Cited by 294Motor Control and AdaptationNeuroscience and Neuropharmacology ResearchTactile and Sensory Interactions

Sensory input to primate spinal cord is presynaptically inhibited during voluntary movement

Seki, Kazuhiko, Perlmutter, Steve I, Fetz, Eberhard E·2003·Nature Neuroscience

Abstract

During normal voluntary movements, re-afferent sensory input continuously converges on the spinal circuits that are activated by descending motor commands. This time-varying input must either be synergistically combined with the motor commands or be appropriately suppressed to minimize interference. The earliest suppression could be produced by presynaptic inhibition, which effectively reduces synaptic transmission at the initial synapse. Here we report evidence from awake, behaving monkeys that presynaptic inhibition decreases the ability of afferent impulses to affect postsynaptic neurons in a behaviorally dependent manner. Evidence indicates that cutaneous afferent input to spinal cord interneurons is inhibited presynaptically during active wrist movement, and this inhibition is effectively produced by descending commands. Our results further suggest that this presynaptic inhibition has appropriate functional consequences for movement generation and may underlie increases in perceptual thresholds during active movement.

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Crossref · 10.1038/nn1154

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  • CD signals influence proprioceptive processing at multiple points in the neuraxis, ranging from the spinal cord to the cortex.

    “More generally, CD signals influence proprioceptive processing at multiple points in the neuraxis, ranging from the spinal cord83 to the cortex84.”

    From Corollary discharge across the animal kingdom (2008) · cites this paper as [83]

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Authors
Seki, K., Perlmutter, S. I., & Fetz, E. E.
Affiliations
University of Washington (US)
Corresponding author
Seki, Kazuhiko
Venue
Nature Neuroscience
Published
2003-11-16
Volume
6
Issue
12
Pages
1309-1316
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2033086077
Cited by
294
References
51
Citations by year
2026: 10 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 12 · 2021: 13 · 2020: 15 · 2019: 15 · 2018: 12 · 2017: 9 · 2016: 13 · 2015: 16 · 2014: 11 · 2013: 13 · 2012: 16
FWCI
6.21
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ns036781-02)
  • National Institute of Neurological Disorders and Stroke (NS12542, NS36781)
  • National Center for Research Resources (RR00166, P51RR000166)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords
presynaptic inhibition, spinal cord, voluntary movement, cutaneous afferents, spinal interneurons, descending motor commands, sensorimotor integration, wrist kinematics, perceptual thresholds, monkeys
MeSH terms
Action Potentials, Animals, Macaca nemestrina, Male, Movement, Neural Inhibition, Neural Pathways, Neurons, Afferent, Spinal Cord, Presynaptic Terminals

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