The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Frequency-dependent modulation of dopamine release by nicotine
Abstract
Although nicotine activation of dopamine release is implicated in addiction, it also desensitizes nicotinic acetylcholine receptors (nAChRs), leading to a prolonged depression of evoked dopamine release. Here we show that nicotine's effects depend on the firing pattern of dopamine neurons, so that while desensitization of nAChRs indeed curbs dopamine released by stimuli emulating tonic firing, it allows a rapid rise in dopamine from stimuli emulating phasic firing patterns associated with incentive/salience paradigms. Nicotine may thus enhance the contrast of dopamine signals associated with behavioral cues.
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“desensitization of β2* nAChRs on DA terminals in the NAc leading to decreased transmission of tonic DA neuronal firing, but maintained release of DA in response to phasic DA neuronal firing (Rice and Cragg, 2004; Zhang and Sulzer, 2004)”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Zhang and Sulzer, 2004
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Cites
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113
Role of dopamine in the behavioural actions of nicotine related to addiction
Chiara, G. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00122-9 · Cited by 698
Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
Zhou, F.-M., Liang, Y., & Dani, J. A. (2001) · Nature Neuroscience · doi:10.1038/nn769 · Cited by 585
Firing modes of midbrain dopamine cells in the freely moving rat
Hyland, B. I., Reynolds, J. N. J., HAY, J. G., Perk, C. G., & Miller, R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00267-1 · Cited by 487
Nicotinic effects on the firing pattern of midbrain dopamine neurons
GRENHOFF, J., ASTON‐JONES, G., & SVENSSON, T. H. (1986) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1986.tb07988.x · Cited by 399
Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey
Schultz, W. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.5.1439 · Cited by 390
Schilström, B., Svensson, H. M., Svensson, T. H., & Nomikos, G. G. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00114-6 · Cited by 207
Presynaptic regulation of dopaminergic neurotransmission
Schmitz, Y., Benoit‐Marand, M., Gonon, F., & Sulzer, D. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02050.x · Cited by 202
Self-citationNicotinic Treatment for Cognitive Dysfunction
Levin, E. D., & Rezvani, A. H. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007023339102 · Cited by 195
Jones, I. W., Bolam, J. P., & Wonnacott, S. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1345 · Cited by 168
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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197
Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons
Threlfell, S., Lalic, T., Platt, N. J., Jennings, K. A., Deisseroth, K., & Cragg, S. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.038 · Cited by 845
Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
Day, J. J., Roitman, M. F., Wightman, R. M., & Carelli, R. M. (2007) · Nature Neuroscience · doi:10.1038/nn1923 · Cited by 710
Monitoring Rapid Chemical Communication in the Brain
Robinson, D. L., Hermans, A., Seipel, A. T., & Wightman, R. M. (2008) · Chemical Reviews · doi:10.1021/cr068081q · Cited by 672
Metadata
- Authors
- Zhang, H., & Sulzer, D.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Sulzer, David
- Venue
- Nature Neuroscience
- Published
- 2004-05-16
- Volume
- 7
- Issue
- 6
- Pages
- 581-582
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1977353877
- Cited by
- 361
- References
- 15
- Citations by year
- 2026: 4 · 2025: 20 · 2024: 11 · 2023: 10 · 2022: 20 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 23 · 2017: 13 · 2016: 19 · 2015: 18 · 2014: 24 · 2013: 13 · 2012: 19
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotine, dopamine release, tonic firing, phasic firing, incentive salience, behavioral addiction
- MeSH terms
- Action Potentials, Animals, Dopamine, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Mice, In Vitro Techniques
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