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Cited by 560Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesMesenchymal stem cell research

Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination

Nait‐Oumesmar, Brahim, Decker, Laurence, Lachapelle, François, Avellana‐Adalid, Virginia, Bachelin, Corinne, Van Evercooren, Anne Baron‐.·1999·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.1999.00873.x
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Abstract

Identifying a source of cells with the capacity to generate oligodendrocytes in the adult CNS would help in the development of strategies to promote remyelination. In the present study, we examined the ability of the precursor cells of the adult mouse subventricular zone (SVZ) to differentiate into remyelinating oligodendrocytes. After lysolecithin-induced demyelination of the corpus callosum, progenitors of the rostral SVZ (SVZa) and the rostral migratory pathway (RMS), expressing the embryonic polysialylated form of the neural cell adhesion molecule (PSA-NCAM), increased progressively with a maximal expansion occurring after 2 weeks. This observation correlated with an increase in the proliferation activity of the neural progenitors located in the SVZa and RMS. Moreover, polysialic acid (PSA)-NCAM-immunoreactive cells arizing from the SVZa were detected in the lesioned corpus callosum and within the lesion. Tracing of the constitutively cycling cells of the adult SVZ and RMS with 3H-thymidine labelling showed their migration toward the lesion and their differentiation into oligodendrocytes and astrocytes but not neurons. These data indicate that, in addition to the resident population of quiescent oligodendrocyte progenitors of the adult CNS, neural precursors from the adult SVZ constitute a source of oligodendrocytes for myelin repair.

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Crossref · 10.1046/j.1460-9568.1999.00873.x

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  • Oligodendrocytes and astrocytes are also generated in the adult V-SVZ.

    “Although oligodendrocytes and astrocytes are also generated in the adult V-SVZ (Menn et al., 2006; Nait-Oumesmar et al., 1999; Ortega et al., 2013; Sohn et al., 2015; Xing et al., 2014), their lineage trajectories are less clear.”

    From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Nait-Oumesmar et al., 1999

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Authors
Nait‐Oumesmar, B., Decker, L., Lachapelle, F., Avellana‐Adalid, V., Bachelin, C., & Van Evercooren, A. B.
Affiliations
Inserm (FR)
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
1999-12
Volume
11
Issue
12
Pages
4357-4366
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.1999.00873.x
OpenAlex
W1760682360
Cited by
560
References
54
Citations by year
2026: 7 · 2025: 10 · 2024: 14 · 2023: 18 · 2022: 14 · 2021: 21 · 2020: 27 · 2019: 19 · 2018: 14 · 2017: 20 · 2016: 20 · 2015: 25 · 2014: 24 · 2013: 36 · 2012: 22
FWCI
3.44
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3220 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Institut National de la Santé et de la Recherche Médicale
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
subventricular zone, oligodendrocyte precursor cells, remyelination, demyelination, lysolecithin-induced demyelination, corpus callosum, rostral migratory stream, PSA-NCAM, neural progenitor proliferation, cell migration, oligodendrocyte differentiation, astrocytes, adult neurogenesis
MeSH terms
Animals, Astrocytes, Cell Count, Cell Differentiation, Cell Division, Cell Movement, Corpus Callosum, Demyelinating Diseases, Myelin Basic Protein, Glial Fibrillary Acidic Protein, Immunohistochemistry, Lysophosphatidylcholines, Mice, Inbred Strains, Myelin Sheath, Oligodendroglia, Sialic Acids, Stem Cells, Thymidine, Neural Cell Adhesion Molecules, Lateral Ventricles, Neural Cell Adhesion Molecule L1, Mice

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