Cited by 385Axon Guidance and Neuronal SignalingProtein Kinase Regulation and GTPase SignalingNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.

Schwamborn, Jens C, Püschel, Andreas W·2004·Nature Neuroscience

DOI 10.1038/nn1295

Open this paper in CoChat — free account

Abstract

The establishment of a polarized morphology is an essential step in the differentiation of neurons with a single axon and multiple dendrites. In cultured rat hippocampal neurons, one of several initially indistinguishable neurites is selected to become the axon. Both phosphatidylinositol 3,4,5-trisphosphate and the evolutionarily conserved Par complex (comprising Par3, Par6 and an atypical PKC (aPKC) such as PKClambda or PKCzeta) are involved in axon specification. However, the initial signals that establish cellular asymmetry and the pathways that subsequently translate it into structural changes remain to be elucidated. Here we show that localization of the GTPase Rap1B to the tip of a single neurite is a decisive step in determining which neurite becomes the axon. Using GTPase mutants and RNA interference, we found that Rap1B is necessary and sufficient to initiate the development of axons upstream of Cdc42 and the Par complex.

Integrity signals

Registry

Crossref · 10.1038/nn1295

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Rho GTPases in cell biology
Etienne-Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,965
Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination
Brewer, G. J., Torricelli, J. R., Evege, E. K., & Price, P. J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350513 · Cited by 2,325
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cellsPreprint
Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J., & Conklin, D. S. (2002) · Genes & Development · doi:10.1101/gad.981002 · Cited by 1,571
RHO GTPASES in neuronal morphogenesis
Luo, L. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044547 · Cited by 985
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta.
Etienne-Manneville, S., & Hall, A. (2001) · Cell · doi:10.1016/s0092-8674(01)00471-8 · Cited by 941
Cdc42 - the centre of polarity
Etienne‐Manneville, S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01115 · Cited by 787
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Rap1 signalling: adhering to new models
Bos, J. L., de Rooij, J., & Reedquist, K. A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073073 · Cited by 625
Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity
Shi, S.-H., Jan, L. Y., & Jan, Y.-N. (2003) · Cell · doi:10.1016/s0092-8674(02)01249-7 · Cited by 600

Flagged first, then by citations

Show all 39 references

1 of the 39 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 385

The RHO-1 RhoGTPase Modulates Fertility and Multiple Behaviors in Adult C. elegans
McMullan, R., & Nurrish, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017265 · Cited by 33
cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells
Inda, C., Bonfiglio, J. J., Claro, P. A. D. S., Senin, S. A., Armando, N. G., Deussing, J. M., & Silberstein, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02021-7 · Cited by 33
Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity
Müller, M., Lutter, D., & Püschel, A. W. (2009) · Journal of Cell Science · doi:10.1242/jcs.058230 · Cited by 35
Self-citation
Myosin 1b promotes axon formation by regulating actin wave propagation and growth cone dynamics
Iuliano, O., Yoshimura, A., Prosperi, M., Martin, R., Knölker, H., & Coudrier, E. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201703205 · Cited by 33
Axon formation: fate versus growth
Jiang, H., & Rao, Y. (2005) · Nature Neuroscience · doi:10.1038/nn0505-544 · Cited by 33
Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy
Ahn, E. H., & Park, J. (2025) · Cells · doi:10.3390/cells14020089 · Cited by 37
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Muñoz-LLancao, P., Henríquez, D. R., Wilson, C., Bodaleo, F. J., Boddeke, E., Lezoualc’h, F., Schmidt, M., & González-Billault, C. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3645-14.2015 · Cited by 33
Molecular Memory of Morphologies by Septins during Neuron Generation Allows Early Polarity Inheritance
Boubakar, L., Falk, J., Ducuing, H., Thoinet, K., Reynaud, F., Derrington, E. A., & Castellani, V. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.027 · Cited by 32
Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation
Shah, S. K., Brock, E. J., Jackson, R. M., Ji, K., Boerner, J. L., Sloane, B. F., & Mattingly, R. R. (2018) · Neoplasia · doi:10.1016/j.neo.2018.07.002 · Cited by 32
Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell–Cell Junctions and Vascular Permeability
Yamamoto, K., Takagi, Y., Ando, K., & Fukuhara, S. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00504 · Cited by 33
Ubiquitination
de la Vega, M., Burrows, J. F., & Johnston, J. A. (2011) · Small GTPases · doi:10.4161/sgtp.2.4.16707 · Cited by 31
Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis
Carbó, C., Duerschmied, D., Goerge, T., Hattori, H., Sakai, J., Cifuni, S. M., White, G., Chrzanowska‐Wodnicka, M., Luo, H. R., & Wagner, D. D. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0110049 · Cited by 31
Regulation of plasma membrane expansion during axon formation
Quiroga, S., Bisbal, M., & Cáceres, A. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22553 · Cited by 29
Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2
Meng, S., Su, Z., Liu, Z., Wang, N., & Wang, Z. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.014 · Cited by 30
Reelin modulates cytoskeletal organization by regulating Rho GTPases
Leemhuis, J., & Bock, H. H. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.4.3.14890 · Cited by 29
How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma
Sequera, C., Manzano, S., Guerrero, C., & Porrás, A. (2018) · Hepatic Oncology · doi:10.2217/hep-2017-0026 · Cited by 30
The role of selective transport in neuronal polarization
Namba, T., Nakamuta, S., Funahashi, Y., & Kaibuchi, K. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20876 · Cited by 30
Erythropoietin promotes axonal growth in a model of neuronal polarization
Ransome, M. I., & Turnley, A. M. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.05.002 · Cited by 28
Hsp90 activity is necessary to acquire a proper neuronal polarization
Benítez, M. J., Sánchez-Ponce, D., Garrido, J. J., & Wandosell, F. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.11.013 · Cited by 28
Rotenone inhibits axonogenesis via an Lfc/RhoA/ ROCK pathway in cultured hippocampal neurons
Bisbal, M., Remedi, M. V., Quassollo, G., Cáceres, A., & Sanchez, M. S. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14547 · Cited by 28
Rit signaling contributes to interferon‐γ‐induced dendritic retraction via p38 mitogen‐activated protein kinase activation
Andres, D., Shi, G., Bruun, D. A., Barnhart, C., & Lein, P. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05708.x · Cited by 28
Influence of neurosteroids on the pathogenesis of multiple sclerosis
Leitner, H. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.02.028 · Cited by 31
Daidzein induces neuritogenesis in DRG neuronal cultures
Yang, S., Liao, C.-C., Chen, Y., Syu, J.-P., Jeng, C., & Wang, S. (2012) · Journal of Biomedical Science · doi:10.1186/1423-0127-19-80 · Cited by 28
How to bake a brain: yeast as a model neuron
Sarto‐Jackson, I., & Tomáška, Ľ. (2016) · Current Genetics · doi:10.1007/s00294-015-0554-2 · Cited by 29
C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development
Shah, B., Lutter, D., Bochenek, M. L., Kato, K., Tsytsyura, Y., Glyvuk, N., Sakakibara, A., Klingauf, J., Adams, R. H., & Püschel, A. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154174 · Cited by 29
Self-citation
Rassf5 and Ndr kinases act in a novel pathway regulating neuronal polarity through Par3 phosphorylation
Yang, R., Kong, E., Jin, J., Hergovich, A., & Püschel, A. W. (2014) · Journal of Cell Science · doi:10.1242/jcs.146696 · Cited by 25
Self-citation
Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction
Rudolph, J. L., Shi, G., Erdogan, E., Fields, A. P., & Andres, D. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.09.008 · Cited by 25
Maresin1 Decreased Microglial Chemotaxis and Ameliorated Inflammation Induced by Amyloid-β 42 in Neuron-Microglia Co-Culture Models
Yin, P., Wang, S., Wei, Y., Wang, X., Zhang, J., Yin, X., Feng, J., & Zhu, M. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190682 · Cited by 24
In Vivo Prenylomic Profiling in the Brain of a Transgenic Mouse Model of Alzheimer’s Disease Reveals Increased Prenylation of a Key Set of Proteins
Jeong, A., Auger, S. A., Maity, S., Fredriksen, K., Zhong, R., Li, L., & Distefano, M. D. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00486 · Cited by 26
Local changes in microtubule network mobility instruct neuronal polarization and axon specification
Burute, M., Jansen, K. I., Mihajlovic, M., Vermonden, T., & Kapitein, L. C. (2022) · Science Advances · doi:10.1126/sciadv.abo2343 · Cited by 27
Cellular‐Scale Matrix Stiffness Gradient at Soft‐Hard Tissue Interfaces Regulates Immunophenotype of Mesenchymal Stem Cells
Zhang, H., Ma, Y., Shu, W., Wang, Y., Cao, C., Wan, W., Shi, N., Zhao, W., Pei, D., Li, A., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202309676 · Cited by 26
PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development
Yu, H., Wang, N., Ju, X., Yang, Y. M., Sun, D., Lai, M., Cui, L., Sheikh, M. A., Zhang, J., Wang, X., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036988 · Cited by 24
Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity
Ulc, A., Gottschling, C., Schäfer, I., Wegrzyn, D., van Leeuwen, S., Luft, V., Reinhard, J., & Faissner, A. (2017) · Biological Chemistry · doi:10.1515/hsz-2016-0275 · Cited by 25
Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra
Guo, X.-X., An, S., Yang, Y., Liu, Y., Qian, H., & Xu, T. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000445612 · Cited by 23
Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity
Sasaki, K., Kojitani, N., Hirose, H., Yoshihama, Y., Suzuki, H., Shimada, M., Takayanagi, A., Yamashita, A., Nakaya, M., Hirano, H., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.088 · Cited by 23
Moving through the crowd. Where are we at understanding physiological axon growth?
Alfadil, E., & Bradke, F. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.07.001 · Cited by 23
Atypical Protein Kinase C and Par3 Are Required for Proteoglycan-Induced Axon Growth Inhibition
Lee, S.-I., Zhang, W., Ravi, M., Weschenfelder, M., Bastmeyer, M., & Levine, J. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3154-12.2013 · Cited by 21
Cdk5 regulates Rap1 activity
Utreras, E., Henríquez, D. R., Contreras-Vallejos, E., Olmos, C., Genova, A. D., Maass, A., Kulkarni, A. B., & González-Billault, C. E. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.02.011 · Cited by 23
RhoE stimulates neurite‐like outgrowth in PC12 cells through inhibition of the RhoA/ROCK‐I signalling
Taléns‐Visconti, R., Peris, B., Guerri, C., & Guasch, R. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06526.x · Cited by 22
Cell type-specific dendritic polarity in the absence of spatially organized external cues
Horton, A. C., Yi, J. J., & Ehlers, M. (2007) · Journal of Neurocytology · doi:10.1007/s11068-006-9003-y · Cited by 22
Protocol for Evaluating Neuronal Polarity in Murine Models
Wilson, C., Rozés‐Salvador, V., & Cáceres, A. (2020) · STAR Protocols · doi:10.1016/j.xpro.2020.100114 · Cited by 21
The role of TSC1 and TSC2 proteins in neuronal axons
Karalis, V., Wood, D., Teaney, N. A., & Sahin, M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02402-7 · Cited by 21
Replicated genetic evidence supports a role for HOMER2 in schizophrenia
Gilks, W. P., Allott, E. H., Donohoe, G. J., Cummings, E., Gill, M., Corvin, A. P., & Morris, D. W. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.003 · Cited by 21
Overcoming Amino-Nogo-induced Inhibition of Cell Spreading and Neurite Outgrowth by 12-O-Tetradecanoylphorbol-13-acetate-type Tumor Promoters
Deng, K., Gao, Y., Cao, Z., Graziani, E. I., Wood, A., Doherty, P., & Walsh, F. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071548 · Cited by 20
Identification of a Proline-rich Inositol Polyphosphate 5-Phosphatase (PIPP)·Collapsin Response Mediator Protein 2 (CRMP2) Complex That Regulates Neurite Elongation
Astle, M. V., Ooms, L. M., Cole, A. R., Binge, L. C., Dyson, J. M., Layton, M. J., Petratos, S., Sutherland, C. D., & Mitchell, C. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.214247 · Cited by 19
Dual Regulation of RA-RhoGAP Activity by Phosphatidic Acid and Rap1 during Neurite Outgrowth
Kurooka, T., Yamamoto, Y., Takai, Y., & Sakisaka, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183772 · Cited by 22
GTPases and the Control of Neuronal Polarity
Schwamborn, J. C., Li, Y., & Püschel, A. W. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)06056-3 · Cited by 20
Self-citation
Integrin Regulators in Neutrophils
Pulikkot, S., Hu, L., Chen, Y., Sun, H., & Fan, Z. (2022) · Cells · doi:10.3390/cells11132025 · Cited by 21
Flexible Search for Single-Axon Morphology during Neuronal Spontaneous Polarization
Naoki, H., Nakamuta, S., Kaibuchi, K., & Ishii, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019034 · Cited by 20
The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases
Wang, N., Dhumale, P., Chiang, J., & Püschel, A. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-34092-5 · Cited by 18
Self-citation
Semaphorin3A accelerates neuronal polarity in vitro and in its absence the orientation of DRG neuronal polarity in vivo is distorted
Lerman, O., Ben‐Zvi, A., Yagil, Z., & Behar, O. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.07.003 · Cited by 19
Vasoactive Intestinal Peptide and PACAP38 Control N-Methyl-D-aspartic Acid-induced Dendrite Motility by Modifying the Activities of Rho GTPases and Phosphatidylinositol 3-Kinases
Henle, F., Fischer, C., Meyer, D., & Leemhuis, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604114200 · Cited by 19
Longest neurite‐specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI 3‐kinase
Nakamura, T., Yasuda, S., Nagai, H., Koinuma, S., Morishita, S., Goto, A., Kinashi, T., & Wada, N. (2013) · Genes to Cells · doi:10.1111/gtc.12097 · Cited by 18
Regulation of neuronal polarity
Lalli, G. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.07.033 · Cited by 21
Tumour cell dormancy as a contributor to the reduced survival of GBM patients who received standard therapy
Tong, L., Li, Y., Liu, P., Abeysekera, I. R., Hai, L., Li, T., Tao, Z., Ma, H., Xie, Y., Huang, Y., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6425 · Cited by 18
Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1(Mtss1) in normal and transformed cerebellar cells
Glassmann, A., Molly, S., Surchev, L., Nazwar, T. A., Holst, M., Hartmann, W., Baader, S. L., Oberdick, J., Pietsch, T., & Schilling, K. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-111 · Cited by 18
Rabs set the stage for polarity
Parker, S. S., Cox, C. M., & Wilson, J. M. (2018) · Small GTPases · doi:10.1080/21541248.2016.1277840 · Cited by 16
Septin functions during neuro-development, a yeast perspective
Falk, J., Boubakar, L., & Castellani, V. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.012 · Cited by 18
Metabolite 1 of Protopanaxadiol-Type Saponins, an Axonal Regenerative Factor, Stimulates Teneurin-2 Linked by PI3-Kinase Cascade
Tohda, C., Hashimoto, I., Kuboyama, T., & Komatsu, K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300943 · Cited by 18
Nup358 interacts with Dishevelled and aPKC to regulate neuronal polarity
Vyas, P., Singh, A. P., Murawala, P., & Joseph, J. (2013) · Biology Open · doi:10.1242/bio.20135363 · Cited by 17
Identification of molecular pathway changes after spinal cord injury by microarray analysis
Zhang, H., & Wang, Y. (2016) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-016-0437-3 · Cited by 17
Crosstalk of cell polarity signaling pathways
Mazel, T. (2017) · PROTOPLASMA · doi:10.1007/s00709-017-1075-2 · Cited by 18
A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis
Liu, Y., Lacal, J., Veltman, D. M., Fusetti, F., Haastert, P. J. M. V., Firtel, R., & Kortholt, A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.05.001 · Cited by 16
Functional impact of splice isoform diversity in individual cells
Yap, K., & Makeyev, E. V. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160103 · Cited by 19
Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation
Muñoz-LLancao, P., Gregorio, C. D., Heras, M. L., Meinohl, C., Noorman, K., Boddeke, E., Cheng, X., Lezoualc’h, F., Schmidt, M., & González-Billault, C. E. (2017) · Cytoskeleton · doi:10.1002/cm.21355 · Cited by 15
Computational Model Provides Insight into the Distinct Responses of Neurons to Chemical and Topographical Cues
Forciniti, L., Schmidt, C. E., & Zaman, M. H. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-008-9613-x · Cited by 15
Towards a mechanistic understanding of axon transport and endocytic changes underlying paclitaxel-induced peripheral neuropathy
Shin, G. J.-E. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114258 · Cited by 17
Protein kinase Mζ is involved in the modulatory effect of fluoxetine on hippocampal neurogenesis in vitro
Wang, Y. X., Zhang, X. R., Zhang, Z. J., Li, L., Xi, G. J., Wu, D., & Wang, Y. J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000364 · Cited by 14
Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway
Yeh, C., & Hsu, L. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9550-2 · Cited by 14
Synchronous Symmetry Breaking in Neurons with Different Neurite Counts
Wissner-Gross, Z. D., Skylar‐Scott, M. A., Steinmeyer, J. D., & Yanik, M. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054905 · Cited by 13
Micellar nanocomplexes for biomagnetic delivery of intracellular proteins to dictate axon formation during neuronal development
Suarato, G., Lee, S.-I., Li, W., Rao, S. B., Khan, T., Meng, Y., & Shelly, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.035 · Cited by 13
Crucial polarity regulators in axon specification
Lalli, G. (2012) · Essays in Biochemistry · doi:10.1042/bse0530055 · Cited by 13
Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium
El-Hashash, A. H. K., Turcatel, G., Varma, S., Alam, D. A., & Warburton, D. (2012) · Journal of Cell Science · doi:10.1242/jcs.102848 · Cited by 13
Retracted
Regulation of Rap GTPases in mammalian neurons
Shah, B., & Püschel, A. W. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0165 · Cited by 14
Self-citation
Overexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activation
Tisdale, E. J., Shisheva, A., & Artalejo, C. R. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.02.014 · Cited by 14
Neuronal Polarity: Until GSK-3 Do Us Part
Li, R. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.008 · Cited by 13
The regulatory landscape of neurite development in Caenorhabditis elegans
Godini, R., Fallahi, H., & Pocock, R. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.974208 · Cited by 12
Involvement of NFκB signaling in mediating the effects of GRK5 on neural stem cells
Zhang, Y., Guang-li, S., Shangguan, L., Yu, Y., & He, M. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.041 · Cited by 12
Aerobic Exercise Induces Alternative Splicing of Neurexins in Frontal Cortex
Innocenzi, E., Cariati, I., Domenico, E. D., Tiberi, E., D’Arcangelo, G., Verdile, V., Paronetto, M. P., Tancredi, V., Barchi, M., Rossi, P., et al. (2021) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk6020048 · Cited by 11
Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders
Akhtar, S. N., Bunner, W., Brennan, E., Lu, Q., & Szatmari, E. M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1084769 · Cited by 13
Rap1b but not Rap1a in the forebrain is required for learned fear
Chen, W., Pan, H., He, Y., Wang, X., Zhang, W., & Pan, B. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00469-1 · Cited by 12
Tuba Activates Cdc42 during Neuronal Polarization Downstream of the Small GTPase Rab8a
Urrutia, P. J., Bodaleo, F. J., Bórquez, D. A., Homma, Y., Rozés‐Salvador, V., Villablanca, C., Conde, C. B., Fukuda, M., & González-Billault, C. E. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0633-20.2020 · Cited by 13
Evaluation of BDE-47-induced neurodevelopmental toxicity in zebrafish embryos
Zhuang, J., Pan, Z., Qin, Y., Liang, H., Zhang, W., Sun, Z.-Y., & Shi, H.-B. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26170-7 · Cited by 13
Presynaptic protein Synaptotagmin1 regulates the neuronal polarity and axon differentiation in cultured hippocampal neurons
Inoue, Y., Kamikubo, Y., EZURE, H., Ito, J., Kato, Y., Moriyama, H., & Otsuka, N. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0231-x · Cited by 13
Rap GTPase-mediated adhesion and migration
Lin, K. B. L., Freeman, S. A., & Gold, M. R. (2010) · Cell Adhesion & Migration · doi:10.4161/cam.4.3.11114 · Cited by 12
Dicer is essential for neuronal polarity
Li, Z., He, X., & Feng, J. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.08.002 · Cited by 11
De novo missense variants in the RAP1B gene identified in two patients with syndromic thrombocytopenia
Niemann, J. H., Du, C., Morlot, S., Schmidt, G., Auber, B., Kaune, B., Göhring, G., Ripperger, T., Schlegelberger, B., Hofmann, W. A., et al. (2020) · Clinical Genetics · doi:10.1111/cge.13807 · Cited by 11
The cytoskeleton regulates symmetry transitions in moving amoeboid cells
Haastert, P. J. M. V., Keizer‐Gunnink, I., & Kortholt, A. (2018) · Journal of Cell Science · doi:10.1242/jcs.208892 · Cited by 10
Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons
Li, A., Zhu, H.-M., Chen, Y., Yan, F., Liu, Z., Li, Z.-L., Dong, W.-R., Zhang, L., & Wang, H. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01051-0 · Cited by 11
Calpain Activation by Wingless-type Murine Mammary Tumor Virus Integration Site Family, Member 5A (Wnt5a) Promotes Axonal Growth
Yang, G., Liang, B., Zhu, J. Y., & Luo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.196568 · Cited by 10
A Role for Second Messengers in Axodendritic Neuronal Polarity
Urrutia, P. J., & González-Billault, C. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.1065-19.2023 · Cited by 9
Perspectives on Mechanisms Supporting Neuronal Polarity From Small Animals to Humans
Wilson, C., Moyano, A. L., & Cáceres, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.878142 · Cited by 9
The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center
Wang, J. C., Lee, J. Y.-J., Dang-Lawson, M., Pritchard, C., & Gold, M. R. (2018) · Small GTPases · doi:10.1080/21541248.2018.1441626 · Cited by 9
Expression and functional characterization of a Rho-family small GTPase CDC42 from Trichinella spiralis
Yang, Y.-R., Qin, W., Tian, G.-M., & Jian, W. (2010) · Parasitology Research · doi:10.1007/s00436-010-1851-9 · Cited by 9
Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety
Pan, H., Liu, W.-Z., Yang, C., Jiang, S.-Y., Zhang, M.-X., Hu, P., Yang, H.-T., Wang, Y., Li, Y.-Q., Tu, J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adt3163 · Cited by 8
Expression of the guanine nucleotide exchange factor, RAPGEF5, during mouse and human embryogenesis
Alharatani, R., Griffin, J. N., & Liu, K. J. (2019) · Gene Expression Patterns · doi:10.1016/j.gep.2019.119057 · Cited by 8
Liver Kinase B1 Functions as a Regulator for Neural Development and a Therapeutic Target for Neural Repair
Huang, E., & Li, S. (2022) · Cells · doi:10.3390/cells11182861 · Cited by 8
Implication of Wnt signaling in neuronal polarization
Yang, G., & Luo, Z. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20851 · Cited by 8
Molecular cloning and phylogenetic analysis of small GTPase protein Tscdc42 from Trichinella spiralis
Yang, Y., Jian, W., & Qin, W. (2010) · Parasitology Research · doi:10.1007/s00436-010-1735-z · Cited by 8
Mechanisms of axon polarization in pyramidal neurons
Arikkath, J. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103522 · Cited by 11

Authors: Schwamborn, J. C., & Püschel, A. W.
Affiliations: University of Münster (DE)
Corresponding author: Püschel, Andreas W
ORCID: Schwamborn, Jens C
Püschel, Andreas W
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-08-01
Volume: 7
Issue: 9
Pages: 923-929
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1295
OpenAlex: W2059346427
Cited by: 385
References: 39
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 15 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 13 · 2013: 20 · 2012: 28
FWCI: 11.00
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: Rap1b, Cdc42, neuronal polarity, axon specification, GTPase, Par complex, phosphatidylinositol 3,4,5-trisphosphate, atypical PKC, hippocampal neurons, neuronal differentiation
MeSH terms: Animals, Animals, Newborn, Antibodies, Monoclonal, Axons, Carrier Proteins, Cells, Cultured, Dendrites, Embryo, Mammalian, Hippocampus, Immunohistochemistry, Luminescent Proteins, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, Phalloidine, Protein Kinase C, Proto-Oncogene Proteins, RNA, Messenger, Time Factors, Transfection, Cytochalasin D, Protein Serine-Threonine Kinases, Gene Transfer Techniques, Body Patterning, Reverse Transcriptase Polymerase Chain Reaction, GTP Phosphohydrolases, rap GTP-Binding Proteins, rhoA GTP-Binding Protein, cdc42 GTP-Binding Protein, RNA Interference, Green Fluorescent Proteins, Proto-Oncogene Proteins c-akt, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks