The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
False discovery rate estimation for cross-linked peptides identified by mass spectrometry
Open accessAbstract
The mass spectrometric identification of chemically cross-linked peptides (CXMS) specifies spatial restraints of protein complexes; these values complement data obtained from common structure-determination techniques. Generic methods for determining false discovery rates of cross-linked peptide assignments are currently lacking, thus making data sets from CXMS studies inherently incomparable. Here we describe an automated target-decoy strategy and the software tool xProphet, which solve this problem for large multicomponent protein complexes.
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Cites
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Self-citationIdentification of cross-linked peptides from large sequence databases
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Self-citationReliable identification of protein-protein interactions by crosslinking mass spectrometry
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“Isotope-tagging introduces an isotopic mass shift which detects crosslinks as isotopic pairs and aids in identifying the fragment ions derived from the two crosslinked peptides by the search engine xQuest (7).”
Background
Metadata
- Authors
- Walzthoeni, T., Claassen, M., Leitner, A., Herzog, F., Bohn, S., Förster, F., Beck, M., & Aebersold, R.
- Venue
- Nature Methods
- Published
- 2012-07-08
- Volume
- 9
- Issue
- 9
- Pages
- 901-903
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W1975057169
- Cited by
- 301
- References
- 18
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- green
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