Promotion of sleep by targeting the orexin system in rats, dogs and humans

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

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The use of analogue scales in rating subjective feelings

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Hypocretin (orexin) deficiency in human narcolepsy

Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,403

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

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Distribution of orexin neurons in the adult rat brain

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Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

Lee, M. G., Hassani, O. K., & Jones, B. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1887-05.2005 · Cited by 871

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

Mileykovskiy, B. Y., Kiyashchenko, L. I., & Siegel, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.035 · Cited by 848

Fos Expression in Orexin Neurons Varies with Behavioral State

Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01656.2001 · Cited by 654

Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00330-1 · Cited by 645

Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

Bourgin, P., Huitrón-Reséndiz, S., Spier, A. D., Fabre, V., Morte, B., Criado, J. R., Sutcliffe, J. G., Henriksen, S. J., & de Lecea, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07760.2000 · Cited by 508

Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities

Yoshida, Y., Fujiki, N., Nakajima, T., Ripley, B., Matsumura, H., Yoneda, H., Mignot, E., & Nishino, S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01725.x · Cited by 448

The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders

Kilduff, T. S., & Peyron, C. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01594-0 · Cited by 438

The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

Piper, D. C., Upton, N., Smith, M. I., & Hunter, A. J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00919.x · Cited by 351

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400590101 · Cited by 341

Release of Hypocretin (Orexin) during Waking and Sleep States

Kiyashchenko, L. I., Mileykovskiy, B. Y., Maidment, N., Lam, H. A., Wu, M.-F., John, J., Peever, J., & Siegel, J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05282.2002 · Cited by 340

Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats

Ida, T., Nakahara, K., Katayama, T., Murakami, N., & Nakazato, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01131-2 · Cited by 315

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action

España, R. A., Baldo, B. A., Kelley, A. E., & Berridge, C. W. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00319-0 · Cited by 311

Concomitant loss of dynorphin, NARP, and orexin in narcolepsy

Crocker, A., España, R. A., Papadopoulou, M., Saper, C. B., Faraco, J., Sakurai, T., Honda, M., Mignot, E., & Scammell, T. E. (2005) · Neurology · doi:10.1212/01.wnl.0000168173.71940.ab · Cited by 301

Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects

Salomon, R. M., Ripley, B., Kennedy, J. S., Johnson, B., Schmidt, D., Zeitzer, J. M., Nishino, S., & Mignot, E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01740-7 · Cited by 285

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness

Zeitzer, J. M., Buckmaster, C. L., Parker, K. J., Hauck, C. M., Lyons, D. M., & Mignot, E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03555.2003 · Cited by 277

The Clinical Use of the Multiple Sleep Latency Test

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Hypocretin-2-Saporin Lesions of the Lateral Hypothalamus Produce Narcoleptic-Like Sleep Behavior in the Rat

Gerashchenko, D., Kohls, M. D., Greco, M., Waleh, N. S., Salin-Pascual, R., Kilduff, T. S., Lappi, D. A., & Shiromani, P. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07273.2001 · Cited by 272

Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat

Xi, M.-C., Morales, F. R., & Chase, M. H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02317-4 · Cited by 188

Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system

Taheri, S., Sunter, D., Dakin, C., Moyes, S., Seal, L., Gardiner, J., Rossi, M., Ghatei, M., & Bloom, S. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00955-6 · Cited by 174

From slow waves to sleep homeostasis: new perspectives.

Borbély, A. A. (2001) · PubMed · Cited by 149

Hypocretin and Nicotine Excite the Same Thalamocortical Synapses in Prefrontal Cortex: Correlation with Improved Attention in Rat

Lambe, E. K., Olausson, P., Horst, N. K., Taylor, J. R., & Aghajanian, G. K. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0719-05.2005 · Cited by 135

Effects of lateral preoptic area application of orexin-A on sleep–wakefulness

Methippara, M. M., Alam, M. N., Szymusiak, R. S., & McGinty, D. (2000) · Neuroreport · doi:10.1097/00001756-200011090-00004 · Cited by 126

Increased and Decreased Muscle Tone With Orexin (Hypocretin) Microinjections in the Locus Coeruleus and Pontine Inhibitory Area

Kiyashchenko, L. I., Mileykovskiy, B. Y., Lai, Y.-Y., & Siegel, J. M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.2008 · Cited by 108

The Diurnal Rhythm of Hypocretin in Young and Old F344 Rats

Désarnaud, F., Murillo‐Rodríguez, E., Lin, L., Xu, M., Gerashchenko, D., Shiromani, S. N., Nishino, S., Mignot, E. J.-M., & Shiromani, P. J. (2004) · SLEEP · doi:10.1093/sleep/27.5.851 · Cited by 102

Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro

Ishibashi, M., Takano, S., Yanagida, H., Takatsuna, M., Nakajima, K., Oomura, Y., Wayner, M. J., & Sasaki, K. (2004) · Peptides · doi:10.1016/j.peptides.2004.10.014 · Cited by 98

Short-Term Triazolam Use Improves Nocturnal Sleep of Narcoleptics

Thorpy, M. J., Snyder, M., Alóe, F., Ledereich, P. S., & Starz, K. E. (1992) · SLEEP · doi:10.1093/sleep/15.3.212 · Cited by 89

Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat

Smith, M. I., Piper, D. C., Duxon, M. S., & Upton, N. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00066-1 · Cited by 87

Diurnal and nocturnal rodents show rhythms in orexinergic neurons

Martínez, G. S., Smale, L., & Núñez, A. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03264-x · Cited by 83

Multiple Sleep Latency Test

Roehrs, T., & Roth, T. G. (1992) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199201000-00007 · Cited by 83

Canine model of obstructive sleep apnea: model description and preliminary application

Kimoff, R. J., Makino, H., Horner, R. L., KOZAR, L. F., Lue, F. A., Slutsky, A. S., & Phillipson, E. A. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.4.1810 · Cited by 76

REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation.

Thakkar, M. M., Ramesh, V., Cape, E., Winston, S. H., Strecker, R. E., & McCarley, R. W. (1999) · PubMed · Cited by 54

Chemistry and Biology Of Multicomponent Reactions

Dömling, A., Wang, W., & Wang, K. (2012) · Chemical Reviews · doi:10.1021/cr100233r · Cited by 2,547

The hyperarousal model of insomnia: A review of the concept and its evidence

Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789

Control of sleep and wakefulness

Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276

The role of orexin in motivated behaviours

Sakurai, T. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3837 · Cited by 464