An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex
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Abstract
We investigated how landmarks influence the brain's computation of head direction and found that in a bidirectionally symmetrical environment, some neurons in dysgranular retrosplenial cortex showed bidirectional firing patterns. This indicates dominance of neural activity by local environmental cues even when these conflicted with the global head direction signal. It suggests a mechanism for associating landmarks to or dissociating them from the head direction signal, according to their directional stability and/or utility.
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Landmark and head-direction information within retrosplenial cortex presumably reflects its cingulum connections.
“One potential example of the latter concerns landmark and head-direction information within retrosplenial cortex (Jacob et al., 2016), which presumably reflect its cingulum connections.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Jacob et al., 2016
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BackgroundMaintaining a stable head direction representation in naturalistic visual environments
Haberkern, H., Chitnis, S. S., Hubbard, P. M., Goulet, T., Hermundstad, A. M., & Jayaraman, V. (2022) · doi:10.1101/2022.05.17.492284 · Cited by 21 · see citing works
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“Although spatial representations make goal-directed behavior more robust to changes in sensory cues [3–5], these representations are themselves impacted by repeating patterns in the animal’s surroundings [16, 18, 19, 31].”
BackgroundVisual objects refine head direction coding
Siegenthaler, D., Denny, H., Carrasco, S. S., Mayer, J. L., Levenstein, D., Peyrache, A., Trenholm, S., & Macé, É. (2025) · Science · doi:10.1126/science.adu9828 · Cited by 16 · see citing works
- Authors
- Jacob, P.-Y., Casali, G., Spieser, L., Page, H., Overington, D., & Jeffery, K.
- Affiliations
- University College London (GB)
- University of London (GB)
- Venue
- Nature Neuroscience
- Published
- 2016-12-19
- Volume
- 20
- Issue
- 2
- Pages
- 173-175
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5274535
- OpenAlex
- W2561396560
- Cited by
- 227
- References
- 4
- Citations by year
- 2026: 20 · 2025: 15 · 2024: 26 · 2023: 18 · 2022: 23 · 2021: 29 · 2020: 27 · 2019: 21 · 2018: 33 · 2017: 12 · 2016: 3
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Nature Neuroscience (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (103896, 103896AIA, 103896/Z/14/Z)
- Medical Research Council (G1100669)
- Biotechnology and Biological Sciences Research Council (BB/J009792/1, 1209669)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- head direction, retrosplenial cortex, landmark-based navigation, spatial cognition, environmental cues, directional stability
- MeSH terms
- Animals, Brain, Cues, Head, Male, Neurons, Orientation, Rotation, Head Movements, Rats
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