The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Tuned thalamic excitation is amplified by visual cortical circuits
Open accessAbstract
Cortical neurons in thalamic recipient layers receive excitation from the thalamus and the cortex. The relative contribution of these two sources of excitation to sensory tuning is poorly understood. We optogenetically silenced the visual cortex of mice to isolate thalamic excitation onto layer 4 neurons during visual stimulation. Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields. This receptive field structure predicted the orientation tuning of thalamic excitation. Finally, both thalamic and total excitation were similarly tuned to orientation and direction and had the same temporal phase relationship to the visual stimulus. Our results indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-selective thalamic neurons and that a principal role of cortical circuits is to amplify tuned thalamic excitation.
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Cites
Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex
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Modulation of visual responses by behavioral state in mouse visual cortex
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Wiring specificity in the direction-selectivity circuit of the retina
Briggman, K. L., Helmstaedter, M., & Denk, W. (2011) · Nature · doi:10.1038/nature09818 · Cited by 883
A neural circuit for spatial summation in visual cortex
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Self-citationGain control by layer six in cortical circuits of vision
Olsen, S. R., Bortone, D. S., Adesnik, H., & Scanziani, M. (2012) · Nature · doi:10.1038/nature10835 · Cited by 539
Self-citationOrientation selectivity of cortical neurons during intracellular blockade of inhibition
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Functional organization of excitatory synaptic strength in primary visual cortex
Cossell, L., Iacaruso, M. F., Muir, D. R., Houlton, R., Sader, E. N., Ko, H., Hofer, S. B., & Mrsic-Flogel, T. D. (2015) · Nature · doi:10.1038/nature14182 · Cited by 527
Neural elements for predictive coding
Shipp, S. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01792 · Cited by 340
Thalamocortical Circuit Motifs: A General Framework
Halassa, M. M., & Sherman, S. M. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.005 · Cited by 322
Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity
Turner, N. L., Macrina, T., Bae, J. A., Yang, R., Wilson, A. M., Schneider-Mizell, C., Lee, K., Lu, R., Wu, J., Bodor, A. L., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.023 · Cited by 206
Metadata
- Authors
- Lien, A. D., & Scanziani, M.
- Venue
- Nature Neuroscience
- Published
- 2013-08-11
- Volume
- 16
- Issue
- 9
- Pages
- 1315-1323
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2039814229
- Cited by
- 339
- References
- 6
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- green
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