Sensory input to primate spinal cord is presynaptically inhibited during voluntary movement
Abstract
During normal voluntary movements, re-afferent sensory input continuously converges on the spinal circuits that are activated by descending motor commands. This time-varying input must either be synergistically combined with the motor commands or be appropriately suppressed to minimize interference. The earliest suppression could be produced by presynaptic inhibition, which effectively reduces synaptic transmission at the initial synapse. Here we report evidence from awake, behaving monkeys that presynaptic inhibition decreases the ability of afferent impulses to affect postsynaptic neurons in a behaviorally dependent manner. Evidence indicates that cutaneous afferent input to spinal cord interneurons is inhibited presynaptically during active wrist movement, and this inhibition is effectively produced by descending commands. Our results further suggest that this presynaptic inhibition has appropriate functional consequences for movement generation and may underlie increases in perceptual thresholds during active movement.
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CD signals influence proprioceptive processing at multiple points in the neuraxis, ranging from the spinal cord to the cortex.
“More generally, CD signals influence proprioceptive processing at multiple points in the neuraxis, ranging from the spinal cord83 to the cortex84.”
From Corollary discharge across the animal kingdom (2008) · cites this paper as [83]
Cites
Sensory Mechanisms of the Spinal Cord
Willis, W. D., & Coggeshall, R. E. (1978) · Springer eBooks · doi:10.1007/978-1-4757-1688-7 · Cited by 1,456 · see citing works
Amplitude modulation of the soleus H-reflex in the human during walking and standing
Capaday, C., & Stein, R. B. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-05-01308.1986 · Cited by 981 · see citing works
Sensory Mechanisms of the Spinal Cord
Willis, W. D., & Coggeshall, R. E. (1991) · Springer eBooks · doi:10.1007/978-1-4899-0597-0 · Cited by 934 · see citing works
Presynaptic inhibition in the vertebrate spinal cord revisited
Rudomin, P., & Schmidt, R. F. (1999) · Experimental Brain Research · doi:10.1007/s002210050933 · Cited by 739 · see citing works
Integration in Spinal Neuronal Systems
Baldissera, F. G., Hultborn, H., & Illert, M. (1981) · Comprehensive physiology · doi:10.1002/cphy.cp010212 · Cited by 675 · see citing works
Excitability changes in afferent fibre terminations and their relation to slow potentials
Wall, P. D. (1958) · The Journal of Physiology · doi:10.1113/jphysiol.1958.sp005997 · Cited by 610 · see citing works
Changes in presynaptic inhibition of Ia fibres at the onset of voluntary contraction in man.
Hultborn, H., Meunier, S., Pierrot‐Deseilligny, E., & Shindo, M. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016681 · Cited by 480 · see citing works
Eccles, J. C., Eccles, R. M., & Magni, F. (1961) · The Journal of Physiology · doi:10.1113/jphysiol.1961.sp006798 · Cited by 419 · see citing works
GATING OF SOMATOSENSORY EVOKED POTENTIALS DURING DIFFERENT KINDS OF MOVEMENT IN MAN
Rushton, D. N., ROGHWELL, J. C., & Craggs, M. D. (1981) · Brain · doi:10.1093/brain/104.3.465 · Cited by 345 · see citing works
Cutaneous reflex responses and their central nervous pathways studied in man
Jenner, J., & Stephens, J. A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014461 · Cited by 323 · see citing works
Hulliger, M., Nordh, E., Thelin, A. E., & Vallbo, Å. B. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012809 · Cited by 317 · see citing works
Miller, R. J. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.201 · Cited by 304 · see citing works
Garnett, R., & Stephens, J. A. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013290 · Cited by 280 · see citing works
The regulation of presynaptic inhibition during co‐contraction of antagonistic muscles in man.
Nielsen, J. B., & Kagamihara, Y. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019652 · Cited by 239 · see citing works
Dopamine D2 Receptor–Mediated Presynaptic Inhibition of Olfactory Nerve Terminals
Ennis, M. J., Zhou, F.-M., Ciombor, K. J., Aroniadou‐Anderjaska, V., Hayar, A. M., Borrelli, E., Zimmer, L. A., Margolis, F. L., & Shipley, M. T. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.2986 · Cited by 234 · see citing works
Burke, R. E., Jankowska, E., & ten Bruggencate, G. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009090 · Cited by 216 · see citing works
Fetz, E. E., Finocchio, D. V., Baker, M., & Soso, M. J. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.4.1070 · Cited by 214 · see citing works
Self-citationVelocity-dependent suppression of cutaneous sensitivity during movement
Angel, R. W., & Malenka, R. C. (1982) · Experimental Neurology · doi:10.1016/0014-4886(82)90244-8 · Cited by 206 · see citing works
Fetz, E. E., Cheney, P. D., Mewes, K., & Palmer, S. S. (1989) · Progress in brain research · doi:10.1016/s0079-6123(08)62241-4 · Cited by 172 · see citing works
Self-citationPyramidal tract effects on interneurons in the cat lumbar dorsal horn.
Fetz, E. E. (1968) · Journal of Neurophysiology · doi:10.1152/jn.1968.31.1.69 · Cited by 162 · see citing works
Self-citationKřı́ž, N., Syková, E., Ujec, E., & Vyklický, L. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010507 · Cited by 157 · see citing works
Primary Afferent Depolarization Evoked from the Sensorimotor Cortex
Carpenter, D. O., Lundberg, A., & Norrsell, U. (1963) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1963.tb02729.x · Cited by 149 · see citing works
Reduction in perceived intensity of cutaneous stimuli during movement: a quantitative study
Milne, R. J., Aniss, A. M., Kay, N., & Gandevia, S. C. (1988) · Experimental Brain Research · doi:10.1007/bf00247604 · Cited by 146 · see citing works
DEPOLARIZATION OF PRESYNAPTIC FIBERS IN THE CUNEATE NUCLEUS
Andersen, P. N., Eccles, J. C., Schmidt, R. F., & Yokota, T. (1964) · Journal of Neurophysiology · doi:10.1152/jn.1964.27.1.92 · Cited by 146 · see citing works
DEPOLARIZATION OF THE CENTRAL TERMINALS OF CUTANEOUS AFFERENT FIBERS
Eccles, J. C., Schmidt, R. F., & Willis, W. D. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.4.646 · Cited by 137 · see citing works
DORSAL COLUMN NUCLEI AND ASCENDING SPINAL AFFERENTS IN MACAQUES
Rustioni, A., Hayes, N. L., & O’NEILL, S. (1979) · Brain · doi:10.1093/brain/102.1.95 · Cited by 134 · see citing works
Increased amplitude of cutaneous reflexes during human running as compared to standing
Duysens, J., Tax, A. A. M., Trippel, M., & Dietz, V. (1993) · Brain Research · doi:10.1016/0006-8993(93)90903-z · Cited by 126 · see citing works
Basic Mechanisms of Synaptic Transmission in the Central Nervous System
Frank, K. (1959) · IRE Transactions on Medical Electronics · doi:10.1109/iret-me.1959.5007923 · Cited by 119 · see citing works
Perlmutter, S. I., Maier, M. A., & Fetz, E. E. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.5.2475 · Cited by 117 · see citing works
Self-citationNon‐monosynaptic transmission of the cortical command for voluntary movement in man.
Burke, D. J., Graciès, J., Mazevet, D., Meunier, S., & Pierrot-Deseilligny, E. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020352 · Cited by 108 · see citing works
J�nig, W., Schmidt, R. F., & Zimmermann, M. (1968) · Experimental Brain Research · doi:10.1007/bf00239166 · Cited by 97 · see citing works
Excitability changes of ankle extensor group Ia and Ib fibers during fictive locomotion in the cat
Dueñas, S. H., & Rudomin, P. (1988) · Experimental Brain Research · doi:10.1007/bf00271842 · Cited by 94 · see citing works
Gossard, J., Cabelguen, J., & Rossignol, S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90334-8 · Cited by 83 · see citing works
Flament, D., Fortier, P. A., & Fetz, E. E. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.4.875 · Cited by 82 · see citing works
Self-citationA flexible method for fabrication of nerve cuff electrodes
Haugland, M. K. (2002) · Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.1996.656992 · Cited by 79 · see citing works
Pre-movement gating of short-latency somatosensory evoked potentials
Shimazu, H., Kaji, R., Murase, N., Kohara, N., Ikeda, A., Shibasaki, H., Kimura, J., & Rothwell, J. C. (1999) · Neuroreport · doi:10.1097/00001756-199908200-00004 · Cited by 68 · see citing works
Eguibar, J. R., Quevedo, J. N., Jiménez, I., & Rudomin, P. (1994) · Brain Research · doi:10.1016/0006-8993(94)90042-6 · Cited by 56 · see citing works
Moschovakis, A. K., Sholomenko, G. N., & Burke, R. E. (1991) · Experimental Brain Research · doi:10.1007/bf00229826 · Cited by 53 · see citing works
Hongo, T., Kitazawa, S., Ohki, Y., & Xi, M.-C. (1989) · Brain Research · doi:10.1016/0006-8993(89)90132-7 · Cited by 51 · see citing works
Spinal Neurons Project to the Dorsal Column Nuclei of Rhesus Monkeys
Rustioni, A. (1977) · Science · doi:10.1126/science.404704 · Cited by 45 · see citing works
Jim�nez, I., Rudomin, P., & Solodkin, M. (1987) · Experimental Brain Research · doi:10.1007/bf00247042 · Cited by 40 · see citing works
Presynaptic Inhibition in Primate Lateral Geniculate Nucleus
Pecci-Saavedra, J., Wilson, P. D., & Doty, R. W. (1966) · Nature · doi:10.1038/210740a0 · Cited by 40 · see citing works
Convergence onto interneurons subserving primary afferent depolarization of group I afferents
Brink, E. E., Jankowska, E., & Skoog, B. (1984) · Journal of Neurophysiology · doi:10.1152/jn.1984.51.3.432 · Cited by 40 · see citing works
Cairns, B. E., Fragoso, M. C., & Soja, P. J. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.3.1152 · Cited by 36 · see citing works
Distribution of the postsynaptic dorsal column projection in the cuneate nucleus of monkeys
Cliffer, K. D., & Willis, W. D. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450106 · Cited by 33 · see citing works
Sensory Integration in Presynaptic Inhibitory Pathways During Fictive Locomotion in the Cat
Ménard, A., Leblond, H., & Gossard, J. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.1.163 · Cited by 33 · see citing works
Jankowska, E., Sławińska, U., & Hammar, I. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.014068 · Cited by 27 · see citing works
Depolarization of Central Terminals of Group la Muscle Afferent Fibres during Desynchronized Sleep
MORRISON, A. R., & Pompeiano, O. (1966) · Nature · doi:10.1038/210201a0 · Cited by 19 · see citing works
Dorsal horn cells in the cat responding to stimulation of the plantar cushion
Egger, M. D., Freeman, N. C. G., Jacquin, M. F., Proshansky, E., & Semba, K. (1986) · Brain Research · doi:10.1016/0006-8993(86)90009-0 · Cited by 15 · see citing works
Dick, S. H., French, A. S., & Rasmusson, D. D. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02787-1 · Cited by 7 · see citing works
Baldissera, F. G., Broggi, G., & Mancia, M. (1967) · Cellular and Molecular Life Sciences · doi:10.1007/bf02144542 · Cited by 6 · see citing works
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Proske, U., & Gandevia, S. C. (2012) · Physiological Reviews · doi:10.1152/physrev.00048.2011 · Cited by 2,223 · see citing works
Coding and use of tactile signals from the fingertips in object manipulation tasks
Johansson, R. S., & Flanagan, J. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2621 · Cited by 2,063 · see citing works
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Wolpert, D. M., Diedrichsen, J., & Flanagan, J. R. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3112 · Cited by 1,391 · see citing works
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Scott, S. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1427 · Cited by 1,073 · see citing works
Corollary discharge across the animal kingdom
Crapse, T. B., & Sommer, M. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2457 · Cited by 789 · see citing works
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Lebedev, M., & Nicolelis, M. A. L. (2017) · Physiological Reviews · doi:10.1152/physrev.00027.2016 · Cited by 655 · see citing works
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Turner, R. S., & Desmurget, M. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.022 · Cited by 422 · see citing works
Computational principles of sensorimotor control that minimize uncertainty and variability
Bays, P. M., & Wolpert, D. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120121 · Cited by 359 · see citing works
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Pierrot-Deseilligny, E., & Burke, D. J. (2009) · Cited by 271 · see citing works
Sensory signals during active versus passive movement
Cullen, K. E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.002 · Cited by 262 · see citing works
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Fink, A. J. P., Croce, K. R., Huang, Z. J., Abbott, L. F., Jessell, T. M., & Azim, E. (2014) · Nature · doi:10.1038/nature13276 · Cited by 260 · see citing works
Motor cortex stimulation for neuropathic pain: From phenomenology to mechanisms
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Ueno, M., Nakamura, Y., Li, J., Gu, Z., Niehaus, J. K., Maezawa, M., Crone, S. A., Goulding, M., Baccei, M. L., & Yoshida, Y. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.137 · Cited by 222 · see citing works
Seki, K., & Fetz, E. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4958-11.2012 · Cited by 219 · see citing works
Self-citationSensorimotor attenuation by central motor command signals in the absence of movement
Voss, M., Ingram, J. N., Haggard, P., & Wolpert, D. M. (2006) · Nature Neuroscience · doi:10.1038/nn1592 · Cited by 220 · see citing works
Random change in cortical load representation suggests distinct control of posture and movement
Kurtzer, I. L., Herter, T. M., & Scott, S. H. (2005) · Nature Neuroscience · doi:10.1038/nn1420 · Cited by 209 · see citing works
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Hultborn, H. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.04.001 · Cited by 154 · see citing works
Approaches to revealing the neural basis of muscle synergies: a review and a critique
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Self-citationMotor modulation of afferent somatosensory circuits
Lee, S., Carvell, G. E., & Simons, D. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2227 · Cited by 155 · see citing works
D’Amico, J. M., Condliffe, E. G., Martins, K. J. B., Bennett, D. J., & Gorassini, M. A. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00036 · Cited by 147 · see citing works
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Hantman, A. W., & Jessell, T. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2637 · Cited by 144 · see citing works
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Mottram, C. J., Suresh, N. L., Heckman, C. J., Gorassini, M. A., & Rymer, W. Z. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00151.2009 · Cited by 129 · see citing works
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Yang, S. C., Wolpert, D. M., & Lengyel, M. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.06.009 · Cited by 119 · see citing works
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Rudomin, P. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1758-9 · Cited by 121 · see citing works
Central Signals Rapidly Switch Tactile Processing in Rat Barrel Cortex during Whisker Movements
Hentschke, H., Haiss, F., & Schwarz, C. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj056 · Cited by 110 · see citing works
Barra, B., Conti, S., Perich, M. G., Zhuang, K., Schiavone, G., Fallegger, F., Galan, K., James, N. D., Barraud, Q., Delacombaz, M., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01106-5 · Cited by 109 · see citing works
Perceptual Constancy of Texture Roughness in the Tactile System
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Predictive Sensing: The Role of Motor Signals in Sensory Processing
Brooks, J. X., & Cullen, K. E. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.06.003 · Cited by 101 · see citing works
Witham, C. L. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00038 · Cited by 96 · see citing works
Differential Controls Over Tactile Detection in Humans by Motor Commands and Peripheral Reafference
Chapman, C. E., & Beauchamp, E. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00214.2006 · Cited by 94 · see citing works
Kida, T., Wasaka, T., Inui, K., Akatsuka, K., Nakata, H., & Kakigi, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.015 · Cited by 83 · see citing works
Direct Evidence for Cortical Suppression of Somatosensory Afferents during Visuomotor Adaptation
Bernier, P., Burle, B., Vidal, F., Hasbroucq, T., & Blouin, J. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn233 · Cited by 78 · see citing works
Multisensory enhancement: gains in choice and in simple response times
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Enhancement of response times to bi- and tri-modal sensory stimuli during active movements
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Jackson, A., Baker, S. N., & Fetz, E. E. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.100537 · Cited by 75 · see citing works
Self-citationKurtzer, I. L., Pruszynski, J. A., & Scott, S. H. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00453.2009 · Cited by 75 · see citing works
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Nerve-Specific Input Modulation to Spinal Neurons during a Motor Task in the Monkey
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Self-citationPredictive attenuation of touch and tactile gating are distinct perceptual phenomena
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Beyond Muscles Stiffness: Importance of State-Estimation to Account for Very Fast Motor Corrections
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Location specificity of plantar cutaneous reflexes involving lower limb muscles in humans
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A critical speed for gating of tactile detection during voluntary movement
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Paulus, W., & Schomburg, E. D. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2006.01.004 · Cited by 59 · see citing works
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Tactile gating in a reaching and grasping task
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Self-citationCan prepared anticipatory postural adjustments be updated by proprioception?
Ruget, H., Blouin, J., Teasdale, N., & Mouchnino, L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.021 · Cited by 52 · see citing works
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Limited Pre-Speech Auditory Modulation in Individuals Who Stutter: Data and Hypotheses
Max, L., & Daliri, A. (2019) · Journal of Speech Language and Hearing Research · doi:10.1044/2019_jslhr-s-csmc7-18-0358 · Cited by 48 · see citing works
Nakajima, T., Kamibayashi, K., Takahashi, M. K., Komiyama, T., Akai, M., & Nakazawa, K. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06120.x · Cited by 43 · see citing works
Sensory modulation of movement, posture and locomotion
Saradjian, A. H. (2015) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2015.09.004 · Cited by 41 · see citing works
Facilitation of cutaneous inputs during the planning phase of gait initiation
Mouchnino, L., Fontan, A., Tandonnet, C., Perrier, J., Saradjian, A. H., Blouin, J., & Simoneau, M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00668.2014 · Cited by 41 · see citing works
Piovesan, D., Pierobon, A., DiZio, P. A., & Lackner, J. R. (2013) · Journal of Neurophysiology · doi:10.1152/jn.01013.2012 · Cited by 42 · see citing works
Remote synchronization in human cerebral cortex network with identical oscillators
Kang, L., Wang, Z., Huo, S., Tian, C., & Liu, Z. (2019) · Nonlinear Dynamics · doi:10.1007/s11071-019-05375-x · Cited by 41 · see citing works
Cortical modulation of sensory flow during active touch in the rat whisker system
Chakrabarti, S., & Schwarz, C. (2018) · Nature Communications · doi:10.1038/s41467-018-06200-6 · Cited by 41 · see citing works
Voisin, J. I. A., Rodrigues, É. C., Hétu, S., Jackson, P. L., Vargas, C. D., Malouin, F., Chapman, C. E., & Mercier, C. (2010) · Experimental Brain Research · doi:10.1007/s00221-010-2448-3 · Cited by 39 · see citing works
Overeem, S., Reijntjes, R. H. A. M., Huyser, W., Lammers, G. J., & van Dijk, J. G. (2004) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2004.00411.x · Cited by 39 · see citing works
Vitello, M., Ernst, M. O., Fritschi, M., & Bayart, A. (2006) · MPG.PuRe (Max Planck Society) · Cited by 39 · see citing works
Can you tickle yourself if you swap bodies with someone else?
Doorn, G. H. V., Hohwy, J., & Symmons, M. A. (2013) · Consciousness and Cognition · doi:10.1016/j.concog.2013.10.009 · Cited by 38 · see citing works
Internal and External Feedback Circuits for Skilled Forelimb MovementPreprint
Azim, E., Fink, A. J. P., & Jessell, T. M. (2014) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2014.79.024786 · Cited by 37 · see citing works
Dependence of auditory spatial updating on vestibular, proprioceptive, and efference copy signals
Genzel, D., Firzlaff, U., Wiegrebe, L., & MacNeilage, P. R. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00052.2016 · Cited by 36 · see citing works
Cutaneous reflexes evoked during human walking are reduced when self‐induced
Baken, B. C. M., Nieuwenhuijzen, P. H. J. A., Bastiaanse, C. M., Dietz, V., & Duysens, J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.095240 · Cited by 35 · see citing works
Hermes, D., Siero, J. C. W., Aarnoutse, E. J., Leijten, F. S. S., Petridou, N., & Ramsey, N. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0357-12.2012 · Cited by 35 · see citing works
Wasaka, T., Nakata, H., Kida, T., & Kakigi, R. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-2333-7 · Cited by 35 · see citing works
Keen, D. A., Chou, L., Nordstrom, M. A., & Fuglevand, A. J. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01154.2011 · Cited by 34 · see citing works
Cycling, a tool for locomotor recovery after motor lesions?
Mazzocchio, R., Meunier, S., Ferrante, S., Molteni, F., & Cohen, L. G. (2008) · Neurorehabilitation · doi:10.3233/nre-2008-23107 · Cited by 34 · see citing works
Adaptation to a novel multi-force environment
Kurtzer, I. L., DiZio, P. A., & Lackner, J. R. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-2216-y · Cited by 34 · see citing works
The art and science behind piano touch: A review connecting multi-disciplinary literature
MacRitchie, J. (2015) · Musicae Scientiae · doi:10.1177/1029864915572813 · Cited by 33 · see citing works
Roles for inhibition: studies on networks controlling swimming in young frog tadpoles
Roberts, A., Li, W., & Soffe, S. R. (2008) · Journal of Comparative Physiology A · doi:10.1007/s00359-007-0273-3 · Cited by 32 · see citing works
Selective presynaptic inhibition of leg proprioception in behaving Drosophila
Dallmann, C. J., Luo, Y., Agrawal, S., Mamiya, A., Chou, G. M., Cook, A., Sustar, A., Brunton, B. W., & Tuthill, J. C. (2025) · Nature · doi:10.1038/s41586-025-09554-2 · Cited by 34 · see citing works
Spinal stretch reflexes support efficient control of reaching
Weiler, J., Gribble, P. L., & Pruszynski, J. A. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00487.2020 · Cited by 31 · see citing works
Hochman, S. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.014 · Cited by 28 · see citing works
Laryngeal reflex responses are not modulated during human voice and respiratory tasks
Henriquez, V. M., Schulz, G. M., Bielamowicz, S. A., & Ludlow, C. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143438 · Cited by 31 · see citing works
Imaging spinal cord activity in behaving animals
Nelson, N. A., Wang, X., Cook, D., Carey, E. M., & Nimmerjahn, A. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112974 · Cited by 30 · see citing works
Short-term habituation of equine limb kinematics to tactile stimulation of the coronet
White, A., Kaiser, L. J., Nauwelaerts, S., Lavagnino, M., Stubbs, N. C., & Clayton, H. M. (2008) · Veterinary and Comparative Orthopaedics and Traumatology · doi:10.1055/s-0037-1617363 · Cited by 30 · see citing works
Cutaneous afferent regulation of motor function
Panek, I., Bui, T. V., Wright, A., & Brownstone, R. M. (2014) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2014-1982 · Cited by 29 · see citing works
Hardesty, R. L., Boots, M. T., Yakovenko, S., & Gritsenko, V. (2020) · Scientific Reports · doi:10.1038/s41598-020-67403-w · Cited by 27 · see citing works
Centrifugal regulation of task-relevant somatosensory signals to trigger a voluntary movement
Kida, T., Wasaka, T., Nakata, H., & Kakigi, R. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-0141-8 · Cited by 27 · see citing works
Seki, K., Perlmutter, S. I., & Fetz, E. E. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91113.2008 · Cited by 27 · see citing works
Self-citationModulation of somatosensory evoked potentials during force generation and relaxation
Wasaka, T., Kida, T., & Kakigi, R. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3082-z · Cited by 26 · see citing works
Manzone, D. M., Inglis, J. T., Franks, I. M., & Chua, R. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.024 · Cited by 26 · see citing works
Chávez, D., Rodríguez‐Torres, E. E., Jiménez, I., & Rudomin, P. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.223271 · Cited by 26 · see citing works
Ia-afferent input to motoneurons during shortening and lengthening muscle contractions in humans
Petersen, N., Butler, J. E., Carpenter, M. G., & Cresswell, A. G. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00362.2006 · Cited by 26 · see citing works
Yıldız, M. Z., Toker, İ., Özkan, F. B., & Güçlü, B. (2015) · Somatosensory & Motor Research · doi:10.3109/08990220.2015.1091771 · Cited by 25 · see citing works
Scheidt, R., Lillis, K., & Emerson, S. S. (2010) · Experimental Brain Research · doi:10.1007/s00221-010-2308-1 · Cited by 25 · see citing works
Central nervous system control of interactions between vocalization and respiration in mammals
Ludlow, C. L. (2011) · Head & Neck · doi:10.1002/hed.21904 · Cited by 25 · see citing works
Iscru, E., Serinagaoglu, Y., Schilling, K., Tian, J., Bowers-Kidder, S. L., Zhang, R., Morgan, J. I., DeVries, A. C., Nelson, R. J., Zhu, M. X., et al. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.09.002 · Cited by 25 · see citing works
- Authors
- Seki, K., Perlmutter, S. I., & Fetz, E. E.
- Affiliations
- University of Washington (US)
- Corresponding author
- Seki, Kazuhiko
- Venue
- Nature Neuroscience
- Published
- 2003-11-16
- Volume
- 6
- Issue
- 12
- Pages
- 1309-1316
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2033086077
- Cited by
- 294
- References
- 51
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 12 · 2021: 13 · 2020: 15 · 2019: 15 · 2018: 12 · 2017: 9 · 2016: 13 · 2015: 16 · 2014: 11 · 2013: 13 · 2012: 16
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ns036781-02)
- National Institute of Neurological Disorders and Stroke (NS12542, NS36781)
- National Center for Research Resources (RR00166, P51RR000166)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- presynaptic inhibition, spinal cord, voluntary movement, cutaneous afferents, spinal interneurons, descending motor commands, sensorimotor integration, wrist kinematics, perceptual thresholds, monkeys
- MeSH terms
- Action Potentials, Animals, Macaca nemestrina, Male, Movement, Neural Inhibition, Neural Pathways, Neurons, Afferent, Spinal Cord, Presynaptic Terminals
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