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Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Abstract
Dendritic arborization is required for proper neuronal connectivity. Rho GTPases have been implicated in the regulation of dendrite development. However, the signaling pathways that impinge on these molecular switches remain poorly understood. Here we show that Wnt7b, which is expressed in the mouse hippocampus, increases dendritic branching in cultured hippocampal neurons. This effect is mimicked by the expression of Dishevelled (Dvl) and is blocked by Sfrp1, a secreted Wnt antagonist. Consistent with these findings, hippocampal neurons from mice lacking Dvl1 show reduced dendritic arborization. Activation of the canonical Wnt-Gsk3beta pathway does not affect dendritic development. In contrast, Wnt7b and Dvl activate Rac and JNK in hippocampal neurons. Dominant-negative Rac, dominant-negative JNK or inhibition of JNK blocks Dvl-mediated dendritic growth. These findings demonstrate a new function for the non-canonical Wnt pathway in dendrite development and identify Dvl as a regulator of Rho GTPases and JNK during dendritic morphogenesis.
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“However, as clearly summarized by Kalkman (Kalkman, 2012), one must recognize the multiple roles of Wnt signaling, not only in cell adhesion and dendritic remodeling but also in early brain development (Rosso et al., 2005; Salinas and Zou, 2008; Ueda et al., 2008; Wayman et al., 2006; Yu and Malenka, 2003).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Rosso et al., 2005
Citations
Cites
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
Coso, O. A., Chiariello, M., Yu, J., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Gutkind, J. S. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,629
The JNK signal transduction pathway
Weston, C. R. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,551
Cell migration: Rho GTPases lead the way
Raftopoulou, M., & Hall, A. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.06.003 · Cited by 1,494
Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,481
RHO GTPASES in neuronal morphogenesis
Luo, L. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044547 · Cited by 985
Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842
GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
Meijer, L., Skaltsounis, A., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., Ryan, X. P., Vonica, A., Brivanlou, A. H., Dajani, R., et al. (2003) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.11.010 · Cited by 814
Nakayama, A. Y., Harms, M. B., & Luo, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05329.2000 · Cited by 708
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A founder variant expands the phenotype of WNT7B ‐related PDAC syndrome
AlAbdi, L., Rahbeeni, Z. A., Maddirevula, S., Helaby, R., Abdulwahab, F., Khan, A. O., Riley, L. G., Alhashem, A. M., Chassaing, N., Jamieson, R. V., et al. (2024) · Clinical Genetics · doi:10.1111/cge.14512 · Cited by 2
Wang, W., & Rui, M. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.06.010 · Cited by 2
Wnt Signaling in Neurite Development
Rosso, S. B., & Salinas, P. C. (2007) · Springer eBooks · doi:10.1007/978-0-387-68561-8_10 · Cited by 2
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Hale, C., Moulton, J. K., Otis, Y., & Ganter, G. K. (2022) · Molecular Pain · doi:10.1177/17448069221111155 · Cited by 3
“β-Catenin has furthermore been shown in mammalian hippocampal neurons to influence dendrite morphogenesis through its role in the cadherin-catenin complex, influencing actin cytoskeleton stabilization and cell-cell adhesion, a role separate from β-catenin’s role in the canonical Wnt signaling pathway.(96,97) Our findi…”
BackgroundIntroduction to β‐Catenin‐Independent Wnt Signaling Pathways
Kühl, S. J., & Kühl, M. (2014) · Wiley eBooks · doi:10.1002/9781118444122.ch6 · Cited by 2
A dendritic guidance receptor functions in both ligand dependent and independent modes
Reddy, A. R., Machera, S. J., Cook, Z. T., Deng, H., Nawrocka, W. I., Özkan, E., & Shen, K. (2025) · PLOS Genetics · doi:10.1371/journal.pgen.1011942 · Cited by 1
“Similar findings studying other ligand-receptor systems, such as Netrin/Frazzled and Wnt/Frizzled, supported a model in which cognate guidance receptors are activated by ligand binding, thereby triggering downstream intracellular effectors to regulate dendrite outgrowth [1,5].”
Zhang, S., Xiang, P., Suo, M., Yi, Z., Wei, Z., Li, J., Zeng, Y., & Chen, Y. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111710 · Cited by 1
Mehta, D., Paradkar, A., Rekhi, B., Nayak, P., Mohanty, B. S., Chaudhari, P., Gera, P. B., Rane, S. U., Chaturvedi, P., & Waghmare, S. K. (2026) · Nature Communications · doi:10.1038/s41467-026-71996-7 · Cited by 1
“Furthermore, the regulation of Wnt7b by Sfrp1 or Sfrp2 during early mouse embryogenesis 12 ; Wnt7b expressed in the mouse hippocampus activates the Dvl2, Rac , and Jnk in the neuronal hippocampus 38 .”
Wnt Pathway at a Glance: From the Deep of the Crypts to the Current Ways of Targeting
Barbáchano, A., Larriba, M. J., Ferrer‐Mayorga, G., Múñoz, A., & González‐Sancho, J. M. (2014) · Springer eBooks · doi:10.1007/978-94-017-8754-3_4 · Cited by 1
Cline, H. T., Ghosh, A., Jan, Y. N., & Sanes, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385870-2.00020-2 · Cited by 1
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Namjoo, E., Shekari, M., Pirouzi, A., Forouzandeh, H., Khalafkhany, D., Vahedi, A., & Ahmadi, I. (2020) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.11.1.1272.1 · Cited by 1
Salinas, P. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00006-5 · Cited by 1
Self-citationAnchesi, I., Betto, F., Chiricosta, L., Gugliandolo, A., Pollastro, F., Salamone, S., & Mazzon, E. (2023) · Plants · doi:10.3390/plants12010193 · Cited by 1
“It is also expressed at the level of dendritic growth cones, and it is crucial in dendrite formation and maturation [29].”
BackgroundDominicci-Cotto, C., Vázquez, M., & Marie, B. (2024) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2024.1322771 · Cited by 1
“…has been widely used to easily identify ghost boutons at the NMJ, in order to quantify ADSP (Ataman et al., 2008; Fuentes-Medel et al., 2009; Freeman et al., 2011; Nesler et al., 2013, 2016; Piccioli and Littleton, 2014; Vasin et al., 2014, 2019; Alicea et al., 2017; Maldonado-Díaz et al., 2021).”
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Domínguez-Berzosa, L., Cantarero, L., Rodríguez-Sanz, M., Tort, G., Garrido, E., Troya-Balseca, J., Sáez, M., Castro-Martínez, X. H., Fernández‐Lizarbe, S., Urquizu, E., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910705 · Cited by 1
“Moreover, Wnt pathways are involved in ventral midbrain neurogenesis and dopaminergic axon morphogenesis during development [58–60] and also in adult neurogenesis [61–63].”
BackgroundWnt7b Promotes Axon Differentiation and Extension by Regulating JNK-Mediated Cytoskeletal Dynamics
Neila, L. P., Luna, S., Vena, R., & Rosso, S. B. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04540-6 · Cited by 1
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InfluentialSelf-citationSalinas, P. C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00106-x · Cited by 1
Self-citationMcLaurin, K. A., Li, H., Mactutus, C. F., & Booze, R. M. (2023) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0008 · Cited by 1
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Jati, S. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.51.008045
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Singh, A. P., Rodrigues, V., & VijayRaghavan, K. (2010) · Wiley eBooks · doi:10.1002/9780470015902.a0021850 · Cited by 1
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Peradziryi, H. (2011) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3158 · Cited by 1
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Halleskog, C. (2013) · Cited by 1
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Tabet, A., Rolland, T., Ducloy, M., Lévy, J., Buratti, J., Mathieu, A., Haye, D., Perrin, L., Dupont, C., Passemard, S., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/117978 · Cited by 1
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BackgroundYasumura, M., Hagiwara, A., Hida, Y., & Ohtsuka, T. (2021) · Research Square · doi:10.21203/rs.3.rs-145755/v1 · Cited by 1
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BackgroundDas, S. C., Das, S., & Maiti, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.09.681388 · Cited by 1
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Anane, D. (2012) · UCL Discovery (University College London)
Halleskog, C. (2013) · Figshare
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Kague, É. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2009.tde-28102009-144108
Ataman, B. (2008) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/87fw-ke54
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BackgroundStructural plasticity of synaptic connectivity in the adult central nervous system
Galimberti, I. (2008) · edoc (University of Basel) · doi:10.5451/unibas-004493278
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Izzi, L., & Charron, F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00134-4
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Rawal, N. (2006) · Figshare
EARLY FUNCTION OF KCC2 AND WNT GENES
Horn, Z. (2008) · Figshare
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Sadhu, A. (2006) · edoc (University of Basel) · doi:10.5451/unibas-003850369
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Čajánek, L. (2011) · Figshare
David, M. D. (2009) · Repositori ObertUDL (University of Lleida)
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Andersson, E. R. (2009) · Figshare
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Miquelajáuregui, A. (2006) · doi:10.53846/goediss-3294
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Bunn, K. J. (2015) · Otago University Research Archive (University of Otago)
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Hayden, L. (2012) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/16591
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Gilman, S. R. (2013) · doi:10.7916/d8k9370f
“Another signaling pathway, the WNT pathway, plays a crucial role in diverse processes associated with formation of neural circuits [26], and is known to be directly involved in the regulation of dendrite morphogenesis [27, 28].”
BackgroundShah, S. (2010) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
EARLY FUNCTION OF KCC2 AND WNT GENES
Horn, Z. (2008)
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Walla, D. A. (2014) · Scholars' Bank (University of Oregon)
The role of adenylyl cyclase signaling pathways in developmental dendritogenesis in vivo
Duncan, B. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072699
Simó, S., & Cooper, J. A. (2012)
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Zhen, M. (2007) · Elsevier eBooks · doi:10.1016/b978-012369437-9/50008-6
Allen, M. (2017) · DigitalGeorgetown (Georgetown University Library)
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Park, K. (2011) · TSpace (University of Toronto)
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Hegazy, S. A. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r33439
Shimell, J. J. (2019) · cIRcle (University of British Columbia) · doi:10.14288/1.0384822
Girardi, R. M. D. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2021.tde-20052021-111343
Cunningham, J. G. (2020) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.7739
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Roker, L. A. (2016) · doi:10.18130/v3cg5f
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Maurer, S. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.65941
Actin Reorganisation in Nerve Morphogenesis
Singh, A. P., Rodrigues, V., & VijayRaghavan, K. (2015) · Wiley eBooks · doi:10.1002/9780470015902.a0021850.pub2
Konopka, G. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717948964.793454068
WNT genes and their roles in traumatic brain injury
Liang, M.-Z., Chang, C.-Y., & Chen, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823036-7.00033-5
Gong, M., Li, J., Liu, Y., Wilke, M. V. M. B., Li, Q., Liu, H., Chen, L., Morales‐Rosado, J. A., Cohen, A. S. A., Hughes, S. S., et al. (2024) · medRxiv · doi:10.1101/2024.04.24.24304501
Development of the Hippocampal Formation
Lavenex, P., Amaral, D. G., Lavenex, P. B., Guillemot, F., Insausti, R., & Urbán, N. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0004
Sowers, L. P., Russo, A. F., Bassuk, A. G., Wemmie, J. A., Gonzalez, P., & Bonthius, D. (2012) · doi:10.17077/etd.ks0p5kv0
Flamingo/Starry Night in embryonic abdominal sensory axon development of Drosophila
Steinel, M. C. (2008) · Minerva Access (University of Melbourne)
Wnt7b Modulates Axon Differentiation and Extension via JNK-Mediated Cytoskeleton DynamicsPreprint
Neila, L. P., Luna, S., Vena, R., & Rosso, S. B. (2024) · Research Square · doi:10.21203/rs.3.rs-4451782/v1
Self-citationLiu, C., Liu, Y., Zhu, J., xiao, T., Xu, M., Duan, J., & Chen, J. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150207
The involvement of AHR in peripehral myelination and nerve sheath tumorigenesis
Sampathkumar, N. K. (2018) · theses.fr (ABES) · doi:10.70675/2a3c9c86z51bez4349z9226z1b32c0210df5
The Scrib1 Interactome and its relevance for synaptic plasticity & neurodevelopmental disorders
Pinheiro, V. L. M. (2014) · theses.fr (ABES) · doi:10.70675/b1c2e418zac9cz44c5zb050z72f9b6a47586
Korkut, C. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/vqef-8314
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BackgroundWnt11-Signaling Regulates Cardiac and Neural Crest Development
Garriock, R. J. (2006) · UA Campus Repository (The University of Arizona)
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Kremer, D., Hartung, H., Stangel, M., & Küry, P. (2015) · Der Nervenarzt · doi:10.1007/s00115-014-4249-6
The Role of Omega-3 Fatty Acids in Hippocampal Neurogenesis
Dyall, S. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410527-0.00021-1
Metadata
- Authors
- Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C.
- Affiliations
- University of London (GB)
- University of Maryland, Baltimore (US)
- University of California San Diego (US)
- Corresponding author
- Salinas, Patricia C
- Venue
- Nature Neuroscience
- Published
- 2004-12-19
- Volume
- 8
- Issue
- 1
- Pages
- 34-42
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2087203385
- Cited by
- 485
- References
- 50
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 21 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 14 · 2018: 23 · 2017: 18 · 2016: 19 · 2015: 27 · 2014: 29 · 2013: 32 · 2012: 43
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institute of Neurological Disorders and Stroke (R01NS073159)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Wnt signaling, Dishevelled, dendritic branching, Wnt7b, SFRP1, non-canonical Wnt pathway, Rac, JNK, Rho GTPases, hippocampal neurons, dendrite morphogenesis, Wnt antagonists
- MeSH terms
- Dishevelled Proteins, Acute-Phase Proteins, Animals, Cells, Cultured, Cytoskeleton, Dendrites, Embryo, Mammalian, Glycoproteins, Hippocampus, Mutation, Neurons, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Tissue Distribution, Signal Transduction, Protein Structure, Tertiary, rac GTP-Binding Proteins, Intercellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Wnt Proteins, Mice
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