The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment
Open accessAbstract
The therapeutic potential of miRNA (miR) in cancer is limited by the lack of efficient delivery vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure comprising two miRNAs—a miR mimic (tumour suppressor miRNA) and an antagomiR (oncomiR inhibitor)—provides outstanding capability to synergistically abrogate tumours. Conjugation of RNA triple helices to dendrimers allows the formation of stable triplex nanoparticles, which form an RNA-triple-helix adhesive scaffold upon interaction with dextran aldehyde, the latter able to chemically interact and adhere to natural tissue amines in the tumour. We also show that the self-assembled RNA-triple-helix conjugates remain functional in vitro and in vivo, and that they lead to nearly 90% levels of tumour shrinkage two weeks post-gel implantation in a triple-negative breast cancer mouse model. Our findings suggest that the RNA-triple-helix hydrogels can be used as an efficient anticancer platform to locally modulate the expression of endogenous miRs in cancer.
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1 retracted
miR-221 Promotes Tumorigenesis in Human Triple Negative Breast Cancer Cells
Nassirpour, R., Mehta, P. P., Baxi, S. M., & Yin, M.-J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062170 · Cited by 93
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Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer
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Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
Lee, H., Lytton-Jean, A. K. R., Chen, Y., Love, K. T., Park, A. I., Karagiannis, E. D., Sehgal, A., Querbes, W., Zurenko, C. S., Jayaraman, M., et al. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.73 · Cited by 1,169
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Cited by
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719
Self-citationIslam, M. A., Xu, Y., Tao, W., Ubellacker, J. M., Lim, M., Aum, D., Lee, G. Y., Zhou, K., Zope, H., Yu, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0284-0 · Cited by 339
Triplex DNA Nanostructures: From Basic Properties to Applications
Hu, Y., Cecconello, A., Idili, A., Ricci, F., & Willner, I. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701868 · Cited by 336
FRET Based Biosensor: Principle Applications Recent Advances and Challenges
Verma, A. K., Noumani, A., Yadav, A. K., & Solanki, P. R. (2023) · Diagnostics · doi:10.3390/diagnostics13081375 · Cited by 202
Metadata
- Authors
- Conde, J., Oliva, N., Atilano, M., Song, H. S., & Artzi, N.
- Venue
- Nature Materials
- Published
- 2015-12-07
- Volume
- 15
- Issue
- 3
- Pages
- 353-363
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2190204638
- Cited by
- 283
- References
- 44
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Conde, J., Oliva, N., Atilano, M., Song, H. S., & Artzi, N. (2016). Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment. Nature Materials. https://doi.org/10.1038/nmat4497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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