Cited by 361Nicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on BehaviorSmoking Behavior and Cessation

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Frequency-dependent modulation of dopamine release by nicotine

Zhang, Hui, Sulzer, David·2004·Nature Neuroscience

DOI 10.1038/nn1243

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Abstract

Although nicotine activation of dopamine release is implicated in addiction, it also desensitizes nicotinic acetylcholine receptors (nAChRs), leading to a prolonged depression of evoked dopamine release. Here we show that nicotine's effects depend on the firing pattern of dopamine neurons, so that while desensitization of nAChRs indeed curbs dopamine released by stimuli emulating tonic firing, it allows a rapid rise in dopamine from stimuli emulating phasic firing patterns associated with incentive/salience paradigms. Nicotine may thus enhance the contrast of dopamine signals associated with behavioral cues.

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Authors: Zhang, H., & Sulzer, D.
Affiliations: Columbia University (US)
New York State Psychiatric Institute (US)
Corresponding author: Sulzer, David
ORCID: Zhang, Hui
Sulzer, David
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-05-16
Volume: 7
Issue: 6
Pages: 581-582
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1243
OpenAlex: W1977353877
Cited by: 361
References: 15
Citations by year: 2026: 4 · 2025: 20 · 2024: 11 · 2023: 10 · 2022: 20 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 23 · 2017: 13 · 2016: 19 · 2015: 18 · 2014: 24 · 2013: 13 · 2012: 19
FWCI: 4.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: nicotine, dopamine release, tonic firing, phasic firing, incentive salience, behavioral addiction
MeSH terms: Action Potentials, Animals, Dopamine, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Mice, In Vitro Techniques

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Frequency-dependent modulation of dopamine release by nicotine

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