Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections
Abstract
The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.
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Locomotion is a homogeneous behavioral state tightly coupled to arousal.
“This is because locomotion—where place cell activity has been classically characterized—is a homogeneous behavioral state, tightly coupled to arousal32–35.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [33]
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- Authors
- Justus, D., Dalügge, D., Bothe, S., Fuhrmann, F., Hannes, C., Kaneko, H., Friedrichs, D., Sosulina, L., Schwarz, I., Elliott, D. A., Schoch, S., Bradke, F., Schwarz, M. K., & Remy, S.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- University of Bonn (DE)
- Corresponding author
- Remy, Stefan
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2016-11-28
- Volume
- 20
- Issue
- 1
- Pages
- 16-19
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2557654004
- Cited by
- 82
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 1
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- Funders
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- glutamatergic projections, medial entorhinal cortex, medial septum, diagonal band of Broca, locomotion speed, pyramidal neurons, stellate cells, interneurons, spatial representation, self-localization, hippocampal circuitry
- MeSH terms
- Animals, Axons, gamma-Aminobutyric Acid, Hippocampus, Interneurons, Locomotion, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Synaptic Transmission, Neurons, Pyramidal Cells, Entorhinal Cortex
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