The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination
Open accessAbstract
The mechanisms that regulate the developmental potential of adult neural progenitor populations under physiological and pathological conditions remain poorly defined. Glutamic acid decarboxylase 65 (GAD65)- and Doublecortin (Dcx)-expressing cells constitute major progenitor populations in the adult mouse subventricular zone (SVZ). Under normal physiological conditions, SVZ-derived GAD65-positive and Dcx-positive cells expressed the transcription factor Pax6 and migrated along the rostral migratory stream to the olfactory bulb to generate interneurons. After lysolecithin-induced demyelination of corpus callosum, however, these cells altered their molecular and cellular properties and migratory path. Demyelination upregulated chordin in the SVZ, which redirected GAD65-positive and Dcx-positive progenitors from neuronal to glial fates, generating new oligodendrocytes in the corpus callosum. Our findings suggest that the lineage plasticity of SVZ progenitor cells could be a potential therapeutic strategy for diseased or injured brain.
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Cites
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Nait‐Oumesmar, B., Decker, L., Lachapelle, F., Avellana‐Adalid, V., Bachelin, C., & Van Evercooren, A. B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00873.x · Cited by 560
Ara, J., See, J., Mamontov, P., Hahn, A., Bannerman, P., Pleasure, D., & Grinspan, J. B. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21462 · Cited by 79
Cited by
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Self-citationA neurocentric perspective on glioma invasion
Cuddapah, V. A., Robel, S., Watkins, S., & Sontheimer, H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3765 · Cited by 831
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
Self-citationOligodendrocyte Development and Plasticity
Bergles, D. E., & Richardson, W. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 585
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Monzel, A. S., Smits, L. M., Hemmer, K., Hachi, S., Moreno, E. L., van Wuellen, T., Jarazo, J., Walter, J., Brüggemann, I., Boussaad, I., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.010 · Cited by 435
Metadata
- Authors
- Jablonska, B., Aguirre, A., Raymond, M., Szabo, G., Kitabatake, Y., Sailor, K. A., Ming, G.-L., Song, H., & Gallo, V.
- Venue
- Nature Neuroscience
- Published
- 2010-04-25
- Volume
- 13
- Issue
- 5
- Pages
- 541-550
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1992187118
- Cited by
- 215
- References
- 3
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
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