Thalamic synchrony and the adaptive gating of information flow to cortex
Open accessAbstract
Although it has long been posited that sensory adaptation serves to enhance information flow in sensory pathways, the neural basis remains elusive. Simultaneous single-unit recordings in the thalamus and cortex in anesthetized rats showed that adaptation differentially influenced thalamus and cortex in a manner that fundamentally changed the nature of information conveyed about vibrissa motion. Using an ideal observer of cortical activity, we found that performance in detecting vibrissal deflections degraded with adaptation while performance in discriminating among vibrissal deflections of different velocities was enhanced, a trend not observed in thalamus. Analysis of simultaneously recorded thalamic neurons did reveal, however, an analogous adaptive change in thalamic synchrony that mirrored the cortical response. An integrate-and-fire model using experimentally measured thalamic input reproduced the observed transformations. The results here suggest a shift in coding strategy with adaptation that directly controls information relayed to cortex, which could have implications for encoding velocity signatures of textures.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adaptive modification of the window of opportunity has been suggested to be important for switching from detecting the presence of a sensory stimulus to discriminating between stimuli.
“Interestingly, this adaptive modification of the window of opportunity has been suggested to be an important component allowing the switching from detecting the presence of a sensory stimulus to discriminating between different stimuli (Wang et al., 2010)”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Wang et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564 · see citing works
Spiking Neuron Models: Single Neurons, Populations, Plasticity
Gerstner, W., & Kistler, W. M. (2002) · Cited by 2,038 · see citing works
The analysis of visual motion: a comparison of neuronal and psychophysical performance
Britten, K., Shadlen, M., Newsome, W., & Movshon, J. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04745.1992 · Cited by 1,958 · see citing works
Weak pairwise correlations imply strongly correlated network states in a neural population
Schneidman, E., Berry, M. J., Segev, R., & Bialek, W. (2006) · Nature · doi:10.1038/nature04701 · Cited by 1,701 · see citing works
Function of the thalamic reticular complex: the searchlight hypothesis
Crick, F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4586 · Cited by 1,651 · see citing works
Correlated neuronal discharge rate and its implications for psychophysical performance
Zohary, E., Shadlen, M. N., & Newsome, W. T. (1994) · Nature · doi:10.1038/370140a0 · Cited by 1,237 · see citing works
Biometric analyses of vibrissal tactile discrimination in the rat
Carvell, G. E., & Simons, D. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02638.1990 · Cited by 870 · see citing works
Efficiency and ambiguity in an adaptive neural code
Fairhall, A. L., Lewen, G. D., Bialek, W., & van Steveninck, R. R. D. R. (2001) · Nature · doi:10.1038/35090500 · Cited by 847 · see citing works
Gamma-band synchronization in visual cortex predicts speed of change detection
Womelsdorf, T., Fries, P., Mitra, P. P., & Desimone, R. (2005) · Nature · doi:10.1038/nature04258 · Cited by 741 · see citing works
Cortex is driven by weak but synchronously active thalamocortical synapses
Bruno, R. M., & Sakmann, B. (2006) · Science · doi:10.1126/science.1124593 · Cited by 714 · see citing works
Integrator or coincidence detector? The role of the cortical neuron revisited
Peter König, B., Engel, A. K., & Singer, W. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80019-1 · Cited by 674 · see citing works
Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
Gabernet, L., Jadhav, S. P., Feldman, D. E., Carandini, M., & Scanziani, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.022 · Cited by 599 · see citing works
Basal forebrain activation enhances cortical coding of natural scenes
Goard, M. J., & Dan, Y. (2009) · Nature Neuroscience · doi:10.1038/nn.2402 · Cited by 558 · see citing works
Chung, S., Li, X., & Nelson, S. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00659-1 · Cited by 530 · see citing works
The impact of 'bursting' thalamic impulses at a neocortical synapse
Swadlow, H. A., & Gusev, A. G. (2001) · Nature Neuroscience · doi:10.1038/86054 · Cited by 500 · see citing works
Temporal precision in the neural code and the timescales of natural vision
Butts, D. A., Weng, C., Jin, J., Yeh, C.-I., Lesica, N. A., Alonso, J., & Stanley, G. B. (2007) · Nature · doi:10.1038/nature06105 · Cited by 415 · see citing works
Self-citationTransformation from temporal to rate coding in a somatosensory thalamocortical pathway
Ahissar, E., Sosnik, R., & Haidarliu, S. (2000) · Nature · doi:10.1038/35018568 · Cited by 393 · see citing works
Berg, R. W., & Kleinfeld, D. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00600.2002 · Cited by 378 · see citing works
Feedforward Mechanisms of Excitatory and Inhibitory Cortical Receptive Fields
Bruno, R. M., & Simons, D. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10966.2002 · Cited by 354 · see citing works
Krupa, D., Matell, M. S., Brisben, A. J., Oliveira, L. M. O., & Nicolelis, M. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05752.2001 · Cited by 276 · see citing works
Balanced Excitation and Inhibition Determine Spike Timing during Frequency Adaptation
Higley, M. J., & Contreras, D. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3506-05.2006 · Cited by 270 · see citing works
Texture Coding in the Rat Whisker System: Slip-Stick Versus Differential Resonance
Wolfe, J., Hill, D. N., Pahlavan, S., Drew, P., Kleinfeld, D., & Feldman, D. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060215 · Cited by 247 · see citing works
Neural codes for perceptual discrimination in primary somatosensory cortex
Luna, R., Hernández, A., Brody, C. D., & Romo, R. (2005) · Nature Neuroscience · doi:10.1038/nn1513 · Cited by 246 · see citing works
Maravall, M., Petersen, R. S., Fairhall, A. L., Arabzadeh, E., & Diamond, M. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050019 · Cited by 242 · see citing works
Synaptic Interactions between Thalamic Inputs to Simple Cells in Cat Visual Cortex
Usrey, W. M., Alonso, J., & Reid, R. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05461.2000 · Cited by 239 · see citing works
Circuit dynamics and coding strategies in rodent somatosensory cortex
Pinto, D. J., Brumberg, J. C., & Simons, D. J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1158 · Cited by 239 · see citing works
Ritt, J., Andermann, M., & Moore, C. I. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.024 · Cited by 236 · see citing works
Encoding of Natural Scene Movies by Tonic and Burst Spikes in the Lateral Geniculate Nucleus
Lesica, N. A., & Stanley, G. B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3059-04.2004 · Cited by 226 · see citing works
Self-citationSparse temporal coding of elementary tactile features during active whisker sensation
Jadhav, S. P., Wolfe, J. H., & Feldman, D. E. (2009) · Nature Neuroscience · doi:10.1038/nn.2328 · Cited by 224 · see citing works
Neuronal Activity in Rat Barrel Cortex Underlying Texture Discrimination
von Heimendahl, M., Itskov, P., Arabzadeh, E., & Diamond, M. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050305 · Cited by 213 · see citing works
Correlated Neuronal Discharges that Increase Coding Efficiency during Perceptual Discrimination
Romo, R., Hernández, A., Zainos, A., & Salinas, E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00287-3 · Cited by 205 · see citing works
Arabzadeh, E., Panzeri, S., & Diamond, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1491-06.2006 · Cited by 187 · see citing works
Active Spatial Perception in the Vibrissa Scanning Sensorimotor System
Mehta, S., Whitmer, D., Figueroa, R., Williams, B. A., & Kleinfeld, D. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050015 · Cited by 182 · see citing works
Synchrony of Thalamocortical Inputs Maximizes Cortical Reliability
Wang, H.-P., Spencer, D., Fellous, J., & B, T. J. S. A. (2010) · Science · doi:10.1126/science.1183108 · Cited by 179 · see citing works
Dynamics of neuronal processing in rat somatosensory cortex
Moore, C. I., Nelson, S. B., & Sur, M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01452-6 · Cited by 156 · see citing works
Shift in the Balance between Excitation and Inhibition during Sensory Adaptation of S1 Neurons
Heiss, J. E., Katz, Y., Ganmor, E., & Lampl, I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2646-08.2008 · Cited by 137 · see citing works
Coincidence Detection or Temporal Integration? What the Neurons in Somatosensory Cortex Are Doing
Roy, S. A., & Alloway, K. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02462.2001 · Cited by 134 · see citing works
Psychophysical and neurometric detection performance under stimulus uncertainty
Stüttgen, M. C., & Schwarz, C. (2008) · Nature Neuroscience · doi:10.1038/nn.2162 · Cited by 132 · see citing works
Khatri, V., Hartings, J. A., & Simons, D. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00257.2004 · Cited by 124 · see citing works
Wilent, W. B., & Contreras, D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4906-04.2005 · Cited by 109 · see citing works
Role of Thalamocortical Sensory Suppression during Arousal: Focusing Sensory Inputs in Neocortex
Castro‐Alamancos, M. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09651.2002 · Cited by 89 · see citing works
Vibrotactile adaptation enhances amplitude discrimination
Goble, A. K., & Hollins, M. (1993) · The Journal of the Acoustical Society of America · doi:10.1121/1.405621 · Cited by 88 · see citing works
Rapid Changes in Thalamic Firing Synchrony During Repetitive Whisker Stimulation
Temereanca, S., Brown, E., & Simons, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1586-08.2008 · Cited by 80 · see citing works
Discrimination of vibrotactile stimuli in the rat whisker system: behavior and neurometrics.
Gerdjikov, T. V., Bergner, C. G., Stüttgen, M. C., Waiblinger, C., & Schwarz, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.007 · Cited by 79 · see citing works
Stability of Thalamocortical Synaptic Transmission across Awake Brain States
Stoelzel, C. R., Bereshpolova, Y., & Swadlow, H. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5983-08.2009 · Cited by 79 · see citing works
Vibrotactile adaptation enhances frequency discrimination
Goble, A. K., & Hollins, M. (1994) · The Journal of the Acoustical Society of America · doi:10.1121/1.410314 · Cited by 77 · see citing works
Human vibrotactile frequency discriminative capacity after adaptation to 25 Hz or 200 Hz stimulation
Tommerdahl, M., Hester, K. D., Felix, E. R., Hollins, M., Favorov, O. V., Quibrera, P. M., & Whitsel, B. L. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.031 · Cited by 72 · see citing works
Ganmor, E., Katz, Y., & Lampl, I. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.032 · Cited by 63 · see citing works
Timing Precision in Population Coding of Natural Scenes in the Early Visual System
Desbordes, G., Jin, J., Weng, C., Lesica, N. A., Stanley, G. B., & Alonso, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060324 · Cited by 58 · see citing works
Self-citationTannan, V., Simons, S. B., Dennis, R. G., & Tommerdahl, M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.024 · Cited by 57 · see citing works
Hartings, J. A., Temereanca, S., & Simons, D. J. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00469.2003 · Cited by 43 · see citing works
Khatri, V., Bruno, R. M., & Simons, D. J. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91151.2008 · Cited by 28 · see citing works
Angularly Nonspecific Response Suppression in Rat Barrel Cortex
Khatri, V., & Simons, D. J. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk006 · Cited by 25 · see citing works
Encoding and Decoding Cortical Representations of Tactile Features in the Vibrissa System
Boloori, A., Jenks, R. A., Desbordes, G., & Stanley, G. B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0807-10.2010 · Cited by 22 · see citing works
Self-citationSelf-motion and the shaping of sensory signals.
Jenks, R. A., Vaziri, A., Boloori, A., & Stanley, G. B. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00106.2009 · Cited by 19 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [7]Barlow H Possible principles underlying the transformation of sensory messages Sensory communication R WA 217 234 MIT Press Cambridge (Massachusetts) 1961
Cited by
Sorted by citations
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033 · see citing works
“Interestingly, this adaptive modification of the window of opportunity has been suggested to be an important component allowing the switching from detecting the presence of a sensory stimulus to discriminating between different stimuli (Wang et al., 2010).”
Less Is More: Expectation Sharpens Representations in the Primary Visual Cortex
Kok, P., Jehee, J. F. M., & de Lange, F. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.034 · Cited by 798 · see citing works
Feldmeyer, D., Brecht, M., Helmchen, F., Petersen, C. C. H., Poulet, J. F. A., Staiger, J. F., Luhmann, H. J., & Schwarz, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.11.002 · Cited by 354 · see citing works
“Together these strong inhibitory effects in L4 are thought to set a short window for synaptic integration by excitatory L4 cells (Brecht and Sakmann, 2002a; Pinto et al., 2003; Bruno and Sakmann, 2006; Wang et al., 2010).”
Relationship between intracortical electrode design and chronic recording function
Karumbaiah, L., Saxena, T., Carlson, D., Patil, K., Patkar, R., Gaupp, E. A., Betancur, M., Stanley, G. B., Carin, L., & Bellamkonda, R. V. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.016 · Cited by 241 · see citing works
Self-citationPsychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
Origins of choice-related activity in mouse somatosensory cortex
Yang, H., Kwon, S. E., Severson, K. S., & O'Connor, D. H. (2016) · Nature Neuroscience · doi:10.1038/nn.4183 · Cited by 180 · see citing works
“This transient difference was also apparent in a measure of thalamic synchrony 29,30 (Supplementary Fig.”
Soft and MRI Compatible Neural Electrodes from Carbon Nanotube Fibers
Lu, L., Fu, X., Liew, Y., Zhang, Y., Zhao, S., Xu, Z., Zhao, J., Li, D., Li, Q., Stanley, G. B., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b04456 · Cited by 146 · see citing works
Self-citationLow-noise encoding of active touch by layer 4 in the somatosensory cortex
Andrew Hires, S., Gutnisky, D. A., Yu, J., O'Connor, D. H., & Svoboda, K. (2015) · eLife · doi:10.7554/elife.06619 · Cited by 79 · see citing works
A computational model that predicts behavioral sensitivity to intracortical microstimulation
Kim, S., Callier, T., & Bensmaia, S. J. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/14/1/016012 · Cited by 21 · see citing works
Sensory adaptation in the barrel cortex during active sensation in the behaving mouse
Colins Rodriguez, A., Loft, M. S. E., Schiessl, I., Maravall, M., & Petersen, R. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-70524-1 · Cited by 6 · see citing works
- Authors
- Wang, Q., Webber, R. M., & Stanley, G. B.
- Affiliations
- Georgia Institute of Technology (US)
- Harvard University (US)
- Corresponding author
- Stanley, Garrett B
- ORCID
- Stanley, Garrett B
- Venue
- Nature Neuroscience
- Published
- 2010-11-21
- Volume
- 13
- Issue
- 12
- Pages
- 1534-1541
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3082843
- OpenAlex
- W2139778447
- Cited by
- 166
- References
- 55
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 13 · 2015: 18 · 2014: 16 · 2013: 18 · 2012: 15
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS048285, R01 NS48285)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- sensory adaptation, velocity discrimination, thalamic neurons, integrate-and-fire model, ideal observer analysis
- MeSH terms
- Action Potentials, Animals, Cerebral Cortex, Electric Stimulation, Female, Neural Pathways, Thalamus, Vibrissae, Rats, Sprague-Dawley, Rats, Sensory Gating
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
