Neuronal PTP1B regulates body weight, adiposity and leptin action

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Items 601–635 of 635

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   Carlos K. Katashima · 2012
5. Faculty Opinions recommendation of PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.
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6. Efeitos do exercício físico sobre a sinalização da leptina no hipotálamo de ratos
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9. Targeting Protein Tyrosine Phosphatases via PROteolysis-TArgeting Chimeras (PROTACs): Current Developments and Prospects
   Rosanna Maccari · 2025 · Molecules
10. An Ongoing Search for Multitarget Ligands as Potential Agents for Diabetes Mellitus and Its Long-Term Complications: New Insights into (5-Arylidene-4-oxothiazolidin-3-yl)alkanoic Acid Derivatives
    Rosanna Maccari, Rosaria Ottanà, Valerij Talagayev, Roberta Moschini, Francesco Balestri, Francesca Felice, Francesca Iannuccilli, Gemma Sardelli, Rebecca Sodano, Gerhard Wolber et al. · 2025 · Pharmaceuticals
11. Identification of novel PTP1B inhibitor for the treatment of LPS-induced myocardial apoptosis: machine learning based virtual screening and biological evaluation
    Xu Dong, Bing Shang, Xin Li, Jie Zhang, Zhen Liu, Bo Feng · 2025 · Journal of Enzyme Inhibition and Medicinal Chemistry
12. Diterpenes as PTP1B Inhibitors for the Treatment of Diabetes Mellitus 2 and Obesity: An in-depth Literature Review and Computational Study
    Md. Shimul Bhuia, Raihan Chowdhury, Tamanna Khatun, Salehin Sheikh · 2025 · Journal of Medicinal Chemistry and Therapeutics
13. Rôle des tanycytes de l’éminence médiane dans le transport de la leptine de la périphérie vers l’hypothalamus
    Églantine Balland · 2012 · theses.fr (ABES)
14. Molecular effects of the anticancer drug cisplatin on the protein tyrosine phosphatase 1B (PTP1B) and structural impact of PTP1B cancer-associated mutations
    Rongxing Liu · 2022
15. Etude de la contribution de l'hormone adipocytaire leptine dans la pathogenèse du syndrome de Rett
    Yasmine Belaïdouni · 2022 · theses.fr (ABES)
16. Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity
    James Dell’Orco, Warren W. Pan, Margaret B. Allison, Abigail J. Tomlinson, Jordan Wean, Paul V. Sabatini, Christopher J. Rhodes, David P. Olson, Martin Grosvenor Myers, Paulette B. Goforth · 2026 · Molecular Metabolism
17. Design, synthesis, and in-vitro evaluation of 2-(heteroarylthio)acetamido-1H-benzo[d]imidazole derivatives as PTP1B inhibitors for the treatment of type 2 diabetes
    Praveen Kumar, Benjamin Ayodipupo Babalola, Zihan Qu, Digambar Kumar Waiker, Ns Hari Narayana Moorthy, Akhilesh Tiwari, Arati Chourasiya, Duangnapa Kiriwan, Fábio G. Martins, Sérgio Filipe Sousa et al. · 2026 · 3 Biotech
18. PTP1B deficiency in the reward system suppressed the rewarding value of a high-fat diet
    Mitsuhiro Kuno, Mariko Sugiyama, Linlin Fu, Kazumasa Asai, Tsubasa Ide, Tadashi Takeda, Tomoko Handa, Takashi Miyata, Tomoko Kobayashi, Takeshi Onoue et al. · 2026 · Brain Research Bulletin
19. Protein Tyrosine Phosphatases in Cancer: From Oncogenic Drivers to Therapeutic Targets
    Sravan Perla, Jonathan V. Pascale, Matthew Liu, Ashish Kumar, Sivaraman Kuppuswamy, Alladi Charanraj Goud, Vishnu Amaram Samara · 2026 · Cells
20. Leptin Resistance and Endoplasmic Reticulum Stress: ER Proteostasis as a Proposed Convergence Node—A Mechanistic Synthesis of Preclinical Evidence
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21. Temporal organization of leptin signaling reveals distinct regulatory roles for STAT3 and ETV6
    Ekta Pathak, Miriam Bernecker, Noémi Mallet, Ann-Christin König, Ruth Gutiérrez‐Aguilar, Cristina Mencias, Sonja Charlotte Schriever, Paul T. Pfluger · 2026 · Journal of Molecular Endocrinology
22. BindingDB Entry 50043693: Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.
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23. BindingDB Entry 50043484: Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.
    BindingDB · 2014 · UC San Diego
24. BindingDB Entry 50007133: An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications.
    BindingDB · 2021 · UC San Diego
25. BindingDB Entry 50023437: A Medicinal Chemistry Perspective on Protein Tyrosine Phosphatase Nonreceptor Type 2 in Tumor Immunology.
    BindingDB · 2026 · UC San Diego
26. BindingDB Entry 50042715: Sesquiterpenes from the rhizomes of Curcuma heyneana.
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27. BindingDB Entry 50018093: Selective Inhibition of PTP1B by New Anthraquinone Glycosides from
    BindingDB · 2023 · UC San Diego
28. BindingDB Entry 50023027: Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives.
    BindingDB · 2026 · UC San Diego
29. BindingDB Entry 50023718: Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders.
    BindingDB · 2026 · UC San Diego
30. BindingDB Entry 50033243: Using small molecules to target protein phosphatases.
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31. BindingDB Entry 50048972: Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents.
    BindingDB · 2019 · UC San Diego
32. BindingDB Entry 50008351: Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
    BindingDB · 2021 · UC San Diego
33. Adipokine Signaling
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34. Caracterização da atividade da PTP1B em hipotálamo de roedores obesos submetidos ao exercício físico
    Eloize Cristina Chiarreotto Ropelle · 2013
35. Apoptose de neuronios hipotalamicos em ratos alimentados com dieta hiperlipidica
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