The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Optical interrogation of neural circuits in Caenorhabditis elegans
Open accessAbstract
The nematode Caenorhabditis elegans has a compact nervous system with only 302 neurons. Whereas most of the synaptic connections between these neurons have been identified by electron microscopy serial reconstructions, functional connections have been inferred between only a few neurons through combinations of electrophysiology, cell ablation, in vivo calcium imaging and genetic analysis. To map functional connections between neurons, we combined in vivo optical stimulation with simultaneous calcium imaging. We analyzed the connections from the ASH sensory neurons and RIM interneurons to the command interneurons AVA and AVD. Stimulation of ASH or RIM neurons using channelrhodopsin-2 (ChR2) resulted in activation of AVA neurons, evoking an avoidance behavior. Our results demonstrate that we can excite specific neurons expressing ChR2 while simultaneously monitoring G-CaMP fluorescence in several other neurons, making it possible to rapidly decipher functional connections in C. elegans neural circuits.
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Cites
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Cited by
Optogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
The development and application of optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113817 · Cited by 1,822
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
Sparta, D. R., Stamatakis, A. M., Phillips, J. L., Hovelsø, N., van Zessen, R., & Stuber, G. D. (2012) · Nature Protocols · doi:10.1038/nprot.2011.413 · Cited by 394
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation
Prakash, R., Yizhar, O., Grewe, B., Ramakrishnan, C., Wang, N., Goshen, I., Packer, A. M., Peterka, D. S., Yuste, R., Schnitzer, M. J., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2215 · Cited by 334
Proprioceptive Coupling within Motor Neurons Drives C. elegans Forward Locomotion
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Neural signal propagation atlas of Caenorhabditis elegans
Randi, F., Sharma, A. K., Dvali, S., & Leifer, A. M. (2023) · Nature · doi:10.1038/s41586-023-06683-4 · Cited by 153
Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic behaviour
Kocabas, A., Shen, C.-H., Guo, Z. V., & Ramanathan, S. (2012) · Nature · doi:10.1038/nature11431 · Cited by 150
Self-citationHow Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli
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Caenorhabditis elegans Body Mechanics Are Regulated by Body Wall Muscle Tone
Petzold, B. C., Park, S.-J., Ponce, P., Roozeboom, C., Powell, C., Goodman, M. B., & Pruitt, B. L. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.02.035 · Cited by 64
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On the development of optical peripheral nerve interfaces
Anderson, H., & Weir, R. F. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.245461 · Cited by 14
Schwarz, J., & Bringmann, H. (2017) · eLife · doi:10.7554/elife.24846 · Cited by 10
“Targeted illumination approaches could be used in the future to control the activation of the SIAs individually and to test the role of the unequal activation patterns (Guo et al., 2009; Leifer et al., 2011; Stirman et al., 2011).”
MethodZalucki, O., Brown, D. J., & Key, B. (2023) · Biology & Philosophy · doi:10.1007/s10539-023-09924-y · Cited by 7
Metadata
- Authors
- Guo, Z. V., Hart, A. C., & Ramanathan, S.
- Venue
- Nature Methods
- Published
- 2009-11-08
- Volume
- 6
- Issue
- 12
- Pages
- 891-896
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2097921303
- Cited by
- 242
- References
- 3
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
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