Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,237

Unbiased stereological estimation of the number of neurons in the human hippocampus

West, M. J., & Gundersen, H. J. G. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960102 · Cited by 1,153

A translational profiling approach for the molecular characterization of CNS cell types

Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

Sanz, E., Yang, L., Su, T., Morris, D. R., McKnight, G. S., & Amieux, P. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907143106 · Cited by 976

Application of a translational profiling approach for the comparative analysis of CNS cell types

Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.029 · Cited by 912

Ghrelin controls hippocampal spine synapse density and memory performance

Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828

Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats

Moser, V. A., Christensen, A., Liu, J., Zhou, A. G., Yagi, S., Beam, C. R., Galea, L. A. M., & Pike, C. J. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.016 · Cited by 20

Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation

do Carmo, J. M., da Silva, A. A., Gava, F. N., Moak, S. P., Dai, X., & Hall, J. E. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00077.2019 · Cited by 19

Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus

Suyama, S., Hirano-Kodaira, M., Otgon-Uul, Z., Ueta, Y., Nakata, M., & Yada, T. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.08.008 · Cited by 18

Dissecting the Brain/Islet Axis in Metabesity

Fuente-Martín, E., Mellado‐Gil, J. M., Cobo‐Vuilleumier, N., Martín‐Montalvo, A., Romero‐Zerbo, S., Contreras, I. D., Hmadcha, A., Soria, B., Bermudo, F. M., Reyes, J. C., et al. (2019) · Genes · doi:10.3390/genes10050350 · Cited by 17

Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice

Skowronski, A. A., LeDuc, C. A., Foo, K. S., Goffer, Y., Burnett, L. C., Egli, D. M., & Leibel, R. L. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax6629 · Cited by 18

Noradrenergic Signaling in Astrocytes Influences Mammalian Sleep Homeostasis

Ingiosi, A. M., & Frank, M. G. (2022) · Clocks & Sleep · doi:10.3390/clockssleep4030028 · Cited by 15

Astrocytes Transplanted during Early Postnatal Development Integrate, Mature, and Survive Long Term in Mouse Cortex

Chierzi, S., Kacerovsky, J. B., Fok, A. H. K., Lahaie, S. C., Rosen, A. S., Farmer, W. T., & Murai, K. K. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0544-22.2023 · Cited by 17

Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-γ Impairs Glucose Metabolism and Estrous Cycling in Female Mice

Fernandez, M. O., Hsueh, K., Park, H. T., Sauceda, C., Hwang, V., Kumar, D., Kim, S., Rickert, E., Mahata, S., & Webster, N. J. G. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00242 · Cited by 17

The timeline of neuronal and glial alterations in experimental obesity

Engel, D. F., & Velloso, L. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108983 · Cited by 21

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Varela, L., Suyama, S., Huang, Y., Shanabrough, M., Tschöp, M. H., Gao, X., Giordano, F. J., & Horváth, T. L. (2017) · Diabetes · doi:10.2337/db16-1106 · Cited by 18

Hypothalamic astrocyte NAD+ salvage pathway mediates the coupling of dietary fat overconsumption in a mouse model of obesity

Park, J.-W., Park, S. E., Koh, W., Jang, W. H., Choi, J. H., Roh, E., Kang, G. M., Kim, S. J., Lim, H. S., Park, C. B., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46009-0 · Cited by 16

Hypothalamic neuronal-glial crosstalk in metabolic disease

Nguyen, L. T., & Dodd, G. T. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00026-1 · Cited by 22

The contribution of hypothalamic macroglia to the regulation of energy homeostasis

Buckman, L. B., & Ellacott, K. L. J. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00212 · Cited by 16

CNS Targets of Adipokines

Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16

Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline

Grasso, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.861350 · Cited by 15

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons

Takahashi, H., Takata, F., Matsumoto, J., Machida, T., Yamauchi, A., Dohgu, S., & Kataoka, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.016 · Cited by 15

SOX2 modulated astrocytic process plasticity is involved in arsenic-induced metabolic disorders

He, Z., Xu, Y., Ma, Q., Zhou, C., Yang, L., Lin, M., Deng, P., Yang, Z., Gong, M., Zhang, H., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128942 · Cited by 14

A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice

Depaauw-Holt, L. R., Duquenne, M., Hamane, S., Peyrard, S., Rogers, B., Ireland, C., Nasu, Y., Fulton, S., Bosson, A., Alquier, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61643-y · Cited by 20

Decreased food anticipatory activity of obese mice relates to hypothalamic c-Fos expression

Luna‐Illades, C., Morales, T., & Miranda‐Anaya, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.05.020 · Cited by 13

Brain Volume Loss, Astrocyte Reduction, and Inflammation in Anorexia Nervosa

Seitz, J., Trinh, S., Kogel, V., & Beyer, C. (2021) · Advances in neurobiology · doi:10.1007/978-3-030-77375-5_12 · Cited by 15

Early weaning by maternal prolactin inhibition leads to higher neuropeptide Y and astrogliosis in the hypothalamus of the adult rat offspring

Younes-Rapozo, V., de Moura, E. G., Manhães, A. C., Peixoto‐Silva, N., OLIVEIRA, E. B. D., & Lisboa, P. C. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003882 · Cited by 13

Continual conscious bioluminescent imaging in freely moving somatotransgenic mice

Karda, R., Perocheau, D. P. B., Suff, N., Ng, J., Delhove, J. M. K. M., Buckley, S. M. K., Richards, S., Counsell, J. R., Hagberg, H., Johnson, M. R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06696-w · Cited by 12

Empagliflozin Attenuates High-Glucose-Induced Astrocyte Activation and Inflammation via NF-κB Pathway

Kim, D. H., Lee, M. J., Kang, D., Lee, J. Y., Park, S., Khang, A. R., Bae, J. H., Kim, J. Y., Kim, S. H., Kang, Y. H., et al. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46110737 · Cited by 13

Connexin 30 controls the extension of astrocytic processes into the synaptic cleft through an unconventional non-channel function

Clasadonte, J., & Haydon, P. G. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1476-6 · Cited by 12

Circulating HDL levels control hypothalamic astrogliosis via apoA-I

Götz, A., Lehti, M., Donelan, E. M., Striese, C., Cucuruz, S., Sachs, S., Yi, C., Woods, S. C., Wright, S. D., Müller, T. D., et al. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m085456 · Cited by 11

Endospanin 1 Determines the Balance of Leptin-Regulated Hypothalamic Functions

Roujeau, C., Jockers, R., & Dam, J. (2018) · Neuroendocrinology · doi:10.1159/000494557 · Cited by 12

Neonatal nutritional programming induces gliosis and alters the expression of T-cell protein tyrosine phosphatase and connexins in male rats

Debarba, L. K., Marangon, P. B., Borges, B. C., Veida-Silva, H., Venancio-Brochi, J. C., Almeida‐Pereira, G., Antunes‐Rodrigues, J., & Elias, L. L. K. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104690 · Cited by 12

Physiology of Astroglia: Channels, Receptors, Transporters, Ion Signaling and Gliotransmission

Verkhratsky, A., & Parpura, V. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00123ed1v01y201501ngl004 · Cited by 12

PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges

Borges, B. C., Elias, C. F., & Elias, L. L. K. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.005 · Cited by 13

Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward

Huang, Q., Lee, H. H., Volpe, B., Zhang, Q., Xue, C., Liu, B. C., Abuhasan, Y. R., Li, L., Yang, J. S., Egholm, J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02692-5 · Cited by 11

Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction

Zhang, Y., Li, D., Cai, Y., Zou, R., Zhang, Y., Deng, X., Wang, Y., Tang, T., Ma, Y., Wu, F., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00218-x · Cited by 11

Temporal Leptin to Determine Cardiovascular and Metabolic Fate throughout the Life

Kim, J. G., Lee, B. J., & Jeong, J. K. (2020) · Nutrients · doi:10.3390/nu12113256 · Cited by 11

The Emerging Science of Glioception: Contribution of Glia in Sensing, Transduction, Circuit Integration of Interoception

Fabbri, R., Spennato, D., Conte, G., Konstantoulaki, A., Lazzarini, C., Saracino, E., Nicchia, G. P., Frigeri, A., Zamboni, R., Spray, D. C., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108403 · Cited by 10

Astrocytic FoxO1 in the hypothalamus regulates metabolic homeostasis by coordinating neuropeptide Y neuron activity

Doan, K. V., Tran, T. L., Yang, D. J., Ha, T. T. A., Dang, T., Kim, S. K., DePinho, R. A., Shin, D. M., Choi, Y., & Kim, K. W. (2023) · Glia · doi:10.1002/glia.24448 · Cited by 10

fDWI Evaluation of Hypothalamic Appetite Regulation Pathways in Mice Genetically Deficient in Leptin or Neuropeptide Y

Lizarbe, B., López‐Larrubia, P., & Cerdán, S. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1596-z · Cited by 11

Hypothalamic Inflammation and Glioses as Aetiopathogenetic Factor in High Fat Diet Induced Obesity and Various Therapeutic Options to Resolve it

Kaur, K. K., Allahbadia, G. N., & Singh, M. (2017) · Obesity Research - Open Journal · doi:10.17140/oroj-4-132 · Cited by 9

Intracellular interplay between cholecystokinin and leptin signalling for satiety control in rats

Koizumi, H., Mohammad, S., Ozaki, T., Kiyokazu, M., Matsuba, N., Kim, J., Pan, W., Morioka, E., Mochizuki, T., & Ikeda, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69035-6 · Cited by 9

Astrocytic circadian clock control of energy expenditure by transcriptional stress responses in the ventromedial hypothalamus

Mendoza-Viveros, L., Marmolejo‐Gutierrez, C., Cid‐Castro, C., Escalante‐Covarrubias, Q., Montellier, E., Carreño‐Vázquez, E., Noriega, L. G., Velázquez‐Villegas, L. A., Tovar, A. R., Sassone‐Corsi, P., et al. (2023) · Glia · doi:10.1002/glia.24360 · Cited by 10

Glial cells in anorexia

Reyes‐Haro, D. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.983577 · Cited by 9

When Size Matters: How Astrocytic Processes Shape Metabolism

Sharif, A., & Prévot, V. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.016 · Cited by 9

The role of TCPTP on leptin effects on astrocyte morphology

Debarba, L. K., Vechiato, F. M. V., Veida-Silva, H., Borges, B. C., Jamur, M. C., Antunes‐Rodrigues, J., & Elias, L. L. K. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.010 · Cited by 10

mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis

Meng, A., Ameroso, D., & Rios, M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0193-23.2023 · Cited by 9

Swimming reduces fatty acids-associated hypothalamic damage in mice

Nogueira, P. A. S., Pereira, M. P., Soares, J. J. G., Gomes, J. D. A. S., Ribeiro, D. L., Razolli, D. S., Velloso, L. A., Neto, M. B., & Zanon, R. G. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.101713 · Cited by 8

Alteration in the relationship between tanycytes and gonadotrophin‐releasing hormone neurosecretory terminals following long‐term metabolic manipulation in the sheep

Neto, R. P. R., Clarke, I. J., & Conductier, G. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12509 · Cited by 8

Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies

Milewski, T. M., Lee, W., Young, R. L., Hofmann, H. A., & Curley, J. P. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011548 · Cited by 7

MEMRI detects neuronal activity and connectivity in hypothalamic neural circuit responding to leptin

Юрьевна, У. А., To, X. V., Asad, A. B. M. A., Han, W., & Chuang, K. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.10.012 · Cited by 7

Astrocytes Imagined

Koob, A. O. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2104112 · Cited by 7

Leptin and its Relation to Autonomic Activity, Endothelial Cell Activation and Blood Pressure in a Young Black and White Population: The African-PREDICT study

Ahiante, B. O., Smith, W. T., Lammertyn, L., & Schutte, A. E. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-122236 · Cited by 7

Hypothalamic astrocytes: connecting brain and periphery in metabolic control

Thuc, O. L., Lechner, F. M., & García‐Cáceres, C. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09995-0 · Cited by 6

Hypothalamic circuits and aging: keeping the circadian clock updated

Vázquez-Lizárraga, R., Mendoza-Viveros, L., Cid‐Castro, C., Ruiz-Montoya, S., Carreño‐Vázquez, E., & Orozco-Solís, R. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389624 · Cited by 7

Lateral parabrachial nucleus astrocytes control food intake

Mishra, D., Richard, J. E., Marić, I., Shevchouk, O. T., Börchers, S., Eerola, K., Krieger, J.-P., & Skibicka, K. P. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1389589 · Cited by 6

Insulin and leptin acutely modulate the energy metabolism of primary hypothalamic and cortical astrocytes

Wolff, C., John, D., Winkler, U., Hochmuth, L., Hirrlinger, J., & Köhler, S. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16211 · Cited by 7

Characterization of the Astrocyte Calcium Response to Norepinephrine in the Ventral Tegmental Area

Speggiorin, M., Chiavegato, A., Zonta, M., & Gómez‐Gonzalo, M. (2024) · Cells · doi:10.3390/cells14010024 · Cited by 7

Metabolic Profiling of the Hypothalamus of Mice during Short-Term Food Deprivation

Kim, Y. J., Kang, D., Yang, H. R., Park, B. S., Tu, T. H., Jeong, B., Lee, B. J., Kim, J. K., & Kim, J. G. (2022) · Metabolites · doi:10.3390/metabo12050407 · Cited by 6

Developmental Responses of the Lateral Hypothalamus to Leptin in Neonatal Rats, and its Implications for the Development of Functional Connections with the Ventral Tegmental Area

Gjerde, E. M., Long, H., Richard, D., & Walker, C. D. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12354 · Cited by 6

Cross-Organ Mitochondrial Communication in Stress and Disease

Shen, K., Durieux, J., & Dillin, A. G. (2025) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-062124-024150 · Cited by 5

Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks

Sharif, A., & Prévot, V. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101154 · Cited by 7

Glial adaptations to high-fat diet in the mediobasal hypothalamus and effects on metabolic control

Batista, K. N. I., Bouchat, A., & Foll, C. L. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115017 · Cited by 6

Synergism Between Hypothalamic Astrocytes and Neurons in Metabolic Control

Frago, L. M., Gómez-Romero, A., Collado‐Perez, R., Argente, J., & Chowen, J. A. (2024) · Physiology · doi:10.1152/physiol.00009.2024 · Cited by 5

Astrocytes at the intersection of ageing, obesity, and neurodegeneration

Firth, W., Pye, K. R., & Potter, P. G. W. (2024) · Clinical Science · doi:10.1042/cs20230148 · Cited by 6

The Effect of Feeding Behavior on Hypothalamus in Obese Type 2 Diabetic Rats with Glucagon-like Peptide-1 Receptor Agonist Intervention

Lu, K., Chen, X., Yan, J., Li, X., Huang, C. Y., Wan, Q., Deng, X., & Zou, Q. (2018) · Obesity Facts · doi:10.1159/000486316 · Cited by 5

Control of Systemic Metabolism by Astrocytes in the Brain

Thuc, O. L., Gruber, T., Tschöp, M. H., & García‐Cáceres, C. (2021) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-62383-8_6 · Cited by 5

From blood to brain through BBB and astrocytic signaling

Pan, W. (2015) · Peptides · doi:10.1016/j.peptides.2015.06.003 · Cited by 5

Traditional Chinese Medicine Treats Obesity by Regulating the Central Nervous System via Short-chain Fatty Acids

Yi, C., Xu, M., Zhang, W., Huang, S., Guo, L., Huang, F., Xia, T., Dai, Y., Yu, B., & Li, H. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128354909241213070313 · Cited by 4

Opposite Association of Adropin Concentrations with Obesity in Prepubertal Children Compared with Adolescents

Herrero, L., de Dios, O., Gavela‐Pérez, T., Riestra, P., Jois, A., Soriano‐Guillén, L., & Garcés, C. (2020) · Obesity · doi:10.1002/oby.22886 · Cited by 4

Astroglial physiology

Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00009-2 · Cited by 5

Cell-Type-Specific Expression of Leptin Receptors in the Mouse Forebrain

Canepa, C. R., Kara, J. A., & Lee, C. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189854 · Cited by 4

Brain Inflammation and Endoplasmic Reticulum Stress

Çakır, I., & Nillni, E. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_4 · Cited by 4

Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic but Not Cortical Primary Rat Astrocytes

Potter, P. G. W., Ellacott, K. L. J., Randall, A. D., & Beall, C. (2022) · Cells · doi:10.3390/cells11213422 · Cited by 4

Astrocytes: targets in obesity

Yang, Y. (2015) · Oncotarget · doi:10.18632/oncotarget.4297 · Cited by 4

Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery

Choi, Y., Kim, M. W., Go, G., & Cai, D. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01474-3 · Cited by 4

Review on the role of hypothalamic astrocytes in the neuroendocrine control of metabolism

Farhadi, Z., Khaksari, M., Alivirdiloo, V., Mehrjerdi, F. Z., Alborzi, N., Baktash, K. B., & Rezvani, M. E. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01465-9 · Cited by 3

Neurogliovascular alterations in brain pathologies across lifespan

Daigle, B., Bevilacqua, L. M., Noël, V. P., Lebel, M., Côté, D. C., Lévesque, L., & Ménard, C. (2024) · Glial health research. · doi:10.1016/j.ghres.2024.100004 · Cited by 4

Dietary strategies targeting the interplay between obesity and neurodegenerative disease pathogenesis

Guan, T., Liu, X., Song, J., Li, Y., Song, X., Zhang, Z., Yu, Y., & Ma, Y. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117072 · Cited by 3

Leptin Interaction with Brain Orexigenic and Anorexigenic Pathways

Baskin, D. G. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_3 · Cited by 4

12. Some chronobiological investigations relevant to cholesterol

Cornélissen, G., Singh, R. K., Singh, R. K., Singh, R. B., & Meester, F. D. (2016) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-821-6_12 · Cited by 3

Proliferative Markers and Neural Stem Cells Markers in Tanycytes of the Third Cerebral Ventricle in Rats

Суфиева, Д. А., & Korzhevsky, D. E. (2023) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-023-05748-8 · Cited by 3

Immortalization and Characterization of GFAP-expressing Glial Cells from the Adult Mouse Hypothalamus, Cortex, and Brain Stem

Loganathan, N., Lieu, C. V., & Belsham, D. D. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.022 · Cited by 2

An immunological panacea for cancer-related cachexia

Xue, J., Lu, T., Yang, K., Birbrair, A., & Zhou, S. (2026) · Trends in cancer · doi:10.1016/j.trecan.2026.06.005 · Cited by 3

AstroGenesis: And there was leptin on the sixth day

Fisette, A., & Alquier, T. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.009 · Cited by 2

Synaptic plasticity and the role of astrocytes in central metabolic circuits

Ameroso, D., & Rios, M. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1632 · Cited by 3

A New Role for Glia in Leptin Action and Energy Balance

Pan, W. W., & Myers, M. G. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.020 · Cited by 2

Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism

Pérez–Tilve, D. (2017) · Endocrinology · doi:10.1210/en.2016-1944 · Cited by 2

The Evolution from Lean to Obese State and the Influence of Modern Human Society

Nillni, E. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_1 · Cited by 2

Contextual guidance: An integrated theory for astrocytes function in brain circuits and behaviorPreprint

Murphy‐Royal, C., Ching, S., & Papouin, T. (2022) · arXiv (Cornell University) · doi:10.48550/arxiv.2211.09906 · Cited by 3

Dynamic and Homeostatic Neuron–Astrocyte Interactions at GABAergic Synapses

Clarke, D., Lacaille, J., & Robitaille, R. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04554-0 · Cited by 1

Environmental and Physiological Cues on the Hypothalamus During Aging

Nehlin, J. O. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_9 · Cited by 1

The Glial Perspective of Energy Homeostasis, Neuroinflammation, and Neuro-nutraceuticals

Sinha, S., Patro, N., & Patro, I. K. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_23 · Cited by 1

Beyond neurons: computer vision methods for analysis of morphologically complex astrocytes

Syed, T. A., Youssef, M., Schober, A. L., Kubota, Y., Murai, K. K., & Salmon, C. K. (2024) · Frontiers in Computer Science · doi:10.3389/fcomp.2024.1156204 · Cited by 2

Function of Amino Acids and Neuropeptides in Feeding Behavior in Chicks

Tran, P. V. (2025) · The Journal of Poultry Science · doi:10.2141/jpsa.2025013 · Cited by 1

Neuroplasticité cérébrale et régulation de la balance énergétique

Magnan, C. (2017) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2017.10.003 · Cited by 1

The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes

Kalsbeek, M. J. T., & Yi, C. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00019-7 · Cited by 1

Single-cell analysis reveals cellular heterogeneity and molecular determinants of hypothalamic leptin-receptor cellsPreprint

Kakava-Georgiadou, N., Severens, J. F., Jørgensen, A. M., Stoltenborg, I., Garner, K. M., Luijendijk, M. C. M., Drkelic, V., van Dijk, R. E., Dickson, S. L., Pers, T. H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.23.217729 · Cited by 1

Astrocytes control oxytocin-based maternal behavior via connexin 30Preprint

Arnoux, I., Garnero, M., Moulard, J., Rollenhagen, A., Meinung, C.-P., Mota, N. D., Barbe, P., Ezan, P., Laugeray, A., de Concini, V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.09.698569 · Cited by 1

A broader remit for leptin

Lewis, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3780

Setting the TRAP for central leptin targets

Schriever, S. C., & Pfluger, P. T. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.02.008

Estudo das respostas dos astrócitos hipotalâmicos ao tratamento in vitro com ácidos graxos saturados

Oliveira, A. D. A. B. (2015) · doi:10.14393/ufu.di.2015.513

Efeitos da programação nutricional neonatal em células da glia hipotalâmica em ratos juvenis e adultos

Debarba, L. K. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-23042018-144057

CNS hormonal and nutritional regulation of glucose and energy homeostasis

Abraham, M. A. (2017) · TSpace (University of Toronto)

The effect of adiposity, age and deletion of acyl-ghrelin on pulsatile growth hormone release in male mice

Xie, T. Y. (2018) · The University of Queensland · doi:10.14264/uql.2018.450

A broader remit for leptin

Lewis, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3780

Obesity induces functional astrocytic leptin receptors in hypothalamus.

Hung, H.-C., He, Y., Kastin, A., Tu, H., Markadakis, E. N., Rogers, R., Fossier, P., & Pan, W. (2008) · Brain : a journal of neurology · doi:10.1093/brain/awp029 · Cited by 181

Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels

García‐Cáceres, C., Fuente-Martín, E., Burgos‐Ramos, E., Granado, M., Frago, L. M., Barrios, V., Horváth, T. L., Argente, J., & Chowen, J. A. (2011) · Endocrinology · doi:10.1210/en.2010-1252 · Cited by 115

Role of Astrocytes in Leptin Signaling

Wang, Y., Hsuchou, H., He, Y., Kastin, A. J., & Pan, W. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0518-5 · Cited by 53

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

Yang, L., Qi, Y., & Yang, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.002 · Cited by 248