Cancer Immunotherapy
Abstract
This year marks a turning point in cancer, as long-sought efforts to unleash the immune system against tumors are paying off—even if the future remains a question mark.
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CRISPR-Cas9 has been applied in T cell modification and immune modulation.
“Given that CRISPR-Cas9 has been applied in T cell modification 70 and immune modulation, 70 71”
From CRISPR-Cas9: a new and promising player in gene therapy (2015) · cites this paper as [70]
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“1).”
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“Discussion The vital contribution of the immune surveillance system to cancer progression has been swiftly translated to the clinical setting with the introduction of immunotherapeutics to treat various cancers (3, 4).”
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“While cancer immunotherapy targeting ICR has emerged as a major therapeutic advance (34), biomarkers of response are inadequate and have so far focused on ligand expression (i.”
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“Registration of other ICIs and additional indications for ICIs is highly anticipated in the near future [8].”
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- Authors
- Couzin-Frankel, J.
- Corresponding author
- Couzin-Frankel, Jennifer
- Venue
- Science
- Published
- 2013-12-20
- Volume
- 342
- Issue
- 6165
- Pages
- 1432-1433
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2209812019
- Cited by
- 2,051
- References
- 0
- Citations by year
- 2026: 34 · 2025: 100 · 2024: 133 · 2023: 154 · 2022: 172 · 2021: 215 · 2020: 220 · 2019: 197 · 2018: 206 · 2017: 206 · 2016: 138 · 2015: 169 · 2014: 103 · 2013: 2 · 2012: 1
- FWCI
- 73.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- cancer immunotherapy, tumor immunology, immune checkpoint inhibitors
- MeSH terms
- Ipilimumab, Antibodies, Antibodies, Monoclonal, Clinical Trials as Topic, Humans, Immunotherapy, Melanoma, Neoplasms, T-Lymphocytes, CTLA-4 Antigen
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