Neuronal PTP1B regulates body weight, adiposity and leptin action
Bence, Kendra K, Delibegovic, Mirela, Xue, Bingzhong, Gorgun, Cem Z, Hotamisligil, Gokhan S, Neel, Benjamin G, Kahn, Barbara B·2006·Nature Medicine
DOI 10.1038/nm1435
Cited by (635)
Items 101–200 of 635
- Molecular mechanisms of central leptin resistance in obesityChang Hee Jung, Min-Seon Kim · 2013 · Archives of Pharmacal Research
- Central nervous control of energy and glucose balance: focus on the central melanocortin systemYong Xu, Joel Keith Elmquist, Makoto Fukuda · 2011 · Annals of the New York Academy of Sciences
- The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin ResistanceShahenda Salah Abdelsalam, Hesham Mohamed Korashy, Asad Zeidan, Abdelali Agouni · 2019 · Biomolecules
- Interleukin-1 beta targeted therapy for type 2 diabetesKathrin Maedler, Gitanjali Dharmadhikari, Desirée Schumann, Joachim Størling · 2009 · Expert Opinion on Biological Therapy
- Targets and consequences of protein SUMOylation in neuronsKevin A. Wilkinson, Yasuko Nakamura, Jeremy Martin Henley · 2010 · Brain Research Reviews
- Molecular Mechanisms Underlying Obesity-Induced Hypothalamic Inflammation and Insulin Resistance: Pivotal Role of Resistin/TLR4 PathwaysYacir Benomar, Mohammed Taouis · 2019 · Frontiers in Endocrinology
- In vivo self-assembled small RNAs as a new generation of RNAi therapeuticsZheng Fu, Xiang Zhang, Xinyan Zhou, Uzair Ur-Rehman, Mengchao Yu, Hongwei Liang, Hongyuan Guo, Xu Guo, Yan Kong, Yuanyuan Su et al. · 2021 · Cell Research
- Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese RatsPaty K. Picardi, Vivian C. Calegari, Patrícia O. Prada, Juliana Contin Moraes, ELIANA PEREIRA DE ARAUJO, Maria Cristina Cintra Gomes‐Marcondes, Miriam Ueno, José Barreto Campello Carvalheira, Licio Augusto Velloso, Mário J.A. Saad · 2008 · Endocrinology
- Curcumin Inhibits Hepatic Protein-Tyrosine Phosphatase 1B and Prevents Hypertriglyceridemia and Hepatic Steatosis in Fructose-Fed RatsJian‐Mei Li, Yucheng Li, Ling‐Dong Kong, Qinghua Hu · 2010 · Hepatology
- Obesity, leptin, and Alzheimer's diseaseLee, Edward B. · 2011 · Annals of the New York Academy of Sciences
- PTP1B and TC-PTP: regulators of transformation and tumorigenesisMatthew Stuible, Karen M. Doody, Michel L. Tremblay · 2008 · Cancer and Metastasis Reviews
- PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011 – 2014)Akhilesh Kumar Tamrakar, Chandan Kumar Maurya, Amit K Rai · 2014 · Expert Opinion on Therapeutic Patents
- The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complicationsMaryam Teimouri, Hossein Hosseini, Zahra Arab Sadeghabadi, Reyhaneh Babaei Khorzoughi, Sattar Gorgani‐Firuzjaee, Reza Meshkani · 2022 · Journal of Physiology and Biochemistry
- Appetite Regulation: An OverviewWaljit Singh Dhillo · 2007 · Thyroid
- Leptin as a Mediator of Obesity-Induced HypertensionBalyssa Bell, Kamal Rahmouni · 2016 · Current Obesity Reports
- Small molecules for fat combustion: targeting obesityJingxin Liu, Yitao Wang, Ligen Lin · 2018 · Acta Pharmaceutica Sinica B
- Amylin Modulates the Mesolimbic Dopamine System to Control Energy BalanceElizabeth G. Mietlicki‐Baase, David J. Reiner, Jackson J. Cone, Diana R. Olivos, Lauren E. McGrath, Derek J. Zimmer, Mitchell F. Roitman, Matthew R. Hayes · 2014 · Neuropsychopharmacology
- Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes MellitusSuresh Thareja, Saurabh Aggarwal, Tulika Bhardwaj, Manoj Kumar · 2010 · Medicinal Research Reviews
- Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater AdiposityKaren Koeninger Ryan, Stephen C. Woods, Randy J. Seeley · 2012 · Cell Metabolism
- Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin ActionClaudia Lindtner, Thomas Scherer, Elizabeth Zieliński, Nika Filatova, M Faßhauer, Nicholas K. Tonks, Michelle Puchowicz, Christoph Buettner · 2013 · Science Translational Medicine
- CNS Regulation of Glucose HomeostasisCarol Lam, Madhu Chari, Tony K.T. Lam · 2009 · Physiology
- Role of oxytocin signaling in the regulation of body weightBlevins, James E., Ho, Jacqueline M. · 2013 · Reviews in Endocrine and Metabolic Disorders
- Investigation of Protein-tyrosine Phosphatase 1B Function by Quantitative ProteomicsPhilipp Mertins, H. Christian Eberl, Jörg Renkawitz, Jesper Velgaard Olsen, Michel L. Tremblay, Matthias Mann, Axel Ullrich, Henrik Daub · 2008 · Molecular & Cellular Proteomics
- Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stressAbdelali Agouni, Nimesh Mody, Carl Owen, Alicja Czopek, Derek J. Zimmer, Mohamed Bentires‐Alj, Kendra K. Bence, Mirela Delibegović · 2011 · Biochemical Journal
- Increased Hypothalamic Protein Tyrosine Phosphatase 1B Contributes to Leptin Resistance with AgeMorrison, Christopher D., White, Christy L., Wang, Zhong, Lee, Seung-Yub, Lawrence, David S., Cefalu, William T., Zhang, Zhong-Yin, Gettys, Thomas W. · 2007 · Endocrinology
- Use of Protein Tyrosine Phosphatase Inhibitors as Promising Targeted Therapeutic DrugsPetr Heneberg · 2009 · Current Medicinal Chemistry
- PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial CellsAnthony A. Lanahan, Diana Lech, Alexandre Dubrac, Jiasheng Zhang, Zhen W. Zhuang, Anne Eichmann, Michael Simons · 2014 · Circulation
- New insights in leptin resistance mechanisms in miceÉglantine Balland, Michael Alexander Cowley · 2015 · Frontiers in Neuroendocrinology
- T‐cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human diseaseKaren M. Doody, Annie Bourdeau, Michel L. Tremblay · 2009 · Immunological Reviews
- Retinoic Acid Receptor β Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in MiceYu Li, Kimberly Wong, Kenneth Walsh, Bin Gao, Mengwei Zang · 2013 · Journal of Biological Chemistry
- New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue ApproachEnrico G. Petretto, Leonardo Bottolo, Sarah R. Langley, Matthias Heinig, Chris McDermott‐Roe, Rizwan Sarwar, Michal Pravenec, Norbert Hübner, Timothy J. Aitman, Stuart A. Cook et al. · 2010 · PLoS Computational Biology
- Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance RegulationHai Zhang, Guo Zhang, Frank J. Gonzalez, Sung-min Park, Dongsheng Cai · 2011 · PLoS Biology
- The soluble leptin receptorMichael Schaab, Jüergen Kratzsch · 2015 · Best Practice & Research Clinical Endocrinology & Metabolism
- Protein tyrosine phosphatases: molecular switches in metabolism and diabetesEsteban N. Gurzov, William J. Stanley, Thomas C. Brodnicki, Helen E. Thomas · 2014 · Trends in Endocrinology and Metabolism
- Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food IntakeElizabeth G. Mietlicki‐Baase, Laura E. Rupprecht, Diana R. Olivos, Derek J. Zimmer, Mark D. Alter, R. Christopher Pierce, Heath D. Schmidt, Matthew R. Hayes · 2013 · Neuropsychopharmacology
- Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in ObesityGarron T. Dodd, Chrysovalantou E. Xirouchaki, Matthew J. Eramo, Christina Anne Mitchell, Zane Bruce Andrews, Belinda A. Henry, Michael Alexander Cowley, Tony Tiganis · 2019 · Cell Reports
- Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic CounterregulationCandace M. Reno, Erwin C. Puente, Zhenyu Sheng, Dorit Daphna-Iken, Adam J. Bree, Vanessa H. Routh, Barbara B. Kahn, Simon J. Fisher · 2016 · Diabetes
- Neurobiology of overeating and obesity: The role of melanocortins and beyondRahul Pandit, Johannes W. de Jong, Louk J. M. J. Vanderschuren, Roger A.H. Adan · 2011 · European Journal of Pharmacology
- Leptin and Nutrition in Gestational DiabetesAntonio Pérez‐Pérez, Teresa Vilariño‐García, Pilar Guadix, José L. Dueñas, Víctor Sánchez‐Margalet · 2020 · Nutrients
- T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate GluconeogenesisAtsushi Fukushima, Kim Loh, Sandra Galić, Barbara Christianne Fam, Ben Shields, Florian Wiede, Michel L. Tremblay, Matthew J. Watt, Sofianos Andrikopoulos, Tony Tiganis · 2010 · Diabetes
- Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male MiceHakim, Fahed, Wang, Yang, Carreras, Alba, Hirotsu, Camila, Zhang, Jing, Peris, Eduard, Gozal, David · 2015 · Sleep
- Modulation of Leptin Resistance by Protein Tyrosine PhosphatasesJulie St‐Pierre, Michel L. Tremblay · 2012 · Cell Metabolism
- Protein tyrosine phosphatase 1B in metabolic diseases and drug developmentMirela Delibegović, Sergio Dall’Angelo, Ruta Dekeryte · 2024 · Nature Reviews Endocrinology
- Diet-Induced Obesity and the Mechanism of Leptin ResistanceAtilla Engin · 2017 · Advances in experimental medicine and biology
- Central Leptin Receptor Action and Resistance in ObesityChristian Bjørbæk · 2009 · Journal of Investigative Medicine
- Central Regulation of Metabolism by Protein Tyrosine PhosphatasesRyan C. Tsou, Kendra K. Bence · 2013 · Frontiers in Neuroscience
- Neuroendocrine body weight regulation: integration between fat tissue, gastrointestinal tract, and the brain.César Luiz Boguszewski, Gilberto Paz-Filho, Licio Augusto Velloso · 2010 · PubMed
- Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in miceLiufeng Wu, Jia Meng, Qing Xiang Shen, Yi Zhang, Susu Pan, Zhuo Chen, Ling‐Qiang Zhu, Youming Lu, Yuan Huang, Guo Zhang · 2017 · Nature Communications
- Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forwardKevin Jon Williams, Xiangdong Wu · 2016 · Atherosclerosis
- Recent advances in PTP1B signaling in metabolism and cancerOlga Villamar-Cruz, Marco A. Loza-Mejía, Luis E. Arias-Romero, Ignacio Camacho-Arroyo · 2021 · Bioscience Reports
- In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosisMatthew Stuible, Michel L. Tremblay · 2010 · Trends in Cell Biology
- Central lactate metabolism regulates food intakeCarol Lam, Madhu Chari, Penny Y.T. Wang, Tony K.T. Lam · 2008 · American Journal of Physiology-Endocrinology and Metabolism
- Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesityChristopher D. Morrison, Peter Huypens, Laura K. Stewart, Thomas W. Gettys · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal proteinNimesh Mody, Abdelali Agouni, George D. Mcilroy, Bettina Platt, Mirela Delibegović · 2011 · Diabetologia
- Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral TissuesBingzhong Xue, Thomas Pulinilkunnil, Incoronata Murano, Kendra K. Bence, Huamei He, Yasuhiko Minokoshi, Kenji Asakura, Anna Lee, Fawaz G. Haj, Noboru Furukawa et al. · 2009 · Molecular and Cellular Biology
- Short-term exposure to air pollution (PM2.5) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice.Campolim, Clara Machado, Weissmann, Lais, Ferreira, Clílton Kraüss de Oliveira, Zordão, Olivia Pizetta, Dornellas, Ana Paula Segantine, de Castro, Gisele, Zanotto, Tamires Marques, Boico, Vitor Ferreira, Quaresma, Paula Gabriele Fernandes, Lima, Raquel Patrícia Ataíde et al. · 2020 · Scientific Reports
- Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanismGrant, Louise, Shearer, Kirsty D., Czopek, Alicja, Lees, Emma K., Owen, Carl, Agouni, Abdelali, Workman, James, Martin-Granados, Cristina, Forrester, John V., Wilson, Heather M. et al. · 2014 · Diabetes
- Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compoundZhaohong Qin, Nihar R. Pandey, Xun Zhou, Chloe A. Stewart, Aswin Hari, Hua Huang, Alexandre F.R. Stewart, Jean Michel Brunel, Hsiao‐Huei Chen · 2015 · Biochemical and Biophysical Research Communications
- Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-AymiceAyumi Maeda, Kenji Kai, Megumi Ishii, Takeshi Ishii, Mitsugu Akagawa · 2014 · Molecular Nutrition & Food Research
- Hypothalamic S1P/S1PR1 axis controls energy homeostasisVagner Ramon Rodrigues Silva, Thayana Oliveira Micheletti, Gustavo D. Pimentel, Carlos K. Katashima, Luciene Lenhare, Joseane Morari, Maria Carolina Santos Mendes, Daniela Soares Razolli, Guilherme Z. Rocha, Cláudio Teodoro de Souza et al. · 2014 · Nature Communications
- The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complicationsDanielle Camer, Yinghua Yu, Alexander Szabo, Xu‐Feng Huang · 2014 · Molecular Nutrition & Food Research
- Insulin action in the brain: Roles in energy and glucose homeostasisGarron T. Dodd, Tony Tiganis · 2017 · Journal of Neuroendocrinology
- Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in MonkeysMichael M. Swarbrick, Peter Joseph Havel, Arthur A. Levin, Andrew A. Bremer, Kimber L. Stanhope, Madeline Butler, Sheri L. Booten, James Lawrence Graham, Robert A. McKay, Susan F. Murray et al. · 2009 · Endocrinology
- Induction of Leptin Resistance by Activation of cAMP-Epac SignalingMakoto Fukuda, Kevin W. Williams, Laurent Gautron, Joel Keith Elmquist · 2011 · Cell Metabolism
- Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistanceElaine Xu, Michael G. Schwab, André Marette · 2013 · Reviews in Endocrine and Metabolic Disorders
- Protein tyrosine phosphatase 1B inhibitors from natural sourcesBing Tian Zhao, Duc Hung Nguyen, Duc Dat Le, Jae Sue Choi, Byung Sun Min, Mi Hee Woo · 2017 · Archives of Pharmacal Research
- Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the HypothalamusEleni Kyriakou, Stefanie Schmidt, Garron T. Dodd, Katrin Pfuhlmann, Stephanie E. Simonds, Dominik Lenhart, Arie Geerlof, Sonja Charlotte Schriever, Meri De Angelis, K.‐W. Schramm et al. · 2018 · Journal of Medicinal Chemistry
- Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy HomeostasisMina Thon, Toru Hosoi, Koichiro Ozawa · 2016 · Frontiers in Endocrinology
- PTP 1B markedly promotes breast cancer progression and is regulated by miR‐193a‐3pMengchao Yu, Zhijian Liu, Yuan Liu, Xinyan Zhou, Feng Sun, Yanqing Liu, Liuyi Li, Shiyu Hua, Yi Zhao, Haidong Gao et al. · 2018 · FEBS Journal
- Double Knockouts Reveal that Protein Tyrosine Phosphatase 1B Is a Physiological Target of Calpain-1 in PlateletsShafi Kuchay, Nayoung Kim, Elizabeth A. Grunz, William P. Fay, Athar H. Chishti · 2007 · Molecular and Cellular Biology
- Leptin receptor modulation of adiposity and fertilityDavelene Davinah Israel, Streamson C. Chua · 2009 · Trends in Endocrinology and Metabolism
- Leptin Enhances the Potency of Circulating Angiogenic Cells Via Src Kinase and Integrin αvβ5Nana-Maria Heida, Maren Leifheit‐Nestler, Marco Robin Schroeter, Jan-Peter Müller, I‐Fen Cheng, Sarah Henkel, Anne Limbourg, Florian P. Limbourg, Frauke Alves, James P. Quigley et al. · 2009 · Arteriosclerosis Thrombosis and Vascular Biology
- Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic diseaseLin Jiang, Haoran Su, Xiaoyin Wu, Hong Shen, Min‐Hyun Kim, Yuan Li, Martin Grosvenor Myers, Chung Owyang, Liangyou Rui · 2020 · Nature Communications
- Protein tyrosine phosphatase 1B ( PTP1B ) function, structure, and inhibition strategies to develop antidiabetic drugsAndrea Coronell‐Tovar, Juan Pablo Pardo, Adela Rodríguez‐Romero, Alejandro Sosa‐Peinado, Luz X. Vásquez-Bochm, Patricia Cano‐Sánchez, Laura I. Álvarez‐Añorve, Martín González‐Andrade · 2024 · FEBS Letters
- New Pharmacological Perspectives for the Leptin Receptor in the Treatment of ObesityClara Roujeau, Ralf Jockers, Julie Dam · 2014 · Frontiers in Endocrinology
- Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytesMaria Carmela Ferrante, Paola Amero, Anna Natalizia Santoro, Anna Monnolo, Raffaele Simeoli, Francesca Guida, Giuseppina Mattace Raso, Rosaria Meli · 2014 · Toxicology and Applied Pharmacology
- Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in MiceRyan C. Tsou, Derek J. Zimmer, Bart C. De Jonghe, Kendra K. Bence · 2012 · Endocrinology
- Kinin B1 Receptor Deficiency Leads to Leptin Hypersensitivity and Resistance to ObesityMarcelo A. Mori, Ronaldo C. Araújo, Felipe C.G. Reis, Daniela G. Sgai, Raphael Gomes Fonseca, Carlos Castilho Barros, Vanessa F. Merino, Mariana Doce Passadore, Ana Maria Barbosa, Bernard Ferrari et al. · 2008 · Diabetes
- Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in MiceKonrad M. Ricke, Shelly Abad Cruz, Zhaohong Qin, Kaveh Farrokhi, Fariba Sharmin, Li Zhang, MICHAEL A. ZASLOFF, Alexandre F.R. Stewart, Hsiao‐Huei Chen · 2020 · Journal of Neuroscience
- Insights into amylin–leptin synergyJames L. Trevaskis, David G. Parkes, Jonathan David Roth · 2010 · Trends in Endocrinology and Metabolism
- Biology of GM3 GangliosideJin‐ichi Inokuchi, Kei‐ichiro Inamori, Kazuya Kabayama, Masakazu Nagafuku, Satoshi Uemura, Shinji Go, Akemi Suzuki, Isao Ohno, Hirotaka Kanoh, Fumi Shishido · 2018 · Progress in molecular biology and translational science
- Protein-tyrosine Phosphatase 1B Deficiency Reduces Insulin Resistance and the Diabetic Phenotype in Mice with Polygenic Insulin ResistanceBingzhong Xue, Young‐Bum Kim, Anna Lee, Elena Toschi, Susan Bonner‐Weir, C. Ronald Kahn, Benjamin G. Neel, Barbara B. Kahn · 2007 · Journal of Biological Chemistry
- Novel Regulatory Mechanisms for Generation of the Soluble Leptin Receptor: Implications for Leptin ActionMichael Schaab, H Kausch, Jürgen Klammt, Marcin Nowicki, Ulf Anderegg, Rolf Gebhardt, Stefan Rose‐John, Jürgen Scheller, Joachim Thiery, Jüergen Kratzsch · 2012 · PLoS ONE
- Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult miceCarl Owen, Emma K. Lees, L. Grant, Derek J. Zimmer, Nimesh Mody, Kendra K. Bence, Mirela Delibegović · 2013 · Diabetologia
- Neurobiology of Nutrition and ObesityChristopher D. Morrison, Hans‐Rudolf Berthoud · 2007 · Nutrition Reviews
- Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in MiceJoão A.B. Pedroso, Marina Augusto Silveira, Leandro B. Lima, Isadora C. Furigo, Thais T. Zampieri, Angela M. Ramos-Lobo, Daniella do Carmo Buonfiglio, Pryscila D. S. Teixeira, Renata Frazão, José Donato · 2016 · Endocrinology
- Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in MicrogliaTaku Tsunekawa, Ryoichi Banno, Akira Mizoguchi, Mariko Sugiyama, Takashi Tominaga, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto et al. · 2017 · EBioMedicine
- Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balanceMárta Balaskó, Szilvia Soós, Miklós Székely, Erika Pétervári · 2014 · Journal of Chemical Neuroanatomy
- Topiramate Treatment Improves Hypothalamic Insulin and Leptin Signaling and Action and Reduces Obesity in MiceAndréa M. Caricilli, Érica Penteado, Lélia L. de Abreu, Paula G.F. Quaresma, Andressa C. Santos, Dioze Guadagnini, Daniela Soares Razolli, Francine Cappa Mittestainer, José Barreto Campello Carvalheira, Licio Augusto Velloso et al. · 2012 · Endocrinology
- Inflammation: a way to understanding the evolution of portal hypertensionMaría‐Angeles Aller, Jorge-Luis Arias, Arturo Cruz, Jaime Árias · 2007 · Theoretical Biology and Medical Modelling
- Inhibition of protein tyrosine phosphatase (PTP1B) and α-glucosidase by geranylated flavonoids from Paulownia tomentosaYeong Hun Song, Zia Uddin, Young Min Jin, Zuopeng Li, Marcus J. C. Long, Kwang Dong Kim, Jung Keun Cho, Ki Hun Park · 2017 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Protein-tyrosine Phosphatase 1B (PTP1B) Is a Novel Regulator of Central Brain-derived Neurotrophic Factor and Tropomyosin Receptor Kinase B (TrkB) SignalingCeren Ozek, Scott E. Kanoski, Zhong‐Yin Zhang, Harvey J. Grill, Kendra K. Bence · 2014 · Journal of Biological Chemistry
- Role of protein tyrosine phosphatase 1B in cardiovascular diseasesPierre‐Alain Thiébaut, Marie Besnier, Élodie Gomez, Vincent J. Richard · 2016 · Journal of Molecular and Cellular Cardiology
- Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose HomeostasisCarl Owen, Alicja Czopek, Abdelali Agouni, Louise Grant, Robert N. Judson, Emma K. Lees, George D. Mcilroy, Olga Göransson, Andy Welch, Kendra K. Bence et al. · 2012 · PLoS ONE
- Pregnancy Induces Resistance to the Anorectic Effect of Hypothalamic Malonyl-CoA and the Thermogenic Effect of Hypothalamic AMPK Inhibition in Female RatsPablo Blanco Martínez de Morentin, Ricardo Lage, Ismael González‐García, Francisco Ruíz-Pino, Luís Martins, Diana Fernández-Mallo, Rosalı́a Gallego, Johan Fernø, Rosa María Señarís, Asish K. Saha et al. · 2014 · Endocrinology
- Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and LearningFederico Fuentes, Derek J. Zimmer, Marybless Atienza, Jamie Schottenfeld, Ian J. Penkala, Tracy L. Bale, Kendra K. Bence, Carlos O. Arregui · 2012 · PLoS ONE
- Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage ActivationVirginia Pardo, Águeda González‐Rodríguez, Carlos Guijas, Jesús Balsinde, Ángela M. Valverde · 2015 · Journal of Biological Chemistry
- Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy BalanceNadège Briançon, David E. G. McNay, Eleftheria Maratos–Flier, Jeffrey S. Flier · 2010 · Diabetes
- Neuronal human BACE1 knockin induces systemic diabetes in miceKaja Plucińska, Ruta Dekeryte, David J. Koss, Kirsty Shearer, Nimesh Mody, Phillip D. Whitfield, Mary K. Doherty, Marco Mingarelli, Andy Welch, Gernot Riedel et al. · 2016 · Diabetologia
- A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPasesYu Zhang, Yan Li, Yue‐Wei Guo, Hualiang Jiang, Xu Shen · 2009 · Acta Pharmacologica Sinica