Type II monocytes modulate T cell–mediated central nervous system autoimmune disease

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works

RAG-1-deficient mice have no mature B and T lymphocytes

Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898 · see citing works

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628 · see citing works

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858 · see citing works

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

Johnson, K., Brooks, B., Cohen, J. A., Ford, C., Goldstein, J., Lisak, R., Myers, L., Panitch, H., Rose, J., Schiffer, R., et al. (1995) · Neurology · doi:10.1212/wnl.45.7.1268 · Cited by 1,667 · see citing works

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

Kuchroo, V. K., Das, M. P., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N., & Glimcher, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90349-6 · Cited by 1,642 · see citing works

Untitled work

Binder (2004) · doi:10.1080/08977190410001723308 · Cited by 1,481 · see citing works

Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

Thornton, A. M., & Shevach, E. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.183 · Cited by 1,229 · see citing works

Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

Bettelli, E., Pagany, M., Weiner, H. L., Linington, C., Sobel, R. A., & Kuchroo, V. K. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021603 · Cited by 828 · see citing works

Multiple immuno-regulatory defects in type-1 diabetes

Kukreja, A., Cost, G., Marker, J., Zhang, C., Sun, Z., Lin‐Su, K., Ten, S., Sanz, M. M., Exley, M. A., Wilson, B., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13605 · Cited by 640 · see citing works

Multiple immuno-regulatory defects in type-1 diabetes

Kukreja, A., Cost, G., Marker, J., Zhang, C., Sun, Z., Lin‐Su, K., Ten, S., Sanz, M. M., Exley, M. A., Wilson, B., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213605 · Cited by 567 · see citing works

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

Zamvil, S. S., Nelson, P. A., Trotter, J., Mitchell, D. J., Knobler, R., Fritz, R. B., & Steinman, L. (1985) · Nature · doi:10.1038/317355a0 · Cited by 532 · see citing works

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J., Akiba, H., Tushima, F., Azuma, M., Yagita∥, H., Sayegh, M. H., & Khoury, S. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022119 · Cited by 501 · see citing works

How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis.

Steinman, L., & Zamvil, S. S. (2006) · Annals of Neurology · doi:10.1002/ana.20913 · Cited by 479 · see citing works

Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

Duda, P. W., Schmied, M. C., Cook, S. L., Krieger, J. I., & Hafler, D. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8970 · Cited by 416 · see citing works

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., & Neumann, H. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040124 · Cited by 414 · see citing works

Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice.

Tran, E., Hoekstra, K., van Rooijen, N., Dijkstra, C., & Owens, T. (1998) · Journal of Immunology · doi:10.4049/jimmunol.161.7.3767 · Cited by 373 · see citing works

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

Flesch, I. E. A., Hess, J., Huang, S., Aguet, M., Rothe, J., Bluethmann, H., & Kaufmann, S. H. E. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.5.1615 · Cited by 346 · see citing works

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

Neuhaus, O., Farina, C., Yassouridis, A., Wiendl, H., Bergh, F. T., Dose, T., Wekerle, H., & Hohlfeld, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7452 · Cited by 299 · see citing works

Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis

Aharoni, R., Teitelbaum, D., Sela, M., & Arnon, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10821 · Cited by 270 · see citing works

Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy

Ziemssen, T. (2002) · Brain · doi:10.1093/brain/awf252 · Cited by 268 · see citing works

Induction of CD4 + CD25 + regulatory T cells by copolymer-I through activation of transcription factor Foxp3

Hong, J., Li, N., Zhang, X., Zheng, B. Q., & Zhang, J. Z. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502187102 · Cited by 264 · see citing works

Mechanisms of action of glatiramer acetate in multiple sclerosis

Neuhaus, O., Farina, C., Wekerle, H., & Hohlfeld, R. (2001) · Neurology · doi:10.1212/wnl.56.6.702 · Cited by 248 · see citing works

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity.

Fridkis‐Hareli, M., Teitelbaum, D., Gurevich, E. P., Pecht, I., Brautbar, C., Kwon, O.-J., Brenner, T., Arnon, R., & Sela, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4872 · Cited by 243 · see citing works

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

Chitnis, T., Najafian, N., Benou, C., Salama, A. D., Grusby, M. J., Sayegh, M. H., & Khoury, S. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12563 · Cited by 230 · see citing works

Glatiramer Acetate (Copolymer-1, Copaxone) Promotes Th2 Cell Development and Increased IL-10 Production Through Modulation of Dendritic Cells

Vieira, P. L., Heystek, H. C., Wormmeester, J., Wierenga, E. A., & Kapsenberg, M. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4483 · Cited by 219 · see citing works

Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1

Aharoni, R., Teitelbaum, D., Leitner, O., Meshorer, A., Sela, M., & Arnon, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11472 · Cited by 215 · see citing works

Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications

Arnon, R., & Aharoni, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404887101 · Cited by 205 · see citing works

Type 2 Monocyte and Microglia Differentiation Mediated by Glatiramer Acetate Therapy in Patients with Multiple Sclerosis1

Kim, H., Ifergan, I., Antel, J., Séguin, R., Duddy, M., Lapierre, Y., Jalili, F., & Bar-Or, A. (2004) · Journal of Immunology · doi:10.4049/jimmunol.172.11.7144 · Cited by 197 · see citing works

Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis

Dhib-Jalbut, S. S. (2002) · Neurology · doi:10.1212/wnl.58.8_suppl_4.s3 · Cited by 185 · see citing works

Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1

Aharoni, R., Teitelbaum, D., Sela, M., & Arnon, R. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00166-0 · Cited by 173 · see citing works

Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo.

Weber, M. S., Starck, M., Wagenpfeil, S., Meinl, E., Hohlfeld, R., & Farina, C. (2004) · Brain : a journal of neurology · doi:10.1093/brain/awh163 · Cited by 161 · see citing works

Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses

Teitelbaum, D., Fridkis‐Hareli, M., Arnon, R., & Sela, M. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00180-8 · Cited by 153 · see citing works

B7–2 (CD86) is essential for the development of IL-4-producing T cells

Ranger, A. M., Das, M. P., Kuchroo, V. K., Glimcher, L. H., & Ploegh, H. L. (1996) · International Immunology · doi:10.1093/intimm/8.10.1549 · Cited by 145 · see citing works

pSTAT1, pSTAT3, and T‐bet expression in peripheral blood mononuclear cells from relapsing‐remitting multiple sclerosis patients correlates with disease activity

Frisullo, G., Angelucci, F., Caggiula, M., Nociti, V., Iorio, R., Patanella, A. K., Sancricca, C., Massimiliano Mirabella, A., Tonali, P. A., & Batocchi, A. P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20995 · Cited by 138 · see citing works

Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action

Farina, C., Weber, M. S., Meinl, E., Wekerle, H., & Hohlfeld, R. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70167-8 · Cited by 138 · see citing works

Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis

Stasiołek, M., Bayas, A., Kruse, N., Wieczarkowiecz, A., Toyka, K. V., Gold, R., & Selmaj, K. W. (2006) · Brain · doi:10.1093/brain/awl043 · Cited by 129 · see citing works

T cells with two functional antigen-specific receptors.

Hardardottir, F., Baron, J. L., & Janeway, C. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.2.354 · Cited by 119 · see citing works

Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity

Stüve, O. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25805 · Cited by 107 · see citing works

Glatiramer acetate induces a Th2-biased response and crossreactivity with myelin basic protein in patients with MS

Chen, M., Gran, B., Costello, K., Johnson, K. P., Martinꝉ, R., & Dhib-Jalbut, S. S. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700401 · Cited by 106 · see citing works

STAT-1α and IFN-γ as Modulators of TNF-α Signaling in Macrophages: Regulation and Functional Implications of the TNF Receptor 1:STAT-1α Complex

Wesemann, D. R., & Benveniste, E. N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5313 · Cited by 89 · see citing works

Dendritic cell vaccination for cancer therapy

Nestle, F. O. (2000) · Oncogene · doi:10.1038/sj.onc.1204095 · Cited by 84 · see citing works

Effect of glatiramer acetate (Copaxone) on CD4+CD25high T regulatory cells and their IL-10 production in multiple sclerosis

Putheti, P. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.08.001 · Cited by 74 · see citing works

Effect of treatment with copolymer 1 (Cop-1) on the in vivo and in vitro manifestations of experimental allergic encephalomyelitis (EAE)

Lisak, R. P., Zweiman, B., Blanchard, N., & RORKE, L. B. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90205-8 · Cited by 46 · see citing works

Copolymer 1 inhibits experimental autoimmune uveoretinitis

Zhang, M., Chan, C., Vistica, B. P., Hung, V., Wiggert, B. O., & Gery, I. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00239-8 · Cited by 42 · see citing works

Conditional Ablation of MHC-II Suggests an Indirect Role for MHC-II in Regulatory CD4 T Cell Maintenance

Shimoda, M., Mmanywa, F., Joshi, S. K., Li, T., Miyake, K., Pihkala, J. P. S., Abbas, J. A., & Koni, P. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6503 · Cited by 38 · see citing works

STAT‐1‐mediated repression of monocyte interleukin‐10 gene expression in vivo

VanDeusen, J. B., Shah, M. H., Becknell, B., Blaser, B. W., Ferketich, A. K., Nuovo, G. J., Ahmer, B. M. M., Durbin, J. E., & Caligiuri, M. A. (2006) · European Journal of Immunology · doi:10.1002/eji.200535241 · Cited by 32 · see citing works

Do Th2 cells mediate the effects of glatiramer acetate in experimental autoimmune encephalomyelitis?

Jee, Y., Liu, R., Bai, X., Campagnolo, D. I., Shi, F., & Vollmer, T. L. (2006) · International Immunology · doi:10.1093/intimm/dxh394 · Cited by 22 · see citing works

Inhibitory Effects of Incomplete Freund's Adjuvant on Experimental Autoimmune Encephalomyelitis

Zamora, A., Matejuk, A., Silverman, M., Vandenbark, A. A., & Offner, H. (2002) · Autoimmunity · doi:10.1080/08916930290005873 · Cited by 18 · see citing works

Amelioration of experimental colitis by Copaxone is associated with class-II-restricted CD4 immune blocking

Gur, C., Karussis, D., Golden, E., Doron, S., Ilan, Y., & Safadi, R. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.10.004 · Cited by 14 · see citing works

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,788 · see citing works

Multiple Sclerosis: Mechanisms and Immunotherapy

Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938 · see citing works

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

Shechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000113 · Cited by 770 · see citing works

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

Yoshizaki, A., Miyagaki, T., DiLillo, D. J., Matsushita, T., Horikawa, M., Kountikov, E. I., Spolski, R. J., Poe, J. C., Leonard, W. J., & Tedder, T. F. (2012) · Nature · doi:10.1038/nature11501 · Cited by 631 · see citing works

Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing

Zhang, Q.-Z., Su, W., Shi, S., Wilder-Smith, P. B. B., Xiang, A. P., Wong, A. K., Nguyen, A. L., Kwon, C. W., & Le, A. D. (2010) · Stem Cells · doi:10.1002/stem.503 · Cited by 620 · see citing works

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2230 · Cited by 568 · see citing works

Inhibitory role for GABA in autoimmune inflammation

Bhat, R., Axtell, R., Mitra, A., Miranda, M., Lock, C., Tsien, R. W., & Steinman, L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915139107 · Cited by 509 · see citing works

Comparison of polarization properties of human adult microglia and blood‐derived macrophages

Durafourt, B. A., Moore, C. S., Zammit, D., Johnson, T., Zaguia, F., Guiot, M., Bar‐Or, A., & Antel, J. P. (2012) · Glia · doi:10.1002/glia.22298 · Cited by 470 · see citing works

Multiple Sclerosis: Pathogenesis and Treatment

Loma, I. P., & Heyman, R. A. (2011) · Current Neuropharmacology · doi:10.2174/157015911796557911 · Cited by 382 · see citing works

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

Mikita, J., Dubourdieu-Cassagno, N., Deloire, M. S., Vekris, A., Biran, M., Raffard, G., Brochet, B., Canron, M.-H., Franconi, J.-M., Boiziau, C., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458510379243 · Cited by 358 · see citing works

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

Starossom, S. C., Mascanfroni, I. D., Imitola, J., Cao, L., Raddassi, K., Hernandez, S. F., Bassil, R., Croci, D. O., Cerliani, J. P., Delacour, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.023 · Cited by 356 · see citing works

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

Ghoreschi, K., Brück, J., Kellerer, C., Deng, C., Peng, H., Rothfuss, O. C., Hussain, R. Z., Gocke, A. R., Respa, A., Glocova, I., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100977 · Cited by 352 · see citing works

The Immune Response in Multiple Sclerosis

Murúa, S. R., Farez, M., & Quintana, F. J. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052920-040318 · Cited by 347 · see citing works

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

Byström, J., Evans, I. M., Newson, J., Stables, M. J., Toor, I. S., van Rooijen, N., Crawford, M., Colville‐Nash, P., Farrow, S. N., & Gilroy, D. W. (2008) · Blood · doi:10.1182/blood-2007-12-129767 · Cited by 335 · see citing works

B‐cell activation influences T‐cell polarization and outcome of anti‐CD20 B‐cell depletion in central nervous system autoimmunity

Weber, M. S., Prod’homme, T., Patarroyo, J. C., Molnarfi, N., Karnezis, T., Lehmann‐Horn, K., Danilenko, D. M., Eastham‐Anderson, J., Slavin, A., Linington, C., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22081 · Cited by 321 · see citing works

Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases

Yan, Z., Gibson, S. A., Buckley, J. A., Qin, H., & Benveniste, E. N. (2018) · Clinical Immunology · doi:10.1016/j.clim.2016.09.014 · Cited by 318 · see citing works

Function of microglia and macrophages in secondary damage after spinal cord injury

Ren, Y., Zhou, X., & He, X. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.143423 · Cited by 317 · see citing works

In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

Hunter, M. M., Wang, A., Parhar, K. K. S., Johnston, M. J. G., van Rooijen, N., Beck, P. L., & McKay, D. M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.041 · Cited by 310 · see citing works

Immune Modulation of Stem Cells and Regeneration

Aurora, A., & Olson, E. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.009 · Cited by 293 · see citing works

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

Piccio, L. M., Buonsanti, C., Cella, M., Tassi, I., Schmidt, R. E., Fenoglio, C., Rinker, J. R., Naismith, R. T., Panina‐Bordignon, P., Passini, N., et al. (2008) · Brain · doi:10.1093/brain/awn217 · Cited by 308 · see citing works

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

Schulze‐Topphoff, U., Varrin‐Doyer, M., Pekarek, K. L., Spencer, C. M., Shetty, A., Sagan, S. A., Cree, B., Sobel, R. A., Wipke, B. T., Steinman, L., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603907113 · Cited by 292 · see citing works

Multiple Sclerosis: Immunopathology and Treatment Update

Dargahi, N., Κατσάρα, Μ., Tselios, T. V., Androutsou, M., de Courten, M., Matsoukas, J., & Apostolopoulos, V. (2017) · Brain Sciences · doi:10.3390/brainsci7070078 · Cited by 289 · see citing works

Can the immune system be harnessed to repair the CNS?

Popovich, P. G., & Longbrake, E. E. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2398 · Cited by 287 · see citing works

Macrophage subsets and microglia in multiple sclerosis

Bogie, J. F. J., Stinissen, P., & Hendriks, J. J. A. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1310-2 · Cited by 279 · see citing works

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

Wang, Q., He, Z., Huang, M., Liu, T., Wang, Y., Xu, H., Duan, H., Ma, P., Zhang, L., Zamvil, S. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03050-0 · Cited by 279 · see citing works

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, J. K., Petersen, M. A., Murray, S. G., Baeten, K. M., Meyer-Franke, A., Chan, J. P., Vagena, E., Bedard, C., Machado, M. R., Coronado, P. E. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms9164 · Cited by 271 · see citing works

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

Qin, H., Yeh, W.-I., Sarno, P. D., Holdbrooks, A. T., Liu, Y., Muldowney, M., Reynolds, S. L., Yanagisawa, L. L., Fox, T. H., Park, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117218109 · Cited by 266 · see citing works

An optimized Protocol for Human M2 Macrophages using M‐ CSF and IL ‐4/ IL ‐10/ TGF ‐β Yields a Dominant Immunosuppressive Phenotype

Mia, S., Warnecke, A., Zhang, X., Malmström, V., & Harris, R. A. (2014) · Scandinavian Journal of Immunology · doi:10.1111/sji.12162 · Cited by 253 · see citing works

Discrete functions of M 2a and M 2c macrophage subsets determine their relative efficacy in treating chronic kidney disease

Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V. W. S., Zheng, G., Tan, T. K., et al. (2013) · Kidney International · doi:10.1038/ki.2013.135 · Cited by 242 · see citing works

The role of regulatory T cells in multiple sclerosis

Zozulya, A. L., & Wiendl, H. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0832 · Cited by 241 · see citing works

Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

Filardy, A. A., Pires, D. R., Nunes, M. P., Takiya, C. M., Freire-de-Lima, C. G., Ribeiro-Gomes, F. L., & DosReis, G. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000017 · Cited by 237 · see citing works

Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

He, W., Kapate, N., Shields, C. W., & Mitragotri, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.001 · Cited by 237 · see citing works

Harnessing monocyte‐derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

Shechter, R., & Schwartz, M. (2012) · The Journal of Pathology · doi:10.1002/path.4106 · Cited by 225 · see citing works

Crucial Role of Granulocytic Myeloid-Derived Suppressor Cells in the Regulation of Central Nervous System Autoimmune Disease

Ιωάννου, Μ., Alissafi, T., Lazaridis, I., Deraos, G., Matsoukas, J., Gravanis, A., Mastorodemos, V. C., Plaitakis, A., Sharpe, A. H., Boumpas, D. T., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101816 · Cited by 224 · see citing works

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

Parsa, R., Andresen, P., Gillett, A., Mia, S., Zhang, X., Mayans, S., Holmberg, D., & Harris, R. A. (2012) · Diabetes · doi:10.2337/db11-1635 · Cited by 222 · see citing works

Cell type-specific regulation of IL-10 expression in inflammation and disease

Hedrich, C. M., & Bream, J. H. (2010) · Immunologic Research · doi:10.1007/s12026-009-8150-5 · Cited by 220 · see citing works

The benefits and detriments of macrophages/microglia in models of multiple sclerosis

Rawji, K. S., & Yong, V. W. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/948976 · Cited by 217 · see citing works

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216 · see citing works

Central nervous system (CNS)–resident natural killer cells suppress Th17 responses and CNS autoimmune pathology

Hao, J., Liu, R., Piao, W., Zhou, Q., Vollmer, T. L., Campagnolo, D. I., Xiang, R., Cava, A. L., Kaer, L. V., & Shi, F. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092749 · Cited by 214 · see citing works

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

London, A., Itskovich, E., Benhar, I., Kalchenko, V., Mack, M., Jung, S., & Schwartz, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101202 · Cited by 213 · see citing works

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Langer, H. F., Choi, E. Y., Zhou, H. Y., Schleicher, R., Chung, K., Tang, Z., Göbel, K., Bdeir, K. H., Chatzigeorgiou, A., Wong, C. H. Y., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.256370 · Cited by 204 · see citing works

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis

Linker, R. A., Lee, D.-H., Demir, S., Wiese, S., Kruse, N., Siglienti, I., Gerhardt, E., Neumann, H., Sendtner, M., Lühder, F., et al. (2010) · Brain · doi:10.1093/brain/awq179 · Cited by 202 · see citing works

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

Moehle, M. S., & West, A. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.018 · Cited by 198 · see citing works

Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis

Jiang, Z., Jiang, J., & Zhang, G. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.03.006 · Cited by 197 · see citing works

Functional diversity of microglia – how heterogeneous are they to begin with?

Hanisch, U.-K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00065 · Cited by 195 · see citing works

Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior

Svensson, M., Lexell, J. E., & Deierborg, T. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314562108 · Cited by 189 · see citing works

The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

Gomez‐Lopez, N., Galaz, J., Miller, D., Farías, M., Liu, Z., Arenas‐Hernandez, M., Garcia‐Flores, V., Shaffer, Z. D., Greenberg, J. M., Theis, K. R., et al. (2022) · Reproduction · doi:10.1530/rep-22-0046 · Cited by 186 · see citing works

Myeloid cells — targets of medication in multiple sclerosis

Mishra, M. K., & Yong, V. W. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.110 · Cited by 182 · see citing works

Traumatic brain injury induces macrophage subsets in the brain

Hsieh, C. L., Kim, C. C., Ryba, B. E., Niemi, E. C., Bando, J. K., Locksley, R. M., Liu, J., Nakamura, M. C., & Seaman, W. E. (2013) · European Journal of Immunology · doi:10.1002/eji.201243084 · Cited by 179 · see citing works

Glatiramer Acetate in the Treatment of Multiple Sclerosis

Lalive, P. H., Neuhaus, O., Benkhoucha, M., Burger, D., Hohlfeld, R., Zamvil, S. S., & Weber, M. S. (2011) · CNS Drugs · doi:10.2165/11588120-000000000-00000 · Cited by 177 · see citing works

Inflammation in Neurological Disorders: A Help or a Hindrance?

Yong, V. W. (2010) · The Neuroscientist · doi:10.1177/1073858410371379 · Cited by 175 · see citing works

CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury

Hsieh, C. L., Niemi, E. C., Wang, S. H., Lee, C. C., Bingham, D., Zhang, J., Cozen, M. L., Charo, I., Huang, E. J., Liu, J., et al. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3252 · Cited by 174 · see citing works

Multiple sclerosis immunology

Kasper, L. H., & Shoemaker, J. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c97c8f · Cited by 167 · see citing works

Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses

Jetten, N., Roumans, N., Gijbels, M. J., Romano, A., Post, M. J., de Winther, M. P. J., van der Hulst, R. R. W. J., & Xanthoulea, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102994 · Cited by 162 · see citing works

Neuro-immune crosstalk in CNS diseases

Kerschensteiner, M., Meinl, E., & Hohlfeld, R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.009 · Cited by 158 · see citing works

Immunological Aspects of Approved MS Therapeutics

Rommer, P. S., Milo, R., Han, M. H., Satyanarayan, S., Sellner, J., Hauer, L., Illés, Z., Warnke, C., Laurent, S. A., Weber, M. S., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01564 · Cited by 157 · see citing works

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Yang, F., He, Z., Duan, H., Zhang, D., Li, J., Yang, H., Dorsey, J. F., Zou, W., Nabavizadeh, S. A., Bagley, S. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23832-3 · Cited by 157 · see citing works

Therapeutic Efficacy of Suppressing the JAK/STAT Pathway in Multiple Models of Experimental Autoimmune Encephalomyelitis

Liu, Y., Holdbrooks, A. T., Sarno, P. D., Rowse, A. L., Yanagisawa, L. L., McFarland, B. C., Harrington, L. E., Raman, C., Sabbaj, S., Benveniste, E. N., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301513 · Cited by 155 · see citing works

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

Locatelli, G., Theodorou, D., Kendirli, A., Jordão, M. J. C., Staszewski, O., Phulphagar, K., Cantuti-Castelvetri, L., Dagkalis, A., Bessis, A., Simons, M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0212-3 · Cited by 155 · see citing works

Therapeutic effects of glatiramer acetate and grafted CD115⁺monocytes in a mouse model of Alzheimer’s disease

Koronyo, Y., Salumbides, B. C., Sheyn, J., Pelissier, L., Li, S., Ljubimov, V., Moyseyev, M., Daley, D., Fuchs, D.-T., Pham, M., et al. (2015) · Brain · doi:10.1093/brain/awv150 · Cited by 153 · see citing works

Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

Wang, J., Wang, J., Wang, J., Yang, B., Weng, Q., & He, Q. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00286 · Cited by 148 · see citing works

Dendritic Cell-Specific ICAM-3–Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10

Domínguez‐Soto, Á., Sierra‐Filardi, E., Puig‐Kröger, A., Pérez-Maceda, B. T., Gómez, F., Corcuera, M. T., Sánchez‐Mateos, P., & Corbí, A. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000475 · Cited by 147 · see citing works

MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis

Pan, W. Q., Zhu, S., Dai, D., Liu, Z., Li, D., Li, B., Gagliani, N., Zheng, Y., Tang, Y., Weirauch, M. T., et al. (2015) · Nature Communications · doi:10.1038/ncomms8096 · Cited by 138 · see citing works

Pathologic heterogeneity persists in early active multiple sclerosis lesions

Metz, I., Weigand, S. D., Popescu, B. F. G., Frischer, J. M., Parisi, J. E., Guo, Y. X., Lassmann, H., Brück, W., & Lucchinetti, C. F. (2014) · Annals of Neurology · doi:10.1002/ana.24163 · Cited by 135 · see citing works

The mechanism of action of glatiramer acetate treatment in multiple sclerosis

Racke, M. K., Lovett‐Racke, A. E., & Karandikar, N. J. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c97e39 · Cited by 134 · see citing works

COVID-19 and MS disease-modifying therapies

Berger, J. R., Brandstadter, R., & Bar‐Or, A. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000761 · Cited by 132 · see citing works

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis

Burger, D., Molnarfi, N., Weber, M. S., Brandt, K. J., Benkhoucha, M., Gruaz, L., Chofflon, M., Zamvil, S. S., & Lalive, P. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812183106 · Cited by 132 · see citing works

Modulation of Autoimmune Demyelination by Laquinimod via Induction of Brain-Derived Neurotrophic Factor

Thöne, J., Ellrichmann, G., Seubert, S., Peruga, I., Lee, D.-H., Conrad, R., Hayardeny, L., Comı, G., Wiese, S., Linker, R. A., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.09.037 · Cited by 131 · see citing works

Tumor-Specific Bacteriophages Induce Tumor Destruction through Activation of Tumor-Associated Macrophages

Eriksson, F., Tsagozis, P., Lundberg, K., Parsa, R., Mangsbo, S. M., Persson, M. A. A., Harris, R. A., & Pisa, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800224 · Cited by 130 · see citing works

Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129 · see citing works

Mechanism of Action of Glatiramer Acetate in Treatment of Multiple Sclerosis

Weber, M. S., Hohlfeld, R., & Zamvil, S. S. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.08.002 · Cited by 127 · see citing works

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis

Martinꝉ, R., Sospedra, M., Rosito, M., & Engelhardt, B. (2016) · European Journal of Immunology · doi:10.1002/eji.201646485 · Cited by 125 · see citing works

The mechanism of action of glatiramer acetate in multiple sclerosis and beyond

Aharoni, R. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.09.005 · Cited by 123 · see citing works

The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth

Cavassani, K. A., Carson, W. F., Serezani, A. P. M., Wen, H., Schaller, M. A., Ishii, M., Lindell, D. M., Dou, Y., Lukacs, N. W., Keshamouni, V. G., et al. (2010) · Blood · doi:10.1182/blood-2009-09-241083 · Cited by 120 · see citing works

Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate

Skihar, V., Silva, C., Chojnacki, A. K., Döring, A., Stallcup, W. B., Weiss, S., & Yong, V. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909607106 · Cited by 117 · see citing works

Expansion and preferential activation of the CD14+CD16+ monocyte subset during multiple sclerosis

Chuluundorj, D., Harding, S. A., Abernethy, D. A., & Flamme, A. C. L. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.15 · Cited by 116 · see citing works

CD11c+CD11b+ Dendritic Cells Play an Important Role in Intravenous Tolerance and the Suppression of Experimental Autoimmune Encephalomyelitis

Li, H., Zhang, G., Chen, Y., Xu, H., Fitzgerald, D. C., Zhao, Z., & Rostami, A. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2483 · Cited by 115 · see citing works

Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis

Benveniste, E. N., Liu, Y., McFarland, B. C., & Qin, H. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0012 · Cited by 114 · see citing works

Human macrophages induce CD4+Foxp3+ regulatory T cells via binding and re‐release of TGF‐β

Schmidt, A., Zhang, X., Joshi, R. N., Iqbal, S., Wahlund, C. J. E., Gabrielsson, S., Harris, R. A., & Tegner, J. N. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.34 · Cited by 111 · see citing works

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types

Vereyken, E. J., Heijnen, P. D., Baron, W., de Vries, E. H., Dijkstra, C. D., & Teunissen, C. E. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-58 · Cited by 108 · see citing works

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis

Jolivel, V., Luessi, F., Masri, J., Kraus, S. H. P., Hubo, M., Poisa-Beiro, L., Klebow, S., Paterka, M., Yogev, N., Tumani, H., et al. (2013) · Brain · doi:10.1093/brain/awt023 · Cited by 108 · see citing works

RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course

Lewis, N. D., Hill, J. D., Juchem, K. W., Stefanopoulos, D. E., & Modis, L. K. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.09.014 · Cited by 106 · see citing works

Macrophage Migration Inhibitory Factor Potentiates Autoimmune-Mediated Neuroinflammation

Cox, G. M., Kithcart, A. P., Pitt, D., Guan, Z., Alexander, J., Williams, J. L., Shawler, T. M., Dagia, N. M., Popovich, P. G., Satoskar, A. R., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200485 · Cited by 105 · see citing works

Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10

Ireland, S. J., Monson, N. L., & Davis, L. S. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.009 · Cited by 103 · see citing works

B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis

Kala, M., Rhodes, S. N., Piao, W.-H., Shi, F., Campagnolo, D. I., & Vollmer, T. L. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.10.015 · Cited by 103 · see citing works

The p53 Transcription Factor Modulates Microglia Behavior through MicroRNA-Dependent Regulation of c-Maf

Su, W., Hopkins, S., Nesser, N. K., Sopher, B., Silvestroni, A., Ammanuel, S., Jayadev, S., Möller, T., Weinstein, J., & Garden, G. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301397 · Cited by 103 · see citing works

Neuroprotective Effect of Combination Therapy of Glatiramer Acetate and Epigallocatechin-3-Gallate in Neuroinflammation

Herges, K., Millward, J. M., Hentschel, N., Infante‐Duarte, C., Aktaş, O., & Zipp, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025456 · Cited by 100 · see citing works

Azithromycin Alters Macrophage Phenotype and Pulmonary Compartmentalization during Lung Infection withPseudomonas

Feola, D. J., Garvy, B. A., Cory, T. J., Birket, S. E., Hoy, H., Hayes, D., & Murphy, B. S. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01424-09 · Cited by 100 · see citing works

Managing the side effects of multiple sclerosis therapy: pharmacotherapy options for patients

Rommer, P. S., & Zettl, U. K. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1446944 · Cited by 97 · see citing works

CD8+ T-Cells as Immune Regulators of Multiple Sclerosis

Sinha, S., Boyden, A. W., Itani, F. R., Crawford, M. P., & Karandikar, N. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00619 · Cited by 97 · see citing works

Therapeutic Decisions in Multiple Sclerosis

Brück, W., Gold, R., Lund, B. T., Oreja‐Guevara, C., Prat, A., Spencer, C. M., Steinman, L., Tintoré, M., Vollmer, T. L., Weber, M. S., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3510 · Cited by 96 · see citing works

Lessons from multiple sclerosis: models, concepts, observations

Wekerle, H. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.098020 · Cited by 96 · see citing works

Laquinimod, a Quinoline-3-Carboxamide, Induces Type II Myeloid Cells That Modulate Central Nervous System Autoimmunity

Schulze‐Topphoff, U., Shetty, A., Varrin‐Doyer, M., Molnarfi, N., Sagan, S. A., Sobel, R. A., Nelson, P. A., & Zamvil, S. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033797 · Cited by 95 · see citing works

Polarization of macrophages and microglia in inflammatory demyelination

Cao, L., & He, C. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1324-0 · Cited by 94 · see citing works

Untargeted Plasma Metabolomics Identifies Endogenous Metabolite with Drug-like Properties in Chronic Animal Model of Multiple Sclerosis

Poisson, L., Suhail, H., Singh, J., Datta, I., Đenić, A., Łabuzek, K., Hoda, M. N., Shankar, A., Kumar, A., Cerghet, M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.679068 · Cited by 94 · see citing works

Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

Dubey, D., Kieseier, B. C., Hartung, H. P., Hemmer, B., Warnke, C., Menge, T., Miller-Little, W. A., & Stüve, O. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1025755 · Cited by 93 · see citing works

Multiple sclerosis therapeutics

Wiendl, H., & Hohlfeld, R. (2009) · Neurology · doi:10.1212/01.wnl.0000344417.42972.54 · Cited by 93 · see citing works

Update on Inflammation, Neurodegeneration, and Immunoregulation in Multiple Sclerosis

Bennett, J. L., & Stüve, O. (2009) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181880359 · Cited by 92 · see citing works

Micro RNA let‐7e is associated with the pathogenesis of experimental autoimmune encephalomyelitis

Guan, H., Fan, D., Mrelashvili, D., Hao, H., Singh, N. P., Singh, U. P., Nagarkatti, P. S., & Nagarkatti, M. (2012) · European Journal of Immunology · doi:10.1002/eji.201242702 · Cited by 91 · see citing works

CD44 Reciprocally Regulates the Differentiation of Encephalitogenic Th1/Th17 and Th2/Regulatory T Cells through Epigenetic Modulation Involving DNA Methylation of Cytokine Gene Promoters, Thereby Controlling the Development of Experimental Autoimmune Encephalomyelitis

Guan, H., Nagarkatti, P. S., & Nagarkatti, M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004043 · Cited by 91 · see citing works

Type 2 Monocyte and Microglia Differentiation Mediated by Glatiramer Acetate Therapy in Patients with Multiple Sclerosis1

Kim, H., Ifergan, I., Antel, J., Séguin, R., Duddy, M., Lapierre, Y., Jalili, F., & Bar-Or, A. (2004) · Journal of Immunology · doi:10.4049/jimmunol.172.11.7144 · Cited by 197 · see citing works

Glatiramer Acetate Treatment Directly Targets CD11b+Ly6G− Monocytes and Enhances the Suppression of Autoreactive T cells in Experimental Autoimmune Encephalomyelitis

Toker, A., Slaney, C. Y., Bäckström, B. T., & Harper, J. L. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02575.x · Cited by 32 · see citing works

Do Th2 cells mediate the effects of glatiramer acetate in experimental autoimmune encephalomyelitis? Int

Jee, Y., Liu, R., Bai, X.-F., Campagnolo, D. I., Shi, F.-D., & Vollmer, T. L. (2014)

Do Th2 cells mediate the effects of glatiramer acetate in experimental autoimmune encephalomyelitis?

Jee, Y., Liu, R., Bai, X., Campagnolo, D. I., Shi, F., & Vollmer, T. L. (2006) · International Immunology · doi:10.1093/intimm/dxh394 · Cited by 22 · see citing works

Glatiramer acetate treatment normalized the monocyte activation profile in MS patients to that of healthy controls

Chuluundorj, D., Harding, S. A., Abernethy, D. A., & Flamme, A. C. L. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.99 · Cited by 24 · see citing works