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Cited by 444

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Increased structural connectivity in grapheme-color synesthesia

Rouw, Romke, Scholte, H Steven·2007·Nature Neuroscience

Abstract

Diffusion tensor imaging allowed us to validate for the first time the hypothesis that hyperconnectivity causes the added sensations in synesthesia. Grapheme-color synesthetes (n = 18), who experience specific colors with particular letters or numbers (for example, 'R is sky blue'), showed greater anisotropic diffusion compared with matched controls. Greater anisotropic diffusion indicates more coherent white matter. Anisotropy furthermore differentiated subtypes of grapheme-color synesthesia. Greater connectivity in the inferior temporal cortex was particularly strong for synesthetes who see synesthetic color in the outside world ('projectors') as compared with synesthetes who see the color in their 'mind's eye' only ('associators'). In contrast, greater connectivity (as compared with non-synesthetes) in the superior parietal or frontal cortex did not differentiate between subtypes of synesthesia. In conclusion, we found evidence that increased structural connectivity is associated with the presence of grapheme-color synesthesia, and has a role in the subjective nature of synesthetic color experience.

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Metadata

Authors
Rouw, R., & Scholte, H. S.
Venue
Nature Neuroscience
Published
2007-05-21
Volume
10
Issue
6
Pages
792-797
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2012648954
Cited by
444
References
44
FWCI
32.54
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Increased structural connectivity in grapheme-color synesthesia. https://app.cochat.ai/papers/10.1038/nn1906
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Rouw, R., & Scholte, H. S. (2007). Increased structural connectivity in grapheme-color synesthesia. Nature Neuroscience. https://doi.org/10.1038/nn1906

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