The DOI matches its Crossref record; 112 of the 113 references it cites were found in a registry or an index.
Delivery materials for siRNA therapeutics
Abstract
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues. This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the most effective and clinically advanced classes of siRNA delivery systems, including lipid nanoparticles and siRNA conjugates, are designed to surmount these challenges. The systems that we discuss are diverse in their approaches to the delivery problem, and provide valuable insight to guide the design of future siRNA delivery materials.
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In the citing paper
“Several miRNAs and antisense oligonucleotides (ASOs) are currently under investigation in clinical trials for various diseases (Kanasty et al., 2013;van Rooij and Kauppinen, 2014;Gaudet et al., 2015).”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Kanasty et al., 2013
In the citing paper
“The main role of PEGylated lipid in LNPs is to reduce aggregation and non-specific uptake by immune cells.304–306”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [306]
In the citing paper
“we believe that recent advances in the delivery of nucleic acid therapeutics provide hope that CRISPR-Cas9–mediated correction may be translatable to humans15.”
From Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype (2014) · cites this paper as [15]
Citations
Cites
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Strategies in the design of nanoparticles for therapeutic applications
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Hannon, G. J. (2002) · Nature · doi:10.1038/418244a · Cited by 3,651
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
Self-citationAsymmetry in the Assembly of the RNAi Enzyme Complex
Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,922
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D. B., Tolcher, A. W., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,541
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,206
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Flagged first, then by citations
1 of the 113 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873
mRNA vaccines — a new era in vaccinology
Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Self-citationCheng, Q., Wei, T., Farbiak, L., Johnson, L. T., Dilliard, S. A., & Siegwart, D. J. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0669-6 · Cited by 2,383
Nanotechnology for Multimodal Synergistic Cancer Therapy
Fan, W., Yung, B. C., Huang, P., & Chen, X. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00258 · Cited by 1,813
Metadata
- Authors
- Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Boston Children's Hospital (US)
- Corresponding author
- Anderson, Daniel
- Venue
- Nature Materials
- Published
- 2013-10-23
- Volume
- 12
- Issue
- 11
- Pages
- 967-977
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W1995770815
- Cited by
- 1,800
- References
- 113
- Citations by year
- 2026: 77 · 2025: 103 · 2024: 111 · 2023: 138 · 2022: 139 · 2021: 148 · 2020: 159 · 2019: 129 · 2018: 164 · 2017: 151 · 2016: 183 · 2015: 179 · 2014: 114 · 2013: 4
- FWCI
- 15.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- siRNA delivery, RNA interference therapy, lipid nanoparticles, siRNA conjugates, gene silencing, drug delivery materials
- MeSH terms
- Animals, Drug Carriers, Humans, RNA, Small Interfering, Nanoparticles
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