The GPR17 receptor-A promising goal for therapy and a potential marker of the neurodegenerative process in multiple sclerosis
Open accessAbstract
One of the most important goals in the treatment of demyelinating diseases such as multiple sclerosis (MS) is, in addition to immunomodulation, reconstruction of the lost myelin sheath. The modulator of the central nervous system myelination is the metabotropic receptor coupled to the G-protein: GPR17. GPR17 receptors are considered to be sensors of local damage to the myelin sheath, and play a role in the reconstruction and repair of demyelinating plaques caused by ongoing inflammatory processes. GPR17 receptors are present on nerve cells and precursor oligodendrocyte cells. Under physiological conditions, they are responsible for the differentiation and subsequent maturation of oligodendrocytes, while under pathological conditions (during damage to nerve cells), their expression increases to become mediators in the demyelinating processes. Moreover, they are essential not only in both the processes of inducing damage and the death of neurons, but also in the local repair of the damaged myelin sheath. Therefore, GPR17 receptors may be recognized as the potential goal in creating innovative therapies for the treatment of the neurodegenerative process in MS, based on the acceleration of the remyelination processes. This review examines the role of GRP17 in pathomechanisms of MS development.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The strong activation of immune- and inflammation-related genes, as well as differential expression of remyelination regulators like Gpr17, suggest that the homeostasis of white matter is compromised at old age.
“The strong activation of immune- and inflammation-related genes, as well as differential expression of remyelination regulators like Gpr17 (Dziedzic et al., 2020; Rivera et al., 2021), suggest that the homeostasis of this region is compromised at old age.”
From Atlas of the aging mouse brain reveals white matter as vulnerable foci (2023) · cites this paper as Dziedzic et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167 · see citing works
Monocyte Chemoattractant Protein-1 (MCP-1): An Overview
Deshmane, S. L., Kremlev, S., Amini, S., & Sawaya, B. E. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0027 · Cited by 3,889 · see citing works
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568 · see citing works
Cytokines, Inflammation, and Pain
Zhang, J., & An, J. (2007) · International Anesthesiology Clinics · doi:10.1097/aia.0b013e318034194e · Cited by 2,958 · see citing works
Fredriksson, R., Lagerström, M. C., Lundin, L.-G., & Schiöth, H. B. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1256 · Cited by 2,941 · see citing works
The structure and function of G-protein-coupled receptors
Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature · doi:10.1038/nature08144 · Cited by 2,534 · cited 1× · see citing works
“GPCRs also mediate our sense of vision, olfaction, taste, and pain [64].”
BackgroundImmunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149 · see citing works
T2Rs Function as Bitter Taste Receptors
Chandrashekar, J. V., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., Guo, W., Zuker, C. S., & Ryba, N. J. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80706-0 · Cited by 1,402 · see citing works
Neves, S. R., Ram, P. T., & Iyengar, R. (2002) · Science · doi:10.1126/science.1071550 · Cited by 1,300 · see citing works
G-protein-coupled receptors and signaling networks: emerging paradigms
Marinissen, M. J., & Gutkind, J. S. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01678-3 · Cited by 1,049 · see citing works
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
Fletcher, J. M., Lalor, S. J., Sweeney, C. M., Tubridy, N. J., & Mills, K. H. G. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04143.x · Cited by 937 · see citing works
Oligodendrocytes: biology and pathology
Bradl, M., & Lassmann, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0601-5 · Cited by 933 · see citing works
Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927 · see citing works
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865 · see citing works
Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864 · see citing works
Oligodendrocytes: Myelination and Axonal SupportPreprint
Simons, M., & Nave, K. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020479 · Cited by 862 · see citing works
Remyelination is extensive in a subset of multiple sclerosis patients
Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807 · see citing works
Neurodegenerative disease: models, mechanisms, and a new hope
Gitler, A. D., Dhillon, P., & Shorter, J. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030205 · Cited by 752 · see citing works
Molecular Mimicry, Bystander Activation, or Viral Persistence: Infections and Autoimmune Disease
Fujinami, R. S., von Herrath, M. G., Christen, U., & Whitton, J. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.1.80-94.2006 · Cited by 685 · see citing works
Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy
Ghasemi, N., Razavi, S., & Nikzad, E. (2016) · Cell journal · doi:10.22074/cellj.2016.4867 · Cited by 647 · see citing works
Bjartmar, C., Wujek, J. R., & Trapp, B. D. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00069-2 · Cited by 573 · see citing works
Evidence of early cortical atrophy in MS
de Stefano, N., Matthews, P. M., Filippi, M., Agosta, F., Luca, M. D., Bartolozzi, M. L., Guidi, L., Ghezzi, A., Montanari, E., Cifelli, A., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000055926.69643.03 · Cited by 519 · see citing works
Boyd, J. G., & Gordon, T. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:277 · Cited by 515 · see citing works
Korn, T., Mitsdoerffer, M., Croxford, A. L., Awasthi, A., Dardalhon, V., Galileos, G., Vollmar, P., Stritesky, G. L., Kaplan, M. H., Waisman, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809850105 · Cited by 510 · see citing works
Regulation, signaling, and physiological functions of G-Proteins
Syrovatkina, V., Alegre, K. O., Dey, R., & Huang, X.-Y. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.002 · Cited by 498 · see citing works
Diversity and Modularity of G Protein-Coupled Receptor Structures
Katritch, V., Cherezov, V., & Stevens, R. (2011) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.003 · Cited by 495 · see citing works
Ciana, P., Fumagalli, M., Trincavelli, M. L., Verderio, C., Rosa, P., Lecca, D., Ferrario, S., Parravicini, C., Capra, V., Gelosa, P., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601341 · Cited by 438 · see citing works
Karussis, D. M. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.022 · Cited by 384 · see citing works
p27 kip1 independently promotes neuronal differentiation and migration in the cerebral cortexPreprint
Nguyen, L., Besson, A., Heng, J. I., Schuurmans, C. J., Teboul, L., Parras, C. M., Philpott, A., Roberts, J. M., & Guillemot, F. (2006) · Genes & Development · doi:10.1101/gad.377106 · Cited by 367 · see citing works
Chen, Y., Wu, H., Wang, S., Koito, H., Li, J., Ye, F., Hoang, J., Escobar, S. S., Gow, A., Arnett, H. A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2410 · Cited by 346 · see citing works
Oligodendrocyte development and the onset of myelination in the human fetal brain
Jakovcevski, I. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.005.2009 · Cited by 323 · see citing works
Roles of Wnt proteins in neural development and maintenance
Patapoutian, A., & Reichardt, L. F. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00100-8 · Cited by 319 · see citing works
Simon, C., Götz, M., & Dimou, L. (2011) · Glia · doi:10.1002/glia.21156 · Cited by 313 · see citing works
The GRAFS classification system of G-protein coupled receptors in comparative perspective
Schiöth, H. B., & Fredriksson, R. (2005) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2004.12.018 · Cited by 313 · see citing works
Lewczuk, P., Riederer, P. F., O’Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramı́rez, A., Parnetti, L., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1375556 · Cited by 308 · see citing works
The NG2 proteoglycan: Past insights and future prospects
Stallcup, W. B. (2002) · Journal of Neurocytology · doi:10.1023/a:1025731428581 · Cited by 296 · see citing works
Signaling and regulation of G protein-coupled receptors in airway smooth muscle
Billington, C. K., & Penn, R. B. (2003) · Respiratory Research · doi:10.1186/1465-9921-4-2 · Cited by 284 · see citing works
The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes
Dupré, D. J., Robitaille, M., Rebois, R. V., & Hébert, T. E. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061008-103038 · Cited by 274 · see citing works
G13 is an essential mediator of platelet activation in hemostasis and thrombosis
Moers, A., Nieswandt, B., Maßberg, S., Wettschureck, N., Grüner, S., Konrad, I., Schulte, V., Aktas, B., Gratacap, M., Simon, M. I., et al. (2003) · Nature Medicine · doi:10.1038/nm943 · Cited by 264 · see citing works
Pathology of Multiple Sclerosis: Where Do We Stand?
Popescu, B. F. G., Pirko, I., & Lucchinetti, C. F. (2013) · Continuum · doi:10.1212/01.con.0000433291.23091.65 · Cited by 261 · see citing works
A Role for the Helix-Loop-Helix Protein Id2 in the Control of Oligodendrocyte Development
Wang, S., Sdrulla, A. D., Johnson, J. E. B., Yokota, Y., & Barres, B. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00237-9 · Cited by 261 · see citing works
Signaling through G protein coupled receptors
Tuteja, N. K. (2009) · Plant Signaling & Behavior · doi:10.4161/psb.4.10.9530 · Cited by 253 · see citing works
Pathology and disease mechanisms in different stages of multiple sclerosis.
Lassmann, H. (2013) · Journal of Neurological Sciences · doi:10.1016/j.jns.2013.05.010 · Cited by 246 · see citing works
Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging
Ciccarelli, O., Barkhof, F., Bodini, B., Stefano, N. D., Golay, X., Nicolay, K., Pelletier, D., Pouwels, P. J. W., Smith, S. A., Wheeler‐Kingshott, C. A. M. G., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70101-2 · Cited by 241 · see citing works
Relapsing and progressive forms of multiple sclerosis – insights from pathology
Dutta, R., & Trapp, B. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000094 · Cited by 236 · see citing works
Cells of the oligodendroglial lineage, myelination, and remyelination
Miron, V. E., Kuhlmann, T., & Antel, J. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.09.010 · Cited by 236 · see citing works
Lecca, D., Trincavelli, M. L., Gelosa, P., Sironi, L., Ciana, P., Fumagalli, M., Villa, G. C. F., Verderio, C., Grumelli, C., Guerrini, U., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003579 · Cited by 227 · see citing works
Regulation of RhoGEF proteins by G 12/13 ‐coupled receptors
Siehler, S. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00121.x · Cited by 227 · see citing works
Joost, P., & Methner, A. (2002) · Genome biology · doi:10.1186/gb-2002-3-11-research0063 · Cited by 219 · see citing works
Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors
Allen, J. A., & Roth, B. L. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100553 · Cited by 216 · see citing works
Discovery and mapping of ten novel G protein-coupled receptor genes
Lee, D. K., Nguyen, T., Lynch, K. R., Cheng, R., Vanti, W. B., Arkhitko, O., Lewis, T., Evans, J. F., George, S. R., & O’Dowd, B. F. (2001) · Gene · doi:10.1016/s0378-1119(01)00651-5 · Cited by 215 · see citing works
The Id4 HLH protein and the timing of oligodendrocyte differentiation
Kondo, T., & Raff, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.9.1998 · Cited by 203 · see citing works
Multiple Sclerosis and T Lymphocytes: An Entangled Story
Legroux, L., & Arbour, N. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9614-0 · Cited by 196 · see citing works
Remyelination in multiple sclerosis
Lassmann, H., Brück, W., Lucchinetti, C., & Rodriguez, M. (1997) · Multiple Sclerosis Journal · doi:10.1177/135245859700300213 · Cited by 191 · see citing works
Fumagalli, M., Daniele, S., Lecca, D., Lee, P. R., Parravicini, C., Fields, R. D., Rosa, P., Antonucci, F., Verderio, C., Trincavelli, M. L., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.162867 · Cited by 188 · see citing works
Redfern, C. H., Degtyarev, M. Y., Kwa, A., Salomonis, N., Cotte, N., Nanevicz, T., Fidelman, N., Desai, K. H., Vranizan, K., Lee, E. K., et al. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.9.4826 · Cited by 187 · see citing works
Functions and Regulatory Mechanisms of Gq-Signaling Pathways
Mizuno, N., & Itoh, H. (2009) · Neurosignals · doi:10.1159/000186689 · Cited by 181 · see citing works
van Nierop, G. P., van Luijn, M. M., Michels, S. S., Melief, M.-J., Janssen, M., Langerak, A. W., Ouwendijk, W. J. D., Hintzen, R. Q., & Verjans, G. M. G. M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1744-4 · Cited by 174 · see citing works
Disease modifying therapies for relapsing multiple sclerosis
Wingerchuk, D. M., & Weinshenker, B. G. (2016) · BMJ · doi:10.1136/bmj.i3518 · Cited by 166 · see citing works
Molecular diagnostics of neurodegenerative disorders
Agrawal, M., & Biswas, A. (2015) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2015.00054 · Cited by 164 · see citing works
Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?
Ettle, B., Schlachetzki, J. C. M., & Winkler, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9205-3 · Cited by 160 · see citing works
Biomarkers in Multiple SclerosisPreprint
Paul, A., Comabella, M., & Gandhi, R. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029058 · Cited by 157 · see citing works
Zezula, J., Casaccia‐Bonnefil, P., Ezhevsky, S. A., Osterhout, D. J., Levine, J. M., Dowdy, S. F., Chao, M. V., & Koff, A. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve008 · Cited by 151 · see citing works
Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination
Podbielska, M., Banik, N. L., Kurowska, E., & Hogan, E. (2013) · Brain Sciences · doi:10.3390/brainsci3031282 · Cited by 149 · see citing works
dos Passos, G. R., Sato, D. K., Becker, J., & Fujihara, K. (2016) · Mediators of Inflammation · doi:10.1155/2016/5314541 · Cited by 149 · see citing works
Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis
Chard, D., Griffin, C., Rashid, W., Davies, G., Altmann, D., Kapoor, R., Barker, G. J., Thompson, A., & Miller, D. H. (2003) · Multiple Sclerosis · doi:10.1191/1352458504ms1050oa · Cited by 146 · see citing works
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches
Spahn, T. W., Fontana, A., Faria, A. M. C., Slavin, A., Eugster, H., Zhang, X., Koni, P. A., Ruddle, N. H., Flavell, R. A., Rennert, P. D., et al. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200104)31:4 · Cited by 143 · see citing works
Visualizing the GPCR Network: Classification and Evolution
Hu, G., Mai, T., & Chen, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-15707-9 · Cited by 128 · see citing works
The socioeconomic consequences of multiple sclerosis: A controlled national study
Jennum, P., Wanscher, B., Frederiksen, J. L., & Kjellberg, J. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.05.001 · Cited by 124 · see citing works
Neuropathophysiology of Brain Injury
Quillinan, N., Herson, P. S., & Traystman, R. J. (2016) · Anesthesiology Clinics · doi:10.1016/j.anclin.2016.04.011 · Cited by 119 · see citing works
Olig1 Function Is Required for Oligodendrocyte Differentiation in the Mouse Brain
Dai, J., Bercury, K., Ahrendsen, J. T., & Macklin, W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4962-14.2015 · Cited by 108 · see citing works
Signaling property study of adhesion G‐protein‐coupled receptors
Gupte, J., Swaminath, G., Danao, J., Tian, H., Li, Y., & Wu, X. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.014 · Cited by 105 · see citing works
Pelaia, G., Renda, T., Gallelli, L., Vatrella, A., Busceti, M. T., Agati, S., Caputi, M., Cazzola, M., Maselli, R., & Marsico, S. A. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.02.020 · Cited by 103 · see citing works
Orphan G protein-coupled receptors: The role in CNS disorders
Alavi, M. S., Shamsizadeh, A., Azhdari‐Zarmehri, H., & Roohbakhsh, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.056 · Cited by 102 · see citing works
Ligation of the adhesion‐GPCR EMR2 regulates human neutrophil function
Yona, S., Lin, H., Dri, P., Davies, J. Q., Hayhoe, R. P. G., Lewis, S. M., Heinsbroek, S. E. M., Brown, K. A., Perretti, M., Hamann, J., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-9435com · Cited by 101 · see citing works
The NG2 proteoglycan promotes oligodendrocyte progenitor proliferation and developmental myelination
Kuchárová, K., & Stallcup, W. B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.014 · Cited by 100 · see citing works
Biomarkers in Multiple Sclerosis: An Up-to-Date Overview
Katsavos, S., & Anagnostouli, M. C. (2013) · Multiple Sclerosis International · doi:10.1155/2013/340508 · Cited by 100 · see citing works
The physiological roles of secretin and its receptor.
Afroze, S. H., Meng, F., Jensen, K. J., McDaniel, K. M., Rahal, K., Onori, P., Gaudio, E., Alpini, G. D., & Glaser, S. S. (2013) · PubMed Central · doi:10.3978/j.issn.2305-5839.2012.12.01 · Cited by 99 · see citing works
Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression
Peeters, L. M., Vanheusden, M., Somers, V. A., Wijmeersch, B. V., Stinissen, P., Broux, B., & Hellings, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01160 · Cited by 95 · see citing works
New members of the chemokine receptor gene family
Raport, C. J., Schweickart, V. L., Chantry, D., Eddy, R. L., Shows, T. B., Godiska, R., & Gray, P. W. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.1.18 · Cited by 91 · see citing works
Biomarkers of multiple sclerosis: current findings
Harris, V., Tuddenham, J. F., & Sadiq, S. A. (2017) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s98936 · Cited by 88 · see citing works
Regulation of remyelination in multiple sclerosis
Hanafy, K. A., & Sloane, J. A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.048 · Cited by 84 · see citing works
Distinct expression and ligand‐binding profiles of two constitutively active GPR17 splice variants
Benned‐Jensen, T., & ROSENKILDE, M. M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00633.x · Cited by 83 · see citing works
Fumagalli, M., Lecca, D., & Abbracchio, M. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.005 · Cited by 81 · see citing works
Raj, R., Kaprio, J. A., Korja, M., Mikkonen, E. D., Jousilahti, P., & Siironen, J. O. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002316 · Cited by 78 · see citing works
Fields, R. D. (2014) · Science · doi:10.1126/science.1253851 · Cited by 77 · see citing works
Miller, E. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0653-2_17 · Cited by 77 · see citing works
Stilund, M., Carstensen, M., Petersen, T., Møller, H. J., Rasmussen, P. V., & Christensen, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119681 · Cited by 73 · see citing works
Franke, H., Parravicini, C., Lecca, D., Zanier, E. R., Heine, C., Bremicker, K., Fumagalli, M., Rosa, P., Longhi, L. G., Stocchetti, N., et al. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9366-3 · Cited by 71 · see citing works
Increase of oligodendrocyte progenitor cells after spinal cord injury
Ishii, K., Toda, M., Nakai, Y., Asou, H., Watanabe, M., Nakamura, M., Yato, Y., Fujimura, Y., Kawakami, Y., Toyama, Y., et al. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1180 · Cited by 71 · see citing works
Ceruti, S., Viganò, F., Boda, E., Ferrario, S., Magni, G., Boccazzi, M., Rosa, P., Buffo, A., & Abbracchio, M. P. (2010) · Glia · doi:10.1002/glia.21107 · Cited by 70 · see citing works
Modulation of Gq-Protein-Coupled Inositol Trisphosphate and Ca2+Signaling by the Membrane Potential
Billups, D., Billups, B., Challiss, R. A. J., & Nahorski, S. R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2773-06.2006 · Cited by 68 · see citing works
Relevance of rhodopsin studies for GPCR activation
Deupí, X. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.09.002 · Cited by 63 · see citing works
Khan, M. Z., & He, L. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4586-9 · Cited by 63 · see citing works
Gα14 links a variety of Gi‐ and Gs‐coupled receptors to the stimulation of phospholipase C
Ho, M. K. C., Yung, L. Y., Chan, J. S. C., Chan, J. H. P., Wong, C. S. S., & Wong, Y. H. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703933 · Cited by 62 · see citing works
Real-world validation of the 2017 McDonald criteria for pediatric MS
Wong, Y. Y. M., de Mol, C. L., de Vries, R. M. V. D. V., van Pelt, E. D., Ketelslegers, I. A., Catsman‐Berrevoets, C. E., Neuteboom, R. F., & Hintzen, R. Q. (2018) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000528 · Cited by 61 · see citing works
Multiple Sclerosis Cerebrospinal Fluid Biomarkers
Giovannoni, G. (2006) · Disease Markers · doi:10.1155/2006/509476 · Cited by 57 · see citing works
Lu, C., Dong, L., Zhou, H., Li, Q., Huang, G., Bai, S. J., & Liao, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-22452-0 · Cited by 57 · see citing works
LARG and mDia1 Link Gα 12/13 to Cell Polarity and Microtubule Dynamics
Goulimari, P., Knieling, H., Engel, U., & Grosse, R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-11-1045 · Cited by 52 · see citing works
Arbelaez, C. A., Glatigny, S., Duhen, R., Eberl, G., Oukka, M., & Bettelli, E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403135 · Cited by 51 · see citing works
Cunnusamy, K., Baughman, E. J., Franco, J., Ortega, S. B., Sinha, S., Chaudhary, P., Greenberg, B. M., Frohman, E. M., & Karandikar, N. J. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.03.005 · Cited by 50 · see citing works
Olig1 is expressed in human oligodendrocytes during maturation and regeneration
Othman, A. H., Frim, D. M., Polak, P. E., Vujicic, S., Arnason, B. G. W., & Boullerne, A. I. (2011) · Glia · doi:10.1002/glia.21163 · Cited by 48 · see citing works
Leung, C., & Wong, Y. (2017) · Molecules · doi:10.3390/molecules22071239 · Cited by 48 · see citing works
Senanayake, V. K., Jin, W., Mochizuki, A., Chitou, B., & Goodenowe, D. B. (2015) · BMC Neurology · doi:10.1186/s12883-015-0411-4 · Cited by 46 · see citing works
Gray Matter Pathology in MS: Neuroimaging and Clinical Correlations
Honce, J. (2013) · Multiple Sclerosis International · doi:10.1155/2013/627870 · Cited by 44 · see citing works
Gq-Coupled Receptors in Autoimmunity
Zhang, L., & Shi, G. (2016) · Journal of Immunology Research · doi:10.1155/2016/3969023 · Cited by 44 · see citing works
The environment rules: spatiotemporal regulation of oligodendrocyte differentiation
Mayoral, S. R., & Chan, J. R. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.002 · Cited by 35 · see citing works
Interactions between platelets and leukocytes in pathogenesis of multiple sclerosis
Dziedzic, A., & Bijak, M. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/83588 · Cited by 28 · see citing works
GPR17 mediates ischemia-like neuronal injury via microglial activation
Zhao, B., Wang, H., Li, C., Song, S., Fang, S., Wei, E., & Shi, Q. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3848 · Cited by 27 · see citing works
Symptomatic management in multiple sclerosis
Shah, P. (2015) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.164827 · Cited by 26 · see citing works
Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Pleli, T., Mondorf, A. W., Ferreirós, N., Thomas, D., Dvorak, K., Biondi, R. M., zu Heringdorf, D. M., Zeuzem, S., Geißlinger, G., Zimmermann, H., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000488270 · Cited by 26 · see citing works
Insights into the Role of Neuroinflammation in the Pathogenesis of Multiple Sclerosis
Al‐Badri, G., & Castorina, A. (2018) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk3010013 · Cited by 20 · see citing works
McCloskey, D. T., Turcato, S., Wang, G., Turnbull, L., Zhu, B., Bambino, T., Nguyen, A. P., Lovett, D. H., Nissenson, R. A., Karliner, J. S., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00829.2007 · Cited by 19 · see citing works
Satoh, J., Kino, Y., Yanaizu, M., Tosaki, Y., Sakai, K., Ishida, T., & Saito, Y. (2017) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2016.01097 · Cited by 16 · see citing works
Lecca, D., Fumagalli, M., Ceruti, S., & Abbracchio, M. P. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0433 · Cited by 13 · see citing works
cAMP-independent relaxation of smooth muscle cells via G s -coupled receptors
Peters, S. L. M., & Michel, M. C. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0816-2 · Cited by 11 · see citing works
The emergence of follow-on disease-modifying therapies for multiple sclerosis
Moss, B. P., & Cohen, J. A. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458519845106 · Cited by 11 · see citing works
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works
Flagged first, then by citations
2 of the 120 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Atlas of the aging mouse brain reveals white matter as vulnerable foci
Hahn, O., Foltz, A. G., Atkins, M., Kedir, B., Moran-Losada, P., Guldner, I. H., Munson, C., Kern, F., Pálovics, R., Lu, N., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.027 · Cited by 213 · see citing works
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Wong, T., Li, G., Li, S., Gao, W., Chen, G., Gan, S., Zhang, M., Li, H., Wu, S., & Du, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01427-2 · Cited by 168 · see citing works
The beneficial role of autophagy in multiple sclerosis: Yes or No?
Al-Kuraishy, H. M., Jabir, M. S., Al-Gareeb, A. I., Saad, . M., Batiha, G. E., & Klionsky, D. J. (2023) · Autophagy · doi:10.1080/15548627.2023.2259281 · Cited by 86 · see citing works
Strategies for Oligodendrocyte and Myelin Repair in Traumatic CNS Injury
Huntemer-Silveira, A., Patil, N., Brickner, M. A., & Parr, A. M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.619707 · Cited by 70 · see citing works
The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects
Al-Kuraishy, H. M., Al-Gareeb, A. I., Saad, . M., & Batiha, G. E. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01240-x · Cited by 54 · see citing works
Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein
Ye, F., Wong, T., Chen, G., Zhang, Z., Zhang, B., Gan, S., Gao, W., Li, J., Wu, Z., Pan, X., et al. (2022) · MedComm · doi:10.1002/mco2.159 · Cited by 53 · see citing works
Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing
Marques, C. F., Marques, M. M., & Justino, G. C. (2022) · Pharmaceuticals · doi:10.3390/ph15091039 · Cited by 43 · see citing works
Jin, S., Wang, X., Xiang, X., Wu, Y., Hu, J., Li, Y., Dong, Y. L., Tan, Y., & Wu, X. G. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108335 · Cited by 32 · see citing works
Exploring orphan GPCRs in neurodegenerative diseases
Arslan, D. Ö., Yavuz, M., & Kan, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1394516 · Cited by 19 · see citing works
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs
Häberlein, F., Mingardo, E., Merten, N., Köhling, N.-K. S., Reinoß, P., Simon, K., Japp, A. S., Nagarajan, B., Schrage, R., Pégurier, C., et al. (2022) · Cell chemical biology · doi:10.1016/j.chembiol.2022.08.007 · Cited by 18 · see citing works
Targeting Orphan G Protein-Coupled Receptor 17 with T0 Ligand Impairs Glioblastoma Growth
Doan, P., Nguyen, P., Murugesan, A., Subramanian, K., Saravanan, K. M., Vignesh, K., Abraham, B. G., Stringer, B. W., Kadalmani, B., Yli-Harja, O. P., et al. (2021) · Cancers · doi:10.3390/cancers13153773 · Cited by 16 · see citing works
Niedzwiedz‐Massey, V. M., Douglas, J. C., Rafferty, T. M., Kane, C. J. M., & Drew, P. D. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.07.003 · Cited by 16 · see citing works
The Multifaceted Role of GPCRs in Amyotrophic Lateral Sclerosis: A New Therapeutic Perspective?
Bassani, D., Pavan, M., Federico, S., Spalluto, G., Sturlese, M., & Moro, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094504 · Cited by 13 · see citing works
Sajkowska‐Kozielewicz, J. J., Tsang, C. H., & Kozielewicz, P. (2024) · SLAS DISCOVERY · doi:10.1016/j.slasd.2024.100174 · Cited by 12 · see citing works
Mitochondrial complex III bypass complex I to induce ROS in GPR17 signaling activation in GBM
Kari, S., Kandhavelu, J., Murugesan, A., Ramesh, T., Kidambi, S., & Kandhavelu, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114678 · Cited by 11 · see citing works
Holý, P., Hlaváč, V., Ostašov, P., Brynychová, V., Koževnikovová, R., Trnková, M., Kopečková, K., Měšťáková, S., Mrhalová, M., & Souček, P. (2022) · Biochimie · doi:10.1016/j.biochi.2022.04.015 · Cited by 10 · see citing works
Argerich, J., Muñoz-Reyes, D., Val-García, I. D., & García‐Nafría, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110571 · Cited by 9 · see citing works
Transcriptome analysis of rheumatoid arthritis uncovers genes linked to inflammation-induced pain
Hall, B. E., Mazhar, K., Macdonald, E., Cassidy, M. M., Doty, M. E., Judkins, C., Terse, A., Shiers, S. I., Tadros, S., Yun, S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-77212-0 · Cited by 8 · see citing works
A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis
Koukoulitsa, C., Chontzopoulou, E., Kiriakidi, S., Tzakos, A. G., & Mavromoustakos, T. (2020) · Brain Sciences · doi:10.3390/brainsci10060356 · Cited by 8 · see citing works
Maleki, N., Kalkhorann, M. R., Aleagha, M. S. E., Emami, A., & Allameh, A. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04428-w · Cited by 7 · see citing works
Daniele, S., Saporiti, S., Capaldi, S., Pietrobono, D., Russo, L., Guerrini, U., Laurenzi, T., Kachoie, E. A., Palazzolo, L., Russo, V. E. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010261 · Cited by 4 · see citing works
Pietrantonio, F., SERREQI, A. N., Zerbe, H., Svenningsson, P., & Aigner, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1450493 · Cited by 4 · see citing works
Pires, G. N., Laurindo, R. P., Heringer, L. D. S., da Silva, S. C., Portela, D. M., Cardoso, R., de Pádua, A. C., Sá, A. C. D. S. G., Cruz, S. A. A. D., Araújo, S. E. S., et al. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.01.004 · Cited by 4 · see citing works
Zheng, S., & Zhao, J. (2020) · PubMed Central · doi:10.3785/j.issn.1008-9292.2020.08.12 · Cited by 3 · see citing works
Integrating Deep Learning and Molecular Dynamics to Identify GPR17 Ligands for Glioblastoma Therapy
Ramalakshmi, S., Priya, S. S., Senthil, R., Anand, T., & Saravanan, K. M. (2024) · Current Chemical Biology · doi:10.2174/0122127968351148241129071716 · Cited by 2 · see citing works
GPR17 in Glioblastoma: Structure, Ligand Interactions, and Therapeutic Targeting
Ramalakshmi, S., Chaitanya, S. S., Kumar, I. S., Ramesh, T., Sureka, C., Abass, K. S., Saravanan, K. M., Anand, T., & Kandhavelu, M. (2025) · ACS Omega · doi:10.1021/acsomega.5c04079 · Cited by 2 · see citing works
Nie, R., Zhou, X., Fu, J., Hu, S., Zhang, Q., Jiang, W., Yan, Y., Cao, X., Yuan, D., Long, Y., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.08.005 · Cited by 1 · see citing works
Adeoye, B. O., Akano, O. P., Awojebe, D. R., Ogunbiyi, B. T., Adeoye, A. D., Ukangwa, N. A., Elizabeth, O. A., Olosunde, O. A., & Oyebanji, A. H. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10184-9 · Cited by 1 · see citing works
Xie, W., Chen, C., Lin, Q., & Li, H. (2021) · Research Square · doi:10.21203/rs.3.rs-428432/v1
Safronova, N. A., Luginina, A. P., Sadova, A. A., Shevtsov, M. B., Moiseeva, O. V., Borshchevskiy, V. I., & Mishin, A. (2025) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s106816202501025x
Puorro-Radzwill, K., Pang, P. T., Giera, S., Sheng, G., Farley, J. E., Garron, C., Danthi, S. J., Gans, J., Kumar, D., Agrawal, R. G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.08.659146
Imaging progenitor cell differentiation during CNS remyelination using an MRI gene reporter
Brechbühl, E. E. S., Hill, M. F. E., Chen, C. Z.-Y., Gaitsch, H., R�os, S., Porcu, L., Wright, A. J., Reich, D. S., Franklin, R. J. M., & Brindle, K. M. (2026) · Brain · doi:10.1093/brain/awag127
Babaie, N. A., Farnia, M., & Ghasemi, J. B. (2026) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2026.2678411
Structure-Guided Prioritization and Synthesis of New Ligands for GPR17 Receptor
Rabuffetti, M., Rinaldi, F., Palazzolo, L., Bianchi, D., Trincavelli, M. L., Balloni, I., Daniele, S., Capaldi, S., Speranza, G., Eberini, I., et al. (2026) · ACS Omega · doi:10.1021/acsomega.6c00828
Liu, G. Q., Wei, M., Zhang, Y., Lü, Z., & Zhang, M. (2026) · World Journal of Surgical Oncology · doi:10.1186/s12957-026-04418-z
Herdt, D. D., Lefevere, E., Brouwers, V., Hartvig, L., Geeraerts, E., Hsiao, C., Chen, J. Q. A., Pinto, R., Duvey, G., Burbidge, S., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0354525
Zhou, C., Zhu, C., Wang, X., Yang, Y., & Wei, J. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179275
- Authors
- Dziedzic, A., Miller, E., Saluk-Bijak, J., & Bijak, M.
- Affiliations
- University of Łódź (PL)
- Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, Poland
- Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
- Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-03-08
- Volume
- 21
- Issue
- 5
- Pages
- 1852
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7084627
- OpenAlex
- W3010042062
- Cited by
- 38
- References
- 120
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Lodz (506/1136)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- GPR17, multiple sclerosis, demyelination, remyelination, oligodendrocyte differentiation, G protein-coupled receptors, neurodegeneration, demyelinating plaques, neuroinflammation, therapeutic target
- MeSH terms
- Remyelination, Animals, Humans, Multiple Sclerosis, Biomarkers, Neurodegenerative Diseases, Receptors, G-Protein-Coupled
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
