Cited by 407Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionIon channel regulation and function

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Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.

Nevian, Thomas, Larkum, Matthew E, Polsky, Alon, Schiller, Jackie·2007·Nature Neuroscience

DOI 10.1038/nn1826

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Abstract

Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties of these cells. Despite the short physical length of rat basal dendrites, synaptic inputs were electrotonically remote from the soma (>30-fold excitatory postsynaptic potential (EPSP) attenuation) and back-propagating action potentials were significantly attenuated. Unitary EPSPs were location dependent, reaching large amplitudes distally (>8 mV), yet their somatic contribution was relatively location independent. Basal dendrites support sodium and NMDA spikes, but not calcium spikes, for 75% of their length. This suggests that basal dendrites, despite their proximity to the site of action potential initiation, do not form a single basal-somatic region but rather should be considered as a separate integrative compartment favoring two integration modes: subthreshold, location-independent summation versus local amplification of incoming spatiotemporally clustered information.

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Authors: Nevian, T., Larkum, M. E., Polsky, A., & Schiller, J.
Affiliations: University of Bern (CH)
Technion – Israel Institute of Technology (IL)
Corresponding author: Schiller, Jackie
ORCID: Nevian, Thomas
Larkum, Matthew E
Schiller, Jackie
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-01-07
Volume: 10
Issue: 2
Pages: 206-214
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1826
OpenAlex: W1987510656
Semantic Scholar: bfeb20cb0d72accc4a3cd0a4d3bd61965d3724d3
Cited by: 406
References: 50
Citations by year: 2026: 11 · 2025: 11 · 2024: 20 · 2023: 14 · 2022: 14 · 2021: 22 · 2020: 20 · 2019: 19 · 2018: 13 · 2017: 25 · 2016: 17 · 2015: 24 · 2014: 24 · 2013: 29 · 2012: 25
FWCI: 12.15
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Bern Open Repository and Information System (University of Bern) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: basal dendrites, layer 5 pyramidal neurons, neocortex, dendritic integration, excitatory postsynaptic potentials, backpropagating action potentials, sodium spikes, calcium spikes, dendritic compartmentalization
MeSH terms: Action Potentials, Animals, Cell Membrane, Cerebral Cortex, Dendrites, Membrane Potentials, Synaptic Transmission, Organ Culture Techniques, Sodium, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Dendritic Spines, Rats

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Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.

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