The Spatial Periodicity of Grid Cells Is Not Sustained During Reduced Theta Oscillations
Abstract
Grid cell firing vanished after medial septum inhibition, while most hippocampal place cell firing was retained.
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Theta oscillations are not necessary for the emergence of the place code but play a major role in organizing place cell activity into temporal sequences that map available space and episodic events.
“Theta oscillations—although not necessary for the emergence of the place code21,22—play a major role in organizing place cell activity into temporal sequences that map the available space (and, similarly, episodic events4,23,24).”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [22]
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Place and behavioral modulation of hippocampal neurons during immobility
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“Theta oscillations — although not necessary for the emergence of the place code 21,22 — play a major role in organizing place cellactivityintotemporalsequencesthatmaptheavailablespace(and, similarly, episodic events 4,23,24 ).”
- Authors
- Koenig, J., Linder, A. N., Leutgeb, J. K., & Leutgeb, S.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Leutgeb, Stefan
- Venue
- Science
- Published
- 2011-04-29
- Volume
- 332
- Issue
- 6029
- Pages
- 592-595
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981694662
- Cited by
- 378
- References
- 26
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 13 · 2023: 14 · 2022: 17 · 2021: 27 · 2020: 21 · 2019: 21 · 2018: 31 · 2017: 38 · 2016: 24 · 2015: 30 · 2014: 37 · 2013: 45 · 2012: 20
- FWCI
- 19.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- grid cells, theta oscillations, entorhinal cortex, parahippocampal cortex, place cells, hippocampus, spatial firing patterns, lidocaine, temporal oscillations, spatial memory, rats
- MeSH terms
- Animals, Hippocampus, Lidocaine, Male, Membrane Potentials, Motor Activity, Nerve Net, Neural Pathways, Neurons, Periodicity, Septum Pellucidum, Space Perception, Theta Rhythm, Entorhinal Cortex, Rats, Long-Evans, Rats
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