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Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

Ito, Rutsuko, Robbins, Trevor W, Everitt, Barry J·2004·Nature Neuroscience

DOI 10.1038/nn1217

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Abstract

Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-administration in rats. Whereas selective excitotoxic lesions of the NAc core had only a minor effect on the acquisition of responding for cocaine under a standard schedule of continuous reinforcement, these lesions profoundly impaired the acquisition of drug-seeking behavior that was maintained by drug-associated conditioned reinforcers and assessed using a second-order schedule of cocaine reinforcement. In contrast, selective excitotoxic lesions of the NAc shell did not impair drug self-administration or the acquisition of cocaine-seeking, but they did attenuate the psychostimulant effects of cocaine. These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior.

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Authors: Ito, R., Robbins, T. W., & Everitt, B. J.
Affiliations: University of Cambridge (GB)
Corresponding author: Everitt, Barry J
ORCID: Ito, Rutsuko
Robbins, Trevor W
Everitt, Barry J
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-03-21
Volume: 7
Issue: 4
Pages: 389-397
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1217
OpenAlex: W2014459415
Cited by: 501
References: 50
Citations by year: 2026: 8 · 2025: 7 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 21 · 2020: 20 · 2019: 17 · 2018: 14 · 2017: 25 · 2016: 20 · 2015: 18 · 2014: 30 · 2013: 31 · 2012: 34
FWCI: 10.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, nucleus accumbens core, nucleus accumbens shell, cocaine self-administration, cocaine-seeking behavior, second-order schedules, excitotoxic lesions, drug reinforcement, double dissociation
MeSH terms: Animals, Appetitive Behavior, Association Learning, Cocaine, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Nucleus Accumbens, Rats, Inbred Strains, Reinforcement, Psychology, Self Administration, Cocaine-Related Disorders, Rats

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Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

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