Cited by 82Memory and Neural MechanismsSpatial Cognition and NavigationNeuroscience and Neuropharmacology Research

Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections

Justus, Daniel, Dalügge, Dennis, Bothe, Stefanie, Fuhrmann, Falko, Hannes, Christian, Kaneko, Hiroshi, Friedrichs, Detlef, Sosulina, Liudmila +6 more·2017·Nature Neuroscience

Abstract

The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.

Integrity signals

Registry

Crossref · 10.1038/nn.4447

Cites

43 of 43 references verified0 citation errors · 0 not checkable

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  • Locomotion is a homogeneous behavioral state tightly coupled to arousal.

    “This is because locomotion—where place cell activity has been classically characterized—is a homogeneous behavioral state, tightly coupled to arousal32–35.”

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Authors
Justus, D., Dalügge, D., Bothe, S., Fuhrmann, F., Hannes, C., Kaneko, H., Friedrichs, D., Sosulina, L., Schwarz, I., Elliott, D. A., Schoch, S., Bradke, F., Schwarz, M. K., & Remy, S.
Affiliations
  • German Center for Neurodegenerative Diseases (DE)
  • University of Bonn (DE)
Corresponding author
Remy, Stefan
Venue
Nature Neuroscience
Published
2016-11-28
Volume
20
Issue
1
Pages
16-19
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2557654004
Cited by
82
References
43
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 1
FWCI
6.15
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • DZNE Pub (submittedVersion)
Funders
Deutsches Zentrum für Neurodegenerative Erkrankungen
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
glutamatergic projections, medial entorhinal cortex, medial septum, diagonal band of Broca, locomotion speed, pyramidal neurons, stellate cells, interneurons, spatial representation, self-localization, hippocampal circuitry
MeSH terms
Animals, Axons, gamma-Aminobutyric Acid, Hippocampus, Interneurons, Locomotion, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Synaptic Transmission, Neurons, Pyramidal Cells, Entorhinal Cortex

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