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Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Open accessAbstract
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
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“Unc13a expression in mushroom bodies plays a fundamental role in olfactory memory encoding in Drosophila [86], and hippocampal expression of lipoprotein lipase (Lpl) is necessary for synaptic vesicle recycling and acquisition of memories in mice [87].”
From Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies (2025) · cites this paper as [87]
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Metadata
- Authors
- Kim, J. G., Suyama, S., Koch, M., Jin, S., Argente-Arizon, P., Argente, J., Liu, Z.-W., Zimmer, M. R., Jeong, J. K., Szigeti-Buck, K., Gao, Y., Garcia-Caceres, C., Yi, C.-X., Salmaso, N., Vaccarino, F. M., Chowen, J., Diano, S., Dietrich, M. O., Tschöp, M. H., & Horvath, T. L.
- Affiliations
- Yale University (US)
- Instituto de Salud Carlos III (ES)
- Helmholtz Munich (DE)
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2014-06-01
- Volume
- 17
- Issue
- 7
- Pages
- 908-910
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4113214
- OpenAlex
- W2018870528
- Cited by
- 336
- References
- 29
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 32 · 2023: 18 · 2022: 28 · 2021: 29 · 2020: 29 · 2019: 27 · 2018: 36 · 2017: 48 · 2016: 25 · 2015: 33 · 2014: 5
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD006850)
- National Institute on Aging (R01AG040236)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058, R01DK097566)
- National Institute of Neurological Disorders and Stroke (P01NS062686)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- leptin signaling, astrocytes, leptin receptor, hypothalamus, arcuate nucleus, POMC neurons, AgRP neurons, synaptic remodeling, food intake regulation, ghrelin, glial morphology, conditional gene deletion, fasting
- MeSH terms
- Animals, Astrocytes, Cell Count, Eating, Glial Fibrillary Acidic Protein, Hypothalamus, Immunohistochemistry, Male, Microscopy, Electron, Nerve Net, Neurons, Pro-Opiomelanocortin, Pulmonary Gas Exchange, RNA, Messenger, Signal Transduction, In Situ Hybridization, Mice, Knockout, Excitatory Postsynaptic Potentials, Leptin, Mice, Melanocortins, Real-Time Polymerase Chain Reaction, Primary Cell Culture
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