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Cited by 302Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionIon channel regulation and function

Maintaining the Stability of Neural Function: A Homeostatic Hypothesis

Davis, Graeme W, Bezprozvanny, Ilya·2001·Annual Review of Physiology
DOI 10.1146/annurev.physiol.63.1.847
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Abstract

The precise regulation of neural excitability is essential for proper nerve cell, neural circuit, and nervous system function. During postembryonic development and throughout life, neurons are challenged with perturbations that can alter excitability, including changes in cell size, innervation, and synaptic input. Numerous experiments demonstrate that neurons are able to compensate for these types of perturbation and maintain appropriate levels of excitation. The mechanisms of compensation are diverse, including regulated changes to synaptic size, synaptic strength, and ion channel function in the plasma membrane. These data are evidence for homeostatic regulatory systems that control neural excitability. A model of neural homeostasis suggests that information about cell activity, cell size, and innervation is fed into a system of cellular monitors. Intracellular- and intercellular-signaling systems transduce this information into regulated changes in synaptic and ion channel function. This review discusses evidence for such a model of homeostatic regulation in the nervous system.

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Crossref · 10.1146/annurev.physiol.63.1.847

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3 of 3 references verified0 citation errors · 0 not checkable

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  • Perturbations in postsynaptic function can lead to compensatory changes in presynaptic release, and vice versa, at mammalian and invertebrate NMJ.

    “More recently work at the mammalian and invertebrate NMJ has shown that perturbations in postsynaptic function can lead to compensatory changes in presynaptic release, and vice versa (Davis and Bezprozvanny 2001).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Davis and Bezprozvanny 2001

  • Some forms of homeostatic plasticity occur through presynaptic and others through postsynaptic changes in function.

    “Similarly, some forms of homeostatic plasticity occur through presynaptic and others through postsynaptic changes in function (Davis and Bezprozvanny 2001).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Davis and Bezprozvanny 2001

  • Under some circumstances, additional presynaptic changes can be recruited during synaptic scaling.

    “It is widely agreed that synaptic scaling involves postsynaptic changes in receptor accumulation (Turrigiano 2008), but under some circumstances additional presynaptic changes can also be recruited (Davis and Bezprozvanny 2001;Rich and Wenner 2007;Thiagarajan et al. 2007).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Davis and Bezprozvanny 2001

  • The presence of normal EPSPs despite smaller mEPSPs can likely be attributed to a homeostatic increase in quantal content.

    “The presence of normal EPSPs despite smaller mEPSPs can likely be attributed to a homeostatic increase in quantal content (Davis and Bezprozvanny, 2001;Heckscher et al, 2007).”

    From Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst (2013) · cites this paper as Davis and Bezprozvanny, 2001

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Authors
Davis, G. W., & Bezprozvanny, I.
Affiliations
  • University of California, San Francisco (US)
  • Department of Biochemistry, University of California, San Francisco, San Francisco, California 94143-0448;
ORCID
Davis, Graeme W
Venue
Annual Review of Physiology
Publisher
Annual Reviews
Published
2001-03
Volume
63
Issue
1
Pages
847-869
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
DOI
10.1146/annurev.physiol.63.1.847
OpenAlex
W2168028420
Cited by
302
References
3
Citations by year
2026: 5 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 14 · 2016: 7 · 2015: 11 · 2014: 5 · 2013: 17 · 2012: 13
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS39552, R01NS039313, R01NS039552, NS39313-01)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
neuronal homeostasis, neuronal excitability, homeostatic regulation, synaptic plasticity, synaptic efficacy, ion channel modulation, neuron size, innervation, postembryonic development, intracellular signaling, intercellular communication, neural circuit function
MeSH terms
Animals, Homeostasis, Neuronal Plasticity, Neurons, Synapses

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