Host response: a trigger for neurodegeneration?

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works

Control of brain development, function, and behavior by the microbiome

Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060 · see citing works

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

Kumar, D. K. V., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1059 · Cited by 971 · see citing works

Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis

Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works

Collective unconscious: How gut microbes shape human behavior

Dinan, T. G., Stilling, R. M., Stanton, C., & Cryan, J. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.021 · Cited by 571 · see citing works

Microbes and Alzheimer’s Disease

Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., Bullido, M. J., Carter, C., Clerici, M., Cosby, S. L., et al. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160152 · Cited by 532 · see citing works

Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease

Riviere, G. R., Riviere, K. H., & Smith, K. S. (2002) · Oral Microbiology and Immunology · doi:10.1046/j.0902-0055.2001.00100.x · Cited by 362 · see citing works

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

Judith Miklossy, A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-90 · Cited by 356 · see citing works

Bacterial Infection and Alzheimer's Disease: A Meta-Analysis

Maheshwari, P., & Eslick, G. D. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-140621 · Cited by 183 · see citing works

Could Toxoplasma gondii Have any Role in Alzheimer Disease?

Küsbeci, Ö. Y., Miman, Ö., Yaman, M., Aktepe, O. C., & Yazar, S. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181f73bc2 · Cited by 164 · see citing works

Infection, systemic inflammation, and Alzheimer's disease

Lim, S., Rodríguez‐Ortiz, C. J., & Kitazawa, M. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.04.004 · Cited by 109 · see citing works

Toxoplasma gondii Infection in the Brain Inhibits Neuronal Degeneration and Learning and Memory Impairments in a Murine Model of Alzheimer's Disease

Jung, B.-K., Pyo, K., Shin, K. Y., Hwang, Y. S., Lim, H., Lee, S. J., Moon, J.-H., Lee, S. H., Suh, Y., Chai, J.-Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033312 · Cited by 106 · see citing works

Alzheimer’s disease Braak Stage progressions: Reexamined and redefined as Borrelia infection transmission through neural circuits

MacDonald, A. B. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.09.054 · Cited by 26 · see citing works

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works

Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence

Hampel, H. J., Nisticò, R., Seyfried, N. T., Levey, A. I., Modeste, E. S., Lemercier, P., Baldacci, F., Toschi, N., Garaci, F., Perry, G. L., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101346 · Cited by 142 · see citing works

Multiomics technologies: role in disease biomarker discoveries and therapeutics

Dar, M. A., Arafah, A. M., Bhat, K. A., Khan, A., Khan, M. S., Ali, A., Ahmad, S. M., Rashid, S. M., & Rehman, M. U. (2022) · Briefings in Functional Genomics · doi:10.1093/bfgp/elac017 · Cited by 96 · see citing works

Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases

Rosário, D., Borén, J., Uhlén, M., Proctor, G., Aarsland, D., Mardinoğlu, A., & Shoaie, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00716 · Cited by 66 · see citing works

Infection-Induced Systemic Inflammation Is a Potential Driver of Alzheimer's Disease Progression

Giridharan, V. V., Masud, F. N., Petronilho, F. C., Dal‐Pizzol, F., & Barichello, T. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00122 · Cited by 67 · see citing works

Human Gut-Microbiota Interaction in Neurodegenerative Disorders and Current Engineered Tools for Its Modeling

Ceppa, F., Izzo, L., Sardelli, L., Raimondi, I., Tunesi, M., Albani, D., & Giordano, C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00297 · Cited by 55 · see citing works

Innate Immune and Fungal Model of Alzheimer’s Disease

Parady, B. (2018) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-180073 · Cited by 39 · see citing works

Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis

Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works

Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability

Barnes, S. E., Zera, K. A., Ivison, G. T., Buckwalter, M. S., & Engleman, E. G. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02262-4 · Cited by 33 · see citing works

Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimer's disease: Amyloid beta peptides and beyond

Grasso, G. (2018) · Mass Spectrometry Reviews · doi:10.1002/mas.21566 · Cited by 30 · see citing works

Obesity and the Brain

Karczewski, J., Zielińska, A., Staszewski, R., Eder, P., Dobrowolska, A., & Souto, E. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116145 · Cited by 27 · see citing works

Neurodegenerative Disorders and the Gut-Microbiome-Brain Axis: A Literature Review

Dandamudi, B. J., Dimaano, K. A. M., Shah, N., AlQassab, O., Al-Sulaitti, Z., Nelakuditi, B., & Mohammed, L. (2024) · Cureus · doi:10.7759/cureus.72427 · Cited by 12 · see citing works

The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective

Yu, X., Li, M., & Li, H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118846 · Cited by 11 · see citing works

Advances in Autophagy–Lysosomal Pathway and Neurodegeneration via Brain–Gut Axis

Yao, P., & Han, H. (2025) · Biomedicines · doi:10.3390/biomedicines13061390 · Cited by 9 · see citing works

Need for more holistic therapeutic and management strategies to understand the causal or correlative link of the Aβ amyloid pathway with Alzheimer’s disease for a more efficiënt treatment

Timmermans, J. (2018) · Peptides · doi:10.1016/j.peptides.2018.03.002

Additional file 1 of Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability

Barnes, S. E., Zera, K. A., Ivison, G. T., Buckwalter, M. S., & Engleman, E. G. (2021) · Figshare · doi:10.6084/m9.figshare.16608929

Insight into the specificity of antimicrobial peptides towards biological membranes as studied by bioinformatics and experimental biophysics

Ramos‐Martín, F. (2021) · doi:10.70675/1ce5f4c2z985cz4727zbb4az35a0be6dd690

Amyloid: An evolutionarily conserved protein to fight infection or a toxic protein that causes Alzheimer's disease?

Shriram, J., Nathan, U., Decourt, B., & Sabbagh, M. N. (2026) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70235

Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunity

Vojtechova, I., Machacek, T., Kristofikova, Z., Stuchlik, A., & Petrasek, T. (2022) · PLOS Pathogens · doi:10.1371/journal.ppat.1010929 · Cited by 92 · see citing works

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection

Brown, M. R., Radford, S. E., & Hewitt, E. W. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.609073 · Cited by 67 · see citing works

Alzheimer's Progenitor Amyloid‐β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function (Adv. Sci. 29/2023)

Ali, S. A., Chung, K. H. K., Forgham, H., Olsen, W. P., Käkinen, A., Balaji, A., Otzen, D. E., Davis, T. P., & Javed, I. (2023) · Advanced Science · doi:10.1002/advs.202370200

Alzheimer’s-Associated Protein Might Help Brain Fight Infections

Zagorski, N. (2016) · Psychiatric News · doi:10.1176/appi.pn.2016.6b20