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Cited by 159Visual perception and processing mechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation

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McCurry, Cortina L, Shepherd, Jason D, Tropea, Daniela, Wang, Kuan H, Bear, Mark F, Sur, Mriganka·2010·Nature Neuroscience
DOI 10.1038/nn.2508PMC PMC2864583
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Abstract

A myriad of mechanisms have been suggested to account for the full richness of visual cortical plasticity. We found that visual cortex lacking Arc is impervious to the effects of deprivation or experience. Using intrinsic signal imaging and chronic visually evoked potential recordings, we found that Arc(-/-) mice did not exhibit depression of deprived-eye responses or a shift in ocular dominance after brief monocular deprivation. Extended deprivation also failed to elicit a shift in ocular dominance or open-eye potentiation. Moreover, Arc(-/-) mice lacked stimulus-selective response potentiation. Although Arc(-/-) mice exhibited normal visual acuity, baseline ocular dominance was abnormal and resembled that observed after dark-rearing. These data suggest that Arc is required for the experience-dependent processes that normally establish and modify synaptic connections in visual cortex.

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  1. [1]Tropea D Van Wart A Sur M Molecular mechanisms of experience-dependent plasticity in visual cortex Phil. Trans. R. Soc 2009 364 341 355 PMC2674480 18977729
  2. [2]Gordon JA Stryker MP Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse J Neurosci 1996 16 3274 3286 8627365 PMC6579137
  3. [3]Mrsic-Flogel TD Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity Neuron 2007 54 961 972 17582335
  4. [4]Kaneko M Stellwagen D Malenka M Stryker MP Reduced response to monocular deprivation in TNF-alpha knockout mouse suggests that homeostatic synaptic scaling contributes to rapidly activity-dependent plasticity in developing visual cortex Neuron 2006 58 673 680 18549780 PMC2884387
  5. [5]Frenkel MY Bear MF How monocular deprivation shifts ocular dominance in visual cortex of young mice Neuron 2004 44 917 923 15603735
  6. [7]Hensch TK Local GABA circuit control of experience-dependent plasticity in developing visual cortex Science 1998 282 1504 1508 9822384 PMC2851625
  7. [8]Taha S Hanover JL Silva AJ Stryker MP Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity Neuron 2002 36 483 491 12408850
  8. [9]Heynen AJ Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation Nat Neurosci 2003 6 854 862 12886226
  9. [10]Allen CB Celikel T Feldman DE Long-term depression induced by sensory deprivation during cortical map plasticity in vivo Nat Neurosci 2003 6 291 299 12577061
  10. [11]Crozier RA Wang Y Liu CH Bear MF Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex Proc Natl Acad Sci USA 2007 104 1383 1388 17227847 PMC1783104
  11. [12]Shepherd JD Huganir RL The cell biology of synaptic plasticity: AMPA receptor trafficking Annual Review of Cell and Developmental Biology 2007 23 613 643 17506699
  12. [13]Yoon BJ Smith GB Heynen AJ Neve RL Bear MF Essential role for a long-term depression mechanism in ocular dominance plasticity Proc Natl Acad Sci U S A 2009 106 9860 9865 19470483 PMC2685742
  13. [14]Goel A Lee HK Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex J Neurosci 2007 27 6692 6700 17581956 PMC2601561
  14. [15]Desai NS Cudmore RH Nelson SB Turrigiano GG Critical periods for experience-dependent synaptic scaling in visual cortex Nat Neurosci 2002 5 783 789 12080341
  15. [16]Frenkel MY Instructive effect of visual experience in mouse visual cortex Neuron 2006 51 339 349 16880128
  16. [17]Plath N Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories Neuron 2006 52 437 444 17088210
  17. [18]Messaoudi E Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo J. Neurosci 2007 27 10445 10455 17898216 PMC6673172
  18. [19]Guzowski JF Inhibition of activity-dependent Arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory J. Neurosci 2000 20 3993 4001 10818134 PMC6772617
  19. [20]Park S Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD Neuron 2008 59 70 83 18614030 PMC2743934
  20. [22]Shepherd JD Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors Neuron 2006 52 475 484 17088213 PMC1764219
  21. [23]Rial Verde EM Lee-Osbourne J Worley PF Malinow R Cline HT Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission Neuron 2006 52 461 474 17088212 PMC3951199
  22. [24]Lyford GL Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites Neuron 1995 14 433 445 7857651
  23. [25]Steward O Worley PF Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation Cell 2001 30 227 240 11343657
  24. [26]Dolen G Correction of fragile X syndrome in mice Neuron 2007 56 955 962 18093519 PMC2199268
  25. [27]Sawtell NB NMDA receptor-dependent ocular dominance plasticity in adult visual cortex Neuron 2003 38 977 985 12818182
  26. [28]Daw NW Reid SN Beaver CJ Development and function of metabotropic glutamate receptors in cat visual cortex J Neurobiol 1999 41 102 107 10504197
  27. [29]Tagawa Y Kanold PO Majdan M Shatz CJ Multiple periods of functional ocular dominance plasticity in mouse visual cortex Nat Neurosci 2005 8 380 388 15723060
  28. [30]Wang KH In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex Cell 2006 126 389 402 16873068
  29. [31]Vazdarjanova A Spatial exploration induces Arc, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain The Journal of Comparative Neurology 2006 498 317 329 16871537
  30. [32]Kalatsky VA Stryker MP New paradigm for optical imaging: temporally encoded maps of intrinsic signal Neuron 2003 38 529 545 12765606
  31. [34]Porciatti V Pizzorusso T Maffei L The visual physiology of the wild type mouse determined with pattern VEPs Vision Res 1999 39 3071 3081 10664805
  32. [35]Cang J Kalatsky VA Ouml Wel S Stryker MP Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse Visual Neuroscience 2005 22 685 691 16332279 PMC2553096
  33. [36]Chowdhury S Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking Neuron 2006 52 445 459 17088211 PMC1784006
  34. [37]Kim TJ Ye EA Jeon CJ Distribution of AMPA glutamate receptor GluR1 subunitimmunoreactive neurons and their co-localization with calcium-binding proteins and GABA in the mouse visual cortex Mol Cells 2006 21 34 41 16511345
  35. [38]Lu W Constantine-Paton M Eye opening rapidly induces synaptic potentiation and refinement Neuron 2004 43 237 249 15260959
  36. [39]Pfeiffenberger C Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping Nat Neurosci 2005 8 1022 1027 16025107 PMC1352169
  37. [40]Smith SL Trachtenberg JT Experience-dependent binocular competition in the visual cortex begins at eye opening Nat Neurosci 2007 10 370 375 17293862
  38. [41]Gianfranceschi L Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF Proc Natl Acad Sci U S A 2003 100 12486 12491 14514885 PMC218784
  39. [42]Rittenhouse CD Stimulus for rapid ocular dominance plasticity in visual cortex J Neurophysiol 2006 95 2947 2950 16481452
  40. [43]Roberts EB Meredith MA Ramoa AS Suppression of NMDA receptor function using antisense DNA blocks ocular dominance plasticity while preserving visual responses J Neurophysiol 1998 80 1021 1032 9744918
  41. [44]Di Cristo G Requirement of ERK activation for visual cortical plasticity Science 2001 292 2337 2340 11423664
  42. [45]Cho K Khibnik L Philpot BD The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex Proc Natl Acad Sci USA 2009 106 5377 5382 19276107 PMC2654025
  43. [46]Waltereit R Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation J. Neurosci 2001 21 5484 5493 11466419 PMC6762636
  44. [47]Sato M Stryker MP Distinctive features of adult ocular dominance plasticity J. Neurosci 2008 28 10278 10286 18842887 PMC2851628
  45. [48]Fagiolini M Pizzorusso T Berardi N Domenici L Maffei L Functional postnatal development of the rat primary visual cortex and the role of visual experience: dark rearing and monocular deprivation Vision Res 1994 34 709 720 8160387
  46. [49]Coleman JE Law K Bear MF Anatomical origins of ocular dominance in mouse primary visual cortex Neuroscience 2009 161 561 571 19327388 PMC2735235
  47. [50]Cynader M Prolonged sensitivity to monocular deprivation in dark-reared cats Journal of Neurophysiology 1980 43 1026 1040 7359175

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Authors
McCurry, C. L., Shepherd, J. D., Tropea, D., Wang, K. H., Bear, M. F., & Sur, M.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Howard Hughes Medical Institute (US)
  • National Institute of Mental Health (US)
Corresponding author
  • Bear, Mark F
  • Sur, Mriganka
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2010-03-14
Volume
13
Issue
4
Pages
450-457
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.2508
PMC
PMC2864583
OpenAlex
W1570674668
Cited by
159
References
3
Citations by year
2026: 1 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 11 · 2017: 20 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 12 · 2012: 24
FWCI
11.64
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
  • PubMed Central
Funders
  • Howard Hughes Medical Institute
  • National Eye Institute (R01EY018648, R01EY017098, F32EY017240)
  • National Institute of General Medical Sciences (T32GM007484)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
Arc gene, immediate early genes, visual cortex, experience-dependent plasticity, monocular deprivation, ocular dominance, dark rearing, synaptic plasticity
MeSH terms
Animals, Cytoskeletal Proteins, Darkness, Mice, Inbred C57BL, Nerve Tissue Proteins, Synaptic Transmission, Photic Stimulation, Sensory Deprivation, Visual Cortex, Visual Perception, Mice, Knockout, Mice

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