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Cited by 221Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

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Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons

Hartman, Kenichi N, Pal, Sumon K, Burrone, Juan, Murthy, Venkatesh N·2006·Nature Neuroscience
DOI 10.1038/nn1677
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Abstract

Neural activity regulates the number and properties of GABAergic synapses in the brain, but the mechanisms underlying these changes are unclear. We found that blocking spike activity globally in developing hippocampal neurons from rats reduced the density of GABAergic terminals as well as the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs). Chronic inactivity later in development led to a reduction in the mIPSC amplitude, without any change in GABAergic synapse density. By contrast, hyperpolarizing or abolishing spike activity in single neurons did not alter GABAergic synaptic inputs. Suppressing activity in individual presynaptic GABAergic neurons also failed to decrease synaptic output. Our results indicate that GABAergic synapses are regulated by the level of activity in surrounding neurons. Notably, we found that the expression of GABAergic plasticity involves changes in the amount of neurotransmitter in individual vesicles.

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Metadata

Authors
Hartman, K. N., Pal, S. K., Burrone, J., & Murthy, V. N.
Affiliations
Harvard University (US)
Corresponding author
Murthy, Venkatesh N
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2006-04-02
Volume
9
Issue
5
Pages
642-649
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn1677
OpenAlex
W2156087438
Cited by
221
References
0
Citations by year
2026: 3 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 12 · 2013: 25 · 2012: 11
FWCI
5.53
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
activity-dependent synaptic plasticity, GABAergic synapses, synaptic inhibition, miniature inhibitory postsynaptic currents, hippocampal neurons, synaptic density, presynaptic inhibition, neuronal activity regulation
MeSH terms
Animals, Animals, Newborn, Carrier Proteins, Cells, Cultured, Drug Interactions, Electric Stimulation, Glutamate Decarboxylase, Hippocampus, Isoenzymes, Membrane Potentials, Membrane Proteins, Microtubule-Associated Proteins, Neural Inhibition, Synaptic Transmission, Neurons, Phosphinic Acids, Pyridines, Tetrodotoxin, Transfection, Patch-Clamp Techniques, Potassium Channels, Inwardly Rectifying, Vesicular Glutamate Transport Protein 1, Rats

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