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Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
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We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
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“Unc13a expression in mushroom bodies plays a fundamental role in olfactory memory encoding in Drosophila [86], and hippocampal expression of lipoprotein lipase (Lpl) is necessary for synaptic vesicle recycling and acquisition of memories in mice [87].”
From Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies (2025) · cites this paper as [87]
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Metadata
- Authors
- Kim, J. G., Suyama, S., Koch, M., Jin, S., Argente-Arizon, P., Argente, J., Liu, Z.-W., Zimmer, M. R., Jeong, J. K., Szigeti-Buck, K., Gao, Y., Garcia-Caceres, C., Yi, C.-X., Salmaso, N., Vaccarino, F. M., Chowen, J., Diano, S., Dietrich, M. O., Tschöp, M. H., & Horvath, T. L.
- Affiliations
- Yale University (US)
- Instituto de Salud Carlos III (ES)
- Helmholtz Munich (DE)
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2014-06-01
- Volume
- 17
- Issue
- 7
- Pages
- 908-910
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4113214
- OpenAlex
- W2018870528
- Cited by
- 336
- References
- 29
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 32 · 2023: 18 · 2022: 28 · 2021: 29 · 2020: 29 · 2019: 27 · 2018: 36 · 2017: 48 · 2016: 25 · 2015: 33 · 2014: 5
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD006850)
- National Institute on Aging (R01AG040236)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058, R01DK097566)
- National Institute of Neurological Disorders and Stroke (P01NS062686)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- leptin signaling, astrocytes, leptin receptor, hypothalamus, arcuate nucleus, POMC neurons, AgRP neurons, synaptic remodeling, food intake regulation, ghrelin, glial morphology, conditional gene deletion, fasting
- MeSH terms
- Animals, Astrocytes, Cell Count, Eating, Glial Fibrillary Acidic Protein, Hypothalamus, Immunohistochemistry, Male, Microscopy, Electron, Nerve Net, Neurons, Pro-Opiomelanocortin, Pulmonary Gas Exchange, RNA, Messenger, Signal Transduction, In Situ Hybridization, Mice, Knockout, Excitatory Postsynaptic Potentials, Leptin, Mice, Melanocortins, Real-Time Polymerase Chain Reaction, Primary Cell Culture
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