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Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

Ito, Rutsuko, Robbins, Trevor W, Everitt, Barry J·2004·Nature Neuroscience

DOI 10.1038/nn1217

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Abstract

Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-administration in rats. Whereas selective excitotoxic lesions of the NAc core had only a minor effect on the acquisition of responding for cocaine under a standard schedule of continuous reinforcement, these lesions profoundly impaired the acquisition of drug-seeking behavior that was maintained by drug-associated conditioned reinforcers and assessed using a second-order schedule of cocaine reinforcement. In contrast, selective excitotoxic lesions of the NAc shell did not impair drug self-administration or the acquisition of cocaine-seeking, but they did attenuate the psychostimulant effects of cocaine. These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior.

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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
Self-citation
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,261
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219
Activation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936

Show all 50 references

Research works printed but not linked: 1

Caine, S.B., Lintz, R. & Koob, G.F. Intravenous self-administration techniques in animals. in Behavioral Neuroscience: a Practical Approach Vol. 2 (ed. Sahgal, A.) 117–143 (IRL Press, Oxford, UK, 1992).

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Authors: Ito, R., Robbins, T. W., & Everitt, B. J.
Affiliations: University of Cambridge (GB)
Corresponding author: Everitt, Barry J
ORCID: Ito, Rutsuko
Robbins, Trevor W
Everitt, Barry J
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-03-21
Volume: 7
Issue: 4
Pages: 389-397
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1217
OpenAlex: W2014459415
Cited by: 501
References: 50
Citations by year: 2026: 8 · 2025: 7 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 21 · 2020: 20 · 2019: 17 · 2018: 14 · 2017: 25 · 2016: 20 · 2015: 18 · 2014: 30 · 2013: 31 · 2012: 34
FWCI: 10.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, nucleus accumbens core, nucleus accumbens shell, cocaine self-administration, cocaine-seeking behavior, second-order schedules, excitotoxic lesions, drug reinforcement, double dissociation
MeSH terms: Animals, Appetitive Behavior, Association Learning, Cocaine, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Nucleus Accumbens, Rats, Inbred Strains, Reinforcement, Psychology, Self Administration, Cocaine-Related Disorders, Rats

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Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

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