Generation of stable heading representations in diverse visual scenes
Open accessAbstract
Many animals rely on an internal heading representation when navigating in varied environments 1-10. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the ellipsoid body 3,11,12. Each compass neuron receives inputs from 'ring' neurons that are selective for particular visual features 13-16; this combination provides an ideal substrate for the extraction of directional information from a visual scene. Here we combine two-photon calcium imaging and optogenetics in tethered flying flies with circuit modelling, and show how the correlated activity of compass and visual neurons drives plasticity 17-22, which flexibly transforms two-dimensional visual cues into a stable heading representation. We also describe how this plasticity enables the fly to convert a partial heading representation, established from orienting within part of a novel setting, into a complete heading representation. Our results provide mechanistic insight into the memory-related computations that are essential for flexible navigation in varied surroundings.
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Each R neuron connects to all E-PGs and these connections are plastic, enabling flexible remapping of the outside world onto the compass neurons.
“Each R neuron connects to all E-PGs [13,19] and these connections are plastic, enabling flexible remapping of the outside world onto the compass neurons [16,20,21].”
From A model of cue integration as vector summation in the insect brain (2023) · cites this paper as [20]
The lack of plasticity in [43] does not reflect known phenomena in fruit flies and dung beetles.
“This is noted as a strength of the model (conceptual simplicity), however, it does not reflect known phenomena in fruit flies and dung beetles [16,20,22].”
From A model of cue integration as vector summation in the insect brain (2023) · cites this paper as [20]
As cues change and learning proceeds, changes in synaptic weights and resulting changes in profile are expected.
“Thus, as cues change and learning proceeds, we might expect to see changes in synaptic weights20–28 and resulting changes in profile49,50.”
From Multimodal cue integration and learning in a neural representation of head direction (2025) · cites this paper as [22]
Most previous models do not investigate multi-cue behaviour.
“Most previous models do not investigate multi-cue behaviour [8,20,28,42].”
From A model of cue integration as vector summation in the insect brain (2023) · cites this paper as [20]
The ‘Attractor model with plasticity creates a stable visual-motor compass’ section describes this paper’s model and mentions earlier models, but does not assess whether most previous models investigate multi-cue behaviour. The ‘Stability of heading representation in 2D visual scenes’ section discusses multiple visual maps and other possible sensory cues, not the prevalence of multi-cue work in previous models. No page numbers are available in our copy. (LLM, conf=0.72)
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Cites
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works
Self-citationCompetitive Hebbian learning through spike-timing-dependent synaptic plasticity
Song, S., Miller, K. D., & Abbott, L. F. (2000) · Nature Neuroscience · doi:10.1038/78829 · Cited by 2,738 · see citing works
Self-citationIndependent optical excitation of distinct neural populations
Klapoetke, N. C., Murata, Y., Kim, S. S., Pulver, S. R., Birdsey-Benson, A., Cho, Y. K., Morimoto, T. K., Chuong, A. S., Carpenter, E. J., Tian, Z., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2836 · Cited by 2,344 · see citing works
Self-citationScanImage: Flexible software for operating laser scanning microscopes
Pologruto, T. A., Sabatini, B. L., & Svoboda, K. (2003) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-2-13 · Cited by 1,297 · see citing works
Representation of Geometric Borders in the Entorhinal Cortex
Solstad, T., Boccara, C. N., Kropff, E., Moser, M.-B., & Moser, E. I. (2008) · Science · doi:10.1126/science.1166466 · Cited by 1,213 · see citing works
Refinement of Tools for Targeted Gene Expression in Drosophila
Pfeiffer, B. D., Ngo, T.-T. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010) · Genetics · doi:10.1534/genetics.110.119917 · Cited by 1,153 · see citing works
The Head Direction Signal: Origins and Sensory-Motor Integration
Taube, J. S. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112854 · Cited by 916 · see citing works
Hippocampal remapping and grid realignment in entorhinal cortex
Fyhn, M., Hafting, T., Treves, A., Moser, M.-B., & Moser, E. I. (2007) · Nature · doi:10.1038/nature05601 · Cited by 749 · see citing works
Neural dynamics for landmark orientation and angular path integration
Seelig, J. D., & Jayaraman, V. (2015) · Nature · doi:10.1038/nature14446 · Cited by 718 · see citing works
Self-citationConjunctive input processing drives feature selectivity in hippocampal CA1 neurons
Bittner, K. C., Grienberger, C., Vaidya, S. P., Milstein, A. D., Macklin, J. J., Suh, J., Tonegawa, S., & Magee, J. C. (2015) · Nature Neuroscience · doi:10.1038/nn.4062 · Cited by 540 · see citing works
Luan, H., Peabody, N. C., Vinson, C. R., & White, B. H. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.028 · Cited by 500 · see citing works
Active flight increases the gain of visual motion processing in Drosophila
Maimon, G., Straw, A. D., & Dickinson, M. H. (2010) · Nature Neuroscience · doi:10.1038/nn.2492 · Cited by 420 · see citing works
Ring attractor dynamics in the <i>Drosophila</i> central brain
Kim, S. S., Rouault, H., Druckmann, S., & Jayaraman, V. (2017) · Science · doi:10.1126/science.aal4835 · Cited by 417 · see citing works
Self-citation(1995) · PubMed · Cited by 411 · see citing works
Visual place learning in Drosophila melanogaster
Ofstad, T. A., Zuker, C. S., & Reiser, M. B. (2011) · Nature · doi:10.1038/nature10131 · Cited by 399 · see citing works
Grid cell symmetry is shaped by environmental geometry
Krupic, J., Bauža, M., Burton, S., Barry, C., & O'Keefe, J. M. (2015) · Nature · doi:10.1038/nature14153 · Cited by 374 · see citing works
Analysis of a spatial orientation memory in Drosophila
Neuser, K., Triphan, T., Mronz, M., Poeck, B., & Strauß, R. (2008) · Nature · doi:10.1038/nature07003 · Cited by 363 · see citing works
Maplike Representation of Celestial E -Vector Orientations in the Brain of an Insect
Heinze, S., & Homberg, U. (2007) · Science · doi:10.1126/science.1135531 · Cited by 360 · see citing works
Neuronal architecture of the central complex in Drosophila melanogaster
Hanesch, U., Fischbach, K., & Heisenberg, M. (2004) · Cell and Tissue Research · doi:10.1007/bf00261838 · Cited by 349 · see citing works
Two-photon calcium imaging from head-fixed Drosophila during optomotor walking behavior
Seelig, J. D., Chiappe, M. E., Lott, G. K., Dutta, A., Osborne, J. E., Reiser, M. B., & Jayaraman, V. (2010) · Nature Methods · doi:10.1038/nmeth.1468 · Cited by 345 · see citing works
Self-citationHebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts
Cassenaer, S., & Laurent, G. (2007) · Nature · doi:10.1038/nature05973 · Cited by 331 · see citing works
A neural circuit architecture for angular integration in Drosophila
Green, J., Adachi, A., Shah, K. K., Hirokawa, J. D., Magani, P. S., & Maimon, G. (2017) · Nature · doi:10.1038/nature22343 · Cited by 331 · see citing works
Dopaminergic neurons write and update memories with cell-type-specific rules
Aso, Y., & Rubin, G. M. (2016) · eLife · doi:10.7554/elife.16135 · Cited by 306 · see citing works
Knierim, J. J., Kudrimoti, H. S., & McNaughton, B. L. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.425 · Cited by 297 · see citing works
Feature detection and orientation tuning in the Drosophila central complex
Seelig, J. D., & Jayaraman, V. (2013) · Nature · doi:10.1038/nature12601 · Cited by 290 · see citing works
Self-citationAngular velocity integration in a fly heading circuit
Turner-Evans, D., Wegener, S., Rouault, H., Franconville, R., Wolff, T., Seelig, J. D., Druckmann, S., & Jayaraman, V. (2017) · eLife · doi:10.7554/elife.23496 · Cited by 281 · see citing works
Self-citationA modular display system for insect behavioral neuroscience
Reiser, M. B., & Dickinson, M. H. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.07.019 · Cited by 272 · see citing works
Sun Compass Integration of Skylight Cues in Migratory Monarch Butterflies
Heinze, S., & Reppert, S. M. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.025 · Cited by 268 · see citing works
Spatial cognition in bats and rats: from sensory acquisition to multiscale maps and navigation
Geva‐Sagiv, M., Las, L., Yovel, Y., & Ulanovsky, N. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3888 · Cited by 262 · see citing works
An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex
Jacob, P.-Y., Casali, G., Spieser, L., Page, H., Overington, D., & Jeffery, K. (2017) · Nature Neuroscience · doi:10.1038/nn.4465 · Cited by 227 · see citing works
Multiple stored views and landmark guidance in ants
Judd, S. P. D., & Collett, T. S. (1998) · Nature · doi:10.1038/33681 · Cited by 214 · see citing works
Neural coding underlying the cue preference for celestial orientation
el Jundi, B., Warrant, E. J., Byrne, M. J., Khaldy, L., Baird, E., Smolka, J., & Dacke, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501272112 · Cited by 203 · see citing works
Campbell, M. G., Ocko, S. A., Mallory, C. S., Low, I. I. C., Ganguli, S., & Giocomo, L. M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0189-y · Cited by 171 · see citing works
Sensorimotor experience remaps visual input to a heading-direction network
Fisher, Y. E., Lu, J., D’Alessandro, I., & Wilson, R. I. (2019) · Nature · doi:10.1038/s41586-019-1772-4 · Cited by 165 · see citing works
Sun Navigation Requires Compass Neurons in Drosophila
Giraldo, Y. M., Leitch, K. J., Ros, I. G., Warren, T. L., Weir, P. T., & Dickinson, M. H. (2018) · Current Biology · doi:10.1016/j.cub.2018.07.002 · Cited by 161 · see citing works
Conditioned visual flight orientation in Drosophila: dependence on age, practice, and diet.Preprint
Guo, A., Li, L., Xia, S. Z., Feng, C. H., Wolf, R., & Heisenberg, M. (1996) · Learning & Memory · doi:10.1101/lm.3.1.49 · Cited by 156 · see citing works
Wolff, T., & Rubin, G. M. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24512 · Cited by 156 · see citing works
Object tracking in motion-blind flies
Bahl, A., Ammer, G., Schilling, T., & Borst, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3386 · Cited by 152 · see citing works
Turner‐Evans, D. B., & Jayaraman, V. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.006 · Cited by 147 · see citing works
Self-citationHead Direction Cells and the Neural Mechanisms of Spatial Orientation
(2005) · The MIT Press eBooks · doi:10.7551/mitpress/3447.001.0001 · Cited by 139 · see citing works
Mapping the navigational knowledge of individually foraging ants,<i>Myrmecia croslandi</i>
Narendra, A., Gourmaud, S., & Zeil, J. (2013) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2013.0683 · Cited by 137 · see citing works
Omoto, J. J., Keleş, M. F., Nguyen, B.-C. M., Bolanos, C., Lovick, J. K., Frye, M. A., & Hartenstein, V. (2017) · Current Biology · doi:10.1016/j.cub.2017.02.063 · Cited by 137 · see citing works
A neural heading estimate is compared with an internal goal to guide oriented navigation
Green, J., Vijayan, V., Mussells Pires, P., Adachi, A., & Maimon, G. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0444-x · Cited by 137 · see citing works
Integration of objects and space in perception and memory
Connor, C. E., & Knierim, J. J. (2017) · Nature Neuroscience · doi:10.1038/nn.4657 · Cited by 132 · see citing works
Representations of Novelty and Familiarity in a Mushroom Body Compartment
Hattori, D., Aso, Y., Swartz, K. J., Rubin, G. M., Abbott, L. F., & Axel, R. (2017) · Cell · doi:10.1016/j.cell.2017.04.028 · Cited by 130 · see citing works
Self-citationNeural signatures of dynamic stimulus selection in Drosophila
Sun, Y., Nern, A., Franconville, R., Dana, H., Schreiter, E. R., Looger, L. L., Svoboda, K., Kim, D. S., Hermundstad, A. M., & Jayaraman, V. (2017) · Nature Neuroscience · doi:10.1038/nn.4581 · Cited by 112 · see citing works
Self-citationEncoding of Wind Direction by Central Neurons in Drosophila
Suver, M. P., Matheson, A. M. M., Sarkar, S., Damiata, M., Schoppik, D., & Nagel, K. I. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.012 · Cited by 99 · see citing works
Cellular Basis of Head Direction and Contextual Cues in the Insect Brain
Varga, A. G., & Ritzmann, R. E. (2016) · Current Biology · doi:10.1016/j.cub.2016.05.037 · Cited by 77 · see citing works
The Head-Direction Signal Plays a Functional Role as a Neural Compass during Navigation
Butler, W. N., Smith, K. S., van der Meer, M. A. A., & Taube, J. S. (2017) · Current Biology · doi:10.1016/j.cub.2017.03.033 · Cited by 77 · see citing works
A Snapshot-Based Mechanism for Celestial Orientation
el Jundi, B., Foster, J. J., Khaldy, L., Byrne, M. J., Dacke, M., & Baird, E. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.030 · Cited by 76 · see citing works
Emergent elasticity in the neural code for space
Ocko, S. A., Hardcastle, K., Giocomo, L. M., & Ganguli, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805959115 · Cited by 76 · see citing works
Neuronal constituents and putative interactions within the Drosophila Ellipsoid Body Neuropil
Omoto, J. J., Nguyen, B.-C. M., Kandimalla, P., Lovick, J. K., Donlea, J. M., & Hartenstein, V. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00103 · Cited by 72 · see citing works
Landmark-Based Updating of the Head Direction System by Retrosplenial Cortex: A Computational Model
Page, H. J. I., & Jeffery, K. J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00191 · Cited by 71 · see citing works
Insect learning flights and walks
Collett, T. S., & Zeil, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.050 · Cited by 71 · see citing works
Rupprecht, P., Prendergast, A. E., Wyart, C., & Friedrich, R. W. (2016) · Biomedical Optics Express · doi:10.1364/boe.7.001656 · Cited by 69 · see citing works
Parallel encoding of recent visual experience and self-motion during navigation in Drosophila
Shiozaki, H. M., & Kazama, H. (2017) · Nature Neuroscience · doi:10.1038/nn.4628 · Cited by 60 · see citing works
Kuntz, S., Poeck, B., & Strauß, R. (2017) · Current Biology · doi:10.1016/j.cub.2016.12.056 · Cited by 52 · see citing works
A computational model of the integration of landmarks and motion in the insect central complex
Cope, A. J., Sabo, C., Vasilaki, E., Barron, A. B., & Marshall, J. A. R. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172325 · Cited by 51 · see citing works
Dewar, A., Wystrach, A., Philippides, A. O., & Graham, P. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005735 · Cited by 15 · see citing works
Knierim, J. J. (2005) · The MIT Press eBooks · doi:10.7551/mitpress/3447.003.0013 · Cited by 5 · see citing works
Colour Vision: A Fresh View of Lateral Inhibition in Drosophila
Longden, K. D. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.052 · Cited by 3 · see citing works
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- [29]Green J, Vijayan V, Mussells Pires P, Adachi A. & Maimon G. A neural heading estimate is compared with an internal goal to guide oriented navigation. Nat Neurosci 22, 1460– 1468 (2019). 31332373 PMC7688015
- [39]Buchner E. Dunkelanregung des stationaeren flugs der fruchtfliege Drosophila. Dipl. thesis. Univ Tübingen (1971).
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Hulse, B. K., Haberkern, H., Franconville, R., Turner-Evans, D., Takemura, S.-Y., Wolff, T., Noorman, M., Dreher, M., Dan, C., Parekh, R., et al. (2021) · eLife · doi:10.7554/elife.66039 · Cited by 392 · see citing works
Self-citationSensorimotor experience remaps visual input to a heading-direction network
Fisher, Y. E., Lu, J., D’Alessandro, I., & Wilson, R. I. (2019) · Nature · doi:10.1038/s41586-019-1772-4 · Cited by 165 · see citing works
The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor
Turner-Evans, D. B., Jensen, K. T., Ali, S., Paterson, T., Sheridan, A., Ray, R. P., Wolff, T., Lauritzen, J. S., Rubin, G. M., Bock, D. D., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.006 · Cited by 168 · see citing works
Self-citationThe neuroanatomical ultrastructure and function of a biological ring attractor
Turner-Evans, D. B., Jensen, K. T., Ali, S., Paterson, T., Sheridan, A., Ray, R. P., Wolff, T., Lauritzen, S., Rubin, G. M., Bock, D., et al. (2019) · doi:10.1101/847152 · Cited by 166 · see citing works
Self-citationMechanisms Underlying the Neural Computation of Head Direction
Hulse, B. K., & Jayaraman, V. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031516 · Cited by 130 · see citing works
Self-citationNetwork statistics of the whole-brain connectome of Drosophila
Lin, A., Yang, R., Dorkenwald, S., Matsliah, A., Sterling, A. R., Schlegel, P., Yu, S.-C., McKellar, C. E., Costa, M., Eichler, K., et al. (2024) · Nature · doi:10.1038/s41586-024-07968-y · Cited by 147 · see citing works
A Neural Network for Wind-Guided Compass Navigation
Okubo, T. S., Patella, P., D’Alessandro, I., & Wilson, R. I. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.022 · Cited by 114 · see citing works
A visual pathway for skylight polarization processing in Drosophila
Hardcastle, B. J., Omoto, J. J., Kandimalla, P., Nguyen, B.-C. M., Keleş, M. F., Boyd, N. K., Hartenstein, V., & Frye, M. A. (2021) · eLife · doi:10.7554/elife.63225 · Cited by 111 · see citing works
Converting an allocentric goal into an egocentric steering signal
Mussells Pires, P., Zhang, L., Parache, V., Abbott, L. F., & Maimon, G. (2024) · Nature · doi:10.1038/s41586-023-07006-3 · Cited by 110 · see citing works
Self-citationA decentralised neural model explaining optimal integration of navigational strategies in insects
Sun, X., Yue, S., & Mangan, M. (2020) · eLife · doi:10.7554/elife.54026 · Cited by 96 · see citing works
Transforming a head direction signal into a goal-oriented steering command
Westeinde, E. A., Kellogg, E., Dawson, P. M., Lu, J., Hamburg, L., Midler, B., Druckmann, S., & Wilson, R. I. (2024) · Nature · doi:10.1038/s41586-024-07039-2 · Cited by 85 · see citing works
Flexible navigational computations in the Drosophila central complex
Fisher, Y. E. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.12.001 · Cited by 74 · see citing works
Neural circuit mechanisms for steering control in <i>walking Drosophila</i>
Rayshubskiy, A., Holtz, S. L., Bates, A. S., Vanderbeck, Q. X., Capdevila, L. S., Rockwell, V., & Wilson, R. I. (2020) · doi:10.1101/2020.04.04.024703 · Cited by 64 · see citing works
Dopamine promotes head direction plasticity during orienting movements
Fisher, Y. E., Marquis, M., D’Alessandro, I., & Wilson, R. I. (2022) · Nature · doi:10.1038/s41586-022-05485-4 · Cited by 67 · see citing works
A unified mechanism for innate and learned visual landmark guidance in the insect central complex
Goulard, R., Buehlmann, C., Niven, J. E., Graham, P., & Webb, B. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009383 · Cited by 51 · see citing works
Hulse, B. K., Haberkern, H., Franconville, R., Turner-Evans, D. B., Takemura, S., Wolff, T., Noorman, M., Dreher, M., Dan, C., Parekh, R., et al. (2020) · doi:10.1101/2020.12.08.413955 · Cited by 392 · see citing works
“…only the generation of hypotheses for the computations that may be carried out by subnetworks at each layer, but, increasingly, tests of these hypotheses (Fisher et al., 2019; Green et al., 2017; Kim et al., 2019; Kim et al., 2017b; Lu et al., 2020a; Lyu et al., 2020; Turner-Evans et al., 2017).”
BackgroundMethodInfluentialSelf-citationNeural networks for navigation: From connections to computations
Wilson, R. I. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-032645 · Cited by 38 · see citing works
A neural circuit architecture for rapid learning in goal-directed navigation
Dan, C., Hulse, B. K., Kappagantula, R., Jayaraman, V., & Hermundstad, A. M. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.036 · Cited by 51 · see citing works
“44 More broadly, it is not known whether flies can learn multiple distinct goal headings, nor to what extent they can form more complex policies beyond the single-goal-heading policy invoked here.”
BackgroundMethodInfluentialTowards a common terminology for arthropod spatial orientation
Grob, R., el Jundi, B., & Fleischmann, P. N. (2021) · Ethology Ecology & Evolution · doi:10.1080/03949370.2021.1905075 · Cited by 22 · see citing works
Maintaining a stable head direction representation in naturalistic visual environments
Haberkern, H., Chitnis, S. S., Hubbard, P. M., Goulet, T., Hermundstad, A. M., & Jayaraman, V. (2022) · doi:10.1101/2022.05.17.492284 · Cited by 21 · see citing works
Self-citationA neural circuit architecture for rapid behavioral flexibility in goal-directed navigation
Dan, C., Hulse, B. K., Kappagantula, R., Jayaraman, V., & Hermundstad, A. M. (2021) · doi:10.1101/2021.08.18.456004 · Cited by 51 · see citing works
“This triggers a competition between two sets of compass neurons that are activated by the same ring neurons [16, 31, 34, 71], and the bump jumps across the EB to the location that is most weakly inhibited by the same active ring neurons (Fig 2d, right column).”
BackgroundMethodInfluentialSelf-citationA model of cue integration as vector summation in the insect brain
Mitchell, R., Shaverdian, S., Dacke, M., & Webb, B. (2023) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2023.0767 · Cited by 13 · see citing works
“This is noted as a strength of the model (conceptual simplicity), however, it does not reflect known phenomena in fruit flies and dung beetles [16,20,22].”
BackgroundInfluentialConverting an allocentric goal into an egocentric steering signal
Pires, P. M., Abbott, L. F., & Maimon, G. (2022) · doi:10.1101/2022.11.10.516026 · Cited by 110 · see citing works
Self-citationEvolving consciousness: insights from Turing, and the shaping of experience.
Lacalli, T. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.598561 · Cited by 15 · see citing works
Multimodal cue integration and learning in a neural representation of head direction
Basnak, M. A., Kutschireiter, A., Okubo, T. S., Chen, A., Gorelik, P., Drugowitsch, J., & Wilson, R. I. (2025) · Nature Neuroscience · doi:10.1038/s41593-024-01823-z · Cited by 13 · see citing works
“…and differences in experienced cue intensity, we varied the ER amplitude (11 values of ˜ A k from 0 to 1 in steps of 0.05) of one ER population while holding the ER amplitude of the other ER population constant (ER amplitude scale set to 0.75) and vice versa, producing 22 ER amplitude pairs.”
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Weighted cue integration for straight-line orientation
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- Authors
- Kim, S. S., Hermundstad, A. M., Romani, S., Abbott, L. F., & Jayaraman, V.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kim, Sung Soo
- Jayaraman, Vivek
- Venue
- Nature
- Published
- 2019-11-20
- Volume
- 576
- Issue
- 7785
- Pages
- 126-131
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC8115876
- OpenAlex
- W2991430622
- Cited by
- 172
- References
- 61
- Citations by year
- 2026: 29 · 2025: 17 · 2024: 32 · 2023: 21 · 2022: 22 · 2021: 21 · 2020: 24 · 2019: 6
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (2t32ns064929-16a1)
- National Institute of Neurological Disorders and Stroke (T32-NS-064929)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- ellipsoid body, visual navigation, neuroplasticity, Drosophila, circuit modeling, optogenetics, tethered flight
- MeSH terms
- Orientation, Spatial, Animals, Calcium, Drosophila melanogaster, Head, Neuronal Plasticity, Neurons, Visual Perception, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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