Cited by 49Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?

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Shepherd, Jason D.·2012·Frontiers in Molecular Neuroscience

Abstract

Experience shapes and molds the brain throughout life.These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor (AMPAR), is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity.These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target.

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Crossref · 10.3389/fnmol.2012.00049

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  • In animals, sleep-dependent plastic changes critically depend on glutamatergic and LTP-related mechanisms.

    “In animals, sleep-dependent plastic changes were also revealed to critically depend on glutamatergic and LTP-related mechanisms (411, 1066).”

    From About Sleep's Role in Memory (2013) · cites this paper as [1066]

    The section “CP-AMPARs Are Modulated by Sleep/Wake Cycles” (page unavailable) reports sleep–wake changes in AMPA receptors and synaptic strength in rodents, and describes LTP-like potentiation during wakefulness and LTD-like depression during sleep. But it presents the LTP/LTD account as a theory and says the significance of CP-AMPAR changes is unclear; it does not establish that sleep-dependent plasticity critically depends on those mechanisms. (LLM, conf=0.85)

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Research works printed but not linked: 6

  1. Bellone C. Luscher C. (2005). mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors. Eur. J. Neurosci. 21 1280– 1288 15813937
  2. Gao M. Sossa K. Song L. Errington L. Cummings L. Hwang H. Kuhl D. Worley P. Lee H. K. (2010). A specific requirement of Arc/Arg3.1 for visual experience-induced home-ostatic synaptic plasticity in mouse primary visual cortex. J. Neurosci. 30 7168– 7178 20505084 PMC2881313
  3. Lante F. Toledo-Salas J. C. Ondrej-cak T. Rowan M. J. Ulrich D. (2011). Removal of synaptic Ca2+-permeable AMPA receptors during sleep. J. Neurosci. 31 3953– 3961 21411638 PMC6623525
  4. Man H. Y. (2011). GluA2-lacking, calcium-permeable AMPA receptors – inducers of plasticity? Curr. Opin. Neurobiol. 21 291– 298 21295464 PMC3092818
  5. Shepherd J. D. Rumbaugh G. Wu J. Chowdhury S. Plath N. Kuhl D. Huganir R. L. Worley P. F. (2006). Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron 52 475– 484 17088213 PMC1764219
  6. Stellwagen D. Malenka R. C. (2006). Synaptic scaling mediated by glial TNF-alpha. Nature 440 1054– 1059 16547515

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Authors
Shepherd, J. D.
Affiliations
Massachusetts Institute of Technology (US)
Corresponding author
Shepherd, Jason D.
Venue
Frontiers in Molecular Neuroscience
Published
2012
Volume
5
Pages
49-49
ISSN
1662-5099 (ISSN-L)
OpenAlex
W1504963153
Cited by
49
References
48
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 13
FWCI
2.64
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Frontiers in Molecular Neuroscience (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Frontiers Research Foundation
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (K99NS076364)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
calcium-permeable AMPA receptors, GluR2 subunit, AMPA receptors, synaptic plasticity, metaplasticity, experience-dependent plasticity, sleep, memory, drug addiction, memory disorders, synaptic transmission

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