Neuronal PTP1B regulates body weight, adiposity and leptin action

Bence, Kendra K, Delibegovic, Mirela, Xue, Bingzhong, Gorgun, Cem Z, Hotamisligil, Gokhan S, Neel, Benjamin G, Kahn, Barbara B·2006·Nature Medicine

DOI 10.1038/nm1435

Cited by (635)

Items 201–300 of 635

A Balance of Lipid-Sensing Mechanisms in the Brain and Liver
Caspi, Liora, Wang, Penny Y.T., Lam, Tony K.T. · 2007 · Cell Metabolism
Insulin Resistance in Brain and Possible Therapeutic Approaches
Şevki Çetinkalp, Ilgin Yildirim Simsir, Sibel Ertek · 2014 · Current Vascular Pharmacology
Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation
Ahmed Bettaieb, Jesse Bakke, Naoto Nagata, Kosuke Matsuo, Yannan Xi, Siming Liu, Daniel AbouBechara, Ramzi Melhem, Kimber L. Stanhope, Bethany P. Cummings et al. · 2013 · Journal of Biological Chemistry
Differential leptin access into the brain — A hierarchical organization of hypothalamic leptin target sites?
Heike Münzberg · 2008 · Physiology & Behavior
Pre‐ and postnatal calorie restriction perturbs early hypothalamic neuropeptide and energy balance
Bo‐Chul Shin, Yun Dai, Manikkavasagar Thamotharan, Leena Caroline Gibson, Sherin U. Devaskar · 2012 · Journal of Neuroscience Research
Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases
Jennifer M. Erichsen, Jim R. Fadel, Lawrence Patrick Reagan · 2021 · Neuropharmacology
Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter
Xiaohe Shi, Xizu Wang, Q. Li, Michelle Yu-Fah Su, Elaine Guo Yan Chew, Ee Tsin Wong, Zsombor Lacza, G. K. Radda, Vinay Tergaonkar, Weiping Han · 2013 · Diabetologia
PTP1B Regulates Cortactin Tyrosine Phosphorylation by Targeting Tyr446
Matthew Stuible, Nadia Dubé, Michel L. Tremblay · 2008 · Journal of Biological Chemistry
Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells
Rosaria Ottanà, Rosanna Maccari, Jérémie Mortier, Anna Caselli, Simona Amuso, Guido Camici, Archimede Rotondo, Gerhard Wolber, Paolo Paoli · 2013 · European Journal of Medicinal Chemistry
Deletion of protein tyrosine phosphatase 1B rescues against myocardial anomalies in high fat diet-induced obesity: Role of AMPK-dependent autophagy
Machender Reddy Kandadi, Evgeniy Panzhinskiy, Nathan D. Roe, Sreejayan Nair, Dahai Hu, Aijun Sun · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregulating Leptin Signaling in a Phosphorylation-Dependent Manner
Liat Rousso-Noori, Hilla Knobler, Einat Levy-Apter, Yael Kuperman, Adi Neufeld-Cohen, Yonat Keshet, Vasudheva Reddy Akepati, Richard A. Klinghoffer, Alon Chen, Ari Elson · 2011 · Cell Metabolism
Hypothalamic endoplasmic reticulum stress as a key mediator of obesity‐induced leptin resistance
Z. Ye, G. Liu, Jiao Guo, Zhengquan Su · 2018 · Obesity Reviews
An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications
Rosanna Maccari, Antonella DEL CORSO, Paolo Paoli, Ilenia Adornato, Giulia Lori, Francesco Balestri, Mario Cappiello, Alexandra Naß, Gerhard Wolber, Rosaria Ottanà · 2018 · Bioorganic & Medicinal Chemistry Letters
Nutrient-Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice
Clémence Blouet, Gary J. Schwartz · 2011 · Journal of Neuroscience
The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity
Dávid Medgyesi, Elias Hobeika, Robert Biesen, Florian Kollert, Adriano Taddeo, Reinhard Edmund Voll, Falk Hiepe, Michael G. Reth · 2014 · The Journal of Experimental Medicine
Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice
Rajinikanth Gogiraju, Marco Robin Schroeter, Magdalena L. Bochenek, Astrid Hubert, Thomas F. Münzel, Gerd P Hasenfuss, Katrin Schäfer · 2016 · Cardiovascular Research
Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2
Kosuke Matsuo, Mirela Delibegović, Izumi Matsuo, Naoto Nagata, Siming Liu, Ahmed Bettaieb, Yannan Xi, Kazushi Araki, Wentian Yang, Barbara B. Kahn et al. · 2010 · Journal of Biological Chemistry
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
Scott E. Kanoski, Shiru Zhao, Douglas J. Guarnieri, Ralph Dileone, Jianqun Yan, Bart C. De Jonghe, Kendra K. Bence, Matthew R. Hayes, Harvey J. Grill · 2012 · American Journal of Physiology-Endocrinology and Metabolism
Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata
Trần Hồng Quang, Nguyễn Thị Thanh Ngân, Chi‐Su Yoon, Kwang Ho Cho, Dae Gill Kang, Ho Lee, Youn‐Chul Kim, Hyuncheol Oh · 2015 · Molecules
The Genetics ofPTPN1and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
Ryan C. Tsou, Kendra K. Bence · 2012 · Journal of Obesity
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
R. Palanivel, Morgan D. Fullerton, Sandra Galić, Jane E. Honeyman, Kiran Hewitt, Sebastian B. Jørgensen, Gregory R. Steinberg · 2012 · Diabetologia
Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B
Tiantian Jin, Haibo B. Yu, Xu‐Feng Huang · 2016 · Scientific Reports
Leptin Signaling in the Control of Metabolism and Appetite: Lessons from Animal Models
Alberto A. Barrios-Correa, José Antonio Estrada, Irazú Contreras · 2018 · Journal of Molecular Neuroscience
The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling
Nihar R. Pandey, Xiang Yu Zhou, Zhuolin Qin, Tariq Zaman, Mariana Gomez-Smith, K. Keyhanian, Hymie Anisman, Jean Michel Brunel, Alexandre F.R. Stewart, Hsiao‐Huei Chen · 2013 · Journal of Neuroscience
Looking at Marine-Derived Bioactive Molecules as Upcoming Anti-Diabetic Agents: A Special Emphasis on PTP1B Inhibitors
Shahira M. Ezzat, Mahitab Helmy El Bishbishy, Solomon Habtemariam, Bahare Salehi, Mehdi Sharifi‐Rad, Natália Alves Martins, Javad Sharifi‐Rad · 2018 · Molecules
Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update
Zhenyang Liu, Hongwei Gao, Ziyu Zhao, Mengrui Huang, Shengnan Wang, Jiuyu Zhan · 2022 · Biomedicine & Pharmacotherapy
Using small molecules to target protein phosphatases
Viktor V. Vintonyak, Herbert Waldmann, Daniel Rauh · 2011 · Bioorganic & Medicinal Chemistry
Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions
Kentaro Kaneko, Pingwen Xu, Elizabeth Lyn Cordonier, Siyu S. Chen, Amy Ng, Yong Xu, Alexei Morozov, Makoto Fukuda · 2016 · Cell Reports
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia
Samantha Le Sommer, Nicola Morrice, Martina Pesaresi, Dawn Thompson, Mark A. Vickers, Graeme I. Murray, Nimesh Mody, Benjamin G. Neel, Kendra K. Bence, Heather M. Wilson et al. · 2017 · Cancer Research
The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B
Jillian C. Carmichael, Hiroki Yokota, Rebecca C. Craven, Anthony P. Schmitt, John W. Wills · 2018 · PLoS Pathogens
Leptin resistance and the response to positive energy balance
Christopher D. Morrison · 2008 · Physiology & Behavior
Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice
Sun Ju Choi, Zipora Yablonka‐Reuveni, Karl J. Kaiyala, Kayoko Ogimoto, Michael W. Schwartz, Brent E. Wisse · 2011 · American Journal of Physiology-Endocrinology and Metabolism
Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes
Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Shuo Wang, Ramzi Melhem, Antonis E. Koromilas, Fawaz G. Haj · 2012 · PLoS ONE
Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum
Azis Saifudin, Shigetoshi Kadota, Yasuhiro Tezuka · 2012 · Journal of Natural Medicines
Potential relationship between dietary long-chain saturated fatty acids and hypothalamic dysfunction in obesity
Domenico Sergi, Lynda M. Williams · 2019 · Nutrition Reviews
In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues
Abdelali Agouni, Carl Owen, Alicja Czopek, Nimesh Mody, Mirela Delibegović · 2010 · Biochemical and Biophysical Research Communications
Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor
Ryan C. Tsou, Kimberly S. Rak, Derek J. Zimmer, Kendra K. Bence · 2014 · Molecular Metabolism
Protein Tyrosine Phosphatase 1B Impairs Diabetic Wound Healing Through Vascular Endothelial Growth Factor Receptor 2 Dephosphorylation
Jing Zhang, Limin Li, Jing Li, Yuan Liu, Chen‐Yu Zhang, Yujing Zhang, Ke Zen · 2014 · Arteriosclerosis Thrombosis and Vascular Biology
Epithelial Protein-Tyrosine Phosphatase 1B Contributes to the Induction of Mammary Tumors by HER2/Neu but Is Not Essential for Tumor Maintenance
Kamal Kumar Balavenkatraman, Nicola Aceto, Adrian Britschgi, Urs Mueller, Kendra K. Bence, Benjamin G. Neel, Mohamed Bentires‐Alj · 2011 · Molecular Cancer Research
Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications
Sergio Montserrat‐de la Paz, Antonio Pérez‐Pérez, Teresa Vilariño‐García, Carlos Jiménez‐Cortegana, Francisco J.G. Muriana, María C. Millán-Linares, Víctor Sánchez‐Margalet · 2020 · The Journal of Nutritional Biochemistry
Molecular Targets for Obesity Therapy in the Brain
Obici, Silvana · 2009 · Endocrinology
A talk between fat tissue, gut, pancreas and brain to control body weight
Jenny L. Wilson, Pablo J. Enriori · 2015 · Molecular and Cellular Endocrinology
Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling
Kazuki Kimura, Mayumi Takada, Takeshi Ishii, Kentaro Tsuji, Mitsugu Akagawa · 2012 · Free Radical Biology and Medicine
The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF
Gaia Scabia, Ilaria Barone, Marco Mainardi, Giovanni Ceccarini, Manuela Scali, Emma Buzzigoli, Alessia Dattilo, Paolo Vitti, Amalia Gastaldelli, Ferruccio Santini et al. · 2018 · Scientific Reports
Inter-organ metabolic communication involved in energy homeostasis: Potential therapeutic targets for obesity and metabolic syndrome
Tetsuya Yamada, Yoshitomo Oka, Hideki Katagiri · 2007 · Pharmacology & Therapeutics
Leptin Signaling in the Arcuate Nucleus Reduces Insulin’s Capacity to Suppress Hepatic Glucose Production in Obese Mice
Balland, Eglantine, Chen, Weiyi, Dodd, Garron T., Conductier, Gregory, Coppari, Roberto, Tiganis, Tony, Cowley, Michael A. · 2019 · Cell Reports
Leptin Resistance Is Not the Primary Cause of Weight Gain Associated With Reduced Sex Hormone Levels in Female Mice
Regina P. da Silva, Thais T. Zampieri, João A.B. Pedroso, Vanessa Sayuri Nagaishi, Angela M. Ramos-Lobo, Isadora C. Furigo, Niels Olsen Saraiva Câmara, Renata Frazão, José Donato · 2014 · Endocrinology
Multiple Leptin Signalling Pathways in the Control of Metabolism and Fertility: A Means to Different Ends?
Maggie C. Evans, Rebecca A Lord, Greg M. Anderson · 2021 · International Journal of Molecular Sciences
Receptor-Interacting Protein 140 Orchestrates the Dynamics of Macrophage M1/M2 Polarization
Yi-Wei Lin, Bomi Lee, Pu-Ste Liu, Li‐Na Wei · 2015 · Journal of Innate Immunity
Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
Dongmei Wu, Yifu Qiu, Xiang Gao, Xiao‐bing Yuan, Qiwei Zhai · 2011 · PLoS ONE
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents
Rosaria Ottanà, Paolo Paoli, Alexandra Naß, Giulia Lori, Venera Cardile, Ilenia Adornato, Archimede Rotondo, Adriana Carol Eleonora Graziano, Gerhard Wolber, Rosanna Maccari · 2016 · European Journal of Medicinal Chemistry
Protein tyrosine phosphatase 1B dephosphorylates PITX1 and regulates p120RasGAP in hepatocellular carcinoma
Wei‐Tien Tai, Yao‐Li Chen, Pei‐Yi Chu, Li‐Ju Chen, Man‐Hsin Hung, Chung‐Wai Shiau, Jui‐Wen Huang, Ming‐Hsien Tsai, Kuen‐Feng Chen · 2016 · Hepatology
A cellular and molecular basis of leptin resistance
Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Alexandre Moura‐Assis, Ji‐Dung Luo, Joshua D. Rabinowitz, Jeffrey M. Friedman · 2025 · Cell Metabolism
Murine models of sleep apnea: functional implications of altered macrophage polarity and epigenetic modifications in adipose and vascular tissues
Wojciech Trzépizur, Rene Cortese, David Gozal · 2017 · Metabolism
Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor
Andrea Frassetto, Jiaping Zhang, Julie Z. Lao, Amanda T. White, Joseph M. Metzger, Tung Ming Fong, Richard Z. Chen · 2008 · Brain Research
Regulation of Brown Fat Adipogenesis by Protein Tyrosine Phosphatase 1B
Kosuke Matsuo, Ahmed Bettaieb, Naoto Nagata, Izumi Matsuo, Heike Keilhack, Fawaz G. Haj · 2011 · PLoS ONE
Drug targeting of leptin resistance
Anna Natalizia Santoro, Giuseppina Mattace Raso, Rosaria Meli · 2015 · Life Sciences
ROCK1 in AgRP Neurons Regulates Energy Expenditure and Locomotor Activity in Male Mice
Huang Hu, Seung‐Hwan Lee, Chianping Ye, Inês Sousa‐Lima, Byung‐Chul Oh, Bradford B. Lowell, Janice M. Zabolotny, Young‐Bum Kim · 2013 · Endocrinology
Protein Tyrosine Phosphatase 1B (PTP1B) Deficiency Accelerates Hepatic Regeneration in Mice
Jesús Revuelta‐Cervantes, Rafael Mayoral, Soledad Miranda, Águeda González‐Rodríguez, Margarita Fernández, Paloma Martín‐Sanz, Ángela M. Valverde · 2011 · American Journal Of Pathology
Liraglutide, leptin and their combined effects on feeding: additive intake reduction through common intracellular signalling mechanisms
Scott E. Kanoski, Zhi Yi Ong, Samantha M. Fortin, E. S. Schlessinger, Harvey J. Grill · 2014 · Diabetes Obesity and Metabolism
PAQR3 Has Modulatory Roles in Obesity, Energy Metabolism, and Leptin Signaling
Lingdi Wang, Xiao Wang, Zhenghu Li, Tingting Xia, Lu Zhu, Bin Liu, Yongxian Zhang, Fei Xiao, Yi Pan, Yong Liu et al. · 2013 · Endocrinology
Ventromedial hypothalamus–specific Ptpn1 deletion exacerbates diet-induced obesity in female mice
Franck Chiappini, Karyn J. Catalano, Jennifer Lee, Odile D. Peroni, Jacqueline E. Lynch, Abha S. Dhaneshwar, Kerry Wellenstein, Alexandra Sontheimer-Phelps, Benjamin G. Neel, Barbara B. Kahn · 2014 · Journal of Clinical Investigation
Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress
Santiago Vernia, Caroline Morel, Joseph C. Madara, Julie Cavanagh, Tamera Barrett, Kathryn O. Chase, Norman J. Kennedy, Dae Young Jung, Jason K. Kim, Neil Aronin M. D et al. · 2016 · eLife
PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance
Takafumi Shintani, Satoru Higashi, Ryoko Suzuki, Yasushi Takeuchi, Reina Ikaga, Tomomi Yamazaki, Kenta Kobayashi, Masaharu Noda · 2017 · Scientific Reports
Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects
Anjali K. Nath, Michael O. Krauthammer, Puyao Li, Eugene Davidov, Lucas C. Butler, Joshua A. Copel, Mikko Katajamaa, Matej Orešič, Irina Alexandra Buhimschi, Catalin S. Buhimschi et al. · 2009 · PLoS ONE
Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors
Naoya Yamashita, Rajshri Joshi, Sheng Zhang, Zhong‐Yin Zhang, Rejji Kuruvilla · 2017 · Developmental Cell
Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance
Garron T. Dodd, Seung Jae Kim, Mathieu Méquinion, Chrysovalantou E. Xirouchaki, Jens C. Brüning, Zane Bruce Andrews, Tony Tiganis · 2021 · Science Advances
Binding and discerning interactions of PTP1B allosteric inhibitors: Novel insights from molecular dynamics simulations
Ranajit Nivrutti Shinde, Masilamani Elizabeth Sobhia · 2013 · Journal of Molecular Graphics and Modelling
“Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress
Pablo Blanco Martínez de Morentin, Miguel López · 2010 · PLoS Biology
Phosphorylated Grb14 Is an Endogenous Inhibitor of Retinal Protein Tyrosine Phosphatase 1B, and Light-Dependent Activation of Src Phosphorylates Grb14
Devaraj K. Basavarajappa, Vivek Gupta, Radhika Dighe, Ammaji Rajala, Raju V. S. Rajala · 2011 · Molecular and Cellular Biology
Deletion of protein tyrosine phosphatase 1B obliterates endoplasmic reticulum stress-induced myocardial dysfunction through regulation of autophagy
Shuyi Wang, Xiyao Chen, Sreejayan Nair, Dongdong Sun, Xiaoming Wang, Jun Tao Ren · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin
Stefanie Fruhwürth, Heike Vogel, Annette Schürmann, Kevin Jon Williams · 2018 · Frontiers in Endocrinology
Obesity: the hormonal milieu
Anne Lenz, Frank Diamond · 2008 · Current Opinion in Endocrinology Diabetes and Obesity
The Mechanism of Leptin Resistance in Obesity and Therapeutic Perspective
Atilla Engin · 2024 · Advances in experimental medicine and biology
Protein Tyrosine Phosphatase-1B Modulates Pancreatic β-cell Mass
Rebeca Fernandez‐Ruiz, Elaine Cristina Vieira, Pablo M. García-Rovés, Ramón Gomis · 2014 · PLoS ONE
Glutamate Receptors in the Central Nucleus of the Amygdala Mediate Cisplatin-Induced Malaise and Energy Balance Dysregulation through Direct Hindbrain Projections
Amber L. Alhadeff, Ruby A. Holland, A. Nelson, Harvey J. Grill, Bart C. De Jonghe · 2015 · Journal of Neuroscience
PTP1B, A Potential Target of Type 2 Diabetes Mellitus
Jia Yun Sun, Chao Qu, Yajun Wang, Hui Fang Huang, Mingrui Zhang, Hongyan Li, Yejun Zhang, Yang Wang, Wei Zou · 2016 · Molecular Biology
Hypothalamic Integration of the Endocrine Signaling Related to Food Intake
Anica Klockars, Allen S. Levine, Pawel K. Olszewski · 2018 · Current topics in behavioral neurosciences
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss
Hailan Liu, Yang He, Juli Bai, Chuanhai Zhang, Feng Zhang, Yongjie Yang, Hairong Luo, Meng Yu, Hesong Liu, Longlong Tu et al. · 2023 · Nature Metabolism
Interleukin-Targeted Therapy for Metabolic Syndrome and Type 2 Diabetes
Kathrin Maedler, Gitanjali Dharmadhikari, Desirée Schumann, Joachim Størling · 2011 · Handbook of experimental pharmacology
The use of phage display to generate conformation-sensor recombinant antibodies
Aftabul Haque, Nicholas K. Tonks · 2012 · Nature Protocols
Enhanced Retinal Insulin Receptor-activated Neuroprotective Survival Signal in Mice Lacking the Protein-tyrosine Phosphatase-1B Gene
Raju V. S. Rajala, Masaki Tanito, Benjamin G. Neel, Ammaji Rajala · 2010 · Journal of Biological Chemistry
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
Bart C. De Jonghe, Matthew R. Hayes, Ryoichi Banno, Karolina Patrycja Skibicka, Derek J. Zimmer, Kerisha A. Bowen, Theresa M. Leichner, Amber L. Alhadeff, Scott E. Kanoski, Nicole E. Cyr et al. · 2011 · American Journal of Physiology-Endocrinology and Metabolism
The Role of PTP1B O-GlcNAcylation in Hepatic Insulin Resistance
Yun Zhao, Zhuqi Tang, Aiguo Shen, Tao Tao, Chunhua Wan, Xiaohui Zhu, Jieru Huang, Wanlu Zhang, Nana Xia, Suxin Wang et al. · 2015 · International Journal of Molecular Sciences
Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats
Eloize Cristina Chiarreotto Ropelle, Luciana Santos Souza Pauli, Carlos K. Katashima, Gustavo D. Pimentel, Paty K. Picardi, Vagner Ramon Rodrigues Silva, Cláudio Teodoro de Souza, Patrícia O. Prada, Dennys E. Cintra, José Barreto Campello Carvalheira et al. · 2013 · American Journal of Physiology-Endocrinology and Metabolism · Retracted
Protein Tyrosine Phosphatase 1B Inhibition Protects against Podocyte Injury and Proteinuria
Takanori Kumagai, Cindy Baldwin, Lamine Aoudjit, Lisa Nezvitsky, Richard Robins, Ruihua Jiang, Tomoko Takano · 2014 · American Journal Of Pathology
TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures
Yoshihiro Ito, Ryoichi Banno, Shigeru Hagimoto, Yoshiharu Ozawa, Hiroshi Arima, Yutaka Oiso · 2011 · Regulatory Peptides
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
Bart C. De Jonghe, Matthew R. Hayes, Derek J. Zimmer, Scott E. Kanoski, Harvey J. Grill, Kendra K. Bence · 2012 · American Journal of Physiology-Endocrinology and Metabolism
Binge‐type eating disrupts dopaminergic and GABAergic signaling in the prefrontal cortex and ventral tegmental area
Rebecca L. Corwin, Francis H. E. Wojnicki, Derek J. Zimmer, R.K. Babbs, Lauren E. McGrath, Diana R. Olivos, Elizabeth G. Mietlicki‐Baase, Matthew R. Hayes · 2016 · Obesity
FTO is necessary for the induction of leptin resistance by high-fat feeding
Y.C. Loraine Tung, Pawan Gulati, Che-Hsiung Liu, Debra Rimmington, Rowena J. Dennis, Marcella K.L. Ma, Vladimı́r Saudek, Stephen O’Rahilly, Anthony P. Coll, Giles S.H. Yeo · 2015 · Molecular Metabolism
Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system
Roshanak Asgari, Maria Caceres-Valdiviezo, Sally Wu, Laurie Hamel, Bailey E. Humber, Sri Mahavir Agarwal, Paul J. Fletcher, Stephanie Fulton, Margaret Hahn, Sandra Pereira · 2024 · Molecular Metabolism
Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B
Hanying Ding, Yan Zhang, Chen Xu, Dongxia Hou, Jing Li, Yujing Zhang, Wei Peng, Ke Zen, Chen‐Yu Zhang, Xiaohong Jiang · 2014 · Diabetologia
Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury
Yoshihiro Ito, Ming-Fo Hsu, Ahmed Bettaieb, Shinichiro Koike, Aline Mello, Miguel Calvo‐Rubio, José M. Villalba, Fawaz G. Haj · 2017 · Metabolism
Inhibition of Protein-Tyrosine Phosphatase PTP1B and LMPTP Promotes Palmitate/Oleate-Challenged HepG2 Cell Survival by Reducing Lipoapoptosis, Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic Reticulum Stress
Lynda Bourebaba, Jacek Łyczko, Michalina Alicka, Nabila Bourebaba, Antoni Szumny, Andrzej Fal, Krzysztof Marycz · 2020 · Journal of Clinical Medicine
T-Cell Protein Tyrosine Phosphatase Regulates Bone Resorption and Whole-Body Insulin Sensitivity through Its Expression in Osteoblasts
Tiffany Zee, Carmine Settembre, Robert L. Levine, Gérard Karsenty · 2012 · Molecular and Cellular Biology
Lipoic Acid Decreases the Viability of Breast Cancer Cells and Activity of PTP1B and SHP2
Alicja Kuban‐Jankowska, Magdalena Górska‐Ponikowska, Michał Woźniak · 2017 · Anticancer Research
PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure
Yongheng Cao, Masanori Nakata, Shiki Okamoto, Eisuke Takano, Toshihiko Yada, Yasuhiko Minokoshi, Yukio Hirata, Kazunori Nakajima, Kristy Iskandar, Yoshitake Hayashi et al. · 2011 · PLoS ONE
Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases
Inmaculada García‐Ruíz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruíz-Cañas, Ana Blas‐García, M. Pilar Valdecantos, Montserrat Sanz, J. A. Solís Herruzo, Ángela M. Valverde · 2019 · Redox Biology
New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes
Anna Fosch, Sebastián Zagmutt, Núria Casals, Rosalía Rodríguez‐Rodríguez · 2021 · International Journal of Molecular Sciences
From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues
Oxana B. Kazakova, Gul'nara V. Giniyatullina, Denis A. Babkov, Zdeněk Wimmer · 2022 · International Journal of Molecular Sciences