The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe
Open accessAbstract
Photoacoustic tomography (PAT) of genetically encoded probes allows for imaging of targeted biological processes deep in tissues with high spatial resolution; however, high background signals from blood can limit the achievable detection sensitivity. Here we describe a reversibly switchable nonfluorescent bacterial phytochrome for use in multiscale photoacoustic imaging, BphP1, with the most red-shifted absorption among genetically encoded probes. BphP1 binds a heme-derived biliverdin chromophore and is reversibly photoconvertible between red and near-infrared light-absorption states. We combined single-wavelength PAT with efficient BphP1 photoswitching, which enabled differential imaging with substantially decreased background signals, enhanced detection sensitivity, increased penetration depth and improved spatial resolution. We monitored tumor growth and metastasis with ∼100-μm resolution at depths approaching 10 mm using photoacoustic computed tomography, and we imaged individual cancer cells with a suboptical-diffraction resolution of ∼140 nm using photoacoustic microscopy. This technology is promising for biomedical studies at several scales.
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Cites
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Self-citationCouzin-Frankel, J. (2013) · Science · doi:10.1126/science.342.6165.1432 · Cited by 2,051
Going deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
Cited by
Miao, Q., & Pu, K. (2018) · Advanced Materials · doi:10.1002/adma.201801778 · Cited by 537
Li, L., Zhu, L., Ma, C., Lin, L., Yao, J., Wang, L., Maslov, K., Zhang, R., Chen, W., Shi, J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0071 · Cited by 477
Self-citationWu, Z., Li, L., Yang, Y., Hu, P., Li, Y., Yang, S.-Y., Wang, L. V., & Gao, W. (2019) · Science Robotics · doi:10.1126/scirobotics.aax0613 · Cited by 466
Self-citationAcoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts
Bourdeau, R. W., Lee-Gosselin, A., Lakshmanan, A., Farhadi, A., Kumar, S. R., Nety, S. P., & Shapiro, M. G. (2018) · Nature · doi:10.1038/nature25021 · Cited by 396
Near-Infrared Fluorescent Proteins, Biosensors, and Optogenetic Tools Engineered from Phytochromes
Chernov, K. G., Redchuk, T. A., Omelina, E. S., & Verkhusha, V. V. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00700 · Cited by 264
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Metadata
- Authors
- Yao, J., Kaberniuk, A. A., Li, L., Shcherbakova, D. M., Zhang, R., Wang, L., Li, G., Verkhusha, V. V., & Wang, L. V.
- Venue
- Nature Methods
- Published
- 2015-11-09
- Volume
- 13
- Issue
- 1
- Pages
- 67-73
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2195567999
- Cited by
- 271
- References
- 3
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- green
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