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Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.
Abstract
Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties of these cells. Despite the short physical length of rat basal dendrites, synaptic inputs were electrotonically remote from the soma (>30-fold excitatory postsynaptic potential (EPSP) attenuation) and back-propagating action potentials were significantly attenuated. Unitary EPSPs were location dependent, reaching large amplitudes distally (>8 mV), yet their somatic contribution was relatively location independent. Basal dendrites support sodium and NMDA spikes, but not calcium spikes, for 75% of their length. This suggests that basal dendrites, despite their proximity to the site of action potential initiation, do not form a single basal-somatic region but rather should be considered as a separate integrative compartment favoring two integration modes: subthreshold, location-independent summation versus local amplification of incoming spatiotemporally clustered information.
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“While spine density provides an approximate estimate of the total number of excitatory synapses onto the postsynaptic neuron, the location of a spine influences the contribution of its synaptically transmitted electrical and chemical signals to the integrated response at the soma (Nevian et al., 2007; Spruston, 2008).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Nevian et al., 2007
In the citing paper
“While spine density provides an approximate estimate of the total number of excitatory synapses onto the postsynaptic neuron, the location of a spine influences the contribution of its synaptically transmitted electrical and chemical signals to the integrated response at the soma (Nevian et al., 2007; Spruston, 2008).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Nevian et al., 2007
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Schiess, M., Urbanczik, R., & Senn, W. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004638 · Cited by 75
Dembrow, N. C., Zemelman, B. V., & Johnston, D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4673-14.2015 · Cited by 80
Metadata
- Authors
- Nevian, T., Larkum, M. E., Polsky, A., & Schiller, J.
- Affiliations
- University of Bern (CH)
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Schiller, Jackie
- Venue
- Nature Neuroscience
- Published
- 2007-01-07
- Volume
- 10
- Issue
- 2
- Pages
- 206-214
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1987510656
- Semantic Scholar
- bfeb20cb0d72accc4a3cd0a4d3bd61965d3724d3
- Cited by
- 406
- References
- 50
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 20 · 2023: 14 · 2022: 14 · 2021: 22 · 2020: 20 · 2019: 19 · 2018: 13 · 2017: 25 · 2016: 17 · 2015: 24 · 2014: 24 · 2013: 29 · 2012: 25
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- basal dendrites, layer 5 pyramidal neurons, neocortex, dendritic integration, excitatory postsynaptic potentials, backpropagating action potentials, sodium spikes, calcium spikes, dendritic compartmentalization
- MeSH terms
- Action Potentials, Animals, Cell Membrane, Cerebral Cortex, Dendrites, Membrane Potentials, Synaptic Transmission, Organ Culture Techniques, Sodium, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Dendritic Spines, Rats
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