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Pathological gambling is linked to reduced activation of the mesolimbic reward system
Abstract
By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.
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“A brain imaging study also showed that patients with both substance and behavioral disorders demonstrated the same involvement of dopaminergic and mesolimbic pathways from the ventral tegmental area to the NAcc.²³”
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Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
Temporal difference models and reward-related learning in the human brain
O'Doherty, J. P., Dayan, P., Friston, K., Critchley, H., & Dolan, R. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00169-7 · Cited by 1,522
Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum
Delgado, M. R., Nystrom, L. E., Fissell, C., Noll, D. C., & Fiez, J. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.3072 · Cited by 1,116
Rogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101
Temporal Prediction Errors in a Passive Learning Task Activate Human Striatum
McClure, S. M., Berns, G. S., & Montague, P. R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00154-5 · Cited by 917
Stochastic Designs in Event-Related fMRI
Friston, K. J., Zarahn, E., Josephs, O., Henson, R. N., & Dale, A. M. (1999) · NeuroImage · doi:10.1006/nimg.1999.0498 · Cited by 634
Drug addiction: bad habits add up
Robbins, T. W., & Everitt, B. J. (1999) · Nature · doi:10.1038/19208 · Cited by 599
Volkow, N. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4099 · Cited by 514
Risky Business: Emotion, Decision-Making, and Addiction
Bechara, A. (2003) · Journal of Gambling Studies · doi:10.1023/a:1021223113233 · Cited by 495
Blum, K. (2017) · Sage eBooks · doi:10.4135/9781483365817.n1156 · Cited by 474
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- Blum, K., Cull, J.C., Braverman, E.R. & Comings, D.E. Am. Sci. 84, 132–145 (1996).
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de Oliveira, M. P. M. T., da Silveira, D. X., & Silva, M. T. A. (2008) · Revista de Saúde Pública · doi:10.1590/s0034-89102008000300022 · Cited by 1
Kwak, M. J., Choi, S. J., Cai, W. T., Cho, B. R., Han, J., Park, J. W., Riecken, L. B., Morrison, H., Choi, S.-Y., Kim, W. Y., et al. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102681 · Cited by 2
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Rademacher, L., Spreckelmeyer, K. N., Krach, S., Gründer, G., & Einleitung, Ñ. (2010) · RWTH Publications (RWTH Aachen) · Cited by 1
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Harrow, S.-E. (2009) · UC Research Repository (University of Canterbury) · doi:10.26021/3736 · Cited by 1
Figee, M. (2013) · Data Archiving and Networked Services (DANS) · Cited by 1
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Steinberg, L. (2010) · TSpace (University of Toronto) · Cited by 1
Papp, F. W. (2006) · SSRN Electronic Journal · Cited by 1
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Mathewson, S. A. (2010) · TSpace (University of Toronto) · Cited by 1
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Abbott, M., Binde, P., Clark, L., Hodgins, D. C., Johnson, M., Manitowabi, D., Quilty, L. C., Spångberg, J., Volberg, R. A., Walker, D., et al. (2018) · doi:10.33684/cfhg3.fr · Cited by 1
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Znoj, H., Herpertz, S. C., & Mundt, C. (2008) · Elsevier eBooks · doi:10.1016/b978-343723730-0.50012-4 · Cited by 1
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West, B. L. (2008) · Open ULeth Scholarship (OPUS) (University of Lethbridge) · Cited by 1
Ochoa, C. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Bullock, S. A., & Potenza, M. N. (2015) · Wiley eBooks · doi:10.1002/9781118625392.wbecp288
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Nikolas, M. A., & Hopwood, C. J. (2013) · Wiley eBooks · doi:10.1002/9781118316078.ch6
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Steeves, T. D. L., Miyasaki, J. M., Lang, A. E., & Strafella, A. P. (2011) · Parkinson s Disease · doi:10.1002/9781444397970.ch20
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de Oliveira, M. P. M. T. (2006) · doi:10.11606/t.47.2006.tde-28022008-220447
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Gospic, K. A. M. (2011) · Figshare
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Christie, G. J. (2010) · Open ULeth Scholarship (OPUS) (University of Lethbridge)
Ginty, A. T. (2012) · University of Birmingham Institutional Research Archive (University of Birmingham)
Lobo, D. S. S. (2005) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2005.tde-02092005-150159
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Reimann, M. (2013) · The business & management collection. · doi:10.69645/awjb8903
Fearnley, D. E. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.095968
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Balodis, I., & Potenza, M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_29
Albein‐Urios, N. (2013) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
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Paulo, S. (2006)
Aulakh, H. (2010) · eScholarship@McGill (McGill) · doi:10.82308/54314
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Oscar‐Berman, M., Blum, K., & Gold, M. S. (2012)
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Brocas, I., & Carrillo, J. D. (2014)
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Brunborg, G. S. (2011) · NORA - Norwegian Open Research Archives
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Ledgerwood, D. M., & Petry, N. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-097086-8.21007-6
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Mannheim, G., & Mannheim, S. G. (2010)
Quester, S. (2014) · edoc Publication server (Humboldt University of Berlin) · doi:10.18452/17084
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Nikolaidou, M. (2015) · The University of Bath Online Publications Store (The University of Bath)
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Biback, C. (2015) · TSpace (University of Toronto)
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Metadata
- Authors
- Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C.
- Affiliations
- Universität Hamburg (DE)
- Corresponding author
- Büchel, Christian
- Venue
- Nature Neuroscience
- Published
- 2005-01-09
- Volume
- 8
- Issue
- 2
- Pages
- 147-148
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1991448902
- Semantic Scholar
- 269d7b547795b9876a5cf1eef441c7b241d7e46d
- Cited by
- 734
- References
- 15
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 64 · 2019: 30 · 2018: 27 · 2017: 28 · 2016: 26 · 2015: 30 · 2014: 72 · 2013: 63 · 2012: 59
- FWCI
- 33.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- gambling addiction, mesolimbic reward system, ventral striatum, ventromedial prefrontal cortex, reward sensitivity, gambling severity, guessing games, functional MRI
- MeSH terms
- Adult, Brain Mapping, Gambling, Humans, Functional Laterality, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Psychiatric Status Rating Scales, Regression Analysis, Reward, Risk-Taking, Case-Control Studies, Behavior, Addictive, Prefrontal Cortex
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