The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A culture system to study oligodendrocyte myelination processes using engineered nanofibers
Open accessAbstract
Current methods for studying central nervous system myelination necessitate permissive axonal substrates conducive to myelin wrapping by oligodendrocytes. We have developed a neuron-free culture system in which electron-spun nanofibers of varying sizes substitute for axons as a substrate for oligodendrocyte myelination, thereby allowing manipulation of the biophysical elements of axonal-oligodendroglial interactions. To investigate axonal regulation of myelination, this system effectively uncouples the role of molecular (inductive) cues from that of biophysical properties of the axon. We use this method to uncover the causation and sufficiency of fiber diameter in the initiation of concentric wrapping by rat oligodendrocytes. We also show that oligodendrocyte precursor cells display sensitivity to the biophysical properties of fiber diameter and initiate membrane ensheathment before differentiation. The use of nanofiber scaffolds will enable screening for potential therapeutic agents that promote oligodendrocyte differentiation and myelination and will also provide valuable insight into the processes involved in remyelination.
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Cites
Myelination and support of axonal integrity by glia
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NGF Controls Axonal Receptivity to Myelination by Schwann Cells or Oligodendrocytes
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Cited by
The nature of feelings: evolutionary and neurobiological origins
Damasio, A., & Carvalho, G. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3403 · Cited by 1,280
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
Oligodendrocytes in development, myelin generation and beyond
Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625
Neuronal activity biases axon selection for myelination in vivo
Hines, J. H., Ravanelli, A. M., Schwindt, R., Scott, E. K., & Appel, B. (2015) · Nature Neuroscience · doi:10.1038/nn.3992 · Cited by 454
Ehrlich, M., Mozafari, S., Glatza, M., Starost, L., Velychko, S., Hallmann, A.-L., Cui, Q.-L., Schambach, A., Kim, K.-P., Bachelin, C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614412114 · Cited by 257
Metadata
- Authors
- Lee, S., Leach, M. K., Redmond, S. A., Chong, S. Y. C., Mellon, S. H., Tuck, S. J., Feng, Z.-Q., Corey, J. M., & Chan, J. R.
- Venue
- Nature Methods
- Published
- 2012-07-15
- Volume
- 9
- Issue
- 9
- Pages
- 917-922
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W1975719696
- Cited by
- 434
- References
- 27
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, S., Leach, M. K., Redmond, S. A., Chong, S. Y. C., Mellon, S. H., Tuck, S. J., Feng, Z.-Q., Corey, J. M., & Chan, J. R. (2012). A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nature Methods. https://doi.org/10.1038/nmeth.2105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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