The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
Open accessAbstract
Fragile X syndrome (FXS) results from the loss of the fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates a variety of cytoplasmic mRNAs. FMRP regulates mRNA translation and may be important in mRNA localization to dendrites. We report a third cytoplasmic regulatory function for FMRP: control of mRNA stability. In mice, we found that FMRP binds, in vivo, the mRNA encoding PSD-95, a key molecule that regulates neuronal synaptic signaling and learning. This interaction occurs through the 3′ untranslated region of the PSD-95 (also known as Dlg4) mRNA, increasing message stability. Moreover, stabilization is further increased by mGluR activation. Although we also found that the PSD-95 mRNA is synaptically localized in vivo, localization occurs independently of FMRP. Through our functional analysis of this FMRP target we provide evidence that dysregulation of mRNA stability may contribute to the cognitive impairments in individuals with FXS.
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Cites
Genome-wide atlas of gene expression in the adult mouse brain
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Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
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Self-citationPostsynaptic signaling and plasticity mechanisms
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From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
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Self-citationThe fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
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Cited by
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
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Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
Yoshii, A., & Constantine‐Paton, M. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20765 · Cited by 744
The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., De Rubeis, S., Di Marino, D., Mohr, E., Massimi, M., Falconi, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.031 · Cited by 609
Self-citationGao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516
Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective
Santoro, M. R., Bray, S. M., & Warren, S. T. (2012) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132457 · Cited by 528
Metadata
- Authors
- Zalfa, F., Eleuteri, B., Dickson, K. S., Mercaldo, V., De Rubeis, S., di Penta, A., Tabolacci, E., Chiurazzi, P., Neri, G., Grant, S. G. N., & Bagni, C.
- Venue
- Nature Neuroscience
- Published
- 2007-04-08
- Volume
- 10
- Issue
- 5
- Pages
- 578-587
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2134063049
- Cited by
- 364
- References
- 14
- FWCI
- 14.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zalfa, F., Eleuteri, B., Dickson, K. S., Mercaldo, V., De Rubeis, S., di Penta, A., Tabolacci, E., Chiurazzi, P., Neri, G., Grant, S. G. N., & Bagni, C. (2007). A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nature Neuroscience. https://doi.org/10.1038/nn1893
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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