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Pathological gambling is linked to reduced activation of the mesolimbic reward system
Abstract
By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.
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“A brain imaging study also showed that patients with both substance and behavioral disorders demonstrated the same involvement of dopaminergic and mesolimbic pathways from the ventral tegmental area to the NAcc.²³”
From Cybersex addiction: An overview of the development and treatment of a newly emerging disorder (2020) · cites this paper as [23]
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Metadata
- Authors
- Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C.
- Affiliations
- Universität Hamburg (DE)
- Corresponding author
- Büchel, Christian
- Venue
- Nature Neuroscience
- Published
- 2005-01-09
- Volume
- 8
- Issue
- 2
- Pages
- 147-148
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1991448902
- Semantic Scholar
- 269d7b547795b9876a5cf1eef441c7b241d7e46d
- Cited by
- 734
- References
- 15
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 64 · 2019: 30 · 2018: 27 · 2017: 28 · 2016: 26 · 2015: 30 · 2014: 72 · 2013: 63 · 2012: 59
- FWCI
- 33.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- gambling addiction, mesolimbic reward system, ventral striatum, ventromedial prefrontal cortex, reward sensitivity, gambling severity, guessing games, functional MRI
- MeSH terms
- Adult, Brain Mapping, Gambling, Humans, Functional Laterality, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Psychiatric Status Rating Scales, Regression Analysis, Reward, Risk-Taking, Case-Control Studies, Behavior, Addictive, Prefrontal Cortex
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