Medicine
  30. MORPHOLOGICAL FEATURES OF COMPONENTS OF TISSUES AND ORGANS IN OBESITY
    Т. V. Harapko · 2018 · Bulletin of Problems Biology and Medicine
  31. Hypothalamic AgRP neurons and the regulation of appetite and body weight: A review
    Ping Wang, Guo Zhang · 2018 · Chinese Science Bulletin (Chinese Version)
  32. Roles of Gut Hormones in the Regulation of Food Intake and Body Weight
    Lidia Castagneto‐Gissey, James Rossario Casella Mariolo, Geltrude Mingrone · 2019 · Endocrinology
  33. Neuronal Ptpn1 and Socs3 deletion improves metabolism but not anovulation in a mouse polycystic ovary syndrome model
    Romy I. Kerbus, Megan A. Inglis, Greg M. Anderson · 2023 · Journal of Endocrinology
  34. Effects of p-Hydroxybenzaldehyde, Vanillin, and Syringaldehyde on Protein Tyrosine Phosphatase 1B Activity
    Aminu Mohammed, Joy Atule Peter, Ahmed Olatunde, Suleiman Aminu, Ismaila Alhaji Umar · 2022 · Current Enzyme Inhibition
  35. PTP1B in astrocytes drives pathogen-induced neurodegeneration
    Zhicheng He, Yihui Xing, Jianqi Gu, Daxiang Xu, Peixuan He, Xiaoqian Lin, Wenjing Cui, Huiling Lv, Haoxuan Ding, Kai Sui et al. · 2026 · Journal of Neuroinflammation
  36. Myeloid Cell Protein Tyrosine Phosphatase 1B Drives Retinal Neurodegeneration in Diabetic Mice
    Ayaz Ali, Morgan Boyne, Abrar Othman, Sarah Kamli-Salino, Lucia Kuffová, John V. Forrester, Mirela Delibegović · 2026 · Diabetes
  37. Is Prenatal Exposure to Maternal Obesity Linked to Child Mental Health?
    Alina Rodriguez · 2010 · Elsevier eBooks
  38. Relationship status update for PTP1B and LepR: It׳s complicated
    Katrin Fischer, Timo D. Müller · 2014 · Molecular Metabolism
  39. Adipokines in Health and Disease
    Rexford S. Ahima, Marcus DaSilva Goncalves · 2010 · Springer eBooks
  40. Scientific familial lessons in ingestive behavior research: 2016 Alan N. Epstein research award
    Matthew R. Hayes · 2017 · Physiology & Behavior
  41. Insulin Receptor PTP
    Sofi G. Julien, Michel L. Tremblay · 2010 · Elsevier eBooks
  42. Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet
    Yan Sun, Abhishek Kumar Mishra, Vasanth Chanrasekhar, Michaela M. Door, Chase W. Kessinger, Bing Xu, Peiyang Tang, Yunan Gao, Sarah Kamli-Salino, Katherine Nelson et al. · 2025 · Science Signaling
  43. PTP1B and TCPTP in CNS Signaling and Energy Balance
    Kendra K. Bence, Tony Tiganis · 2013 · Springer eBooks
  44. Molecular Aspects of Obesity and Insulin Resistance in Metabolic Syndrome and Neurological Disorders
    A. A. Farooqui · 2013 · Springer eBooks
  45. Obesity and Neurodegeneration
    Pravir Kumar · 2015 · Advances in Obesity Weight Management & Control
  46. Conceptos tradicionales y emergentes sobre el balance energético
    Erwin Chiquete, Paulina Tolosa · 2013 · Revista de Endocrinología y Nutrición
  47. Fatty Acids and Hypothalamic Dysfunction in Obesity
    Gustavo D. Pimentel, Cristina Contreras, Miguel López · 2016 · Elsevier eBooks
  48. Correlation Between Nasal Epithelial Injury and In Vitro Cytotoxicity Using a Series of Small Molecule Protein Tyrosine Phosphatase 1B Inhibitors Investigated for Reversal of Leptin Resistance in Obesity
    Alan P. Brown, Chandrassegar Saravanan, Patrick J. Devine, Maria Chiara Magnifico, Jiaping Gao, Valérie Beaulieu, Fupeng Ma, Kayo Yasoshima, David Barnes‐Seeman, Ken Yamada · 2017 · International Journal of Toxicology
  49. Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus
    Huangna Quan · 2019 · Clinical Medicine Research
  50. Adipocyte-Derived Hormones
    Allison J. Richard, Jacqueline M. Stephens · 2019 · Elsevier eBooks
  51. Subchronic exposure to 1,2-naphthoquinone induces adipose tissue inflammation and changes the energy homeostasis of mice, partially due to TNFR1 and TLR4
    Clílton Kraüss de Oliveira Ferreira, Clara Machado Campolim, Olívia Pizetta Zordão, Fernando Moreira Simabuco, Chadi Pellegrini Anaruma, Rodrigo Martins Pereira, Vitor Ferreira Boico, Luiz Guilherme Salvino da Silva, Maíra Maftoum Costa, Nathalia Quintero Ruiz et al. · 2023 · Toxicology Reports
  52. La régulation du métabolisme du glucose par la protéine tyrosine phosphatase SHP-1
    Sébastien Bergeron · 2007 · Corpus Université Laval (Université Laval)
  53. Erratum: Corrigendum: Neuronal PTP1B regulates body weight, adiposity and leptin action
    Kendra K. Bence, Mirela Delibegović, Bingzhong Xue, Cem Z. Görgün, Gökhan S. Hotamışlıgil, Benjamin G. Neel, Barbara B. Kahn · 2010 · Nature Medicine
  54. Effect of different surgical weight-loss interventions and ethnicity on GLP-1 secretion
    Noora Al-Rasheid · 2018 · UCL Discovery (University College London)
  55. Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism
    Ari Elson · 2013 · Springer eBooks
  56. SH2B1 Regulates Insulin Sensitivity and Glucose Homeostasis by Multiple Mechanisms.
    David Lee Morris · 2009 · Deep Blue (University of Michigan)
  57. Efecte Hipotalàmic del tungstat de sodi i la seva relació amb la vida de la leptina: una possible teràpia antiobesitat
    Marta Amigó-Correig · 2010 · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
  58. Glucosensing, Hypoglycemia, and the Brain
    Candace M. Reno · 2013 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  59. Funktionelle Untersuchung der Orexin-Rezeptoren 1 und 2 auf humanen hämatopoetischen CD34 + Stamm- und Vorläuferzellen
    Simone Bork · 2007 · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
  60. On the Neurobiology of Physical Activity in Mice and Human : In search of Eating Disorders Determinants
    Elżbieta Kostrzewa · 2014 · Utrecht University Repository (Utrecht University)
  61. Leptin regulates expression of Agouti-related protein in hypothalamus:recent progress
    Bin Wang, Weiping Zhang · 2009 · Academic Journal of Second Military Medical University
  62. Nuevas acciones de p53: Homeostasis metabólica y efecto orexigénico de ghrelin
    Velasquez Raimundo, D. Vitullo Alfredo · 2012 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  63. Regulación de la secreción de GH, la ingesta y el metabolismo lipídico por péptidos derivados del gen de ghrelin
    V del Villar, María Jesús · 2011 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  64. Approaches to the Identification of Protein Tyrosine Phosphatase Substrates
    Anton M. Bennett, Tony Tiganis · 2010 · Elsevier eBooks
  65. Améliorer la sensibilité à la leptine vers un remède contre l’obésité
    Julie Dam, Virginie Vauthier, Ralf Jockers · 2008 · Obésité
  66. Redução hipotalamica da PTP-1B melhora a sensibilidade a insulina e leptina em ratos normais e obesos
    Paty K. Picardi · 2007
  67. The Role of Protein SUMOylation in Neuronal Function
    Kevin A. Wilkinson, Jeremy Martin Henley · 2010 · Springer eBooks
  68. Caracterização da transmissão do sinal da insulina e da leptina em hipotalamo de roedores durante a anorexia induzida pelo cancer
    Eduardo Rochete Ropelle · 2010
  69. A sideway glance: a new role for endoplasmic reticulum chemical chaperones as leptin sensitizers
    Sancia Gaetani · 2009 · Genes & Nutrition
  70. The Effect of Food Restriction on Appetite Regulating Hormones and Adiponectin Activity
    Ki Hoon Kim, Hyun Kook Kim · 2012 · Journal of Nutrition and Health
  71. FARELERDE LEPTİNİN LENFOSİT ALT TİPLERİ ÜZERİNE İN VİVO ETKİLERİ
    Aykut Göktürk Üner · 2009
  72. Molecular and Physiological Adaptations to Weight Perturbation in Mice
    Yann Ravussin · 2011
  73. Kiss1 neurons and Metabolic Sensing
    Xiaoliang Qiu · 2013 · OhioLink ETD Center (Ohio Library and Information Network)
  74. A fractalkina (CX3CL1) está envolvida nas etapas iniciais de ativação da inflamação no hipotálamo de roedores obesos
    Joseane Morari · 2013
  75. Fatores moleculares envolvidos nas alterações metabólicas durante a gestação: papel do SOCS3.
    Thais T. Zampieri · 2016 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  76. Quantitative Modeling Approaches for Understanding the Role of Phosphatases in Cell Signaling Regulation: Applications in Metabolism
    Matthew J. Lazzara · 2013 · Springer eBooks
  77. Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism
    Yannan Xi, Fawaz G. Haj · 2013 · Springer eBooks
  78. The Role of LMO4 in the Regulation of Hippocampal and Amygdalar Synaptic Function
    Zhaohong Qin · 2013 · uO Research (University of Ottawa)
  79. The role of neuronal peroxisome proliferator-activated receptor delta in diet-induced obesity and hypothalamic inflammation
    Heidi E. Kocalis · 2012
  80. Adipokine signal transduction pathways and its secretion in obese patients
    Xin-xin YUE, Zhimin Liu · 2010 · Academic Journal of Second Military Medical University
  81. Regional roles of central TRKB receptors in energy balance and regulation by PTP1B
    Ceren Ozek · 2015 · ScholarlyCommons (University of Pennsylvania)
  82. BASIC AND TRANSLATIONAL—LIVER Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
    Li Yu, Kimberly Wong, Amber Giles, Jianwei Jiang, Jong Woo Lee, Andrew Charles Adams, Alexei Kharitonenkov, Qin Yang, Bin Gao, Leonard Guarente et al. · 2014
  83. 71 Obese Mouse Models
    Deborah J. Good · 2008
  84. Redução da expressão de PTP1B na amígdala de ratos obesos altera o metabolismo energético e diminui a ansiedade relacionada à alimentação
    Natália Ferreira Mendes · 2016
  85. Central Nervous System (CNS) Nutrient Sensing in Diabetes
    Madhu Chari · 2010 · TSpace (University of Toronto)
  86. Efeito da dieta hiperlipídica sobre a responsividade de neurônios kisspeptidérgicos à leptina
    Jade Cabestre Venancio-Brochi · 2016 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  87. O efeito da deleção do SOCS3 em células responsivas à leptina em diferentes condições experimentais.
    João Alfredo Bolivar Pedroso · 2017 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  88. Roles of Gut Hormones in the Regulation of Food Intake and Body Weight
    Lidia Castagneto‐Gissey, James Rossario Casella Mariolo, Geltrude Mingrone · 2017 · Endocrinology
  89. Studies on appetite regulation and lipid biology in vertebrates
    Noor Khalidah Abdul Hamid · 2017 · Figshare
  90. Leptin and Aging in Animal Models
    Márta Balaskó, Ildikó Rostás, Judit Tenk, Szilvia Soós, Erika Pétervári · 2018 · Elsevier eBooks
  91. Research advances in metabolism 2017
    Nikolaos Perakakis, Wael Ghaly, Natia Peradze, Chrysoula Boutari, Saime Batırel, Vivian Paraskevi Douglas, Christos Socrates Mantzoros · 2018 · Metabolism
  92. Role of BRD4 and its target Ptp1b in Endothelial cells and in cardiovascular disease models
    Sidra Shahid · 2019
  93. Insulin resistance and obesity
    A. A. Farooqui · 2020 · Elsevier eBooks
  94. The Effect of Leptin Level Fluctuations by a Repeated Fasting/Refeeding on the Leptin Sensitivity in OLETF Rats
    Min‐Seon Kim · 2008 · Journal of Korean Endocrine Society
  95. The role of protein tyrosine phosphatase 1b in the central regulation of energy homeostasis
    Ryan C. Tsou · 2014 · Scholarly Commons (University of Pennsylvania)
  96. Suitability of Cherokee Reservoir and the upper Holston River for sauger and walleye
    C.J. Edrington, Lynn B. Starnes, Peter A. Hackney · 1979 · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
  97. Faculty Opinions recommendation of Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake.
    Steven J. Siegel · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  98. Papel do exercício físico na regulação da proteína rock em hipotálamo de camundongos obesos
    Luciana Santos Souza Pauli · 2017
  99. Faculty Opinions recommendation of MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity.
    Joel Keith Elmquist, Kevin W. Williams · 2010 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  100. Flavonoids
    Vineet Mehta, Udayabanu Malairaman · 2016 · IGI Global eBooks