Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?
Open accessAbstract
Experience shapes and molds the brain throughout life.These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor (AMPAR), is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity.These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In animals, sleep-dependent plastic changes critically depend on glutamatergic and LTP-related mechanisms.
“In animals, sleep-dependent plastic changes were also revealed to critically depend on glutamatergic and LTP-related mechanisms (411, 1066).”
From About Sleep's Role in Memory (2013) · cites this paper as [1066]
The section “CP-AMPARs Are Modulated by Sleep/Wake Cycles” (page unavailable) reports sleep–wake changes in AMPA receptors and synaptic strength in rodents, and describes LTP-like potentiation during wakefulness and LTD-like depression during sleep. But it presents the LTP/LTD account as a theory and says the significance of CP-AMPAR changes is unclear; it does not establish that sleep-dependent plasticity critically depends on those mechanisms. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,011 · see citing works
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Metaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,783 · see citing works
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · see citing works
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106 · see citing works
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105 · see citing works
Burnashev, N., Monyer, H., Seeburg, P. H., & Sakmann, B. (1992) · Neuron · doi:10.1016/0896-6273(92)90120-3 · Cited by 1,087 · see citing works
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works
Self-citationExtinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories
Monfils, M.-H., Cowansage, K. K., Klann, E., & LeDoux, J. E. (2009) · Science · doi:10.1126/science.1167975 · Cited by 960 · see citing works
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837 · see citing works
The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802 · see citing works
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790 · see citing works
Fear conditioning induces a lasting potentiation of synaptic currents in vitro
McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771 · see citing works
Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing
Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J. R. P., Kuner, T., Monyer, H., Higuchi, M., Bach, A., & Seeburg, P. H. (1994) · Science · doi:10.1126/science.7992055 · Cited by 746 · see citing works
Synaptic mechanisms for plasticity in neocortex
Feldman, D. E. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135516 · Cited by 704 · see citing works
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688 · see citing works
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement
Turrigiano, G. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153238 · Cited by 671 · see citing works
Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.027 · Cited by 660 · see citing works
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633 · see citing works
Map Plasticity in Somatosensory Cortex
Feldman, D. E., & Brecht, M. (2005) · Science · doi:10.1126/science.1115807 · Cited by 587 · see citing works
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death
Liu, S. J., & Zukin, R. S. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.006 · Cited by 530 · see citing works
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
Ju, W. H., Morishita, W., Tsui, J., Gaietta, G. M., Deerinck, T. J., Adams, S., Garner, C. C., Tsien, R. Y., Ellisman, M. H., & Malenka, R. C. (2004) · Nature Neuroscience · doi:10.1038/nn1189 · Cited by 524 · see citing works
Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure
Clem, R. L., & Huganir, R. L. (2010) · Science · doi:10.1126/science.1195298 · Cited by 496 · see citing works
Molecular mechanisms underlying emotional learning and memory in the lateral amygdala
Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.014 · Cited by 491 · see citing works
Neuronal circuits of fear extinction
Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484 · see citing works
Adaptation to Synaptic Inactivity in Hippocampal Neurons
Thiagarajan, T. C., Lindskog, M., & Tsien, R. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.037 · Cited by 482 · see citing works
Bellone, C., & Lüscher, C. (2006) · Nature Neuroscience · doi:10.1038/nn1682 · Cited by 429 · see citing works
Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour
Pascoli, V., Turiault, M., & Lüscher, C. (2011) · Nature · doi:10.1038/nature10709 · Cited by 419 · see citing works
Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
Aoto, J., Nam, C. I., Poon, M. M., Ting, P., & Chen, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.012 · Cited by 397 · see citing works
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
Mameli, M., Halbout, B., Creton, C., Engblom, D., Parkitna, J. M. R., Spanagel, R., & Lüscher, C. (2009) · Nature Neuroscience · doi:10.1038/nn.2367 · Cited by 340 · see citing works
Postsynaptic expression of homeostatic plasticity at neocortical synapses
Wierenga, C. J., Ibata, K., & Turrigiano, G. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5217-04.2005 · Cited by 306 · see citing works
Rapid Synthesis and Synaptic Insertion of GluR2 for mGluR-LTD in the Ventral Tegmental Area
Mameli, M., Balland, B., Luján, R., & Lüscher, C. (2007) · Science · doi:10.1126/science.1142365 · Cited by 265 · see citing works
Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit
Lamsa, K. P., Heeroma, J. H., Somogyi, P., Rusakov, D. A., & Kullmann, D. M. (2007) · Science · doi:10.1126/science.1137450 · Cited by 261 · see citing works
Liu, Z.-W., Faraguna, U., Cirelli, C., Tononi, G., & Gao, X.-B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1409-10.2010 · Cited by 248 · see citing works
Synaptic scaling requires the GluR2 subunit of the AMPA receptor
Gainey, M. A., Hurvitz-Wolff, J. R., Lambo, M. E., & Turrigiano, G. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3753-08.2009 · Cited by 234 · see citing works
Donevan, S. D., & Rogawski, M. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9298 · Cited by 230 · see citing works
Pathway-Specific Trafficking of Native AMPARs by In Vivo Experience
Clem, R. L., & Barth, A. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.019 · Cited by 217 · see citing works
Calcium Microdomains in Aspiny Dendrites
Goldberg, J. H., Tamas, G., Aronov, D., & Yuste, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00714-1 · Cited by 212 · see citing works
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses
Hou, Q., Zhang, D., Jarzylo, L., Huganir, R. L., & Man, H.-Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706447105 · Cited by 179 · see citing works
Arc-dependent synapse-specific homeostatic plasticity
Béïque, J.-C., Na, Y., Kuhl, D., Worley, P. F., & Huganir, R. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017914108 · Cited by 179 · see citing works
Mameli, M., Bellone, C., Brown, M. T. C., & Lüscher, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2763 · Cited by 177 · see citing works
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
McCurry, C. L., Shepherd, J. D., Tropea, D., Wang, K. H., Bear, M. F., & Sur, M. (2010) · Nature Neuroscience · doi:10.1038/nn.2508 · Cited by 159 · see citing works
Self-citationPTP and LTP at a hippocampal mossy fiber-interneuron synapse
Alle, H., Jonas, P., & Geiger, J. R. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251610898 · Cited by 158 · see citing works
McCutcheon, J. E., Loweth, J. A., Ford, K. A., Marinelli, M., Wolf, M. E., & Tseng, K. Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3625-11.2011 · Cited by 136 · see citing works
Kielland, A., Bochorishvili, G., Corson, J. A., Zhang, L., Rosin, D. L., Heggelund, P., & Zhu, J. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.001 · Cited by 68 · see citing works
Input-Specific Critical Periods for Experience-Dependent Plasticity in Layer 2/3 Pyramidal Neurons
Wen, J. A., & Barth, A. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6042-10.2011 · Cited by 64 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- Bellone C. Luscher C. (2005). mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors. Eur. J. Neurosci. 21 1280– 1288 15813937
- Gao M. Sossa K. Song L. Errington L. Cummings L. Hwang H. Kuhl D. Worley P. Lee H. K. (2010). A specific requirement of Arc/Arg3.1 for visual experience-induced home-ostatic synaptic plasticity in mouse primary visual cortex. J. Neurosci. 30 7168– 7178 20505084 PMC2881313
- Lante F. Toledo-Salas J. C. Ondrej-cak T. Rowan M. J. Ulrich D. (2011). Removal of synaptic Ca2+-permeable AMPA receptors during sleep. J. Neurosci. 31 3953– 3961 21411638 PMC6623525
- Man H. Y. (2011). GluA2-lacking, calcium-permeable AMPA receptors – inducers of plasticity? Curr. Opin. Neurobiol. 21 291– 298 21295464 PMC3092818
- Shepherd J. D. Rumbaugh G. Wu J. Chowdhury S. Plath N. Kuhl D. Huganir R. L. Worley P. F. (2006). Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron 52 475– 484 17088213 PMC1764219
- Stellwagen D. Malenka R. C. (2006). Synaptic scaling mediated by glial TNF-alpha. Nature 440 1054– 1059 16547515
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
AMPA receptors as a molecular target in epilepsy therapy
Rogawski, M. A. (2013) · Acta Neurologica Scandinavica · doi:10.1111/ane.12099 · Cited by 232 · see citing works
The neural rejuvenation hypothesis of cocaine addiction
Dong, Y., & Nestler, E. J. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.05.005 · Cited by 163 · see citing works
Whitehead, G., Jo, J., Hogg, E. L., Piers, T. M., Kim, D.-H., Seaton, G., Seok, H., Bru‐Mercier, G., Son, G. H., Regan, P. L., et al. (2013) · Brain · doi:10.1093/brain/awt293 · Cited by 106 · see citing works
Plasticity during sleep is linked to specific regulation of cortical circuit activity
Niethard, N., Burgalossi, A., & Born, J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00065 · Cited by 89 · see citing works
Shindou, T., Shindou, M., Watanabe, S., & Wickens, J. R. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13921 · Cited by 92 · see citing works
Mignogna, M. L., Giannandrea, M., Gurgone, A., Fanelli, F., Raimondi, F., Mapelli, L., Bassani, S., Fang, H., van Anken, E., Alessio, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7504 · Cited by 89 · see citing works
Hardt, O. M., Nader, K., & Wang, Y.-T. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0141 · Cited by 82 · see citing works
Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD
Starr, A., & Sattler, R. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.011 · Cited by 78 · see citing works
Hanley, J. G. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.12.002 · Cited by 66 · see citing works
Impaired fear extinction in adolescent rodents: Behavioural and neural analyses
Baker, K., Bisby, M. A., & Richardson, R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.019 · Cited by 54 · see citing works
GluA1-homomeric AMPA receptor in synaptic plasticity and neurological diseases
Ge, Y., & Wang, Y. T. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108708 · Cited by 49 · see citing works
Ménard, C., Quirion, R., Vigneault, É., Bouchard, S., Ferland, G., Mestikawy, S. E., & Gaudreau, P. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.11.013 · Cited by 41 · see citing works
Kandel, M. B., Yamamoto, S., Midorikawa, R., Morise, J., Wakazono, Y., Oka, S., & Takamiya, K. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14565 · Cited by 39 · see citing works
Wang, T., Zhu, H., Hou, Y., Gu, W., Wu, H., Luan, Y., Xiao, C., & Zhou, C. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.12.034 · Cited by 40 · see citing works
García-Pardo, M. P., Roger-Sánchez, C., Rodríguez‐Arias, M., Miñarro, J., & Aguilar, M. A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.065 · Cited by 39 · see citing works
Yuan, T., & Bellone, C. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.056 · Cited by 38 · see citing works
Morita, D., Rah, J., & Isaac, J. T. R. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0156 · Cited by 36 · see citing works
Blanco‐Suárez, E., & Hanley, J. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.533182 · Cited by 36 · see citing works
Yu, X., Zhang, F., & Shi, J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.014 · Cited by 34 · see citing works
Jo, K., Suh, H. J., & Choi, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.115 · Cited by 33 · see citing works
Wenner, P. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.058 · Cited by 37 · see citing works
Role of calcium-permeable AMPA receptors in memory consolidation, retrieval and updating
Torquato, K. I., Menegolla, A. P., Popik, B., Casagrande, M. A., & Alvares, L. D. O. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.030 · Cited by 29 · see citing works
Garcia-Bereguiain, M. A., Gonzalez-Islas, C., Lindsly, C., Butler, E., Hill, A. W., & Wenner, P. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4025-12.2013 · Cited by 26 · see citing works
Yokoi, R., Okabe, M., Matsuda, N., Odawara, A., Karashima, A., & Suzuki, I. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00554 · Cited by 21 · see citing works
Pharmacological Treatment of Sleep Disorders and Its Relationship with Neuroplasticity
Abad, V. C., & Guilleminault, C. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_365 · Cited by 20 · see citing works
Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review)
TANG, X.-J., & Feng, X. (2013) · Biomedical Reports · doi:10.3892/br.2013.154 · Cited by 20 · see citing works
Involvement of Glutamate in Learning and Memory
Gasbarri, A., & Pompili, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408139-0.00004-3 · Cited by 20 · see citing works
Huang, J.-Y., & Lu, H. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx105 · Cited by 15 · see citing works
Adult neuroplasticity employs developmental mechanisms
Mowery, T. M., & Garraghty, P. E. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.1086680 · Cited by 14 · see citing works
Peng, X., de Vaca, S. C., Ziff, E. B., & Carr, K. D. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3476-7 · Cited by 13 · see citing works
Guo, Z. Y., Li, C. Z., Li, X. J., Wang, Y. L., Mattson, M. P., & Lu, C. B. (2013) · Neuroreport · doi:10.1097/wnr.0b013e32836206b5 · Cited by 12 · see citing works
Zelena, D., Mikics, É., Balázsfi, D., Varga, J. M., Klausz, B., Urbán, E., Sipos, E., Bíró, L., Miskolczi, C., Kovács, K., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4255-4 · Cited by 10 · see citing works
Palumbo, R., Omodei, D., Vicidomini, C., & Roviello, G. N. (2022) · Pharmaceuticals · doi:10.3390/ph15101243 · Cited by 8 · see citing works
Molecular Mechanisms of Emerging Therapeutic Targets in Alzheimer’s Disease: A Systematic Review
Premkumar, T., & Sajitha Lulu, S. (2022) · Neurochemical Journal · doi:10.1134/s1819712422040183 · Cited by 8 · see citing works
ADAR2-mediated Q/R editing of GluA2 in homeostatic synaptic plasticity
Peterson, L. P., Coca, R., Parikh, S., McCarthy, K., & Man, H. (2025) · Science Signaling · doi:10.1126/scisignal.adr1442 · Cited by 6 · see citing works
The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway
Han, J., Wen, C., Sun, R. Q., Tang, M., Li, X., & Lian, H. (2022) · The FASEB Journal · doi:10.1096/fj.202101609rr · Cited by 6 · see citing works
Metabotropic glutamate receptor function and regulation of sleep-wake cycles
Holter, K. M., Pierce, B. E., & Gould, R. W. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2022.11.002 · Cited by 6 · see citing works
Calcium-permeable AMPA and kainate receptors of GABAergic neurons
Зинченко, В. П., Долгачева, Л. П., & Tuleukhanov, S. T. (2024) · Biophysical Reviews · doi:10.1007/s12551-024-01184-8 · Cited by 6 · see citing works
Wang, Y., Zheng, X., Li, K., Gao, J., Huang, J., & Lou, Z. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106550 · Cited by 4 · see citing works
Kiknadze, N., Narmania, N., Sepashvili, M., Barbakadze, T., Zhuravliova, E., Shetekauri, T., Tkemaladze, N., Oniani, N., & Mikeladze, D. (2025) · NeuroSci · doi:10.3390/neurosci6030061 · Cited by 2 · see citing works
Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?Preprint
Amorim, F. E., Chapot, R. L., Moulin, T. C., Lee, J. L. C., & Amaral, O. B. (2021) · Learning & Memory · doi:10.1101/lm.053418.121 · Cited by 2 · see citing works
Systemic Injections of Primidone Cause Wake-Inducing Effects in Rats
Salas-Crisóstomo, M., Franco-Tormo, M. J., Trujillo-Paredes, N., Arankowsky‐Sandoval, G., Arias-Carrión, Ó., Machado, S. E. D. C., & Murillo‐Rodríguez, E. (2018) · Current Psychopharmacologye · doi:10.2174/2211556007666180425143506 · Cited by 1 · see citing works
Формы и механизмы гомеостатической синаптической пластичности
Novgorod, N., & Russian Federation (2013)
forMs anD MechanisMs of hoMeostatic synaptic plasticity
Novgorod, N., & Russian Federation (2013)
Influence of Adenosine on Synaptic Excitability
Boison, D., Dias, R. B., Plumb, T. N., Cristóvão‐Ferreira, S., & Sebastião, A. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803724-9.00003-x
Open Practices DisclosurePreprint
Chatard, A. (2017) · OSF Preprints (OSF Preprints)
Hartnell, I. J. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Lai, P.-H., Hung, W., Min, M., & Yang, H. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70667
- Authors
- Shepherd, J. D.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Shepherd, Jason D.
- ORCID
- Shepherd, Jason D.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 5
- Pages
- 49-49
- ISSN
- 1662-5099 (ISSN-L)
- PMC
- PMC3324118
- OpenAlex
- W1504963153
- Cited by
- 49
- References
- 48
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 13
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Frontiers in Molecular Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Frontiers Research Foundation
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (K99NS076364)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- calcium-permeable AMPA receptors, GluR2 subunit, AMPA receptors, synaptic plasticity, metaplasticity, experience-dependent plasticity, sleep, memory, drug addiction, memory disorders, synaptic transmission
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review