Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association

Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797

Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates

Filipe, V., Hawe, A., & Jiskoot, W. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0073-2 · Cited by 1,885

Measuring the global burden of disease

Murray, C. J. L., & Lopez, A. D. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1201534 · Cited by 1,818

Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy

Libby, P. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1216063 · Cited by 1,262

Mechanical memory and dosing influence stem cell fate

Yang, C., Tibbitt, M. W., Basta, L. P., & Anseth, K. S. (2014) · Nature Materials · doi:10.1038/nmat3889 · Cited by 1,167

Smooth Muscle Cell Phenotypic Transition Associated With Calcification

Steitz, S. A., Speer, M. Y., Curinga, G., Yang, H.-Y. L., Haynes, P. A., Aebersold, R. H., Schinke, T., Karsenty, G., & Giachelli, C. M. (2001) · Circulation Research · doi:10.1161/hh2401.101070 · Cited by 830

Osteogenesis Associates With Inflammation in Early-Stage Atherosclerosis Evaluated by Molecular Imaging In Vivo

Aikawa, E. R., Nahrendorf, M., Figueiredo, J., Świrski, F. K., Shtatland, T., Köhler, R. H., Jaffer, F. A., Aikawa, M., & Weissleder, R. (2007) · Circulation · doi:10.1161/circulationaha.107.732867 · Cited by 694

Spotty Calcification Typifies the Culprit Plaque in Patients With Acute Myocardial Infarction

Ehara, S., 小林, 芳., Yoshiyama, M., Shimada, K., Shimada, Y., Fukuda, D., Nakamura, Y., Yamashita, H., Yamagishi, H., Takeuchi, K., et al. (2004) · Circulation · doi:10.1161/01.cir.0000148131.41425.e9 · Cited by 690

Calcium Density of Coronary Artery Plaque and Risk of Incident Cardiovascular Events

Criqui, M. H., Denenberg, J. O., Ix, J. H., McClelland, R. L., Wassel, C. L., Rifkin, D. E., Carr, J. J., Budoff, M. J., & Allison, M. A. (2014) · JAMA · doi:10.1001/jama.2013.282535 · Cited by 642

Matrix vesicles and calcification

Anderson, H. C. (2003) · Current Rheumatology Reports · doi:10.1007/s11926-003-0071-z · Cited by 606

A Brief Review on Computational Modeling of Rupture in Soft Biological Tissues

Gültekin, O., & Holzapfel, G. A. (2017) · Computational methods in applied sciences · doi:10.1007/978-3-319-60885-3_6 · Cited by 16

Extracellular vesicles and atherosclerotic peripheral arterial disease

Brown, P. A., & Brown, P. D. (2022) · Cardiovascular Pathology · doi:10.1016/j.carpath.2022.107510 · Cited by 15

Plaque volume, composition, and fraction versus ischemia and outcomes in patients with coronary artery disease

Kuneman, J. H., van den Hoogen, I. J., Schultz, J., Maaniitty, T., van Rosendael, A. R., Kamperidis, V., Graaf, M. A. D., Broersen, A., Jukema, J. W., Bax, J. J., et al. (2023) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2023.02.004 · Cited by 15

Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model

Ruiz, J., Hutcheson, J. D., Cardoso, L., Nik, A. B., de Abreu, A. C., Pham, T., Buffolo, F., Busatto, S., Federici, S., Ridolfi, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811725118 · Cited by 15

Mechanisms of Matrix Vesicles Mediating Calcification Transition in Diabetic Plaque

Wang, Z., Zhang, L., Sun, Z., Shao, C., Li, Y., Bao, Z., Jing, L., Geng, Y., Gu, W., Pang, Q., et al. (2019) · Heart Lung and Circulation · doi:10.1016/j.hlc.2019.04.022 · Cited by 15

Exosomes Promote Atherosclerosis Progression by Regulating Circ_100696/miR-503-5p/PAPPA Axis-Mediated Vascular Smooth Muscle Cells Proliferation and Migration

Liu, J., Zhang, X., Yu, Z., & Zhang, T. (2023) · International Heart Journal · doi:10.1536/ihj.23-089 · Cited by 14

Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells

Shaver, M., Gomez, K., Kaiser, K. A., & Hutcheson, J. D. (2024) · BMC Molecular and Cell Biology · doi:10.1186/s12860-024-00504-w · Cited by 14

Plasma Complement Protein C3a Level Was Associated with Abdominal Aortic Calcification in Patients on Hemodialysis

Wang, Y., Miao, Y.-Y., Gong, K., Cheng, X., Chen, Y., & Zhao, M. (2019) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-019-09885-2 · Cited by 14

Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification

Tanaka, T., Asano, T., Okui, T., Kuraoka, S., Singh, S. A., Aikawa, M., & Aïkawa, E. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.826529 · Cited by 14

Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification

Turner, M. E., Bartoli‐Leonard, F., & Aïkawa, E. (2022) · Immunological Reviews · doi:10.1111/imr.13134 · Cited by 15

Biomechanical Assessment of Macro-Calcification in Human Carotid Atherosclerosis and Its Impact on Smooth Muscle Cell Phenotype

Seime, T., van Wanrooij, M., Karlöf, E., Kronqvist, M., Johansson, S., Matic, L. P., Gasser, T. C., & Hedin, U. (2022) · Cells · doi:10.3390/cells11203279 · Cited by 14

Coronary calcium density in relation to coronary heart disease and cardiovascular disease in adults with diabetes or metabolic syndrome: the Multi-ethnic Study of Atherosclerosis (MESA)

Zhao, Y., Malik, S., Criqui, M. H., Allison, M., Budoff, M. J., Sandfort, V., & Wong, N. D. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02956-4 · Cited by 14

Pathologies related to abnormal deposits in dermatology: a physico-chemical approach

Colboc, H., Moguelet, P., Letavernier, E., Frochot, V., Bernaudin, J., Weil, R., Rouzière, S., Senet, P., Bachmeyer, C., Laporte, N., et al. (2022) · Comptes Rendus Chimie · doi:10.5802/crchim.153 · Cited by 13

Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VIPreprint

Kapustin, A. N., Tsakali, S. S., Whitehead, M., Chennell, G., Wu, M., Molenaar, C., Kutikhin, A. G., Chen, Y., Ahmad, S., Bogdanov, L. A., et al. (2023) · eLife · doi:10.7554/elife.90375 · Cited by 13

Size and proximity of micro-scale hard-inclusions increase the risk of rupture in fibroatheroma-like laboratory models

Corti, A., Khalil, D., Paolis, A. D., & Cardoso, L. (2023) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2023.105749 · Cited by 12

Collagen-mediated cardiovascular calcification

Chen, J., Ma, C., Li, J., Niu, X., & Fan, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140225 · Cited by 12

Unlocking the Potential of Extracellular Vesicles in Cardiovascular Disease

Li, H., Wang, L., Cheng, H., Zhang, Q. H., Wang, S., Zhong, W., He, C., & Wei, Q. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70407 · Cited by 12

Association between Vitamins and Minerals with Antioxidant Effects and Coronary Artery Calcification in Adults and Older Adults: A Systematic Review

Machado, A. D., Andrade, G. R. G., Levy, J., Ferreira, S. S., & Marchioni, D. M. L. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190722101954 · Cited by 12

Collagen Fibril Orientation in Tissue Specimens From Atherosclerotic Plaque Explored Using Small Angle X-Ray Scattering

Silva, H., Tassone, C. J., Ross, E., Lee, J. T., Zhou, W., & Nelson, D. V. (2021) · Journal of Biomechanical Engineering · doi:10.1115/1.4052432 · Cited by 12

Osteopontin activity modulates sex‐specific calcification in engineered valve tissue mimics

Schroeder, M. E., Batan, D., Rodriguez, A. G., Speckl, K. F., Peters, D. K., Kirkpatrick, B. E., Hach, G. K., Walker, C. J., Grim, J. C., Aguado, B. A., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10358 · Cited by 12

Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification

Atkins, S. K., Sonawane, A. R., Brouwhuis, R., Barrientos, J., Ha, A. H., Rogers, M. A., Tanaka, T., Okui, T., Kuraoka, S., Singh, S. A., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.925777 · Cited by 12

Positron Emission Tomography Imaging of Coronary Atherosclerosis

Moss, A. J., Adamson, P. D., Newby, D. E., & Dweck, M. R. (2016) · Future Cardiology · doi:10.2217/fca-2016-0017 · Cited by 13

Potential Application of the Plant-Derived Essential Oils for Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic Potential

Dabravolski, S. A., Sukhorukov, V. N., Melnichenko, A. А., Khotina, V. A., & Orekhov, A. N. (2023) · Molecules · doi:10.3390/molecules28155673 · Cited by 11

Effect of collagen denaturation degree on mechanical properties and biological activity of nanofibrous scaffolds

Tenchurin, T. K., Sytina, E. V., Solovieva, E. V., Shepelev, A. D., Mamagulashvili, V. G., Krasheninnikov, S. V., Yastremskiy, E. V., Nesterenko, E. V., Buzin, A. I., Istranova, E. V., et al. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37598 · Cited by 11

Matrix vesicles from osteoblasts promote atherosclerotic calcification

Wang, X., Ren, J., Fang, F., Wang, E., Li, J., He, W., Zhang, Z., Shen, Y., & Liu, X. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.09.003 · Cited by 11

Gla Rich Protein (GRP) Mediates Vascular Smooth Muscle Cell (VSMC) Osteogenic Differentiation, Extracellular Vesicle (EV) Calcification Propensity, and Immunomodulatory Properties

Viegas, C., Carreira, J., Maia, T. M., Macedo, A. L., Matos, A., Neves, J., & Simes, D. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212406 · Cited by 11

Extracellular Vesicles in Atherosclerosis: From Pathogenesis to Theranostic Applications

Fang, F., Yang, H., Wang, X., Zhao, T., Zhao, P., & Liu, X. (2025) · Small · doi:10.1002/smll.202504761 · Cited by 11

The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics

Piddubnyi, A., Kolomiiets, O., Danilchenko, S. M., Stepanenko, A. O., Moskalenko, Y., & Moskalenko, R. (2023) · Diagnostics · doi:10.3390/diagnostics13040737 · Cited by 11

Bacillus amyloliquefaciens SC06 alleviates LPS-induced intestinal damage by inhibiting endoplasmic reticulum stress and mitochondrial dysfunction in piglets

Wang, Q., Jin, Q., Wang, F., Wang, Y., Li, X., Zhou, Y., Xu, S., Fu, A., & Li, W. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137307 · Cited by 10

The current landscape of lipoprotein(a) in calcific aortic valvular disease

Hsieh, G., Rizk, T., Berman, A. N., Biery, D. W., & Blankstein, R. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000901 · Cited by 10

Vulnerable Plaque Imaging

Nakahara, T., Strausś, H. W., Narula, J., & Jinzaki, M. (2022) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2022.08.009 · Cited by 10

Therapeutic strategies for small-diameter vascular graft calcification

Teng, Y., Xu, Y., Lv, P., Song, L., Yang, J., Yang, J., Guo, X., Wang, S., Hou, S., Lv, Q., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150549 · Cited by 10

GRP75 inhibition attenuates arterial calcification

Heyn, J., Gorgels, A., Hense, N., Gombert, A., Buhl, E. M., Stark, L., Vondenhoff, S., Simon, J., Noels, H., Marx, N., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119243 · Cited by 9

CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Matrix Metalloproteinase-7 and Calcifying Extracellular Vesicle Release

Krohn, J. B., Sprehe, L. K., Sicklinger, F., Kawohl, J., Hess, C., Spieler, A., Dihlmann, S., Eis, L., Gleissner, C. A., Katus, H. A., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.322067 · Cited by 9

HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve

Salim, M. T., Villa-Roel, N., Vogel, B., Jo, H., & Yoganathan, A. P. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1002067 · Cited by 9

MV-mediated biomineralization mechanisms and treatments of biomineralized diseases

Li, X., Zhang, W., Fan, Y., & Niu, X. (2022) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2022.100198 · Cited by 9

X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis

Wang, T., Zhou, J., Zhang, X., Wu, Y., Jin, K., Wang, Y., Xu, R., Yang, G., Li, W., & Jiao, L. (2022) · Aging and Disease · doi:10.14336/ad.2022.0824 · Cited by 9

Conscripted by collagen

Miller, J. D. (2016) · Nature Materials · doi:10.1038/nmat4587 · Cited by 9

Correlation between serum sortilin levels and severity of extracranial carotid artery stenosis

Şimşek, Z., Alızade, E., Güner, A., & Zehi̇r, R. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14733 · Cited by 9

Mammalian Sirtuins and Their Relevance in Vascular Calcification

Pan, X., Pi, C., Ruan, X., Zheng, H., Zhang, D., & Liu, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.907835 · Cited by 9

Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease

Yarbrough, D., & Gerecht, S. (2022) · Bioengineering · doi:10.3390/bioengineering9090449 · Cited by 9

Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification

Turner, M. E., & Aïkawa, E. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad139 · Cited by 9

Exploring the Link Between Autophagy‐Lysosomal Dysfunction and Early Heterotopic Ossification in Tendons

Gao, C., Wan, Q., Yan, J., Zhu, Y., Tian, L., Wei, J., Feng, B., Niu, L., & Jiao, K. (2024) · Advanced Science · doi:10.1002/advs.202400790 · Cited by 8

Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle

Behzadi, P., & Hilaire, C. S. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00267.2024 · Cited by 8

Association between atherosclerosis and the development of multi-organ pathologies

Dabravolski, S. A., Churov, A. V., Elizova, N. V., Ravani, A. L., Karimova, A. E., Sukhorukov, V. N., & Orekhov, A. N. (2024) · SAGE Open Medicine · doi:10.1177/20503121241310013 · Cited by 8

Atherosclerosis is associated with amyloid and tau pathology via blood–brain barrier dysfunction in the hippocampus of aged human brains

Jin, Z., Liu, N., & Wei, H. P. (2025) · PLoS ONE · doi:10.1371/journal.pone.0324652 · Cited by 8

Aortic Stenosis: Diagnosis, Molecular Mechanisms and Therapeutic Strategies—A Comprehensive Review

Banceu, C. M., Cristutiu, D., Gurzu, S., Harpa, M. M., Banceu, D. M., & Suciu, H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14144949 · Cited by 8

Intracranial arterial calcification in patients with unruptured and ruptured intracranial aneurysms

Kamphuis, M. J., van der Kamp, L. T., Lette, E., Rinkel, G. J. E., Vergouwen, M. D. I., van der Schaaf, I. C., de Jong, P. A., & Ruigrok, Y. M. (2024) · European Radiology · doi:10.1007/s00330-024-10789-2 · Cited by 8

Emerging role of exosomes in arterial and renal calcification

Bano, S., Tandon, S., & Tandon, C. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211001122 · Cited by 8

Morphological and Crystal-Chemical Features of Macro- and Microcalcifications of Human Aorta

Radomychelski, I.-M., Piddubnyi, A., Danilchenko, S. M., Maksymova, O. S., Moskalenko, Y., & Moskalenko, R. (2021) · Microscopy and Microanalysis · doi:10.1017/s1431927621012721 · Cited by 8

Differentially expressed mRNAs and their upstream miR-491-5p in patients with coronary atherosclerosis as well as the function of miR-491-5p in vascular smooth muscle cells

Ding, H., Pan, Q., Qian, L., & Hu, C. (2022) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2022.26.3.183 · Cited by 8

The Time-Dependent Role of Bisphosphonates on Atherosclerotic Plaque Calcification

Nik, A. B., Ng, H. H., Russo, M. G., Iacoviello, F., Shearing, P. R., Bertazzo, S., & Hutcheson, J. D. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9060168 · Cited by 8

Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence

Richter, E., Lohmann, C. H., Dell’Accio, F., Goettsch, C., & Bertrand, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512343 · Cited by 8

Role of inflammation and immunity in vascular calcification: a bibliometric and visual analysis, 2000–2022

Wang, C., Liang, Q., He, S., Zhu, J., Lin, X., Lin, G., Wu, D., Zhang, W., & Wang, Z. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1258230 · Cited by 8

NaF uptake in unstable plaque: what does fluoride uptake mean?

Nakahara, T., Narula, J., & Strausś, H. W. (2018) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-018-4177-y · Cited by 8

Considerations on the Development of Therapeutics in Vascular Calcification

Cabrera, A. M. V., Ashbrook, S. K., & Hutcheson, J. D. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12060206 · Cited by 7

Engineering Liposomes with Cell Membrane Proteins to Disrupt Melanosome Transfer between Cells

Liu, C., Liu, Y., Xue, C., Yang, C., Weitz, D. A., & Jahnke, K. (2025) · ACS Nano · doi:10.1021/acsnano.5c02767 · Cited by 7

Aortic calcification correlates with pseudoaneurysm or penetrating aortic ulcer of different etiologies

Li, S., Kan, H., Liu, Z., Zeng, R., Shao, J., Chen, Y., Ye, W., & Zheng, Y. (2024) · Scientific Reports · doi:10.1038/s41598-023-49429-y · Cited by 7

Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding

Radvar, E., Griffanti, G., Tsolaki, E., Bertazzo, S., Nazhat, S. N., Addison, O., Mata, Á., Shanahan, C. M., & Elsharkawy, S. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100042 · Cited by 7

Identification of early vascular calcification with18F-sodium fluoride: potential clinical application

Doris, M. K., & Newby, D. E. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2016.1151354 · Cited by 7

The Role of Cell-derived Microparticles in Cardiovascular Diseases: Current Concepts

Stampouloglou, P. K., Siasos, G., Bletsa, E., Oikonomou, E. K., Vogiatzi, G., Kalogeras, K. I., Katsianos, E., Vavuranakis, M., Souvaliotis, N., & Vavuranakis, Μ. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220429081555 · Cited by 7

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Qin, K., Wu, Y., Pan, Y., Wang, K., Kong, D., & Zhao, Q. (2018) · Journal of Visualized Experiments · doi:10.3791/57340 · Cited by 7

PLC and PAD2 Regulate Extracellular Calcium‐Triggered Release of Macrophage Extracellular DNA Traps

Mishra, N., Mohs, M., Wittmann, N., Groß, S., Thompson, P. R., & Bossaller, L. (2025) · European Journal of Immunology · doi:10.1002/eji.202350942 · Cited by 6

MicroRNAs regulate the vicious cycle of vascular calcification-osteoporosis in postmenopausal women

Wang, Q., Peng, F., Yang, J., Chen, X., Peng, Z., Zhang, M., Tang, D., Liu, J., & Zhao, H. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09550-1 · Cited by 6

AI-based modality-agnostic classification system for vascular calcifications

Ramezanpour, M., Robertson, A. M., Tobe, Y., Jia, X., & Cebral, J. R. (2025) · Scientific Reports · doi:10.1038/s41598-025-19422-8 · Cited by 6

Distinguishing Iron and Calcium using MARS Spectral CT

Searle, E., Butler, A. P. H., Raja, A. Y., Gieseg, S. P., Adebileje, S. A., Alexander, S. D., Amma, M. R., Anjomrouz, M., Asghariomabad, F., Atharifard, A., et al. (2018) · IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) · doi:10.1109/nssmic.2018.8824671 · Cited by 6

Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification

Hernyes, A., Piroska, M., Fejér, B., Szalontai, L., Szabó, H., Forgó, B., Jermendy, Á. L., Molnár, A., Maurovich‐Horvat, P., Jermendy, G., et al. (2021) · Medicina · doi:10.3390/medicina57030252 · Cited by 6

Narrative review of exosomes: novel players in vascular calcification of chronic kidney disease

Liu, S., & Zhang, N. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-910 · Cited by 6

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification

Krohn, J. B., Aïkawa, E., Aikawa, M., Hutcheson, J. D., Sahoo, S., & Fish, J. E. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1077124 · Cited by 6

A collagen-based laboratory model to mimic sex-specific features of calcific aortic valve disease

Allgayer, R., Kabir, R., Bergeron, A., Demers, P., Mantovani, D., & Cerruti, M. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.034 · Cited by 5

Whitlockite can be a substrate for apatite growth in simulated body fluid

Hunter, L., Torii, R., Burriesci, G., & Bertazzo, S. (2025) · Materialia · doi:10.1016/j.mtla.2025.102409 · Cited by 5

Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders

Saadh, M. J., Muhammad, F. A., Albadr, R. J., Sanghvi, G. V., Ballal, S., Pathak, P. K., Bareja, L., Aminov, Z., Taher, W. M., Alwan, M., et al. (2025) · European journal of medical research · doi:10.1186/s40001-025-02649-6 · Cited by 5

Oligosaccharides as Potential Therapeutics against Atherosclerosis

Dabravolski, S. A., Sukhorukov, V. N., Melnichenko, A. А., Khotina, V. A., & Orekhov, A. N. (2023) · Molecules · doi:10.3390/molecules28145452 · Cited by 5

Multimodal Analytical Tools to Enhance Mechanistic Understanding of Aortic Valve Calcification

Perez, K. A., Deppe, D. W., Filas, A., Singh, S. A., & Aïkawa, E. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.06.017 · Cited by 5

The ability of Micropure® ultrasound technique to identify microcalcifications in carotid plaques

Ruan, W., He, Y., Shao, X., Yang, S. R., Li, X., Ding, J., Hua, F., & Lian, X. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.106401 · Cited by 5

A Novel, Cell-Free Therapy to Enter Our Hearts: The Potential Role of Small EVs in Prevention and Treatment of CVD

Λαζανά, Ι., & Anagnostopoulos, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073662 · Cited by 5

Calcium-Binding Nanoparticles for Vascular Disease

Chin, D. D., Chowdhuri, S., & Chung, E. J. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0083-x · Cited by 5

18 F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification

Tavakoli, S., & Sadeghi, M. M. (2019) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.118.008712 · Cited by 5

Spatial Transcriptomics: A New Frontier in Atherosclerosis Research?

Cole, J. E., & Monaco, C. G. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321652 · Cited by 5

Investigating the role of elastin and extracellular matrix damage in cardiovascular calcification

Radvar, E., Mehta, K., D’Ambrosio, A., Mastroianni, G., Al‐Jawad, M., Stevens, M. M., Mata, Á., & Elsharkawy, S. (2024) · Journal of Structural Biology · doi:10.1016/j.jsb.2024.108140 · Cited by 5

The effect of presence and location of microcalcifications on atherosclerotic plaque rupture: A tissue-engineering approach

Crielaard, H., Jansen, I. L., der Heiden, K. V., Kremers, G., Gijsen, F. J. H., Farrell, E., & Akyildiz, A. C. (2025) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2025.107139 · Cited by 4

Optical Coherence Tomography in Acute Coronary Syndromes

Synetos, A. G., Koliastasis, L., Ktenopoulos, N., Aghayan, S., Katsaros, O., Vlasopoulou, K., Drakopoulou, M. I., Apostolos, A., Kachrimanidis, I., Vlachakis, P. K., et al. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm43321 · Cited by 4

Molecular mechanisms of aortic stenosis: deciphering the role of cellular metabolism in the pursuit of novel therapeutic targets

Weiß, L., Turner, M. E., Qin, Z., Bäck, M., & Aïkawa, E. (2026) · European Heart Journal - Valvular and Structural Heart Disease · doi:10.1093/ehjvshd/xwag018 · Cited by 4

PALMD haploinsufficiency aggravates extracellular matrix remodeling in vascular smooth muscle cells and promotes calcification

Zhang, J., Yang, Z., Zhang, C.-C., Gao, S., Liu, Y., Li, Y., He, S., Yao, J., Du, J., You, B., et al. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00217.2024 · Cited by 4

Arterial Wall Stiffness and Atherogenesis in Human Coronaries

Jacques Ohayon, A., Yazdani, S. K., Malvè, M., Gharib, A. M., García‐González, A., Finet, G., & Pettigrew, R. I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804009-6.00009-2 · Cited by 4

Intracranial Spotty Calcium Predicts Recurrent Stroke in Patients with Symptomatic Intracranial Atherosclerotic Stenosis

Li, R., Liu, M., Li, J., Jiao, X., & Guo, X. (2023) · Clinical Neuroradiology · doi:10.1007/s00062-023-01299-7 · Cited by 4

The Role of Endoplasmic Reticulum Stress in Calcific Aortic Valve Disease

Liu, X., Li, T., Sun, J., & Wang, Z. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.07.025 · Cited by 4

Altered Caveolin-1 Dynamics Result in Divergent Mineralization Responses in Bone and Vascular Calcification

Nik, A. B., Kaiser, K., Sun, P., Khomtchouk, B. B., & Hutcheson, J. D. (2023) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-023-00779-7 · Cited by 4

Two-Dimensional Immiscible Domain of Cholesterol in the Lipid Bilayer Membrane Promotes Early Stage Calcification by Inducing Oriented Nucleation of Hydroxyapatite

Jing, J., Chen, X., Meng, Z., Su, W., Liu, Y., Zhang, Y., Zhu, H., Yao, W., & Fu, T. (2020) · Langmuir · doi:10.1021/acs.langmuir.9b03489 · Cited by 4

Analysis of atherosclerosis by inductively coupled plasma optical emission spectroscopy and scanning acoustic microscopy

Tanören, B., Uğurlucan, M., & Alkan, F. A. (2020) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ab8e96 · Cited by 4

Gingival epithelial cell-derived microvesicles activate mineralization in gingival fibroblasts

Kobayashi, S., Bi, J., Owen, G., Larjava, N., Koivisto, L., Häkkinen, L., & Larjava, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-19732-1 · Cited by 4

Impact of Femoral Ossification on Local and Systemic Cardiovascular Patients' Condition

Danvin, A., Quillard, T., Espitia, O., Charrier, C., Guyomarch, B., Gouëffic, Y., & Maurel, B. (2019) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2019.03.035 · Cited by 4

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosisPreprint

Mosquera, J. V., Auguste, G. E., Wong, D., Turner, A. W., Hodonsky, C. J., Cardenas, C. L. L., Theofilatos, K., Bos, M. M., Kavousi, M., Peyser, P. A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.24.513520 · Cited by 4

Exploring Macrophage Contribution to Vascular Calcification in Atherosclerosis

Dabravolski, S. A., Popov, M. A., Maltseva, O. N., Pavshintsev, V. V., Utkina, A. S., & Orekhov, A. N. (2025) · IUBMB Life · doi:10.1002/iub.70064 · Cited by 3

1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification

Hense, N., Gorgels, A., Mir, B., van der Vorst, E. P. C., Falgayrac, G., Terliesner, M., Gonçalves, I., Matic, L. P., Edsfeldt, A., Sun, J., et al. (2026) · Circulation Research · doi:10.1161/circresaha.125.326772 · Cited by 3

Emerging Gel Technologies for Atherosclerosis Research and Intervention

Tong, S., Chen, J., Li, Y., & Zhao, W. (2026) · Gels · doi:10.3390/gels12010080 · Cited by 3

Extracellular vesicles in atherosclerotic cardiovascular disease: mechanisms and therapeutic implications

Amabile, N., Aïkawa, E., Dignat‐George, F., Boulanger, C. M., Yao, Y., & Leroyer, A. S. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag404 · Cited by 3

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Ashbrook, S. K., Cabrera, A. M. V., Shaver, M., & Hutcheson, J. D. (2023) · Journal of Visualized Experiments · doi:10.3791/65013 · Cited by 3

Evolutionary Patterns of Collagen Fiber Arrangement and Calcification in Atherosclerosis

Ma, C., Jia, Z., Liu, S., Liao, X., Kang, H., Niu, X., & Fan, Y. (2025) · Research · doi:10.34133/research.0798 · Cited by 3

Harmonic generation microscopy of bone microenvironment in vivo

Wu, P., Shen, Y., Sun, C., Lin, C. P., & Liu, T. (2018) · Optics Communications · doi:10.1016/j.optcom.2018.01.023 · Cited by 3

Zooming in on the genesis of atherosclerotic plaque microcalcifications

Ruiz, J., Weinbaum, S., Aïkawa, E., & Hutcheson, J. D. (2016) · The Journal of Physiology · doi:10.1113/jp271339 · Cited by 52

Abstract 648: Visualizing the Genesis of Microcalcifications via Matrix Vesicle Aggregation: Novel Implications for Plaque Vulnerability

Hutcheson, J. D., Goettsch, C., Ricchiuto, P., Bertazzo, S., Maldonado, N., Aikawa, M., Singh, S. A., & Aïkawa, E. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.34.suppl_1.648

Tissue-engineered models to unravel the role of microcalcifications in atherosclerotic plaque rupture

Jansen, I. (2026) · EUR Research Repository (Erasmus University Rotterdam)

Extracellular vesicles in cardiovascular disease: focus on vascular calcification

Aïkawa, E. (2016) · The Journal of Physiology · doi:10.1113/jp272112 · Cited by 32

Abstract 15888: Scamc-1 is a Novel Extracellular Vesicle Protein Linked to Vascular Calcification

Hutcheson, J. D., Goettsch, C., Maldonado, N., Ricchiuto, P., Singh, S. A., & Aïkawa, E. (2014) · Circulation