The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields
Open accessAbstract
Linking neural microcircuit function to emergent properties of the mammalian brain requires fine-scale manipulation and measurement of neural activity during behavior, where each neuron's coding and dynamics can be characterized. We developed an optical method for simultaneous cellular-resolution stimulation and large-scale recording of neuronal activity in behaving mice. Dual-wavelength two-photon excitation allowed largely independent functional imaging with a green fluorescent calcium sensor (GCaMP3, λ = 920 ± 6 nm) and single-neuron photostimulation with a red-shifted optogenetic probe (C1V1, λ = 1,064 ± 6 nm) in neurons coexpressing the two proteins. We manipulated task-modulated activity in individual hippocampal CA1 place cells during spatial navigation in a virtual reality environment, mimicking natural place-field activity, or 'biasing', to reveal subthreshold dynamics. Notably, manipulating single place-cell activity also affected activity in small groups of other place cells that were active around the same time in the task, suggesting a functional role for local place cell interactions in shaping firing fields.
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Cites
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Self-citationNeural substrates of awakening probed with optogenetic control of hypocretin neurons
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Self-citationLong-term dynamics of CA1 hippocampal place codes
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Self-citationDivision and subtraction by distinct cortical inhibitory networks in vivo
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Self-citationProjections from neocortex mediate top-down control of memory retrieval
Rajasethupathy, P., Sankaran, S., Marshel, J. H., Kim, C. K., Ferenczi, E., Lee, S. Y., Berndt, A., Ramakrishnan, C., Jaffe, A., Lo, M., et al. (2015) · Nature · doi:10.1038/nature15389 · Cited by 509
Self-citationFast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice
Zong, W., Wu, R., Li, M., Hu, Y., Li, Y., Li, J., Rong, H., Wu, H., Xu, Y., Lu, Y., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4305 · Cited by 513
Metadata
- Authors
- Rickgauer, J. P., Deisseroth, K., & Tank, D. W.
- Venue
- Nature Neuroscience
- Published
- 2014-11-17
- Volume
- 17
- Issue
- 12
- Pages
- 1816-1824
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2026425363
- Cited by
- 338
- References
- 12
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- green
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